Citation Impact
Citing Papers
Orientation-specific responses to sustained uniaxial stretching in focal adhesion growth and turnover
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β-Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2
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HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
2001 StandoutScienceNobel
Actin retrograde flow actively aligns and orients ligand-engaged integrins in focal adhesions
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Stress fibers are generated by two distinct actin assembly mechanisms in motile cells
2006
Parkinson-like syndrome induced by continuous MPTP infusion: Convergent roles of the ubiquitin-proteasome system and α-synuclein
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Cargo sorting into multivesicular bodies in vitro
2009 StandoutNobel
Multiubiquitin Chain Binding and Protein Degradation Are Mediated by Distinct Domains within the 26 S Proteasome Subunit Mcb1
1998
Mapping Subunit Contacts in the Regulatory Complex of the 26 S Proteasome
2000
A Mouse Amidase Specific for N-terminal Asparagine
1996
Persistent activation of cAMP-dependent protein kinase by regulated proteolysis suggests a neuron-specific function of the ubiquitin system in Aplysia
1995
Non-muscle myosin II takes centre stage in cell adhesion and migration
2009 Standout
X-ray Structure of Na-ASP-2, a Pathogenesis-related-1 Protein from the Nematode Parasite, Necator americanus, and a Vaccine Antigen for Human Hookworm Infection
2004
Identification, Purification, and Characterization of a PA700-dependent Activator of the Proteasome
1996
Vaccination with Recombinant Aspartic Hemoglobinase Reduces Parasite Load and Blood Loss after Hookworm Infection in Dogs
2005
The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene
1993 Nature
Ubiquitinylation and Ubiquitin-dependent Proteolysis in Vertebrate Photoreceptors (Rod Outer Segments)
1996
Mechanisms of Muscle Wasting — The Role of the Ubiquitin–Proteasome Pathway
1996
Environmental sensing through focal adhesions
2008 Standout
Adhesion-mediated mechanosensitivity: a time to experiment, and a time to theorize
2006
Cell–matrix adhesion
2007
Chemically Synthesized Ubiquitin Extension Proteins Detect Distinct Catalytic Capacities of Deubiquitinating Enzymes
1999
Specific Interactions between ATPase Subunits of the 26 S Protease
1997
Localization of the 26S proteasome during mitosis and meiosis in fission yeast
1998
Formation and Removal of α-Synuclein Aggregates in Cells Exposed to Mitochondrial Inhibitors
2002
PRE5 and PRE6, the Last Missing Genes Encoding 20S Proteasome Subunits from Yeast? Indication for a Set of 14 Different Subunits in the Eukaryotic Proteasome Core
1994
Amyloid β-Protein Inhibits Ubiquitin-dependent Protein Degradation in Vitro
1995
Getting in and out of the proteasome
2000
Ubiquitin in chains
2000
Ubiquitin, proteasomes, and the regulation of intracellular protein degradation
1995
Muscle Protein Breakdown and the Critical Role of the Ubiquitin-Proteasome Pathway in Normal and Disease States
1999
Deubiquitinating Enzymes: Their Diversity and Emerging Roles
1999
Structural and Functional Characterizations of the Proteasome-activating Protein PA26 from Trypanosoma brucei
1999
Integrins and Extracellular Matrix in Mechanotransduction
2010
Distinct Functional Surface Regions on Ubiquitin
2001
Mechanotransduction and extracellular matrix homeostasis
2014 Standout
The human proteasome subunit HsN3 is located inthe inner rings of the complex dimer
1995
Characterization of Recombinant REGα, REGβ, and REGγ Proteasome Activators
1997
Proteasome and cell cycle
1993
The ubiquitin-proteasome proteolytic pathway
1994 StandoutNobel
Nanoscale architecture of integrin-based cell adhesions
2010 Nature
Cyclic Stress at mHz Frequencies Aligns Fibroblasts in Direction of Zero Strain
2011
E2/E3-mediated Assembly of Lysine 29-linked Polyubiquitin Chains
1999
Ubiquitin in homeostasis, development and disease
1995
Vaccination with irradiated Ancylostoma caninum third stage larvae induces a Th2 protective response in dogs
2005
The 20S proteasome mediates the degradation of mouse and yeast ornithine decarboxylase in yeast cells
