Standout Papers

Effect of the Tyrosine Kinase Inhibitor STI571 in a Patient with a Metastatic Gastrointestinal... 2001 2026 2009 2017 1.5k
  1. Effect of the Tyrosine Kinase Inhibitor STI571 in a Patient with a Metastatic Gastrointestinal Stromal Tumor (2001)
    Heikki Joensuu, Peter Roberts‎ et al. New England Journal of Medicine

Citation Impact

Citing Papers

Visualizing enveloping layer glycans during zebrafish early embryogenesis
2010 StandoutNobel
Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants
2019 StandoutScienceNobel
The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency
2008 StandoutScienceNobel
Kinase Mutations and Imatinib Response in Patients With Metastatic Gastrointestinal Stromal Tumor
2003 Standout
Human MicroRNA Targets
2004 Standout
Hearts of Hypoxia-inducible Factor Prolyl 4-Hydroxylase-2 Hypomorphic Mice Show Protection against Acute Ischemia-Reperfusion Injury
2010
Regulation of Angiogenesis by Oxygen and Metabolism
2009
Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice
2002
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Roles for the phosphatidylinositol cycle in early development
1988
Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial
2009 Standout
NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth
2013
Oncogenic kinase signalling
2001 StandoutNature
Molecular characterisation of soft tissue tumours: a gene expression study
2002 Standout
Neural and developmental actions of lithium: A unifying hypothesis
1989 Standout
Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer
2013 Standout
Clinical management of gastrointestinal stromal tumors: Before and after STI-571
2002
Regulation of calcium influx by second messengers in rat mast cells
1988 StandoutNatureNobel
MicroRNAs: Target Recognition and Regulatory Functions
2009 Standout
Molecular Events Mediating T Cell Activation
1990
Visualizing the mechanical activation of Src
2005 StandoutNatureNobel
Gastrointestinal stromal tumors: The incidence, prevalence, clinical course, and prognostication in the preimatinib mesylate era
2005
Lithium-induced teratogenesis in frog embryos prevented by a polyphosphoinositide cycle intermediate or a diacylglycerol analog
1989
Establishment of an erythroid cell line (JK-1) that spontaneously differentiates to red cells
1990 StandoutNobel
Vesicle fusion following receptor-mediated endocytosis requires a protein active in Golgi transport
1989 StandoutNatureNobel
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
Molecular mechanisms and clinical applications of angiogenesis
2011 StandoutNature
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Inhibition by SK&F 96365 of Ca2+ current, IL‐2 production and activation in T lymphocytes
1994
Vascular endothelial growth factor B controls endothelial fatty acid uptake
2010 Nature
In-cell PCR from mRNA: amplifying and linking the rearranged immunoglobulin heavy and light chain V-genes within single cells
1992 StandoutNobel
Extrathymic positive selection of αβ T-cell precursors in nude mice
1992 StandoutNatureNobel
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Cell‐mediated cytotoxicity against ectromelia virus‐infected target cells. I. Specificity and kinetics
1974
Genes required for cytotoxicity against virus-infected target cells in K and D regions of H-2 complex
1975 StandoutNatureNobel
Glycoproteins and antigens of membranes prepared from rat thymocytes after lysis by shearing or with the detergent Tween-40
1978
The LDL Receptor Gene: A Mosaic of Exons Shared with Different Proteins
1985 StandoutScienceNobel
Structural patterns in globular proteins
1976 StandoutNatureNobel
Fatty Acid Binding: A New Kind of Posttranslational Modification of Membrane Proteins
1983
T‐T Cell Interactions during Cytotoxic T Lymphocyte (CTL) Responses: T Cell Derived Helper Factor (Interleukin 2) as a Probe to Analyze CTL Responsiveness and Thymic Maturation of CTL Progenitors
1980
Enhanced immunological surveillance in mice heterozygous at the H-2 gene complex
1975 StandoutNatureNobel
Expression and modulation of specific, high affinity binding sites for erythropoietin on the human erythroleukemic cell line K562
1988
Nucleotide Sequence of Yellow Fever Virus: Implications for Flavivirus Gene Expression and Evolution
1985 StandoutScienceNobel
Quantitation of Transcription and Clonal Selection of Single Living Cells with β-Lactamase as Reporter
1998 StandoutScienceNobel
T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes
1982 StandoutNatureNobel
Differentiation of Monocytes into Dendritic Cells in a Model of Transendothelial Trafficking
1998 StandoutScienceNobel
The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain
1986 StandoutNobel
Intracellular calcium dependence of gene expression in single T lymphocytes.
