Standout Papers
- Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2 (1999)
- Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice. (2002)
- Enhanced Rewarding Properties of Morphine, but not Cocaine, in βarrestin-2 Knock-Out Mice (2003)
- Dopaminergic Supersensitivity in G Protein-Coupled Receptor Kinase 6-Deficient Mice (2003)
- Muscarinic Supersensitivity and Impaired Receptor Desensitization in G Protein–Coupled Receptor Kinase 5–Deficient Mice (1999)
- Differential Mechanisms of Morphine Antinociceptive Tolerance Revealed in βArrestin-2 Knock-Out Mice (2002)
- DESENSITIZATION OF G PROTEIN–COUPLED RECEPTORS AND NEURONAL FUNCTIONS (2004)
- μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence (2000)
Citation Impact
Citing Papers
Activity-Dependent Internalization of Smoothened Mediated by ß-Arrestin 2 and GRK2
2004 StandoutScienceNobel
Targeting of Diacylglycerol Degradation to M1 Muscarinic Receptors by ß-Arrestins
2007 StandoutScienceNobel
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
Comprehensive computational design of ordered peptide macrocycles
2017 StandoutScienceNobel
Dishevelled 2 Recruits ß-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4
2003 StandoutScienceNobel
Spinophilin Blocks Arrestin Actions in Vitro and in Vivo at G Protein-Coupled Receptors
2004 StandoutScienceNobel
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ
2003 StandoutScienceNobel
A unique mechanism of β-blocker action: Carvedilol stimulates β-arrestin signaling
2007 StandoutNobel
Targeting of Cyclic AMP Degradation to β 2 -Adrenergic Receptors by β-Arrestins
2002 StandoutScienceNobel
Emerging Concepts of Guanine Nucleotide-Binding Protein-Coupled Receptor (GPCR) Function and Implications for High Throughput Screening
2007
Computational design of soluble and functional membrane protein analogues
2024 StandoutNatureNobel
G Protein-coupled Receptor Kinases Phosphorylate LRP6 in the Wnt Pathway
2009 StandoutNobel
Evolving Concepts in G Protein-Coupled Receptor Endocytosis: The Role in Receptor Desensitization and Signaling
2001 Standout
New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades
2001 StandoutNobel
An Opiate Cocktail that Reduces Morphine Tolerance and Dependence
2005
The Highly Conserved DRY Motif of Class A G Protein-Coupled Receptors: Beyond the Ground State
2006
G Protein-Coupled Receptor Kinase Function Is Essential for Chemosensation in C. elegans
2004 StandoutNobel
G-protein-coupled Receptor Kinase Specificity for β-Arrestin Recruitment to the β2-Adrenergic Receptor Revealed by Fluorescence Resonance Energy Transfer
2006 StandoutNobel
Classical and new roles of β-arrestins in the regulation of G-PROTEIN-COUPLED receptors
2001 StandoutNobel
Sodium Channel Blockade May Contribute to the Analgesic Efficacy of Antidepressants
2006
Changes in the G-protein-coupled receptor desensitization machinery during relapsing–progressive experimental allergic encephalomyelitis
2003
Prolonged Kappa Opioid Receptor Phosphorylation Mediated by G-protein Receptor Kinase Underlies Sustained Analgesic Tolerance
2004 StandoutNobel
Crystal structure of the human β2 adrenergic G-protein-coupled receptor
2007 StandoutNatureNobel
G protein-independent cell-based assays for drug discovery on seven-transmembrane receptors
2008
Identification of a Circadian Output Circuit for Rest:Activity Rhythms in Drosophila
2014
GRKs and β-arrestins: roles in receptor silencing, trafficking and signaling
2006 StandoutNobel
Trends in GPCR drug discovery: new agents, targets and indications
2017 Standout
βArrestins
2001 StandoutNobel
Arrestin Development: Emerging Roles for β-arrestins in Developmental Signaling Pathways
2009 StandoutNobel
Regulation of G Protein-Coupled Receptor Kinases and Arrestins During Receptor Desensitization
2003 StandoutNobel
β-Arrestin Binding to the β2-Adrenergic Receptor Requires Both Receptor Phosphorylation and Receptor Activation
2005 Nobel
Paradoxical Striatal Cellular Signaling Responses to Psychostimulants in Hyperactive Mice
2006
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
Recent developments in biased agonism
2013 Nobel
Regulation of Opioid Receptor Trafficking and Morphine Tolerance by Receptor Oligomerization
2002
Therapeutic potential of β-arrestin- and G protein-biased agonists
2010 StandoutNobel
β-Arrestin2 Is Critically Involved in CXCR4-mediated Chemotaxis, and This Is Mediated by Its Enhancement of p38 MAPK Activation
