Standout Papers
Citation Impact
Citing Papers
Activity-Dependent Internalization of Smoothened Mediated by ß-Arrestin 2 and GRK2
2004 StandoutScienceNobel
Basal Cell Carcinomas in Mice Overexpressing Sonic Hedgehog
1997 StandoutScience
Comprehensive molecular portraits of human breast tumours
2012 StandoutNature
ANKTM1, a TRP-like Channel Expressed in Nociceptive Neurons, Is Activated by Cold Temperatures
2003 StandoutNobel
A stomatin-like protein necessary for mechanosensation in C. elegans
1995 StandoutNatureNobel
Identification of a Human Homologue of theSchizosaccharomyces pombe rad17+ Checkpoint Gene
1998
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
CeMyoD accumulation defines the body wall muscle cell fate during C. elegans embryogenesis
1990 StandoutNobel
Sonic hedgehog is essential to foregut development
1998
Inhibition of Sonic hedgehog signaling in vivo results in craniofacial neural crest cell death
1999
Genetic Ablation and Restoration of the Olfactory Topographic Map
2000 StandoutNobel
Accelerated Evolution of Nervous System Genes in the Origin of Homo sapiens
2004
Molecular and genetic analysis of cystic fibrosis*1
1988
Mammalian recombination hot spots: properties, control and evolution
2010
Temporal and Spatial Effects of Sonic Hedgehog Signaling in Chick Eye Morphogenesis
2001
Molecular Cloning of Ring Finger Protein 21 (RNF21)/Interferon-Responsive Finger Protein (ifp1), Which Possesses Two RING–B Box–Coiled Coil Domains in Tandem
2000
Heterochronic Genes Control Cell Cycle Progress and Developmental Competence of C. elegans Vulva Precursor Cells
1996 StandoutNobel
Pre-meiotic S phase is linked to reductional chromosome segregation and recombination
2001 StandoutNatureNobel
The hedgehog signaling network
2003
Production of a severe cystic fibrosis mutation in mice by gene targeting
1993 StandoutNobel
Effective targeted gene ‘knockdown’ in zebrafish
2000 Standout
Gene interactions affecting mechanosensory transduction in Caenorhabditis elegans
1994 StandoutNatureNobel
Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis
1993
The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel
2002 StandoutNatureNobel
The seven-transmembrane receptor Smoothened cell-autonomously induces multiple ventral cell types
2000
The Sonic Hedgehog–Patched–Gli Pathway in Human Development and Disease
2000
Retinitis pigmentosa
2006 Standout
A Human Homologue of the Schizosaccharomyces pombe rad1+ Checkpoint Gene Encodes an Exonuclease
1998
Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family
1997 Standout
Salmonella typhi uses CFTR to enter intestinal epithelial cells
1998 StandoutNatureNobel
Clinical and genetic comparisons of patients with cystic fibrosis, with or without meconium ileus
1989
Meiotic chromosomes: it takes two to tango
1997
New players and puzzles in the Hedgehog signaling pathway
1998
A mutation in the cystic fibrosis transmembrane conductance regulator gene associated with elevated sweat chloride concentrations in the absence of cystic fibrosis
1998
Why is the cystic fibrosis gene so frequent?
1989
Sonic hedgehogParticipates in Craniofacial Morphogenesis and Is Down-regulated by Teratogenic Doses of Retinoic Acid
1997
Hedgehog signaling in animal development: paradigms and principles
2001 Standout
Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours
1997 Nature
Familial concordance of pancreatic function in cystic fibrosis
1989
Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
1993 StandoutNobel
Cystic fibrosis: molecular biology and therapeutic implications
1992 StandoutScience
An Ankyrin-like Protein with Transmembrane Domains Is Specifically Lost after Oncogenic Transformation of Human Fibroblasts
1999
A mammalian DNA repair enzyme that excises oxidatively damaged guanines maps to a locus frequently lost in lung cancer
1997
The VPAC2 Receptor Is Essential for Circadian Function in the Mouse Suprachiasmatic Nuclei
2002
The pie-1 and mex-1 genes and maternal control of blastomere identity in early C. elegans embryos
1992 StandoutNobel
Expression of the Sonic hedgehog (SHH) Gene during Early Human Development and Phenotypic Expression of New Mutations Causing Holoprosencephaly
1999
Cystic fibrosis in the mouse by targeted insertional mutagenesis
1992 Nature
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
2004 StandoutNatureNobel
Molecular Mechanisms of Holoprosencephaly
1999
Cohesin Rec8 is required for reductional chromosome segregation at meiosis
1999 StandoutNatureNobel
The C. elegans gene lin-44, which controls the polarity of certain asymmetric cell divisions, encodes a Wnt protein and acts cell nonautonomously
1995 StandoutNobel
WRM-1 Activates the LIT-1 Protein Kinase to Transduce Anterior/Posterior Polarity Signals in C. elegans
1999 StandoutNobel
Mutations in the human Sonic Hedgehog gene cause holoprosencephaly
1996 Standout
Disruption of c-mos causes parthenogenetic development of unfertilized mouse eggs
1994 StandoutNatureNobel
A modular set of lacZ fusion vectors for studying gene expression in Caenorhabditis elegans
1990 StandoutNobel
Coupled oscillators control morning and evening locomotor behaviour of Drosophila
2004 StandoutNatureNobel
The TRA-1A Sex Determination Protein of C. elegans Regulates Sexually Dimorphic Cell Deaths by Repressing the egl-1 Cell Death Activator Gene
1999 StandoutNobel
The Human Condition—A Molecular Approach
2014 StandoutNobel
Correction of the ion transport defect in cystic fibrosis transgenic mice by gene therapy
1993 StandoutNatureNobel
The patched gene in development and cancer
1998
Gli1 is a target of Sonic hedgehog that induces ventral neural tube development
1997
Alternative temporal control systems for hypodermal cell differentiation in Caenorhabditis elegans
1991 StandoutNatureNobel
C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180
1998 StandoutNatureNobel
A Novel Mutation of desert hedgehog in a Patient with 46,XY Partial Gonadal Dysgenesis Accompanied by Minifascicular Neuropathy
2000
The Cystic Fibrosis Transmembrane Conductance Regulator Gene
1995
Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage
1999 StandoutNobel
An Animal Model for Cystic Fibrosis Made by Gene Targeting
1992 StandoutScienceNobel
Identification of the Cystic Fibrosis Gene: Chromosome Walking and Jumping
1989 StandoutScience
Refined linkage map of chromosome 7 in the region of the cystic fibrosis gene.
