Citation Impact
Citing Papers
Nuclear Dvl, c-Jun, β-catenin, and TCF form a complex leading to stabiLization of β-catenin–TCF interaction
2008
The Mechanism of Endogenous Receptor Activation Functionally Distinguishes Prototype Canonical and Noncanonical Wnts
2005
Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions
2007
Where Wnts Went: The Exploding Field of Lrp5 and Lrp6 Signaling in Bone
2008
Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression
2009 Standout
Genome-wide identification of mRNAs associated with the translational regulator PUMILIO in Drosophila melanogaster
2006
LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of β-catenin
2008
Roles of Wnt signaling in bone formation and resorption
2008
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
2022 Standout
DKK1 Antagonizes Wnt Signaling without Promotion of LRP6 Internalization and Degradation
2008
G Protein-coupled Receptor Kinases Phosphorylate LRP6 in the Wnt Pathway
2009 StandoutNobel
Wnt/Ca<sup>2+</sup> signaling pathway: a brief overview
2011
Noncanonical Wnt-4 Signaling Enhances Bone Regeneration of Mesenchymal Stem Cells in Craniofacial Defects through Activation of p38 MAPK
2007
Fracture healing: mechanisms and interventions
2014 Standout
Kremen2 modulates Dickkopf2 activity during Wnt/lRP6 signaling
2003
Building bone to reverse osteoporosis and repair fractures
2008
Role of wnts in prostate cancer bone metastases
2005
Cancer to bone: a fatal attraction
2011 Standout
Identification, Characterization, and Regulation of the Canonical Wnt Signaling Pathway in Human Endometrium
2003
Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis
2012
Mammalian phosphoinositide kinases and phosphatases
2009 StandoutNobel
Wnt signaling in cancer
2016 Standout
Targeting the Wnt/β-Catenin Pathway to Regulate Bone Formation in the Adult Skeleton
2007
The role of magnesium ions in bone regeneration involves the canonical Wnt signaling pathway
2019 Standout
Characterization of the Kremen-binding Site on Dkk1 and Elucidation of the Role of Kremen in Dkk-mediated Wnt Antagonism
2008
WNT signalling pathways as therapeutic targets in cancer
2012 Standout
WNT and β-catenin signalling: diseases and therapies
2004 Standout
TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation
2009 Standout
Secreted and Transmembrane Wnt Inhibitors and Activators
2012
Wingless/Wnt signal transduction requires distinct initiation and amplification steps that both depend on Arrow/LRP
2007
Identification of two novel activities of the Wnt signaling regulator Dickkopf 3 and characterization of its expression in the mouse retina
2007
Multiple determinants within iron-responsive elements dictate iron regulatory protein binding and regulatory hierarchy
2009
Osteocytes, mechanosensing and Wnt signaling
2008
Cellular signaling and factors involved in Müller cell gliosis: Neuroprotective and detrimental effects
2009 Standout
β-Catenin destruction complex: insights and questions from a structural perspective
2006
The Epigenomics of Cancer
2007 Standout
Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling
2005
Osteoporosis: now and the future
2011 Standout
Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions
2008 StandoutNature
Skeletal remodeling in health and disease
2007 Standout
WNT signaling in bone homeostasis and disease: from human mutations to treatments
2013 Standout
Syp1 is a conserved endocytic adaptor that contains domains involved in cargo selection and membrane tubulation
2009
Two to Tango: Regulation of Mammalian Iron Metabolism
2010 Standout
The Mammalian Epigenome
2007 Standout
PTH/cAMP/PKA signaling facilitates canonical Wnt signaling via inactivation of glycogen synthase kinase‐3β in osteoblastic Saos‐2 cells
2007 StandoutNobel
Wnt/β-Catenin Signaling and Disease
2012 Standout
Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases
2009 Standout
Secreted frizzled related protein 1 is a target to improve fracture healing
2009
Structural Basis of Wnt Signaling Inhibition by Dickkopf Binding to LRP5/6
2011
Wnt signaling as a therapeutic target for bone diseases
2009
Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice
2009
Signaling Networks that Control the Lineage Commitment and Differentiation of Bone Cells
2009
Wnt signaling and osteoblastogenesis
2006
A model for familial exudative vitreoretinopathy caused by LPR5 mutations
2008 StandoutNobel
Sclerostin: how human mutations have helped reveal a new target for the treatment of osteoporosis
2013 StandoutNobel
TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation
2012 Standout
A Comprehensive Overview of Skeletal Phenotypes Associated with Alterations in Wnt/β-catenin Signaling in Humans and Mice
2013
What old means to bone
2010 Standout
A Wnt canon orchestrating osteoblastogenesis
2006
Regulation of bone mass by Wnt signaling
2006
Wnt/β-Catenin Signaling in Development and Disease
2006 Standout
Mouse Cristin/R-spondin Family Proteins Are Novel Ligands for the Frizzled 8 and LRP6 Receptors and Activate β-Catenin-dependent Gene Expression
