Standout Papers
Citation Impact
Citing Papers
Sym004: A Novel Synergistic Anti–Epidermal Growth Factor Receptor Antibody Mixture with Superior Anticancer Efficacy
2010
CTLA-4 Control over Foxp3 + Regulatory T Cell Function
2008 StandoutScienceNobel
Protein interaction networks revealed by proteome coevolution
2019 StandoutScienceNobel
Targeting Cytokine Therapy to the Pancreatic Tumor Microenvironment Using PD-L1–Specific VHHs
2018
Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection
2005
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
A sex-biased imbalance between Tfr, Tph, and atypical B cells determines antibody responses in COVID-19 patients
2023 StandoutNobel
Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression
2013 StandoutNobel
Role of STAT3 in CD4+CD25+FOXP3+ Regulatory Lymphocyte Generation: Implications in Graft-versus-Host Disease and Antitumor Immunity
2007
Frequent PTEN genomic alterations and activated phosphatidylinositol 3-kinase pathway in basal-like breast cancer cells
2008
The challenges and molecular approaches surrounding interleukin-2-based therapeutics in cancer
2018
Hierarchical design of pseudosymmetric protein nanocages
2024 StandoutNatureNobel
Resistance to small molecule inhibitors of epidermal growth factor receptor in malignant gliomas.
2003
Computational design of soluble and functional membrane protein analogues
2024 StandoutNatureNobel
A next-generation tumor-targeting IL-2 preferentially promotes tumor-infiltrating CD8+ T-cell response and effective tumor control
2019
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
De Novo Design of a Highly Stable Ovoid TIM Barrel: Unlocking Pocket Shape towards Functional Design
2022
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy
2022 StandoutNobel
The Histone Methyltransferase Ezh2 Controls Mechanisms of Adaptive Resistance to Tumor Immunotherapy
2017
Triple-Negative Breast Cancer
2010 Standout
Elements of cancer immunity and the cancer–immune set point
2017 StandoutNature
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
Approaches to treat immune hot, altered and cold tumours with combination immunotherapies
2019 Standout
Calmodulin-mediated Activation of Akt Regulates Survival of c-Myc-overexpressing Mouse Mammary Carcinoma Cells
2004
Dishevelled Promotes Wnt Receptor Degradation through Recruitment of ZNRF3/RNF43 E3 Ubiquitin Ligases
2015
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
2007 StandoutNatureNobel
Radiotherapy plus Cetuximab for Squamous-Cell Carcinoma of the Head and Neck
2006 Standout
The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength
2014
Egr-2 and Egr-3 are negative regulators of T cell activation
2005
The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases
2015
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
Multifarious Determinants of Cytokine Receptor Signaling Specificity
2014
A Key Role of Leptin in the Control of Regulatory T Cell Proliferation
2007
Type I interferons in infectious disease
2015 Standout
An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor
2006
Epidermal growth factor receptor: mechanisms of activation and signalling
2003
Interleukin-2 Activity Can Be Fine Tuned with Engineered Receptor Signaling Clamps
2015
Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection
2017
CXCR3 expression in regulatory T cells drives interactions with type I dendritic cells in tumors to restrict CD8+ T cell antitumor immunity
2023
Human nutrition, the gut microbiome and the immune system
2011 StandoutNature
Macrophage Diversity Enhances Tumor Progression and Metastasis
2010 Standout
Engineering interferons and interleukins for cancer immunotherapy
2022
Design of biologically active binary protein 2D materials
2021 StandoutNatureNobel
Selective tyrosine kinase inhibition by imatinib mesylate for the treatment of autoimmune arthritis
2006
Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization
2012 StandoutNobel
Immunity, Inflammation, and Cancer
2010 Standout
Programmable synthetic receptors: the next-generation of cell and gene therapies
2024
The advent of de novo proteins for cancer immunotherapy
2020
The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity
2017 StandoutNobel
Induction of T cell anergy: integration of environmental cues and infectious tolerance
2010
Role of IL-2 in cancer immunotherapy
2016
Modulation of EZH2 expression in T cells improves efficacy of anti–CTLA-4 therapy
2018 StandoutNobel
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
2011 StandoutNobel
Cytokines in Cancer Immunotherapy
2017
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
Quantum dot ligands provide new insights into erbB/HER receptor–mediated signal transduction
2004
Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA
2005 StandoutNobel
Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment
2006
Immune escape to PD-L1/PD-1 blockade: seven steps to success (or failure)
2016
Cancer-related inflammation
2008 StandoutNature
Chapter 5 Emergence of the Th17 Pathway and Its Role in Host Defense
2008
TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function
2008 StandoutNature
Transcriptional Regulation by Foxp3 Is Associated with Direct Promoter Occupancy and Modulation of Histone Acetylation
2006
FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT
2006
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
2017 Standout
Engineered IL-21 Cytokine Muteins Fused to Anti-PD-1 Antibodies Can Improve CD8+ T Cell Function and Anti-tumor Immunity
2020
Treg cell-based therapies: challenges and perspectives
2019
Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib
2004 Standout
Modular design of synthetic receptors for programmed gene regulation in cell therapies
2022
Atezolizumab for First-Line Treatment of Metastatic Nonsquamous NSCLC
2018 Standout
Establishment of NOD-Pdcd1-/-mice as an efficient animal model of type I diabetes
2005 StandoutNobel
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
ALKS 4230: a novel engineered IL-2 fusion protein with an improved cellular selectivity profile for cancer immunotherapy
2020
Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy
2018
CD4+CD25−LAG3+regulatory T cells controlled by the transcription factor Egr-2
2009 StandoutNobel
Enhanced apoptosis with combination C225/radiation treatment serves as the impetus for clinical investigation in head and neck cancers.