1994
Hookworm: “The Great Infection of Mankind”
2005
An Archaebacterial ATPase, Homologous to ATPases in the Eukaryotic 26 S Proteasome, Activates Protein Breakdown by 20 S Proteasomes
1999
Expression of the Necator americanus hookworm larval antigen Na-ASP-2 in Pichia pastoris and purification of the recombinant protein for use in human clinical trials
2005
Peptide sequencing identifies MSS1, a modulator of HIV Tat‐mediated transactivation, as subunit 7 of the 26 S protease
1993
Lactacystin and clasto-Lactacystin β-Lactone Modify Multiple Proteasome β-Subunits and Inhibit Intracellular Protein Degradation and Major Histocompatibility Complex Class I Antigen Presentation
1997
Identification of a set of yeast genes coding for a novel family of putative ATPases with high similarity to constituents of the 26S protease complex
1994
Subunits of the regulatory complex of the 26S protease
1995
A protein conjugation system essential for autophagy
1998 StandoutNatureNobel
Homologues of 26S proteasome subunits are regulators of transcription and translation
1998
Inhibition of Ubiquitin-mediated Proteolysis by the Arabidopsis 26 S Protease Subunit S5a
1995
Ubiquitin found in the archaebacterium Thermoplasma acidophilum
1993
The 26S proteasome of the yeast Saccharomyces cerevisiae
1994 StandoutNobel
Aggregated and Monomeric α-Synuclein Bind to the S6′ Proteasomal Protein and Inhibit Proteasomal Function
2003
The Proteasome Subunit, C2, Contains an Important Site for Binding of the PA28 (11S) Activator
1996
cDNA Cloning, Expression, and Functional Characterization of PI31, a Proline-rich Inhibitor of the Proteasome
2000
Subcellular Localization, Stoichiometry, and Protein Levels of 26 S Proteasome Subunits in Yeast
1999
Integrins and the actin cytoskeleton
2006
PRE3, highly homologous to the human major histocompatibility complex‐linked LMP2 (RING12) gene, codes for a yeast proteasome subunit necessary for the peptidylglutamyl‐peptide hydrolyzing activity
1994
Noncanonical MMS2-Encoded Ubiquitin-Conjugating Enzyme Functions in Assembly of Novel Polyubiquitin Chains for DNA Repair
1999
Cell adhesion: integrating cytoskeletal dynamics and cellular tension
2010 Standout
Active site mutants in the six regulatory particle ATPases reveal multiple roles for ATP in the proteasome
1998
Structural and functional effects of PA700 and modulator protein on proteasomes 1 1Edited by W. Baumeister
1997
Neurofibrillary tangles in progressive supranuclear palsy brains exhibit immunoreactivity to frameshift mutant ubiquitin-B protein
2000
The COP9 signalosome is essential for development of Drosophila melanogaster
1999
Effects of Major‐Histocompatibility‐Complex‐Encoded Subunits on the Peptidase and Proteolytic Activities of Human 20S Proteasomes
1996
Ubiquitin C-Terminal Hydrolase Is an Immediate-Early Gene Essential for Long-Term Facilitation in Aplysia
1997 StandoutNobel
Cell–matrix adhesion complexes: Master control machinery of cell migration
2007
Degradation Process of Ligand-stimulated Platelet-derived Growth Factor β -Receptor Involves Ubiquitin-Proteasome Proteolytic Pathway
1995 StandoutNobel
The N‐end rule pathway of protein degradation
1997
Iron Regulates the Intracellular Degradation of Iron Regulatory Protein 2 by the Proteasome
1995
Cloning and characterisation of an aspartyl protease inhibitor (API-1) from Ancylostoma hookworms
2004
Solution Conformation of Lys63-linked Di-ubiquitin Chain Provides Clues to Functional Diversity of Polyubiquitin Signaling
2004
A Proteolytic Pathway That Recognizes Ubiquitin as a Degradation Signal
1995
Characterization of ARC, a divergent member of the AAA ATPase family from Rhodococcus erythropolis
1998
Human mdm2 Mediates Multiple Mono-ubiquitination of p53 by a Mechanism Requiring Enzyme Isomerization
2001
The measurement of ubiquitin and ubiquitinated proteins
1999
Identification of the structural and functional human homolog of the yeast ubiquitin conjugating enzyme UBC9
1996
Sequence analysis of the AAA protein family
1997
Developmental Changes of the 26 S Proteasome in Abdominal Intersegmental Muscles of Manduca sexta during Programmed Cell Death
1995
