Citation Impact
Citing Papers
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
2005 Standout
Phosphorylation Regulates c-Myc's Oncogenic Activity in the Mammary Gland
2011
Ferroptosis regulation by the NGLY1/NFE2L1 pathway
2022 StandoutNobel
Proteomic Analysis of Exosomes from Mutant KRAS Colon Cancer Cells Identifies Intercellular Transfer of Mutant KRAS
2012
Understanding Ras: ‘it ain’t over ’til it’s over’
2000
Hallmarks of Cancer: The Next Generation
2011 Standout
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
2003 Standout
The DNA-damage response in human biology and disease
2009 StandoutNature
The translational landscape of mTOR signalling steers cancer initiation and metastasis
2012 Nature
Tobacco Smoke Promotes Lung Tumorigenesis by Triggering IKKβ- and JNK1-Dependent Inflammation
2010
The Ras branch of small Gtpases: Ras family members don’t fall far from the tree
2000
The RB and p53 pathways in cancer
2002 Standout
MYC on the Path to Cancer
2012 Standout
Discovery of a novel Raf kinase inhibitor.
2001
Ferroptosis as a p53-mediated activity during tumour suppression
2015 StandoutNature
Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression
2011
Targeting HIF-1 for cancer therapy
2003 StandoutNobel
Modulation of allostery by protein intrinsic disorder
2013 Nature
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
2003 StandoutNatureNobel
Cell-cycle checkpoints and cancer
2004 StandoutNature
M-Ras/R-Ras3, a Transforming Ras Protein Regulated by Sos1, GRF1, and p120 Ras GTPase-activating Protein, Interacts with the Putative Ras Effector AF6
1999
The biology and management of non-small cell lung cancer
2018 StandoutNature
The genetics of ageing
2010 StandoutNature
Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression
2009
p53 — a Jack of all trades but master of none
2009
nhl-2 Modulates MicroRNA Activity in Caenorhabditis elegans
2009 StandoutNobel
p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells
2018
AID-Dependent Activation of a MYC Transgene Induces Multiple Myeloma in a Conditional Mouse Model of Post-Germinal Center Malignancies
2008
A microRNA component of the p53 tumour suppressor network
2007 StandoutNature
Disruption of the Mouse Rce1 Gene Results in Defective Ras Processing and Mislocalization of Ras within Cells
1999
Lung Cancer
2008 Standout
Elite and stochastic models for induced pluripotent stem cell generation
2009 StandoutNatureNobel
HIF2α cooperates with RAS to promote lung tumorigenesis in mice
2009 StandoutNobel
Proliferation, cell cycle and apoptosis in cancer
2001 StandoutNature
Endogenous oncogenic K-rasG12D stimulates proliferation and widespread neoplastic and developmental defects
2004
Influence of tumour micro-environment heterogeneity on therapeutic response
2013 StandoutNature
Metastatic Pancreatic Cancer Is Dependent on Oncogenic Kras in Mice
2012
Replication-selective viruses for cancer therapy
2001
Cancer Modeling in the Modern Era
2002
RAS Is Regulated by the let-7 MicroRNA Family
2005 Standout
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
2011 StandoutNature
Stable suppression of tumorigenicity by virus-mediated RNA interference
2002
Regulatory phases of early liver development: paradigms of organogenesis
2002
Cancer genes and the pathways they control
2004 Standout
KLF4, p21 and context-dependent opposing forces in cancer
2005
Myc's other life: stem cells and beyond
2009
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
2007 StandoutNature
Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras
2001
Immune-mediated mechanisms influencing the efficacy of anticancer therapies
2015
Targeting RAS signalling pathways in cancer therapy
2003 Standout
Immunity, Inflammation, and Cancer
2010 Standout
Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan
2012
An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis
2004
Oncolytic viruses: adenoviruses
2017
Oncogene-induced senescence: the bright and dark side of the response
2010
Silencing of microRNAs in vivo with ‘antagomirs’
2005 StandoutNature
A spatially and temporally restricted mouse model of soft tissue sarcoma
2007
Modeling and predicting clinical efficacy for drugs targeting the tumor milieu
2012
The MK5/PRAK Kinase and Myc Form a Negative Feedback Loop that Is Disrupted during Colorectal Tumorigenesis
2011
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
Revealing the world of RNA interference
2004 StandoutNatureNobel
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
2015 StandoutNature
MicroRNA expression profiles classify human cancers
2005 StandoutNatureNobel
Opposing Effects of Ras on p53
2000
Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting
2012 StandoutNatureNobel
The Hallmarks of Aging
2013 Standout
A microRNA polycistron as a potential human oncogene
2005 StandoutNature
Tumours with PI3K activation are resistant to dietary restriction
2009 Nature
New Insights into the Interaction of Ras with the Plasma Membrane
1999
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
2016 StandoutNature
Wnt signalling in stem cells and cancer
2005 StandoutNature
Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors
2011
The combined status of ATM and p53 link tumor development with therapeutic response
2009
All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral
1998
Lung cancer in never smokers — a different disease
2007
Genetics and biology of pancreatic ductal adenocarcinoma
2006
Cellular senescence: hot or what?