2000
Overview of the Generation, Validation, and Application of Phosphosite-Specific Antibodies
2011
Immuno-Navigator, a batch-corrected coexpression database, reveals cell type-specific gene networks in the immune system
2016 StandoutNobel
Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model
2016 StandoutNobel
Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
2005 StandoutScience
New Insights into the Molecular Basis of T Cell Anergy: Anergy Factors, Avoidance Sensors, and Epigenetic Imprinting
2009
Early Growth Response Gene-2, a Zinc-Finger Transcription Factor, Is Required for Full Induction of Clonal Anergy in CD4+ T Cells
2004
Insights into Cytokine–Receptor Interactions from Cytokine Engineering
2014
Emerging Challenges in Regulatory T Cell Function and Biology
2007 StandoutScienceNobel
Modular repeat protein sculpting using rigid helical junctions
2020 StandoutNobel
Type I Interferon as a Powerful Adjuvant for Monocyte-Derived Dendritic Cell Development and Activity in Vitro and in Hu-Pbl-Scid Mice
2000
Live-Cell Labeling of Specific Protein Glycoforms by Proximity-Enhanced Bioorthogonal Ligation
2015 StandoutNobel
Targeting an engineered cytokine with interleukin-2 and interleukin-15 activity to the neovasculature of solid tumors
2020
A Ratiometric CdSe/ZnS Nanocrystal pH Sensor
2006 StandoutNobel
Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+regulatory T cells, evoking antitumor immune responses in humans
2013 StandoutNobel
Type 1 Interferons and the Virus-Host Relationship: A Lesson in Detente
2006 Science
The Fluorescent Toolbox for Assessing Protein Location and Function
2006 StandoutScienceNobel
RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5'-Phosphates
2006 StandoutScience
Scanning the human proteome for calmodulin-binding proteins
2005 StandoutNobel
Predicting protein–protein interactions through sequence-based deep learning
2018
The microbial mimic poly IC induces durable and protective CD4+T cell immunity together with a dendritic cell targeted vaccine
2008 StandoutNobel
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
Mapping Non–Class II H2-Linked Loci for Type 1 Diabetes in Nonobese Diabetic Mice
2004
Works of Leon Su being referenced
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
2018 StandoutScienceNobel
Inhibition of B Cell Receptor-Mediated Apoptosis by IFN
1999
Naive CD4 T Cell Proliferation Is Controlled by Mammalian Target of Rapamycin Regulation of GRAIL Expression
2009
Distinct Mechanisms of STAT Phosphorylation via the Interferon-α/β Receptor
2000
The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design
2021
Structure of the IFNγ receptor complex guides design of biased agonists
2019 Nature
The Single Subunit Transmembrane E3 Ligase Gene Related to Anergy in Lymphocytes (GRAIL) Captures and Then Ubiquitinates Transmembrane Proteins across the Cell Membrane
2008
Epidermal Growth Factor (EGF) Receptor Kinase-independent Signaling by EGF
2001
Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’
2012 Nature
Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells
2021
Protein microarrays for multiplex analysis of signal transduction pathways
2004
Interleukin-2 superkines by computational design
2022
The Gene Related to Anergy in Lymphocytes, an E3 Ubiquitin Ligase, Is Necessary for Anergy Induction in CD4 T Cells
2004
A human orthogonal IL-2 and IL-2Rβ system enhances CAR T cell expansion and antitumor activity in a murine model of leukemia
2021
Cutting Edge: Role of STAT1, STAT3, and STAT5 in IFN-αβ Responses in T Lymphocytes
2005
Selective expansion of regulatory T cells using an orthogonal IL-2/IL-2 receptor system facilitates transplantation tolerance
2021
Murine CD4+CD25+ Regulatory T Cells Fail to Undergo Chromatin Remodeling Across the Proximal Promoter Region of the IL-2 Gene
2004
Impaired Development of CD4+ CD25+ Regulatory T Cells in the Absence of STAT1
2003
Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist
2021
Structure-based decoupling of the pro- and anti-inflammatory functions of interleukin-10
2021 Science