Citation Impact
Citing Papers
On the relationship between folding and chemical landscapes in enzyme catalysis
2008 StandoutNobel
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
2019 StandoutNobel
Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions
2011 StandoutNobel
Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors
2022 StandoutNobel
Incorporation of azides into recombinant proteins for chemoselective modification by the Staudinger ligation
2001 StandoutNobel
Alteration of enzyme specificity by computational loop remodeling and design
2009 StandoutNobel
Importance of hydrogen-bond formation in stabilizing the transition state of subtilisin
1986
Expansive discovery of chemically diverse structured macrocyclic oligoamides
2024 StandoutScienceNobel
A kinetic and fluorimetric investigation of papain modified at tryptophan -69 and -177 by N–bromosuccinimide
1974
X-ray Snapshots of Peptide Processing in Mutants of Tricorn-interacting Factor F1 from Thermoplasma acidophilum
2005 Nobel
X‐ray crystallographic structure of a papain‐leupeptin complex
1993
Improved molecular replacement by density- and energy-guided protein structure optimization
2011 StandoutNatureNobel
How do serine proteases really work?
1989 StandoutNobel
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
Protein Repeats: Structures, Functions, and Evolution
2001
Enzymes and auxiliary factors for GPI lipid anchor biosynthesis and post‐translational transfer to proteins
2003
Structure and mechanism of interleukin-lβ converting enzyme
1994 Nature
Peptidyl (acyloxy)methyl ketones and the quiescent affinity label concept: the departing group as a variable structural element in the design of inactivators of cysteine proteinases
1991
The biochemistry of apoptosis
2000 StandoutNature
Rational design of α-helical tandem repeat proteins with closed architectures
2015 StandoutNatureNobel
Characterization of Three Components of Human Adenovirus Proteinase Activity in Vitro
1996
Genetically programmed chiral organoborane synthesis
2017 StandoutNatureNobel
Crystal structures of two engineered thiol trypsins
1989
Structure of human rhinovirus 3C protease reveals a trypsin-like polypeptide fold, RNA-binding site, and means for cleaving precursor polyprotein
1994
Expanding the Genetic Code
2004
Identification of Proteins Containing Cysteine Residues That Are Sensitive to Oxidation by Hydrogen Peroxide at Neutral pH
2000
The active site of papain
1989
Modification of the Electrostatic Environment is Tolerated in the Oxyanion Hole of the Cysteine Protease Papain
1995
Quantitative reactivity profiling predicts functional cysteines in proteomes
2010 StandoutNatureNobel
Crystal Structure of the Hepatitis C Virus NS3 Protease Domain Complexed with a Synthetic NS4A Cofactor Peptide
1996 StandoutNobel
Introduction of a cysteine protease active site into trypsin
1989
Functional site profiling and electrostatic analysis of cysteines modifiable to cysteine sulfenic acid
2008
Minimalist Active‐Site Redesign: Teaching Old Enzymes New Tricks
2007
On the inactivity of thiol-subtilisin
1981
Evolutionary families of peptidases
1993
Structural patterns in globular proteins
1976 StandoutNatureNobel
Ab Initio Evaluation of the Potential Surface for General Base- Catalyzed Methanolysis of Formamide: A Reference Solution Reaction for Studies of Serine Proteases
2000 StandoutNobel
Molecular Recognition of Protein−Ligand Complexes: Applications to Drug Design
1997 Standout
Computer simulations of enzymatic reactions
1992 StandoutNobel
Studies of asymmetry in the three-dimensional structure of lobster D-glyceraldehyde-3-phosphate dehydrogenase
1975
Dipoles localized at helix termini of proteins stabilize charges.
1991 StandoutNobel
Kinetics of subtilisin and thiolsubtilisin
1983
The Catalytic Role of the Active Site Aspartic Acid in Serine Proteases
1987 Science
Proline-specific endopeptidases from microbial sources: isolation of an enzyme from a Xanthomonas sp
1992 StandoutNobel
Crystal structure of the human adenovirus proteinase with its 11 amino acid cofactor.
