Citation Impact
Citing Papers
The Hepatitis C Virus NS2/3 Protease
2007
Reduction of Hepatitis C Virus NS5A Hyperphosphorylation by Selective Inhibition of Cellular Kinases Activates Viral RNA Replication in Cell Culture
2004
Compensatory Mutations in E1, p7, NS2, and NS3 Enhance Yields of Cell Culture-Infectious Intergenotypic Chimeric Hepatitis C Virus
2006
Targeting of Diacylglycerol Degradation to M1 Muscarinic Receptors by ß-Arrestins
2007 StandoutScienceNobel
Complete Replication of Hepatitis C Virus in Cell Culture
2005 StandoutScienceNobel
Characterization of a canine homolog of hepatitis C virus
2011 StandoutNobel
Plasmacytoid dendritic cells initiate a complex chemokine and cytokine network and are a viable drug target in chronic HCV patients
2007 StandoutNobel
A drug-controllable tag for visualizing newly synthesized proteins in cells and whole animals
2008 StandoutNobel
Evidence for a functional RNA element in the hepatitis C virus core gene
2007 StandoutNobel
The Hepatitis C Virus NS2 Protein Generated by NS2-3 Autocleavage Is Required for NS5A Phosphorylation
1999
Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism
2009 StandoutNobel
The Metal Binding Site of the Hepatitis C Virus NS3 Protease
1998
Hepatitis C Virus NS5A Is a Direct Substrate of Casein Kinase I-α, a Cellular Kinase Identified by Inhibitor Affinity Chromatography Using Specific NS5A Hyperphosphorylation Inhibitors
2006
The Spring α-Helix Coordinates Multiple Modes of HCV (Hepatitis C Virus) NS3 Helicase Action
2016 StandoutNobel
Pan-Genotype Hepatitis E Virus Replication in Stem Cell–Derived Hepatocellular Systems
2017 StandoutNobel
Challenges and successes in developing new therapies for hepatitis C
2005 Nature
Cell Culture Systems for Hepatitis C Virus
2013
Hepatitis C Virus and eliminating post-transfusion hepatitis
2000 StandoutNobel
In vitro selected Con1 subgenomic replicons resistant to 2′-C-Methyl-Cytidine or to R1479 show lack of cross resistance
2006
In Vitro Studies of Cross-resistance Mutations against Two Hepatitis C Virus Serine Protease Inhibitors, VX-950 and BILN 2061
2005
Nonstructural protein 3‐4A: the Swiss army knife of hepatitis C virus
2011
Molecular virology of the hepatitis C virus
1999
Mechanism of autoproteolysis at the NS2–NS3 junction of the hepatitis C virus polyprotein
1998
Dynamic Hepatitis C Virus Genotypic and Phenotypic Changes in Patients Treated With the Protease Inhibitor Telaprevir
2007
euHCVdb: the European hepatitis C virus database
2006 StandoutNobel
Unravelling hepatitis C virus replication from genome to function
2005 StandoutNatureNobel
Architects of assembly: roles of Flaviviridae non-structural proteins in virion morphogenesis
2008 StandoutNobel
Interaction of hepatitis C virus proteins with host cell membranes and lipids
2002
The hepatitis C virus replicon system: From basic research to clinical application
2005
trans-Complementation of an NS2 Defect in a Late Step in Hepatitis C Virus (HCV) Particle Assembly and Maturation
2009
Molecular virology of hepatitis C virus.
