Standout Papers
- Sar1p N-Terminal Helix Initiates Membrane Curvature and Completes the Fission of a COPII Vesicle (2005)
- BI-DIRECTIONAL PROTEIN TRANSPORT BETWEEN THE ER AND GOLGI (2004)
- Multiple Cargo Binding Sites on the COPII Subunit Sec24p Ensure Capture of Diverse Membrane Proteins into Transport Vesicles (2003)
- Ceramide Biosynthesis Is Required for the Formation of the Oligomeric H+-ATPase Pma1p in the Yeast Endoplasmic Reticulum (2002)
Citation Impact
Citing Papers
Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins
2007 Nobel
Differential use of endoplasmic reticulum membrane for phagocytosis in J774 macrophages
2005 StandoutNobel
Membrane fission by protein crowding
2017
Functional specialization of β-arrestin interactions revealed by proteomic analysis
2007 StandoutNobel
Sorting of GPI-anchored proteins into ER exit sites by p24 proteins is dependent on remodeled GPI
2011
α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
2010 StandoutScienceNobel
ER Cargo Properties Specify a Requirement for COPII Coat Rigidity Mediated by Sec13p
2012 Science
In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles
2009 StandoutNobel
Selective export of human GPI-anchored proteins from the endoplasmic reticulum
2010
Localization and activity of the SNARE Ykt6 determined by its regulatory domain and palmitoylation
2004 StandoutNobel
Munc18-1 binds directly to the neuronal SNARE complex
2007 StandoutNobel
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
Protein Sorting Receptors in the Early Secretory Pathway
2010
A Class of Membrane Proteins Shaping the Tubular Endoplasmic Reticulum
2006
p125 Is Localized in Endoplasmic Reticulum Exit Sites and Involved in Their Organization
2004
Membrane deformation by protein coats
2006
Protein export at the ER: loading big collagens into COPII carriers
2011
Discoveries in structure and physiology of mechanically activated ion channels
2020 StandoutNatureNobel
Mechanisms of regulated unconventional protein secretion
2008
Physical Principles of Membrane Shape Regulation by the Glycocalyx
2019 StandoutNobel
A pseudoatomic model of the COPII cage obtained from cryo-electron microscopy and mass spectrometry
2012
Cargo Selectivity of the ERGIC‐53/MCFD2 Transport Receptor Complex
2006
The cancer glycocalyx mechanically primes integrin-mediated growth and survival
2014 StandoutNatureNobel
Caenorhabditis elegans pathways that surveil and defend mitochondria
2014 StandoutNatureNobel
An Evolutionary Perspective on Eukaryotic Membrane Trafficking
2008
The Transport Signal on Sec22 for Packaging into COPII-Coated Vesicles Is a Conformational Epitope
2007
GTP/GDP exchange by Sec12p enables COPII vesicle bud formation on synthetic liposomes
2004 StandoutNobel
Uncoupled Packaging of Amyloid Precursor Protein and Presenilin 1 into Coat Protein Complex II Vesicles
2004 StandoutNobel
The Genetic Basis of a Craniofacial Disease Provides Insight into COPII Coat Assembly
2007 StandoutNobel
Sed4p Stimulates Sar1p GTP Hydrolysis and Promotes Limited Coat Disassembly
2011
Adaptation of endoplasmic reticulum exit sites to acute and chronic increases in cargo load
2008
Sec16 Defines Endoplasmic Reticulum Exit Sites and is Required for Secretory Cargo Export in Mammalian Cells
2006
ER exit sites – Localization and control of COPII vesicle formation
2009
Multiple SNARE interactions of an SM protein: Sed5p/Sly1p binding is dispensable for transport
2004
A structural view of the COPII vesicle coat
2004
Visualization of cargo concentration by COPII minimal machinery in a planar lipid membrane
2009
Multibudded tubules formed by COPII on artificial liposomes
2011 StandoutNobel
The Structure of Sec12 Implicates Potassium Ion Coordination in Sar1 Activation
2012
Mammalian Sec16/p250 Plays a Role in Membrane Traffic from the Endoplasmic Reticulum