1996
Ketosteroid isomerase provides further support for the idea that enzymes work by electrostatic preorganization
2010 StandoutNobel
A new paradigm for electrostatic catalysis of radical reactions in vitamin B 12 enzymes
2007 StandoutNobel
Functional information and the emergence of biocomplexity
2007 StandoutNobel
Amino-acid Sequence of Glyceraldehyde 3-Phosphate Dehydrogenase from Lobster Muscle
1967 Nature
Computational studies on aspartic proteases. I. Active‐site protonation and hydration in the substrate‐free crystalline state
1992
The use of double mutants to detect structural changes in the active site of the tyrosyl-tRNA synthetase (Bacillus stearothermophilus)
1984 StandoutNobel
Testing Geometrical Discrimination within an Enzyme Active Site: Constrained Hydrogen Bonding in the Ketosteroid Isomerase Oxyanion Hole
2008
Computer simulations of enzymatic reactions
1992 StandoutNobel
Targeted metabolic labeling of yeast N-glycans with unnatural sugars
2010 StandoutNobel
A General Method for Site-specific Incorporation of Unnatural Amino Acids into Proteins
1989 Science
Ab initio molecular orbital studies on the active site of papain
1976
Kinetic studies of oxidized nicotinamide–adenine dinucleotide-facilitated reactions of d -glyceraldehyde 3-phosphate dehydrogenase
1974
Probing Protein Structure and Function with an Expanded Genetic Code
1995
Electrostatic effect on catalytic rate enhancement in serine proteinases
1982
Cyclic AMP-dependent protein kinase I: Cyclic nucleotide binding, structural changes, and release of the catalytic subunits
1981 StandoutNobel
A Designed Peptide Ligase for Total Synthesis of Ribonuclease A with Unnatural Catalytic Residues
1994 Science
Sequence and structure of D-glyceraldehyde 3-phosphate dehydrogenase from Bacillus stearothermophilus
1977 StandoutNatureNobel
A simple method for displaying the hydropathic character of a protein
1982 Standout
Site-specific chemical modification of recombinant proteins produced in mammalian cells by using the genetically encoded aldehyde tag
2009 StandoutNobel
Discovery of aminoacyl-tRNA synthetase activity through cell-surface display of noncanonical amino acids
2006 StandoutNobel
Rational design in genetic engineering: dream or reality? A priori predictions for thrombin and ribonuclease a mutants
1989
Update 1 of: Proteases Universally Recognize Beta Strands In Their Active Sites
2010
Active‐site α‐helix in papain and the stability of the ion pair RS− ··· ImH+.Ab initio molecular orbital study
1980
Unusually large electrostatic field effect of the buried aspartate in serine proteinases: Source of catalytic power
1983
THE LYSOSOMAL CYSTEINE PROTEASES
1999
Sequence variability and structure of D-glyceraldehyde-3-phosphate dehydrogenase.
1975
Potentiometric determination of ionizations at the active site of papain
1976
Facilitated Proton Transfer in Enzyme Catalysis
1968 Science
Comparison of protein electrostatic potential along the catalytic triad of serine proteinases
1983
Thiol-beta-lactamase: replacement of the active-site serine of RTEM beta-lactamase by a cysteine residue.
1982
Three-dimensional structure of d-glyceraldehyde-3-phosphate dehydrogenase
1974
Natural and Synthetic Small Boron-Containing Molecules as Potential Inhibitors of Bacterial and Fungal Quorum Sensing
2010
Energetics of enzyme catalysis.
1978 StandoutNobel
A chemical approach to unraveling the biological function of the glycosylphosphatidylinositol anchor
2007 StandoutNobel
Sulfonyl fluorides as privileged warheads in chemical biology
2015
STUDIES OF ASYMMETRY IN THE THREE-DIMENSIONAL STRUCTURE OF LOBSTER D-GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE
1975
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
Ab Initio Evaluation of the Free Energy Surfaces for the General Base/Acid Catalyzed Thiolysis of Formamide and the Hydrolysis of Methyl Thiolformate: A Reference Solution Reaction for Studies of Cysteine Proteases
2001 StandoutNobel
Affinity purification of synthetic peptides.
1976 StandoutNobel
Selective Cleavage and Modification of Peptides and Proteins
1970
Structure of Subtilisin BPN′ at 2.5 Å Resolution
1969 Nature
Enzymatic aminoacylation of tRNA with unnatural amino acids
2006 StandoutNobel
Enzyme millisecond conformational dynamics do not catalyze the chemical step
2009 StandoutNobel
Simulation of enzyme reactions using valence bond force fields and other hybrid quantum/classical approaches
1993 StandoutNobel
Portion-mixing peptide libraries of quenched fluorogenic substrates for complete subsite mapping of endoprotease specificity.
1994 StandoutNobel
Confirmation of the assignment of the low-field proton resonance of serine proteases by using specifically nitrogen-15 labeled enzyme.
1985
The Reliability of Molecular Weight Determinations by Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis
1969 Standout
How important are entropic contributions to enzyme catalysis?
