Standout Papers
- Mutation of the α2A-Adrenoceptor Impairs Working Memory Performance and Annuls Cognitive Enhancement by Guanfacine (2002)
- Abnormal Regulation of the Sympathetic Nervous System in α2A-Adrenergic Receptor Knockout Mice (1999)
- Abnormal Regulation of the Sympathetic Nervous System in α2A-Adrenergic Receptor Knockout Mice (1999)
- Differential effects of GTP on the coupling of β-adrenergic receptors to adenylate cyclase from frog and turkey erythrocytes application of new methods for the analysis of receptor-effector coupling (1979)
- Agonist-induced increase in apparent β-adrenergic receptor size (1978)
- The ß-adrenergic receptor and adenylate cyclase (1976)
- Myocardial guanylate cyclase: Properties of the enzyme and effects of cholinergic agonists in vitro (1975)
- Heterozygous α 2A -adrenergic receptor mice unveil unique therapeutic benefits of partial agonists (2002)
- Beta‐adrenergic receptors: Regulatory role of agonists (1978)
- β-Adrenergic receptors: Evidence for negative cooperativity (1975)
- β-Adrenoreceptors determine affinity but not intrinsic activity of adenylate cyclase stimulants (1979)
- Spinophilin Blocks Arrestin Actions in Vitro and in Vivo at G Protein-Coupled Receptors (2004)
- Adenylate Cyclase-Coupled Beta Adrenergic Receptors: Effect of Membrane Lipid-Perturbing Agents on Receptor Binding and Enzyme Stimulation by Catecholamines (1976)
Citation Impact
Citing Papers
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
International Union of Pharmacology nomenclature of adrenoceptors.
1994 StandoutNobel
Adrenergic α2C-Receptors Modulate the Acoustic Startle Reflex, Prepulse Inhibition, and Aggression in Mice
1998 StandoutNobel
Cardiovascular and Metabolic Alterations in Mice Lacking Both β1- and β2-Adrenergic Receptors
1999 StandoutNobel
Antidepressant-Like Effects of the Histone Deacetylase Inhibitor, Sodium Butyrate, in the Mouse
2006
Ligand-selective receptor conformations revisited: the promise and the problem
2003
S. cerevisiae α pheromone receptors activate a novel signal transduction pathway for mating partner discrimination
1991 StandoutNobel
Localization ofα2c-adrenergic receptor immunoreactivity in catecholaminergic neurons in the rat central nervous system
1998
Cell-type Specific Targeting of the α2c-Adrenoceptor
2000 StandoutNobel
Crystal structure of the human β2 adrenergic G-protein-coupled receptor
2007 StandoutNatureNobel
High-resolution crystal structure of human protease-activated receptor 1
2012 StandoutNatureNobel
Induced Effects of Sodium Ions on Dopaminergic G-Protein Coupled Receptors
2010
Adrenergic Receptors From Molecular Structure to in vivo function
1997 StandoutNobel
GPCR interacting proteins (GIP)
2004
Subtype-Specific Intracellular Trafficking of α2-Adrenergic Receptors
1997 StandoutNobel
Distinct Roles for Src Tyrosine Kinase in β2-Adrenergic Receptor Signaling to MAPK and in Receptor Internalization
2004
Historical review: A brief history and personal retrospective of seven-transmembrane receptors
2004 StandoutNobel
Physiological consequences of β-adrenergic receptor disruption
1998
Gene targeting — homing in on α2-adrenoceptor-subtype function
1997 StandoutNobel
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
α2 Adrenergic Receptor Subtypes Expressed in Chinese Hamster Ovary Cells Activate Differentially Mitogen-activated Protein Kinase by a p21 Independent Pathway
1995
Two functionally distinct α2-adrenergic receptors regulate sympathetic neurotransmission
1999 StandoutNatureNobel
The structure and function of G-protein-coupled receptors
2009 StandoutNatureNobel
Agonist-Receptor-Arrestin, an Alternative Ternary Complex with High Agonist Affinity
1997
The superfamily of heptahelical receptors
2000 StandoutNobel
Structure, function, and regulation of adrenergic receptors
1993
Major Depressive Disorder
2008 Standout
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