Structure of 20S proteasome from yeast at 2.4Å resolution
1997 StandoutNatureNobel
The Human Papillomavirus E7 Oncoprotein Functionally Interacts with the S4 Subunit of the 26 S Proteasome
1997
Existence of a molecular ruler in proteasomes suggested by analysis of degradation products
1994
Recognition of the polyubiquitin proteolytic signal
2000
Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules
1994 Standout
A protein related to a proteasomal subunit binds to the intracellular domain of the p55 TNF receptor upstream to its ‘death domain’
1995
Proteasomes: protein degradation machines of the cell
1994
The Mechanistic Links Between Proteasome Activity, Aging and Agerelated Diseases
2014
Removing the Vertebrate-Specific TBP N Terminus Disrupts Placental β2m-Dependent Interactions with the Maternal Immune System
2002 StandoutNobel
A highly conserved ATPase protein as a mediator between acidic activation domains and the TATA-binding protein
1995 Nature
A gated channel into the proteasome core particle.
2000
The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB
1994 Standout
Specificity of the Ubiquitin Isopeptidase in the PA700 Regulatory Complex of 26 S Proteasomes
1997
The ubiquitin system
1997
Recognition of Misfolding Proteins by PA700, the Regulatory Subcomplex of the 26 S Proteasome
2000
HIV-1 Tat Inhibits the 20 S Proteasome and Its 11 S Regulator-mediated Activation
1997
Vaccination of Dogs with a Recombinant Cysteine Protease from the Intestine of Canine Hookworms Diminishes the Fecundity and Growth of Worms
2004
Son1p is a component of the 26S proteasome of the yeast Saccharomyces cerevisiae
1998
Identification of an Ubiquitin‐Ligation System for the Epidermal‐Growth‐Factor Receptor
1997
26 S Proteasome-mediated Production of an Authentic Major Histocompatibility Class I-restricted Epitope from an Intact Protein Substrate
1999
Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm
2006 Standout
Conformational constraints in protein degradation by the 20S proteasome
1995
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
A Subcomplex of the Proteasome Regulatory Particle Required for Ubiquitin-Conjugate Degradation and Related to the COP9-Signalosome and eIF3
1998
New insights into proteasome function: from archaebacteria to drug development
1995
Peptide antigen production by the proteasome: complexity provides efficiency
1996
Characterization of Two Polyubiquitin Binding Sites in the 26 S Protease Subunit 5a
1998
Tat-Bindung Protein 7 is a Subunit of the 26S Protease
1994
Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin
1995 ScienceNobel
The Tumor Necrosis Factor Ligand and Receptor Families
1996 StandoutNobel
Inhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein–Barr virus nuclear antigen 1
1997 StandoutNobel
Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21
2015 StandoutNobel
The proteasome activator 11 S REG (PA28) and Class I antigen presentation
1999
Arabidopsis MBP1 gene encodes a conserved ubiquitin recognition component of the 26S proteasome.
1996
The Regulatory Complex of Drosophila melanogaster 26s Proteasomes
2000
The mouse and human genes encoding the recognition component of the N-end rule pathway
1998 StandoutNobel
β-Arrestin inhibits NF-κB activity by means of its interaction with the NF-κB inhibitor IκBα
2004 StandoutNobel
Pleiotropic Defects Caused by Loss of the Proteasome-Interacting Factors Rad23 and Rpn10 of Saccharomyces cerevisiae
1999
Architecture of an RNA Polymerase II Transcription Pre-Initiation Complex
2013 StandoutScienceNobel
The Regulatory Particle of the Saccharomyces cerevisiae Proteasome
1998
Proteasome regulation of activation-induced T cell death
1997 StandoutNobel
The 26S Proteasome: A Molecular Machine Designed for Controlled Proteolysis
1999 Standout
Purification and Characterization of a Proteasome from the Hyperthermophilic Archaeon Pyrococcus furiosus
1997
Rad23 Promotes the Targeting of Proteolytic Substrates to the Proteasome
2002
A Ubiquitin Mutant with Specific Defects in DNA Repair and Multiubiquitination
1995
Analysis of mammalian 20S proteasome biogenesis: the maturation of beta-subunits is an ordered two-step mechanism involving autocatalysis.