1988
Purification and characterization of human DNA damage checkpoint Rad complexes
2001 StandoutNobel
β-Arrestin–Mediated Localization of Smoothened to the Primary Cilium
2008 StandoutScienceNobel
Parallel Patterns of Evolution in the Genomes and Transcriptomes of Humans and Chimpanzees
2005 StandoutScienceNobel
Green Fluorescent Protein as a Marker for Gene Expression
1994 StandoutScienceNobel
Sonic hedgehog regulates the growth and patterning of the cerebellum
1999
Pancreas development is promoted by cyclopamine, a Hedgehog signaling inhibitor
1998
Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling
1998 StandoutScience
The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants
1998
Regulation of retinal ganglion cell production by Sonic hedgehog
2001
Bacterial Biofilms: A Common Cause of Persistent Infections
1999 StandoutScience
β-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3
2000 StandoutScienceNobel
ß-Arrestin 2 Regulates Zebrafish Development Through the Hedgehog Signaling Pathway
2004 Science
Genetic Ablation: Targeted Expression of a Toxin Gene Causes Microphthalmia in Transgenic Mice
1987 Science
Identification of the Cystic Fibrosis Gene: Genetic Analysis
1989 StandoutScience
The MKK7 Gene Encodes a Group of c-Jun NH2-Terminal Kinase Kinases
1999
Cell-type-specific and hypoxia-inducible expression of the human erythropoietin gene in transgenic mice.
1991 StandoutNobel
cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein.
1996
A resetting signal between Drosophila pacemakers synchronizes morning and evening activity
2005 StandoutNatureNobel
A Novel Mutation ofdesert hedgehogin a Patient with 46,XY Partial Gonadal Dysgenesis Accompanied by Minifascicular Neuropathy
2000
Analysis of DNA polymorphism haplotypes linked to the cystic fibrosis locus in North American black and Caucasian families supports the existence of multiple mutations of the cystic fibrosis gene.
1989
Regulation of pancreas development by hedgehog signaling
2000
Hedgehog signals regulate multiple aspects of gastrointestinal development
2000
Large-scale analysis of the human and mouse transcriptomes
2002 StandoutNobel
Identification and regional localization of DNA markers on chromosome 7 for the cloning of the cystic fibrosis gene.
1988
A C-terminal motif found in the β 2 -adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na + /H + exchanger regulatory factor family of PDZ proteins
1998 StandoutNobel
Preferential binding of ATR protein to UV-damaged DNA
2002 StandoutNobel
Introduction of a lacZ reporter gene into the mouse int-2 locus by homologous recombination.
1990 StandoutNobel
Retinal fascin: functional nature, subcellular distribution, and chromosomal localization.
2000
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Works of L.-C. Tsui being referenced
Identification and Characterization of Human Genes Encoding Hprp3p and Hprp4p, Interacting Components of the Spliceosome
1997
Chromosomal Localization in Mouse and Human of the Vasoactive Intestinal Peptide Receptor Type 2 Gene: A Possible Contributor to the Holoprosencephaly 3 Phenotype
1996
Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly
1996 Standout
In Situ Detection of β-Galactosidase in Lenses of Transgenic Mice with a γ-Crystallin/ lacZ Gene
1987 Science
Microdissection and microcloning of the long arm of human chromosome 7
1987
Lens-specific promoter activity of a mouse gamma-crystallin gene.
1985
Physical localization of two DNA markers closely linked to the cystic fibrosis locus by pulsed-field gel electrophoresis.
1989
DNA marker haplotype association with pancreatic sufficiency in cystic fibrosis.
1989
Linkage of DNA probe B79a (D7S13) to cystic fibrosis.
1987
High-resolution mapping of mammalian genes by in situ hybridization to free chromatin.
1992
Report of the committee on the genetic constitution of chromosomes 7 and 8
1989
Genetic analysis of cystic fibrosis using linked DNA markers.
1986
Mapping of the Cystic Fibrosis Locus on Chromosome 7
1986
Genetic determination of exocrine pancreatic function in cystic fibrosis.
1992
Regulation of meiotic chromatin loop size by chromosomal position.
1996