Genetic alteration of the α2-adrenoceptor subtype c in mice affects the development of behavioral despair and stress-induced increases in plasma corticosterone levels
1999 StandoutNobel
Seven-transmembrane-spanning receptors and heart function
2002 StandoutNatureNobel
Substitution of three amino acids switches receptor specificity of Gqα to that of Giα
1993 StandoutNatureNobel
β2-Adrenergic Receptor Activates Extracellular Signal-regulated Kinases (ERKs) via the Small G Protein Rap1 and the Serine/Threonine Kinase B-Raf
2000
Modeling and Mutational Analysis of a Putative Sodium-Binding Pocket on the Dopamine D2Receptor
2001
Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation
2005
Structure and dynamics of the M3 muscarinic acetylcholine receptor
2012 StandoutNatureNobel
Oligomerization of G-protein-coupled transmitter receptors
2001
Dosage‐dependent switch from G protein‐coupled to G protein‐independent signaling by a GPCR
2006 StandoutNobel
New Roles for β-Arrestins in Cell Signaling: Not Just for Seven-Transmembrane Receptors
2006 StandoutNobel
In Vivo Mutation of the α2A-Adrenergic Receptor by Homologous Recombination Reveals the Role of This Receptor Subtype in Multiple Physiological Processes
1997
Genetic Alteration of α2C-Adrenoceptor Expression in Mice: Influence on Locomotor, Hypothermic, and Neurochemical Effects of Dexmedetomidine, a Subtype-Nonselective α2-Adrenoceptor Agonist
1997 StandoutNobel
In Vivo Gene Modification Elucidates Subtype-Specific Functions of α2-Adrenergic Receptors
2000
The production and characterization of antibodies against β-adrenergic antagonists
1978
Further evidence that desensitization of beta-adrenergic-sensitive adenylate cyclase proceeds in two steps. Modification of the coupling and loss of beta-adrenergic receptors.
1980
Site-site interactions among insulin receptors. Characterization of the negative cooperativity.
1976
Solubilization of human platelet alpha-adrenergic receptors: evidence that agonist occupancy of the receptor stabilizes receptor--effector interactions.
1981
Hormones, Receptors, and Cyclic AMP: Their Role in Target Cell Refractoriness
1980 StandoutNobel
Adenylate cyclase permanently uncoupled from hormone receptors in a novel variant of S49 mouse lymphoma cells.
1977 StandoutNobel
Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway
1995 StandoutNatureNobel
Effects of phospholipase A2 and filipin on the activation of adenylate cyclase
1979 StandoutNobel
Diverse tissue expression of rat alpha 2-adrenergic receptor genes.
1993
β-Adrenergic and Somatostatin Receptors Regulate Na-H Exchange Independent of cAMP
1989
β-Arrestin-Dependent Formation of β 2 Adrenergic Receptor-Src Protein Kinase Complexes
1999 StandoutScienceNobel
Negative cooperativity among beta-adrenergic receptors in frog erythrocyte membranes.
1976 StandoutNobel
Heterogeneity of radioligand binding to alpha-adrenergic receptors. Analysis of guanine nucleotide regulation of agonist binding in relation to receptor subtypes.
1980 StandoutNobel
Regulation of Adenylate Cyclase Coupled β-Adrenergic Receptors
1976 StandoutNobel
The role of hormone receptors and GTP-regulatory proteins in membrane transduction
1980 StandoutNatureNobel
Agonist-promoted coupling of the beta-adrenergic receptor with the guanine nucleotide regulatory protein of the adenylate cyclase system.
1980 StandoutNobel
Activation and attenuation of adenylate cyclase. The role of GTP-binding proteins as macromolecular messengers in receptor–cyclase coupling
1981
The agonist-specific effect of magnesium ion on binding by beta-adrenergic receptors in S49 lymphoma cells. Interaction of GTP and magnesium in adenylate cyclase activation.
1978
The two-step model of ligand-receptor interaction
1977
Antibodies raised against purified β-adrenergic receptors specifically bind β-adrenergic ligands
1979 StandoutNobel
Structure of the turkey erythrocyte adenylate cyclase system.