2002
The Akt–GSK-3 signaling cascade in the actions of dopamine
2007
The β2-Adrenergic Receptor Mediates Extracellular Signal-regulated Kinase Activation via Assembly of a Multi-receptor Complex with the Epidermal Growth Factor Receptor
2000 StandoutNobel
A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior
2008 StandoutNobel
The structure and function of G-protein-coupled receptors
2009 StandoutNatureNobel
Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling
2011 StandoutNobel
The Recruitment of Raf-1 to Membranes Is Mediated by Direct Interaction with Phosphatidic Acid and Is Independent of Association with Ras
2000
Regulation of Akt Signaling by D2and D3Dopamine ReceptorsIn Vivo
2007
Teaching old receptors new tricks: biasing seven-transmembrane receptors
2010 StandoutNobel
An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior
2005 StandoutNobel
Cellular and Molecular Mechanisms of Pain
2009 StandoutNobel
Molecular Determinants Underlying the Formation of Stable Intracellular G Protein-coupled Receptor-β-Arrestin Complexes after Receptor Endocytosis*
2001
Peptide therapeutics: current status and future directions
2014 Standout
β-Arrestin1 mediates nicotinic acid–induced flushing, but not its antilipolytic effect, in mice
2009 StandoutNobel
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
Non-visual GRKs: are we seeing the whole picture?
2003
Endogenous G Protein-coupled Receptor Kinase 6 Regulates M3 Muscarinic Acetylcholine Receptor Phosphorylation and Desensitization in Human SH-SY5Y Neuroblastoma Cells
2002
Expanding roles for β-arrestins as scaffolds and adapters in GPCR signaling and trafficking
2001 StandoutNobel
Seven-transmembrane-spanning receptors and heart function
2002 StandoutNatureNobel
Seven-transmembrane receptors
2002 StandoutNobel
Morphine-like Opiates Selectively Antagonize Receptor-Arrestin Interactions
2010
Quantitative Phosphoproteomics Dissection of Seven-transmembrane Receptor Signaling Using Full and Biased Agonists
2010
β-Arrestin-2 regulates the development of allergic asthma
2003 StandoutNobel
Crystal Structure of β-Arrestin at 1.9 Å
2001
Collateral efficacy in drug discovery: taking advantage of the good (allosteric) nature of 7TM receptors
2007
Arresting developments in heptahelical receptor signaling and regulation
2002 StandoutNobel
β-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking
2001 StandoutNobel
β-Arrestin2 mediates the initiation and progression of myeloid leukemia
2012 StandoutNobel
Biased ligand quantification in drug discovery: from theory to high throughput screening to identify new biased μ opioid receptor agonists
2016
The Role of a Conserved Region of the Second Intracellular Loop in AT1 Angiotensin Receptor Activation and Signaling
2003
The proliferative and antiapoptotic effects of substance P are facilitated by formation of a β-arrestin-dependent scaffolding complex
2000
Altered CXCR2 Signaling in β-Arrestin-2-Deficient Mouse Models
2005
β-Arrestin–Biased Agonism of the Angiotensin Receptor Induced by Mechanical Stress
2010
β-Arrestin–Dependent Endocytosis of Proteinase-Activated Receptor 2 Is Required for Intracellular Targeting of Activated Erk1/2
2000
Defective lymphocyte chemotaxis in β-arrestin2- and GRK6-deficient mice
2002 StandoutNobel
Physiological Roles of G Protein–Coupled Receptor Kinases and Arrestins
2007
GRK6 deficiency is associated with enhanced CXCR4-mediated neutrophil chemotaxis in vitro and impaired responsiveness to G-CSF in vivo
2004
β-Arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes
2006 StandoutNobel
The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals
2002 StandoutNobel
β-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3
2000 StandoutScienceNobel
Regulation of GPCRs by Endocytic Membrane Trafficking and Its Potential Implications
2007
Adjuvant Arthritis Induces Down-Regulation of G Protein-Coupled Receptor Kinases in the Immune System
2001
β-Arrestins and Cell Signaling
2007 StandoutNobel
Increased Acute Inflammation, Leukotriene B4-Induced Chemotaxis, and Signaling in Mice Deficient for G Protein-Coupled Receptor Kinase 6
2003 StandoutNobel
Different G protein-coupled receptor kinases govern G protein and β-arrestin-mediated signaling of V2 vasopressin receptor
2005 StandoutNobel
beta -Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking
2001
Computational Modeling Approaches to Structure−Function Analysis of G Protein-Coupled Receptors