2007
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
Sec24p and Sec16p cooperate to regulate the GTP cycle of the COPII coat
2011 StandoutNobel
Structural basis of cargo membrane protein discrimination by the human COPII coat machinery
2008
Dissection of COPII subunit-cargo assembly and disassembly kinetics during Sar1p-GTP hydrolysis
2005
The Vesicle Trafficking Protein Sar1 Lowers Lipid Membrane Rigidity
2010
TFG-1 function in protein secretion and oncogenesis
2011
Phosphatidylinositol 4-Phosphate Formation at ER Exit Sites Regulates ER Export
2006
The Biological and Chemical Basis for Tissue-Selective Amyloid Disease
2005
How proteins produce cellular membrane curvature
2005
Ubiquitin-dependent regulation of COPII coat size and function
2012 StandoutNatureNobel
Differential Selection of Golgi Proteins by COPII Sec24 Isoforms in Procyclic Trypanosoma brucei
2011
Membrane bending by protein–protein crowding
2012
Machine learning to design integral membrane channelrhodopsins for efficient eukaryotic expression and plasma membrane localization
2017 StandoutNobel
Coordination of COPII vesicle trafficking by Sec23
2008 StandoutNobel
TANGO1 Facilitates Cargo Loading at Endoplasmic Reticulum Exit Sites
2009 StandoutNobel
COPII-coated vesicles: flexible enough for large cargo?
2005 StandoutNobel
Hsp90 Cochaperone Aha1 Downregulation Rescues Misfolding of CFTR in Cystic Fibrosis
2006
Biogenesis of ER-to-Golgi transport carriers: complex roles of COPII in ER export
2004
Mechanical requirements for membrane fission: Common facts from various examples
2009
Structural design of cage and coat scaffolds that direct membrane traffic
2007
Structure of the mechanically activated ion channel Piezo1
2017 StandoutNatureNobel
Concentration of GPI‐Anchored Proteins upon ER Exit in Yeast
2008
Coupling of ER exit to microtubules through direct interaction of COPII with dynactin
2004
Structure and Organization of Coat Proteins in the COPII Cage
2007
Mechanisms of membrane fusion: disparate players and common principles
2008
Structure of the Sec13/31 COPII coat cage
2006 Nature
Concentrative Export from the Endoplasmic Reticulum of the γ-Aminobutyric Acid Transporter 1 Requires Binding to SEC24D
2007
Insights into COPII Coat Nucleation from the Structure of Sec23•Sar1 Complexed with the Active Fragment of Sec31
2007
The Bacterial Virulence Factor NleA Inhibits Cellular Protein Secretion by Disrupting Mammalian COPII Function
2007 StandoutNobel
SNARE Selectivity of the COPII Coat
2003
Regulation of coat assembly—sorting things out at the ER
2010
The intracellular transport of chylomicrons requires the small GTPase, Sar1b
2004
Purification of active HOPS complex reveals its affinities for phosphoinositides and the SNARE Vam7p
2006
Reconstitution of Coat Protein Complex II (COPII) Vesicle Formation from Cargo-reconstituted Proteoliposomes Reveals the Potential Role of GTP Hydrolysis by Sar1p in Protein Sorting
2004
Structural Basis for Cargo Regulation of COPII Coat Assembly
2008
Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus
2015 StandoutNatureNobel
Differential ER exit in yeast and mammalian cells
2004
Phosphorylation of Chs2p regulates interaction with COPII
2013 StandoutNobel
Svp26 Facilitates Endoplasmic Reticulum to Golgi Transport of a Set of Mannosyltransferases in Saccharomyces cerevisiae
2010
Receptor-mediated protein transport in the early secretory pathway
2007
Secretory Cargo Regulates the Turnover of COPII Subunits at Single ER Exit Sites
2006
Sec24D-Dependent Transport of Extracellular Matrix Proteins Is Required for Zebrafish Skeletal Morphogenesis
2010
Sec24C is required for docking the prechylomicron transport vesicle with the Golgi
2009
Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi trafficking