1981 StandoutNobel
Correlation of beta-adrenergic receptor-stimulated [3H]GDP release and adenylate cyclase activation. Differences between frog and turkey erythrocyte membranes.
1981 StandoutNobel
Cardiovascular Regulation in Mice Lacking α 2 -Adrenergic Receptor Subtypes b and c
1996 StandoutScienceNobel
Evidence for internalization of the recognition site of β-adrenergic receptors during receptor subsensitivity induced by (-)-isoproterenol
1979
G Protein-Coupled Receptors: Functional and Mechanistic Insights Through Altered Gene Expression
1998 StandoutNobel
Unique uncoupling of the frog erythrocyte adenylate cyclase system by manganese. Loss of hormone and guanine nucleotide-sensitive enzyme activities without loss of nucleotide-sensitive, high affinity agonist binding.
1979 StandoutNobel
The evasive nature of drug efficacy: implications for drug discovery
2007
Adipocyte beta-adrenergic receptors. Identification and subcellular localization by (-)-[3H]dihydroalprenolol binding.
1976 StandoutNobel
Uncovering Molecular Mechanisms Involved in Activation of G Protein-Coupled Receptors
2000
Purification and characterization of the mammalian .beta.2-adrenergic receptor
1983
Gi-mediated activation of the p21ras-mitogen-activated protein kinase pathway by alpha 2-adrenergic receptors expressed in fibroblasts.
1993
Antinociceptive Action of Nitrous Oxide Is Mediated by Stimulation of Noradrenergic Neurons in the Brainstem and Activation of α2BAdrenoceptors
2000 StandoutNobel
Hydrodynamic properties of the beta-adrenergic receptor and adenylate cyclase from wild type and varient S49 lymphoma cells.
1977 StandoutNobel
Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin
1986 StandoutNatureNobel
Computational Modeling Approaches to Structure−Function Analysis of G Protein-Coupled Receptors
2005
Differences between agonist and antagonist binding following beta-adrenergic receptor desensitization.
1978 StandoutNobel
Loss of beta-adrenergic receptor-guanine nucleotide regulatory protein interactions accompanies decline in catecholamine responsiveness of adenylate cyclase in maturing rat erythrocytes.
1980 StandoutNobel
The mobile receptor hypothesis and “cooperativity” of hormone binding. Application to insulin
1976
Cloning, sequencing, and expression of the gene encoding the porcine alpha 2-adrenergic receptor. Allosteric modulation by Na+, H+, and amiloride analogs.
1990
In vivo gene modification elucidates subtype-specific functions of alpha(2)-adrenergic receptors.
2000
A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.
1980 StandoutNobel
Multiple receptors coupled to adenylate cyclase regulate Na-H exchange independent of cAMP.
1990
The alpha(2a)-adrenergic receptor plays a protective role in mouse behavioral models of depression and anxiety.
2001
G Protein Selectivity Is Regulated by Multiple Intracellular Regions of GPCRs
2003
Molecular mechanisms of receptor desensitization using the β-adrenergic receptor-coupled adenylate cyclase system as a model
1985 StandoutNatureNobel
Evidence that a beta-adrenergic receptor-associated guanine nucleotide regulatory protein conveys guanosine 5'-O-(3-thiotriphosphate)- dependent adenylate cyclase activity.
1981 StandoutNobel
Update 1 of: Computational Modeling Approaches to Structure–Function Analysis of G Protein-Coupled Receptors
2011
Relationship between the beta-adrenergic receptor and adenylate cyclase.
1977 StandoutNobel
Resolution of beta-adrenergic receptor binding and adenylate cyclase activity by gel exclusion chromatography.
1977 StandoutNobel
Beta-Adrenergic receptor interactions. Direct comparison of receptor interaction and biological activity.
1976
Slowly reversible binding of catecholamine to a nucleotide-sensitive state of the beta-adrenergic receptor.
1977 StandoutNobel
A high affinity agonist . beta-adrenergic receptor complex is an intermediate for catecholamine stimulation of adenylate cyclase in turkey and frog erythrocyte membranes.