1996 Nobel
Regulation of Receptor Fate by Ubiquitination of Activated β 2 -Adrenergic Receptor and β-Arrestin
2001 StandoutScienceNobel
Mechanical forces facilitate actin polymerization at focal adhesions in a zyxin-dependent manner
2008
Retrograde Fluxes of Focal Adhesion Proteins in Response to Cell Migration and Mechanical Signals
2007
Hypoxia-inducible factor 1α protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations
2000 StandoutNobel
Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach
2012
The proteolytic fragments generated by vertebrate proteasomes: structural relationships to major histocompatibility complex class I binding peptides.
1996
Memory Suppressor Genes: Inhibitory Constraints on the Storage of Long-Term Memory
1998 StandoutScienceNobel
Surface hydrophobic residues of multiubiquitin chains essential for proteolytic targeting.
1996
SCF and Cullin/RING H2-Based Ubiquitin Ligases
1999
Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.
1995
Biochemical and Physical Properties of theMethanococcus jannaschii20S Proteasome and PAN, a Homolog of the ATPase (Rpt) Subunits of the Eucaryal 26S Proteasome
2000
Proteolytic processing of ovalbumin and beta-galactosidase by the proteasome to a yield antigenic peptides.
1994
Crystal Structure of the 20 S Proteasome from the Archaeon T. acidophilum at 3.4 Å Resolution
1995 ScienceNobel
Purification of an 11 S regulator of the multicatalytic protease.
1992
Regulated degradation of the transcription factor Gcn4.
1994
Yeast global transcriptional regulators Sin4 and Rgr1 are components of mediator complex/RNA polymerase II holoenzyme.
1995 StandoutNobel
Subunit arrangement in the human 20S proteasome
1997
Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase
1997 StandoutNobel
E2-C, a cyclin-selective ubiquitin carrier protein required for the destruction of mitotic cyclins.
1996 StandoutNobel
Actin machinery and mechanosensitivity in invadopodia, podosomes and focal adhesions
2009
Protein synthesis elongation factor EF-1 alpha is essential for ubiquitin-dependent degradation of certain N alpha-acetylated proteins and may be substituted for by the bacterial elongation factor EF-Tu.
1994 StandoutNobel
Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome
2004 StandoutNobel
Involvement of the Molecular Chaperone Ydj1 in the Ubiquitin-Dependent Degradation of Short-Lived and Abnormal Proteins in Saccharomyces cerevisiae
1996
Proteasomes in the archaea: from structure to function
2000
Distinct 19 S and 20 S subcomplexes of the 26 S proteasome and their distribution in the nucleus and the cytoplasm.
1994
The Multiubiquitin-Chain-Binding Protein Mcb1 Is a Component of the 26S Proteasome in Saccharomyces cerevisiae and Plays a Nonessential, Substrate-Specific Role in Protein Turnover
1996
Characterization of two subunits of Arabidopsis 19S proteasome regulatory complex and its possible interaction with the COP9 complex
1999
Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.
1995 StandoutNobel
The ubiquitin‐mediated proteolytic pathway: mechanisms of recognition of the proteolytic substrate and involvement in the degradation of native cellular proteins
1994 StandoutNobel
UBIQUITIN AND THE CONTROL OF PROTEIN FATE IN THE SECRETORY AND ENDOCYTIC PATHWAYS
1998
Subunit 4 of the 26 S protease is a member of a novel eukaryotic ATPase family
1992
Inhibition of the proteolytic activity of the multicatalytic proteinase complex (proteasome) by substrate-related peptidyl aldehydes.