2005
Functional antagonism of different G protein-coupled receptor kinases for β-arrestin-mediated angiotensin II receptor signaling
2005 StandoutNobel
β-Arrestin-biased ligands at seven-transmembrane receptors
2007 StandoutNobel
Multifaceted roles of β-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling
2003 StandoutNobel
β-Arrestin-2 regulates the development of allergic asthma
2003 StandoutNobel
Akt/GSK3 Signaling in the Action of Psychotropic Drugs
2008
Making Structural Sense of Dimerization Interfaces of Delta Opioid Receptor Homodimers
2011
Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade
2004
A β-Arrestin–Biased Agonist of the Parathyroid Hormone Receptor (PTH1R) Promotes Bone Formation Independent of G Protein Activation
2009 StandoutNobel
Update 1 of: Computational Modeling Approaches to Structure–Function Analysis of G Protein-Coupled Receptors
2011
Regulation of MAP Kinase Signaling Modules by Scaffold Proteins in Mammals
2003
Differential Response to Morphine of the Oligomeric State of μ-Opioid in the Presence of δ-Opioid Receptors
2011
Reduced GRK2 level in T cells potentiates chemotaxis and signaling in response to CCL4
2004
Circadian neuron feedback controls the Drosophila sleep–activity profile
2016 StandoutNatureNobel
G-protein-coupled Receptor (GPCR) Kinase Phosphorylation and β-Arrestin Recruitment Regulate the Constitutive Signaling Activity of the Human Cytomegalovirus US28 GPCR
2003 StandoutNobel
Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors
2000 StandoutNobel
ß-Arrestin 2 Mediates Endocytosis of Type III TGF-ß Receptor and Down-Regulation of Its Signaling
2003 StandoutScienceNobel
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Works of Laura Bohn being referenced
G Protein-Coupled Receptor Kinase/β-Arrestin Systems and Drugs of Abuse: Psychostimulant and Opiate Studies in Knockout Mice
2004
Muscarinic Supersensitivity and Impaired Receptor Desensitization in G Protein–Coupled Receptor Kinase 5–Deficient Mice
1999 StandoutNobel
Kappa opioids promote the proliferation of astrocytes via Gβγ and β‐arrestin 2‐dependent MAPK‐mediated pathways
2008
Physiological and pharmacological implications of beta-arrestin regulation
2008
Serotonin, But Not N -Methyltryptamines, Activates the Serotonin 2A Receptor Via a β-Arrestin2/Src/Akt Signaling Complex In Vivo
2010
Morphine Side Effects in β-Arrestin 2 Knockout Mice
2005
Opioid receptor signaling: relevance for gastrointestinal therapy
2006
A Novel Method for Analyzing Extremely Biased Agonism at G Protein–Coupled Receptors
2015
Functional selectivity of GPCR signaling in animals
2013
An Opioid Agonist that Does Not Induce μ-Opioid Receptor—Arrestin Interactions or Receptor Internalization
2006
Dopaminergic Supersensitivity in G Protein-Coupled Receptor Kinase 6-Deficient Mice
2003 StandoutNobel
Relative Opioid Efficacy Is Determined by the Complements of the G Protein-Coupled Receptor Desensitization Machinery
2004
Opioid Receptor Homo- and Heterodimerization in Living Cells by Quantitative Bioluminescence Resonance Energy Transfer
2005
Drosophila CG8422encodes a functional diuretic hormone receptor
2004
Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2
1999 StandoutScienceNobel
Sustained elevation of extracellular dopamine causes motor dysfunction and selective degeneration of striatal GABAergic neurons
2003
Requirement of Receptor Internalization for Opioid Stimulation of Mitogen-Activated Protein Kinase: Biochemical and Immunofluorescence Confocal Microscopic Evidence
1999
Glutamatergic modulation of hyperactivity in mice lacking the dopamine transporter
2001
μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence
2000 StandoutNatureNobel
Potentiated Opioid Analgesia in Norepinephrine Transporter Knock-Out Mice
2000
Apparent Loss-of-Function Mutant GPCRs Revealed as Constitutively Desensitized Receptors
2002
Enhanced Rewarding Properties of Morphine, but not Cocaine, in βarrestin-2 Knock-Out Mice
2003 StandoutNobel
Differential Mechanisms of Morphine Antinociceptive Tolerance Revealed in βArrestin-2 Knock-Out Mice
2002 StandoutNobel
Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice.
2002 StandoutNobel
DESENSITIZATION OF G PROTEIN–COUPLED RECEPTORS AND NEURONAL FUNCTIONS
2004 StandoutNobel
Agonist-directed signaling of the serotonin 2A receptor depends on β-arrestin-2 interactions in vivo
2008