2009
A KrasG12D-driven genetic mouse model of pancreatic cancer requires glypican-1 for efficient proliferation and angiogenesis
2011
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
2011 StandoutNobel
Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma.
2009
RNA–protein analysis using a conditional CRISPR nuclease
2013 StandoutNobel
Small GTP-Binding Proteins
2001 Standout
Long-range enhancers on 8q24 regulate c-Myc
2010
eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation
2016 StandoutNatureNobel
Involvement of a Small GTP-binding Protein (G Protein) Regulator, Small G Protein GDP Dissociation Stimulator, in Antiapoptotic Cell Survival Signaling
2000
Targeting MYC-Regulated miRNAs to Combat Cancer
2010
Deficiencies in Mouse Myh and Ogg1 Result in Tumor Predisposition and G to T Mutations in Codon 12 of the K-Ras Oncogene in Lung Tumors
2004 StandoutNobel
Oncogenic RAS pathway activation promotes resistance to anti-VEGF therapy through G-CSF–induced neutrophil recruitment
2013
Concepts in Ras-directed therapy
1999
Chemotherapy induces enrichment of CD47 + /CD73 + /PDL1 + immune evasive triple-negative breast cancer cells
2018 StandoutNobel
Regulation of apoptosis by the circadian clock through NF-κB signaling
2011 StandoutNobel
Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells
2012 StandoutNobel
H-ras but Not K-ras Traffics to the Plasma Membrane through the Exocytic Pathway
2000
Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy
2005 StandoutScience
Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells
2010 StandoutNobel
Genetics and biology of pancreatic ductal adenocarcinoma
2016
Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers
2004 Standout
Allosteric Modulation of Substrate Binding within a Tetracationic Molecular Receptor
2015 StandoutNobel
Oncolytic Viruses in Cancer Treatment
2016
Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model
2010
The emerging fields of suicide gene therapy and virotherapy
2002
E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes
2020 StandoutNobel
SIGNALING PATHWAYS IN INTESTINAL DEVELOPMENT AND CANCER
2004
Immunopurification of Ago1 miRNPs selects for a distinct class of microRNA targets
2009 StandoutNobel
Works of Leisa Johnson being referenced
Wildtype Kras2 can inhibit lung carcinogenesis in mice
2001
An adenovirus E1A mutant that demonstrates potent and selective systemic anti-tumoral efficacy
2000
Distinct Thresholds Govern Myc's Biological Output In Vivo
2008
Somatic activation of the K-ras oncogene causes early onset lung cancer in mice
2001 Nature
K-ras is an essential gene in the mouse with partial functional overlap with N-ras
1997
Generation of a prostate from a single adult stem cell
2008 Nature
Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models
2010
Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity
2004
Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease
2004
Selectively replicating adenoviruses targeting deregulated E2F activity are potent, systemic antitumor agents
2002
Using Genetically Engineered Mouse Models of Cancer to Aid Drug Development: An Industry Perspective
2006
Genetically Engineered Mouse Models: Closing the Gap between Preclinical Data and Trial Outcomes
2012