1994
A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits
1998
Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling
2002 StandoutScienceNobel
Translating the Histone Code
2001 StandoutScience
Ubiquitin Aldehyde Increases Adenosine Triphosphate–Dependent Proteolysis of Hemoglobin α-Subunits in β-Thalassemic Hemolysates
1997
Single-particle selection and alignment with heavy atom cluster-antibody conjugates
1998 StandoutNobel
DEGRADATION OF CELL PROTEINS AND THE GENERATION OF MHC CLASS I-PRESENTED PEPTIDES
1999
The Doa4 Deubiquitinating Enzyme Is Required for Ubiquitin Homeostasis in Yeast
1999
PA700, an ATP-dependent activator of the 20 S proteasome, is an ATPase containing multiple members of a nucleotide-binding protein family.
1994
Analysis of a Gene Encoding Rpn10 of the Fission Yeast Proteasome Reveals That the Polyubiquitin-binding Site of This Subunit Is Essential When Rpn12/Mts3 Activity Is Compromised
2000
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
2003 StandoutNobel
Degradation of the tumor suppressor protein p53 by the ubiquitin-mediated proteolytic system requires a novel species of ubiquitin-carrier protein, E2
1994 StandoutNobel
A 26 S protease subunit that binds ubiquitin conjugates.
1994
MECHANISMS OF MHC CLASS I–RESTRICTED ANTIGEN PROCESSING
1998
Antibodies against a secreted protein from hookworm larvae reduce the intensity of hookworm infection in humans and vaccinated laboratory animals
2005
ANTIGEN PROCESSING AND PRESENTATION BY THE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX
1996
Dynamics of cell orientation
2007
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Biogenesis, structure and function of the yeast 20S proteasome.
1995
Regulation and Cellular Roles of Ubiquitin-Specific Deubiquitinating Enzymes
2009
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Altered ubiquitination and stability of aquaporin-1 in hypertonic stress
2001 StandoutNobel
Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-kappa B.
1996 StandoutNobel
Inhibition of the ubiquitin-proteasome system in Alzheimer's disease
2000
Scanning the human proteome for calmodulin-binding proteins
2005 StandoutNobel
Molecular Cloning and Expression of a 26 S Protease Subunit Enriched in Dileucine Repeats
1995
Host Cytokine Production, Lymphoproliferation, and Antibody Responses during the Course of Ancylostoma ceylanicum Infection in the Golden Syrian Hamster
2005
Integrins in cell migration – the actin connection
2008
The Axial Channel of the Proteasome Core Particle Is Gated by the Rpt2 ATPase and Controls Both Substrate Entry and Product Release
2001
Proteolytic processing of ovalbumin and beta-galactosidase by the proteasome to a yield antigenic peptides.
1994
Interaction of the Doa4 Deubiquitinating Enzyme with the Yeast 26S Proteasome
1999
Targeting of substrates to the 26S proteasome
1997
The N-end rule: functions, mysteries, uses.
1996
Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase.
1995 StandoutNobel
Works of Laura Hoffman being referenced
The N Terminus of Antizyme Promotes Degradation of Heterologous Proteins
1996
Nucleotidase Activities of the 26 S Proteasome and Its Regulatory Complex
1996
From the membrane to the nucleus and back again: bifunctional focal adhesion proteins
2006
Cloning, Yeast Expression, Isolation, and Vaccine Testing of RecombinantAncylostoma‐Secreted Protein (ASP)–1 and ASP‐2 fromAncylostoma ceylanicum
2004
Molecular cloning and expression of subunit 9 of the 26S proteasome
1997
Regulatory features of multicatalytic and 26S proteases
1996
Genetic ablation of zyxin causes Mena/VASP mislocalization, increased motility, and deficits in actin remodeling
2006
The multicatalytic and 26 S proteases.
1993
Inhibition of the 26 S Proteasome by Polyubiquitin Chains Synthesized to Have Defined Lengths
1997
Activation of the multicatalytic protease. The 11 S regulator and 20 S ATPase complexes contain distinct 30-kilodalton subunits
1994
Multiple forms of the 20 S multicatalytic and the 26 S ubiquitin/ATP-dependent proteases from rabbit reticulocyte lysate.
1992
Mechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcement
2005