1994
Envelope structure of Semliki Forest virus reconstructed from cryo-electron micrographs
1986 StandoutNatureNobel
Nucleotide sequence of cDNA coding for Semliki Forest virus membrane glycoproteins
1980 Nature
Retention of membrane proteins by the endoplasmic reticulum.
1985
Temporal aspects of the N- and O-glycosylation of human chorionic gonadotropin.
1982
Regulation of hepcidin transcription by interleukin-1 and interleukin-6
2005
Noninvasive Identification and Monitoring of Cancer Mutations by Targeted Deep Sequencing of Plasma DNA
2012
Possible role for fatty acyl-coenzyme A in intracellular protein transport
1987 StandoutNatureNobel
A transcriptional enhancer with specificity for erythroid cells is located in the long terminal repeat of the Friend murine leukemia virus.
1986
Biosynthesis of truncated O-glycans in the T cell line Jurkat. Localization of O-glycan initiation.
1990
Antigen-Binding, Idiotypic T-Lymphocyte Receptors
1977
Prospective Multicentric Randomized Phase III Study of Imatinib in Patients With Advanced Gastrointestinal Stromal Tumors Comparing Interruption Versus Continuation of Treatment Beyond 1 Year: The French Sarcoma Group
2007
Lymphocyte specificity to protein antigens. II. Fine specificity of T-cell activation with cytochrome c and derived peptides as antigenic probes.
1979
Chromosomal Locations of the Murine T-Cell Receptor Alpha-Chain Gene and the T-Cell Gamma Gene
1985 StandoutScienceNobel
Potentiation by lithium of CMP-phosphatidate formation in carbachol-stimulated rat cerebral-cortical slices and its reversal by myo-inositol
1989
Reconstitution of vesicle fusions occurring in endocytosis with a cell-free system.
1986
Cell-Mediated Cytotoxicity, Allograft Rejection, and Tumor Immunity
1974 Standout
Functional expression of a microinjected Edα gene in C57BL/6 transgenic mice
1985 StandoutNatureNobel
Phase III Randomized, Intergroup Trial Assessing Imatinib Mesylate At Two Dose Levels in Patients With Unresectable or Metastatic Gastrointestinal Stromal Tumors Expressing the Kit Receptor Tyrosine Kinase: S0033
2008
Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid.
1980 Standout
CELLULAR FUNCTIONS REGULATED BY SRC FAMILY KINASES
1997 Standout
Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1
2008
Normal Development of Mice Deficient in β 2 M, MCClass I Proteins, and CD8 + T Cells
1990 StandoutScienceNobel
Stimulation of the T3-T cell receptor complex induces a membrane-potential-sensitive calcium influx
1985
Viruses in Human Cancers
1991 StandoutScienceNobel
Biosynthesis of N- and O-linked oligosaccharides of the low density lipoprotein receptor.