2000 StandoutNobel
Glyceraldehyde 3-phosphate dehydrogenases
1965
On Low-Barrier Hydrogen Bonds and Enzyme Catalysis
1995 StandoutScienceNobel
Altered ubiquitination and stability of aquaporin-1 in hypertonic stress
2001 StandoutNobel
Converting Trypsin to Chymotrypsin: The Role of Surface Loops
1992 Science
A Chemically Programmed Proximal Ligand Enhances the Catalytic Properties of a Heme Enzyme
2016
Caspases: Enemies Within
1998 StandoutScience
Conformational Adaptability in Enzymes
1973
On the role of the active site helix in papain, an AB initio molecular orbital study
1979
Synthesis of peptide fluoromethyl ketones and the inhibition of human cathepsin B
1985
Energy considerations show that low-barrier hydrogen bonds do not offer a catalytic advantage over ordinary hydrogen bonds
1996 StandoutNobel
Evidence that the N-terminal domain of nonstructural protein NS3 from yellow fever virus is a serine protease responsible for site-specific cleavages in the viral polyprotein.
1990 StandoutNobel
Exploring challenges in rational enzyme design by simulating the catalysis in artificial kemp eliminase
2010 StandoutNobel
Molecular Dynamics Simulations of the Catalytic Pathway of a Cysteine Protease: A Combined QM/MM Study of Human Cathepsin K
2007
Works of László Polgár being referenced
A New Enzyme Containing a Synthetically Formed Active Site. Thiol-Subtilisin 1
1966
The catalytic triad of serine peptidases
2005
Prolyl Oligopeptidase
1998
pH‐dependent mechanism in the catalysis of prolyl endopeptidase from pig muscle
1991
The prolyl oligopeptidase family
2002
Mechanisms of Protease Action
1989
Molecular orbital analysis of the catalytic process of serine proteinases: Effect of environment on protonation of the histidine-aspartate diad of subtilisin
1982
THE NATURE OF GENERAL BASE-GENERAL ACID CATALYSIS IN SERINE PROTEASES
1969
Mercaptide—imidazolium ion‐pair: The reactive nucleophile in papain catalysis
1974
Spectrophotometric determination of mercaptide ion, an activated form of SH‐group in thiol enzymes
1974
Symmetry and asymmetry in the mechanisms of hydrolysis by serine proteases and their thiol analogues.
1972
On the stereochemistry of catalysis by serine proteases
1974
On the Mode of Activation of the Catalytically Essential Sulfhydryl Group of Papain
1973
The mechanism of action of aspartic proteases involves ‘push‐pull’ catalysis
1987
Prolyl endopeptidase catalysis. A physical rather than a chemical step is rate-limiting
1992
Amino acid sequence around a reactive lysine in glyceraldehyde 3-phosphate dehydrogenase
1965
Current problems in mechanistic studies of serine and cysteine proteinases
1982
Peptic peptide of thiolsubtilisin. Analytical evidence for the chemical transformation of the essential serine-221 to cysteine-221
1981
Mechanism‐Controlled Stereospecificity
1979
On the Reactivity of the Thiol Group of Thiolsubtilisin
1973
Mechanism of action of cysteine proteinases: oxyanion binding site is not essential in the hydrolysis of specific substrates
1985
Deuterium isotope effects on acylation of subtilisin
1973
Molecular orbital analysis of the catalytic process of serine proteinases: Effect of environment on protonation of the histidine aspartate diad of subtilisin
1982
Transition-state stabilization at the oxyanion binding sites of serine and thiol proteinases: hydrolyses of thiono and oxygen esters
1983
The effect of coenzyme on the S→N acyl migration in glyceraldehyde-3-phosphate dehydrogenase
1966
Proton nuclear magnetic resonance evidence for the absence of a stable hydrogen bond between the active site aspartate and histidine residues of native subtilisins and for its presence in thiolsubtilisins
1981
Ion‐Pair Formation as a Source of Enhanced Reactivity of the Essential Thiol Group of d ‐Glyceraldehyde‐3‐Phosphate Dehydrogenase
1975
Chromatography and activity of thiol-subtilisin
1969
The mechanism of action of glyceraldehyde-3-phosphate dehydrogenase
1964
The basic difference in catalyses by serine and cysteine proteinases resides in charge stabilization in the transition state
1986
Negatively Charged Reactants as Probes in the Study of the Essential Mercaptide‐Imidazolium Ion‐Pair of Thiolenzymes
1977
Use of Methyl Iodide for Probing the Polarity of the Immediate Environment of—SH Groups in Thiolenzymes
1976
Catalysis of serine oligopeptidases is controlled by a gating filter mechanism
2000
The Reactivity of Thiol-subtilisin, an Enzyme Containing a Synthetic Functional Group*
1967