2006 StandoutNobel
TRAPPI tethers COPII vesicles by binding the coat subunit Sec23
2007 Nature
Sequential interactions with Sec23 control the direction of vesicle traffic
2011 Nature
COPII and the regulation of protein sorting in mammals
2011 StandoutNobel
The ESCRT Pathway
2011
Purification and Functional Properties of Yeast Sec12 GEF
2005 Nobel
COPII — a flexible vesicle formation system
2013 StandoutNobel
A novel multiprotein complex is required to generate the prechylomicron transport vesicle from intestinal ER
2010
The Mechanisms of Vesicle Budding and Fusion
2004
Protein therapeutics: a summary and pharmacological classification
2007 Standout
SEC23-SEC31 the Interface Plays Critical Role for Export of Procollagen from the Endoplasmic Reticulum
2012 StandoutNobel
Driving membrane curvature in clathrin-dependent and clathrin-independent endocytosis
2009
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure
2009 StandoutNobel
The plant immune system
2006 StandoutNature
Selective Activation of Cognate SNAREpins by Sec1/Munc18 Proteins
2007 StandoutNobel
Amphipathic helices and membrane curvature
2009
Genome Editing B.C. (Before CRISPR): Lasting Lessons from the “Old Testament”
2018
Sar1 assembly regulates membrane constriction and ER export
2010
SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion
2013 StandoutNobel
Discovery of the cellular and molecular basis of cholesterol control
2013 StandoutNobel
ER-Golgi Transport Defects Are Associated with Mutations in the Sed5p-binding Domain of the COPII Coat Subunit, Sec24p
2005 StandoutNobel
Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy
2016 StandoutScienceNobel
Two Mammalian Sec16 Homologues Have Nonredundant Functions in Endoplasmic Reticulum (ER) Export and Transitional ER Organization
2006
p53 and Ceramide as Collaborators in the Stress Response
2013
Unconventional Mechanisms of Protein Transport to the Cell Surface of Eukaryotic Cells
2008
Exomer: a coat complex for transport of select membrane proteins from the trans-Golgi network to the plasma membrane in yeast
2006 StandoutNobel
The Cytoplasmic Tail of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein Contains a Novel Endoplasmic Reticulum Retrieval Signal That Binds COPI and Promotes Interaction with Membrane Protein
2006
A model for the self-organization of exit sites in the endoplasmic reticulum
2007
SNAREpin/Munc18 promotes adhesion and fusion of large vesicles to giant membranes
2008 StandoutNobel
Identification of ERGIC-53 as an intracellular transport receptor of α1-antitrypsin
2008
MAPK signaling to the early secretory pathway revealed by kinase/phosphatase functional screening
2010
A vesicle carrier that mediates peroxisome protein traffic from the endoplasmic reticulum
2010 StandoutNobel
The yeast p24 complex regulates GPI-anchored protein transport and quality control by monitoring anchor remodeling
2011
Organisation of human ER-exit sites: requirements for the localisation of Sec16 to transitional ER
2009
Expression of Sar1b Enhances Chylomicron Assembly and Key Components of the Coat Protein Complex II System Driving Vesicle Budding
2011
Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1
2016 StandoutNobel
Countercurrent Distribution of Two Distinct SNARE Complexes Mediating Transport within the Golgi Stack
2004 StandoutNobel
Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Oxysterols block transport by binding to Insig
2007 Nobel
Site-specific chemical modification of recombinant proteins produced in mammalian cells by using the genetically encoded aldehyde tag
2009 StandoutNobel
Small molecule probes to quantify the functional fraction of a specific protein in a cell with minimal folding equilibrium shifts
2014 StandoutNobel
COPII-mediated vesicle formation at a glance
2010 StandoutNobel