1983 StandoutNobel
Major histocompatibility antigens: The human (HLA-A,-B,-C) and murine (H-2K, H-2D) class I molecules
1981
Protein Sorting by Transport Vesicles
1996 StandoutScienceNobel
Tumor Rejection After Direct Costimulation of CD8 + T Cells by B7-Transfected Melanoma Cells
1993 StandoutScienceNobel
The T-Cell Receptor Problem
1981
Acquired Resistance to Imatinib in Gastrointestinal Stromal Tumor Occurs Through Secondary Gene Mutation
2005
Human erythroid cell lines derived from a patient with acute erythremia
1981
Long-Term Results From a Randomized Phase II Trial of Standard- Versus Higher-Dose Imatinib Mesylate for Patients With Unresectable or Metastatic Gastrointestinal Stromal Tumors Expressing KIT
2008
Analysis of cell surfaces by xenogeneic myeloma-hybrid antibodies: Differentiation antigens of rat lymphocytes
1977 StandoutNobel
HEL Cells: A New Human Erythroleukemia Cell Line with Spontaneous and Induced Globin Expression
1982 Science
Surface antigenic profile and globin phenotype of two new human erythroleukemia lines: characterization and interpretations
1988
STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane
2005 StandoutNature
The human LDL receptor: A cysteine-rich protein with multiple Alu sequences in its mRNA
1984 StandoutNobel
Bioorthogonal Labeling of Human Prostate Cancer Tissue Slice Cultures for Glycoproteomics
2017 StandoutNobel
Resolution and partial characterization of the major plasma membrane sialoglycoproteins of Novikoff tumor cells.
1979 StandoutNobel
Mutation in LDL Receptor: Alu-Alu Recombination Deletes Exons Encoding Transmembrane and Cytoplasmic Domains
1985 StandoutScienceNobel
Nasopharyngeal carcinoma: Significance of changes in epstein‐barr virus‐related antibody patterns following therapy
1977
Immunological Studies of Nude Mice
1974
The Role of Wnt Signaling in Physiological and Pathological Angiogenesis
2010
Stimulatory capacity of human T and B lymphocytes in the mixed leukocyte culture
1974 Nature
T-T-cell interactions during the vitro cytotoxic allograft responses. I. Soluble products from activated Lyl+ T cells trigger autonomously antigen-primed Ly23+ T cells to cell proliferation and cytolytic activity.
1978
Identification of the receptor for erythropoietin on human and murine erythroleukemia cells and modulation by phorbol ester and dimethyl sulfoxide.
1988
Identification of D segments of immunoglobulin heavy-chain genes and their rearrangement in T lymphocytes
1981 StandoutNatureNobel
Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing
2012
Regulation of the Ets-Related Transcription Factor Elf-1 by Binding to the Retinoblastoma Protein
1993 StandoutScienceNobel
Detection of Chromosomal Alterations in the Circulation of Cancer Patients with Whole-Genome Sequencing
2012
Macrophage arginase promotes tumor cell growth and suppresses nitric oxide-mediated tumor cytotoxicity.
2001
Engineering Chemical Reactivity on Cell Surfaces Through Oligosaccharide Biosynthesis
1997 StandoutScienceNobel
Absence of H-2 antigens capable of reacting with cytotoxic T cells on a teratoma line expressing a T/t locus antigen.
1975
Macrosialin, a macrophage-restricted membrane sialoprotein differentially glycosylated in response to inflammatory stimuli.
1991
H–2 gene expression is required for T cell-mediated lysis of virus-infected target cells
1977 StandoutNatureNobel

Works of Leif C. Andersson being referenced

Transcriptional regulation of the ornithine decarboxylase gene by c-Myc/Max/Mad network and retinoblastoma protein interacting with c-Myc
2003
Camp inhibits the okt3‐ induced increase in cytoplasmic free calcium in the jurkat t cell line: the degree of inhibition correlates inversely with the amount of cd3 binding ligand used*
1989
Effect of the Tyrosine Kinase Inhibitor STI571 in a Patient with a Metastatic Gastrointestinal Stromal Tumor
2001 Standout
Transcription Factor PROX1 Induces Colon Cancer Progression by Promoting the Transition from Benign to Highly Dysplastic Phenotype
2008
Flow cytometric analysis of apoptotic subpopulations with a combination of Annexin V-FITC, propidium iodide, and SYTO 17
2001
Regulation of the p59fyn protein tyrosine kinase by the CD45 phosphotyrosine phosphatase
1992
Mitosis-arresting effect of the calcium channel inhibitor SK&F 96365 on human leukemia cells
1992
Use of cancer‐specific genomic rearrangements to quantify disease burden in plasma from patients with solid tumors
2010
Ornithine decarboxylase activity is critical for cell transformation
1992 Nature
Changes in gene expression during progression of ovarian carcinoma
2001
Pulmonary Vascular Endothelial Growth Factor and Flt-1 in Fetuses, in Acute and Chronic Lung Disease, and in Persistent Pulmonary Hypertension of the Newborn
2001
Kinetics of long‐term (72 hr) calcium content during mitogen activation of cultured human T lymphocytes
1985
K562—A human erythroleukemic cell line
1979
Overexpression of Vascular Endothelial Growth Factor-B in Mouse Heart Alters Cardiac Lipid Metabolism and Induces Myocardial Hypertrophy
2008
myo‐Inositol reverses Li+‐induced inhibition of phosphoinositide turnover and ornithine decarboxylase induction during early lymphocyte activation
1986
T cell synergy in mixed lymphocyte culture‐induced cytolysis
1974
Mitogens cause a rapid induction of ornithine decarboxylase activity in human T-lymphocytes
1985
Induction of specific immune unresponsiveness using purified mixed leukocyte culture-activated T lymphoblasts as autoimmunogen. I. Demonstration of general validity as to species and histocompatibility barriers.