1997
Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease–helicase
1999
Hepatitis C virus cell culture replication systems: their potential use for the development of antiviral therapies
2001
The NS3/4A proteinase of the hepatitis C virus: unravelling structure and function of an unusual enzyme and a prime target for antiviral therapy
1999
Structural and Functional Characterization of Nonstructural Protein 2 for Its Role in Hepatitis C Virus Assembly
2008
In Vitro Characterization of a Purified NS2/3 Protease Variant of Hepatitis C Virus
2001
Protective Immune Response to Hepatitis C Virus in Chimpanzees Rechallenged Following Clearance of Primary Infection
2001 StandoutNobel
Prospects for a vaccine against the hepatitis C virus
2005 StandoutNatureNobel
Structure-Function Relationships Among RNA-Dependent RNA Polymerases
2007
Isatoribine, an Agonist of TLR7, Reduces Plasma Virus Concentration in Chronic Hepatitis C Infection *
2005
Chapter 2 Cutting the Gordian Knot-Development and Biological Relevance of Hepatitis C Virus Cell Culture Systems
2008
Zinc coordination sphere in biochemical zinc sites
2001
Structural biology of hepatitis C virus
2003
Molecular Characterization of Hepatitis C Virus
1998 StandoutNobel
Determinants for Membrane Association of the Hepatitis C Virus RNA-dependent RNA Polymerase
2001 StandoutNobel
Sofosbuvir Inhibits Hepatitis E Virus Replication In Vitro and Results in an Additive Effect When Combined With Ribavirin
2015 StandoutNobel
Hepatitis C Virus NS2 Protein Inhibits Gene Expression from Different Cellular and Viral Promoters in Hepatic and Nonhepatic Cell Lines
2003
THE MOLECULAR BIOLOGY OF HEPATITIS C VIRUS
1999
Hepatitis C Virus-Specific Directly Acting Antiviral Drugs
2013
In Vitro Resistance Studies of Hepatitis C Virus Serine Protease Inhibitors, VX-950 and BILN 2061
2004
The Hepatitis C Virus NS2 Protein Is an Inhibitor of CIDE-B-induced Apoptosis
2003
Hepatitis C Virus Entry
2007 StandoutNobel
Metabolism of Phosphatidylinositol 4-Kinase IIIα-Dependent PI4P Is Subverted by HCV and Is Targeted by a 4-Anilino Quinazoline with Antiviral Activity
2012
Mutations Conferring Resistance to SCH6, a Novel Hepatitis C Virus NS3/4A Protease Inhibitor
2005
Structural biology of hepatitis C virus
2004
Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase
2005 StandoutNatureNobel
A computational approach for predicting off-target toxicity of antiviral ribonucleoside analogues to mitochondrial RNA polymerase
2018 StandoutNobel
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Overview of Hepatitis C Virus Genome Structure, Polyprotein Processing, and Protein Properties
2000 StandoutNobel
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies
2013 StandoutNobel
A Hepatitis C Virus (HCV) Vaccine Comprising Envelope Glycoproteins gpE1/gpE2 Derived from a Single Isolate Elicits Broad Cross-Genotype Neutralizing Antibodies in Humans
2013 StandoutNobel
The Hepatitis C Virus Internal Ribosome Entry Site Adopts an Ion-dependent Tertiary Fold
1999 StandoutNobel
The NS5A Protein of Hepatitis C Virus Is a Zinc Metalloprotein
2004 StandoutNobel
Membrane Topology of the Hepatitis C Virus NS2 Protein
2002
Novel Insights into Hepatitis C Virus Replication and Persistence
2004
Hepatitis C Virus NS2/3 Processing Is Required for NS3 Stability and Viral RNA Replication
2005
The molecular virology of hepatitis C
1997
Boceprevir for Untreated Chronic HCV Genotype 1 Infection
2011 Standout
Biochemical and Kinetic Analyses of NS5B RNA-Dependent RNA Polymerase of the Hepatitis C Virus
1998
The way forward in HCV treatment — finding the right path
2007 StandoutNobel
Identification and analysis of fitness of resistance mutations against the HCV protease inhibitor SCH 503034
2006
Modified apoptotic molecule (BID) reduces hepatitis C virus infection in mice with chimeric human livers
2003
Replication of hepatitis C virus
2007 StandoutNobel
Telaprevir and pegylated interferon–alpha-2a inhibit wild-type and resistant genotype 1 hepatitis C virus replication in patients
2007
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
Flying Under the Radar: The Immunobiology of Hepatitis C
2006 StandoutNobel
Replication of Subgenomic Hepatitis C Virus RNAs in a Hepatoma Cell Line
1999 StandoutScience
Replication of hepatitis C virus
2000
The hepatitis C virus NS2/3 protease.