1980 StandoutNobel
Parallel modulation of catecholamine activation of adenylate cyclase and formation of the high-affinity agonist.cntdot.receptor complex in turkey erythrocyte membranes by temperature and cis-vaccenic acid
1980 StandoutNobel
Cooperativity in ligand binding: A new graphic analysis
1975
Catecholamine binding to the beta-adrenergic receptor.
1977 StandoutNobel
Solubilization and characterization of the beta-adrenergic receptor binding sites of frog erythrocytes.
1976 StandoutNobel
Gene targeting — homing in on α2-adrenoceptor-subtype function
1997 StandoutNobel
Activation and desensitization of beta-adrenergic receptor-coupled GTPase and adenylate cyclase of frog and turkey erythrocyte membranes.
1980 StandoutNobel
Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors
2000 StandoutNobel
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Hormone-sensitive adenylate cyclase. Delineation of a trypsin-sensitive site in the pathway of receptor-mediated inhibition.
1982 StandoutNobel
Beta-Adrenergic receptor interactions. Characterization of iodohydroxybenzylpindolol as a specific ligand.
1976
Works of Lee E. Limbird being referenced
Abnormal Regulation of the Sympathetic Nervous System in α2A-Adrenergic Receptor Knockout Mice
1999 StandoutNobel
Nitrous Oxide Produces Antinociceptive Response via α2Band/or α2CAdrenoceptor Subtypes in Mice
1999
The Role of a Conserved Inter-Transmembrane Domain Interface in Regulating α2a-Adrenergic Receptor Conformational Stability and Cell-Surface Turnover
2001
G protein-coupled receptor interacting proteins: Emerging roles in localization and signal transduction
2002
The Three α2-Adrenergic Receptor Subtypes Achieve Basolateral Localization in Madin-Darby Canine Kidney II Cells via Different Targeting Mechanisms
1996
Abnormal Regulation of the Sympathetic Nervous System in α2A-Adrenergic Receptor Knockout Mice
1999 StandoutNobel
Arrestin Serves as a Molecular Switch, Linking Endogenous α2-Adrenergic Receptor to SRC-dependent, but Not SRC-independent, ERK Activation
2006
Stimulation of Mitogen-activated Protein Kinase by G Protein-coupled α2-Adrenergic Receptors Does Not Require Agonist-elicited Endocytosis
1999
The ζ Isoform of 14-3-3 Proteins Interacts with the Third Intracellular Loop of Different α2-Adrenergic Receptor Subtypes
1999
A Point Mutation of the α 2 -Adrenoceptor that Blocks Coupling to Potassium but not Calcium Currents
1992 Science
Receptors linked to inhibition of adenylate cyclase: additional signaling mechanisms
1988
Adenylate Cyclase-Coupled Beta Adrenergic Receptors: Effect of Membrane Lipid-Perturbing Agents on Receptor Binding and Enzyme Stimulation by Catecholamines
1976 StandoutNobel
The α2A-Adrenergic Receptor Plays a Protective Role in Mouse Behavioral Models of Depression and Anxiety
2001
The ß-adrenergic receptor and adenylate cyclase
1976 StandoutNobel
Substitution of a mutant α 2a -adrenergic receptor via “hit and run” gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo
1997
Central Hypotensive Effects of the α 2a -Adrenergic Receptor Subtype
1996 Science
β-Adrenergic receptors: Evidence for negative cooperativity
1975 StandoutNobel
β-Adrenoreceptors determine affinity but not intrinsic activity of adenylate cyclase stimulants
1979 StandoutNatureNobel
A Point Mutation (D79N) of the α2A Adrenergic Receptor Abolishes the Antiepileptogenic Action of Endogenous Norepinephrine
1998
Membrane Trafficking of G Protein–Coupled Receptors
2004
The α2aAdrenergic Receptor Subtype Mediates Spinal Analgesia Evoked by α2Agonists and Is Necessary for Spinal Adrenergic–Opioid Synergy
1997
Agonist-induced increase in apparent β-adrenergic receptor size
1978 StandoutNobel
Differential effects of GTP on the coupling of β-adrenergic receptors to adenylate cyclase from frog and turkey erythrocytes application of new methods for the analysis of receptor-effector coupling
1979 StandoutNobel