1977
Vascular Endothelial Growth Factor-B Acts as a Coronary Growth Factor in Transgenic Rats Without Inducing Angiogenesis, Vascular Leak, or Inflammation
2010
Allograft Response in Vitro
1972
Size Distribution of Killer Cells During Allograft Response.
1973
Generation of T Memory Cells in One‐Way Mixed Lymphocyte Culture
1974
Glycophorin a as a cell surface marker of early erythroid differentiation in acute leukemia
1979
Induction of erythroid differentiation in the human leukaemia cell line K562
1979 Nature
Induction of platelet-derived growth factor gene expression during megakaryoblastic and monocytic differentiation of human leukemia cell lines.
1987
Human prostate epithelium lacks Wee1A-mediated DNA damage-induced checkpoint enforcement
2007
Role of Sialic Acid in the Mobility of Membrane Proteins Containing O‐Linked Oligosaccharides on Polyacrylamide Gel Electrophoresis in Sodium Dodecyl Sulfate
1982
Interaction of Cd2+ with the calmodulin-activated (Ca2+ + Mg2+)-ATPase activity of human erythrocyte ghosts
1985
PROLIFERATION OF B AND T CELLS IN MIXED LYMPHOCYTE CULTURES
1973
Cell‐Free Synthesis and Glycosylatlon of the Major Human‐Red‐Cell Sialoglycoprotein, Glycophorin A
1981
Role of G-proteins in T cell activation: non-hydrolysable GTP analogues induce early ornithine decarboxylase activity in human T lymphocytes.
1986
Rapid activation of ornithine decarboxylase by mitogenic (but not by nonmitogenic) ligands in human T lymphocytes
1985
Selective radioactive labeling of cell surface sialoglycoproteins by periodate-tritiated borohydride.
1977
Biosynthesis of the major human red cell sialoglycoprotein, glycophorin A, in a continuous cell line
1979 Nature
Surface glycoprotein patterns of normal and malignant human lymphoid cells. I. T cells, T blasts and leukemic T cell lines
1977
Mechanism of anaemia in rheumatoid arthritis: demonstration of raised interleukin 1 beta concentrations in anaemic patients and of interleukin 1 mediated suppression of normal erythropoiesis and proliferation of human erythroleukaemia (HEL) cells in vitro.
1988
IDENTIFICATION AND CHARACTERIZATION OF NORMAL AND MALIGNANT HUMAN BLOOD LEUKOCYTES BY SURFACE GLYCOPROTEIN PATTERNS*
1978
Glycophorin A as an Erythroid Marker in Normal and Malignant Hematopoiesis
1981
Differentiation of human erythroid cells is associated with increased O-glycosylation of the major sialoglycoprotein, glycophorin A.
1984
Direct mitogenic effect of ionophore A23187 on isolated human T helper lymphocytes
1984
DNA sequence copy number changes in gastrointestinal stromal tumors: tumor progression and prognostic significance.
2000
Rankless by CCL
2026