2007
Selection and Characterization of Replicon Variants Dually Resistant to Thumb- and Palm-Binding Nonnucleoside Polymerase Inhibitors of the Hepatitis C Virus
2006
Ultrastructural analysis of hepatitis C virus particles
2013 StandoutNobel
Characterization of nonprimate hepacivirus and construction of a functional molecular clone
2015 StandoutNobel
Determinants of the Hepatitis C Virus Nonstructural Protein 2 Protease Domain Required for Production of Infectious Virus
2009 StandoutNobel
Expression of Hepatitis C Virus Proteins Induces Distinct Membrane Alterations Including a Candidate Viral Replication Complex
2002
Efficient Initiation of HCV RNA Replication in Cell Culture
2000 StandoutScienceNobel
Product Inhibition of the Hepatitis C Virus NS3 Protease
1998
Hepatitis C Virus NS2 Protein Serves as a Scaffold for Virus Assembly by Interacting with both Structural and Nonstructural Proteins
2010
Interferon-Stimulated Genes: A Complex Web of Host Defenses
2014 StandoutNobel
Highly Permissive Cell Lines for Subgenomic and Genomic Hepatitis C Virus RNA Replication
2002 StandoutNobel
Hepatitis C Virus NS2 Protein Is Phosphorylated by the Protein Kinase CK2 and Targeted for Degradation to the Proteasome
2005
The NMR–Rosetta capsid model of M13 bacteriophage reveals a quadrupled hydrophobic packing epitope
2015 StandoutNobel
Fluorescent Sensors for Measuring Metal Ions in Living Systems
2014 Standout
Hepatitis C Virus NS2 Protein Contributes to Virus Particle Assembly via Opposing Epistatic Interactions with the E1-E2 Glycoprotein and NS3-NS4A Enzyme Complexes
2009
Genetic diversity and evolution of hepatitis C virus – 15 years on
2004
Phosphatidic acid activation of protein kinase C-ζ overexpressed in COS cells: comparison with other protein kinase C isotypes and other acidic lipids
1994
The α Isoform of Protein Kinase CKI Is Responsible for Hepatitis C Virus NS5A Hyperphosphorylation
2006
Development of a Second-Generation, Highly Efficient Manufacturing Route for the HIV Integrase Inhibitor Raltegravir Potassium
2010
Hyperphosphorylation of the Hepatitis C Virus NS5A Protein Requires an Active NS3 Protease, NS4A, NS4B, and NS5A Encoded on the Same Polyprotein
1999
Review HCV Antiviral Resistance: The Impact of in vitro Studies on the Development of Antiviral Agents Targeting the Viral NS5B Polymerase
2005
Characterization of an Autonomous Subgenomic Pestivirus RNA Replicon
1998
Nuclear localization of the NS3 protein of hepatitis C virus and factors affecting the localization
1997
Continuous human cell lines inducibly expressing hepatitis C virus structural and nonstructural proteins
1998 StandoutNobel
A Cellular J-Domain Protein Modulates Polyprotein Processing and Cytopathogenicity of a Pestivirus
2001
Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs
2002 StandoutNobel
Interaction between hepatitis C virus core protein and E1 envelope protein
1996
A cell protection screen reveals potent inhibitors of multiple stages of the hepatitis C virus life cycle
2010 StandoutNobel
Temporal Modulation of an Autoprotease Is Crucial for Replication and Pathogenicity of an RNA Virus
2004
Molecular Mechanism of Hepatitis C Virus Replicon Variants with Reduced Susceptibility to a Benzofuran Inhibitor, HCV-796
2008
Hepatitis C virus NS2 is a protease stimulated by cofactor domains in NS3
2009
Folding of Hepatitis C Virus E1 Glycoprotein in a Cell-Free System
2001 StandoutNobel
Genetic and Functional Characterization of the N-Terminal Region of the Hepatitis C Virus NS2 Protein
2013 StandoutNobel
Mutations Conferring Resistance to a Potent Hepatitis C Virus Serine Protease Inhibitor In Vitro
2004
Protein-Protein Interactions between Hepatitis C Virus Nonstructural Proteins
2003
Mutations Conferring Resistance to a Hepatitis C Virus (HCV) RNA-Dependent RNA Polymerase Inhibitor Alone or in Combination with an HCV Serine Protease Inhibitor In Vitro
2005
Filamentous Phage Display in the New Millennium
2005
Phosphorylation of hepatitis C virus nonstructural protein 5A modulates its protein interactions and viral RNA replication
2004 StandoutNobel
Characterization of the Hepatitis C Virus NS2/3 Processing Reaction by Using a Purified Precursor Protein
2001
Structure of the catalytic domain of the hepatitis C virus NS2-3 protease
2006 StandoutNatureNobel
Works of Laura Pacini being referenced
2-(3-Thienyl)-5,6-dihydroxypyrimidine-4-carboxylic acids as inhibitors of HCV NS5B RdRp
2009
Mechanismof Action and Antiviral Activity of Benzimidazole-Based AllostericInhibitors of the Hepatitis C Virus RNA-Dependent RNAPolymerase
2003
Muscarinic stimulation of SK-N-BE(2) human neuroblastoma cells elicits phosphoinositide and phosphatidylcholine hydrolysis: relationship to diacylglycerol and phosphatidic acid accumulation
1993
The NS2 protein of hepatitis C virus is a transmembrane polypeptide
1995
Selection of Functional Variants of the NS3-NS4A Protease of Hepatitis C Virus by Using Chimeric Sindbis Viruses
1999
In Vivo Selection of Protease Cleavage Sites by Using Chimeric Sindbis Virus Libraries
2000
Chimeric Sindbis viruses dependent on the NS3 protease of hepatitis C virus
1997
Naturally Occurring Hepatitis C Virus Subgenomic Deletion Mutants Replicate Efficiently in Huh-7 Cells and Are trans -Packaged In Vitro To Generate Infectious Defective Particles
2009
In Vitro Selection and Characterization of Hepatitis C Virus Serine Protease Variants Resistant to an Active-Site Peptide Inhibitor
2003
In vitro study of the NS2-3 protease of hepatitis C virus
1997