2006
Wnt Antagonists Bind through a Short Peptide to the First β-Propeller Domain of LRP5/6
2011
Wnt-independent activation of β-catenin mediated by a Dkk1-Fz5 fusion protein
2005
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions
2006
Molecular mechanism and physiological functions of clathrin-mediated endocytosis
2011 Standout
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia
2006
Role of the intracellular domains of LRP5 and LRP6 in activating the Wnt canonical pathway
2005
Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression
2003
Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs
2007 Standout
Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis
2012 Standout
Signaling and transcriptional regulation in osteoblast commitment and differentiation
2007
Molecular Bases of the Regulation of Bone Remodeling by the Canonical Wnt Signaling Pathway
2006
Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP
2010 Standout
New Insights into the Mechanism of Wnt Signaling Pathway Activation
2011
Wg/Wnt Signal Can Be Transmitted through Arrow/LRP5,6 and Axin Independently of Zw3/Gsk3β Activity
2003 Nobel
Long noncoding RNAs: functional surprises from the RNA world
2009 Standout
Negative Regulation of Bone Formation by the Transmembrane Wnt Antagonist Kremen-2
2010
Networks and hubs for the transcriptional control of osteoblastogenesis
2006
The role of the Wnt signaling pathway in osteoblast commitment and differentiation
2007
Update on Wnt signaling in bone cell biology and bone disease
2011
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
2017 Standout
The Polycomb complex PRC2 and its mark in life
2011 StandoutNature
Inflammatory bone loss: pathogenesis and therapeutic intervention
2012 Standout
Mechanisms of implantation: strategies for successful pregnancy
2012 Standout
Ixodes scapularis salivary gland protein P11 facilitates migration of Anaplasma phagocytophilum from the tick gut to salivary glands
2011
Digital Twin for rotating machinery fault diagnosis in smart manufacturing
2018 Standout
Cloud Computing for Cloud Manufacturing: Benefits and Limitations
2015
Artificial intelligence in drug discovery and development
2020 Standout
Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA) in osteoblasts
2009
Wnt Induces LRP6 Signalosomes and Promotes Dishevelled-Dependent LRP6 Phosphorylation
2007 Science
Regulation of osteogenic differentiation during skeletal development
2007
mRNA vaccination induces tick resistance and prevents transmission of the Lyme disease agent
2021 StandoutNobel
Wnt signals across the plasma membrane to activate the β-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP
2004
Lrp6 Hypomorphic Mutation Affects Bone Mass Through Bone Resorption in Mice and Impairs Interaction With Mesd
2008 StandoutNobel
Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate
2008
Relaxin Augments BMP-2–Induced Osteoblast Differentiation and Bone Formation
2014 Standout
LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:Arrows point the way
2004
Wnt3a-Mediated Formation of Phosphatidylinositol 4,5-Bisphosphate Regulates LRP6 Phosphorylation
2008 Science
Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation
2005 Standout
Artificial intelligence in nanomedicine
2018
Stability elements in the LRP6 cytoplasmic tail confer efficient signalling upon DIX-dependent polymerization
2010
Wise, a context-dependent activator and inhibitor of Wnt signalling
2003
Epigenetic regulation in pluripotent stem cells: a key to breaking the epigenetic barrier
2012 StandoutNobel
Secreted antagonists of the Wnt signalling pathway
2003
From Estrogen-Centric to Aging and Oxidative Stress: A Revised Perspective of the Pathogenesis of Osteoporosis
2010 Standout
THE WNT SIGNALING PATHWAY IN DEVELOPMENT AND DISEASE
2004 Standout
The LRP5 High-Bone-Mass G171V Mutation Disrupts LRP5 Interaction with Mesd
2004
Geometric cues for directing the differentiation of mesenchymal stem cells
2010 Standout
The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity
2005
The amazing osteocyte
2010 Standout
Improving efficiency and accuracy in multilingual entity extraction
2013
Deletion of a Single Allele of the Dkk1 Gene Leads to an Increase in Bone Formation and Bone Mass
2006
Knowledge Graph Embedding: A Survey of Approaches and Applications
2017 Standout
Works of Le Sun being referenced
Neural Relevance Model Using Similarities with Elite Documents for Effective Clinical Decision Support
2018
A Generative Entity-Mention Model for Linking Entities with Knowledge Base
2011
Second Cysteine-rich Domain of Dickkopf-2 Activates Canonical Wnt Signaling Pathway via LRP-6 Independently of Dishevelled
2002
Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation
2005
Cloud service selection: State-of-the-art and future research directions
2014
Neural relevance model using similarities with elite documents for effective clinical decision support
2018