Requirements for Transitional Endoplasmic Reticulum Site Structure and Function in Saccharomyces cerevisiae
2010
cTAGE5 mediates collagen secretion through interaction with TANGO1 at endoplasmic reticulum exit sites
2011
The ER-Golgi intermediate compartment (ERGIC): in search of its identity and function
2006
Cargo selection into COPII vesicles is driven by the Sec24p subunit
2002 StandoutNobel
Role of Sec24 isoforms in selective export of membrane proteins from the endoplasmic reticulum
2007
Unsolved Mysteries in Membrane Traffic
2007
Nuclear repartitioning of galectin-1 by an extracellular glycan switch regulates mammary morphogenesis
2016 StandoutNobel
Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling
2020 StandoutNobel
Conserved Functions of Membrane Active GTPases in Coated Vesicle Formation
2009 Science
COPI coat assembly occurs on liquid-disordered domains and the associated membrane deformations are limited by membrane tension
2008
Efficient coupling of Sec23-Sec24 to Sec13-Sec31 drives COPII-dependent collagen secretion and is essential for normal craniofacial development
2008
Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans -Golgi network
2012 StandoutNobel
Regulation of Sar1 NH2 terminus by GTP binding and hydrolysis promotes membrane deformation to control COPII vesicle fission
2005
Membrane Fusion: Grappling with SNARE and SM Proteins
2009 StandoutScienceNobel
Biogenesis of γ-secretase early in the secretory pathway
2007 StandoutNobel
Rer1p competes with APH-1 for binding to nicastrin and regulates γ-secretase complex assembly in the early secretory pathway
2007
Dependence of Chs2 ER export on dephosphorylation by cytoplasmic Cdc14 ensures that septum formation follows mitosis
2011
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
PLANT RESPONSES TO INSECT HERBIVORY : The Emerging Molecular Analysis
2002
Erv26p Directs Pro-Alkaline Phosphatase into Endoplasmic Reticulum–derived Coat Protein Complex II Transport Vesicles
2006
Chs5/6 Complex: A Multiprotein Complex That Interacts with and Conveys Chitin Synthase III from theTrans-Golgi Network to the Cell Surface
2006 StandoutNobel
Unconventional Secretion, Unconventional Solutions
2013 StandoutScienceNobel
p125A exists as part of the mammalian Sec13/Sec31 COPII subcomplex to facilitate ER-Golgi transport
2010
COPII and COPI Traffic at the ER-Golgi Interface
2011
The structure of a COPII tubule
2010
Stargazin is an AMPA receptor auxiliary subunit
2005
Works of Lee M being referenced
Inhibiting Endoplasmic Reticulum (ER)-associated Degradation of Misfolded Yor1p Does Not Permit ER Export Despite the Presence of a Diacidic Sorting Signal
2007
Multiple Cargo Binding Sites on the COPII Subunit Sec24p Ensure Capture of Diverse Membrane Proteins into Transport Vesicles
2003 StandoutNobel
Identification of a novel four-domain member of the proteinase inhibitor II family from the stigmas of Nicotiana alata
2000
Ceramide Biosynthesis Is Required for the Formation of the Oligomeric H+-ATPase Pma1p in the Yeast Endoplasmic Reticulum
2002 StandoutNobel
A novel two-chain proteinase inhibitor generated by circularization of a multidomain precursor protein.
1999
Sar1p N-Terminal Helix Initiates Membrane Curvature and Completes the Fission of a COPII Vesicle
2005 StandoutNobel
Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases
2012
Molecular mechanisms of COPII vesicle formation
2007
BI-DIRECTIONAL PROTEIN TRANSPORT BETWEEN THE ER AND GOLGI
2004 StandoutNobel
A multicenter study of recombinant factor VIII (recombinate): safety, efficacy, and inhibitor risk in previously untreated patients with hemophilia A. The Recombinate Study Group.
1994
Genomewide Analysis Reveals Novel Pathways Affecting Endoplasmic Reticulum Homeostasis, Protein Modification and Quality Control
2009