Citation Impact
Citing Papers
p130 Is Dispensable in Peripheral T Lymphocytes: Evidence for Functional Compensation by p107 and pRB
1998
Activity-Dependent Internalization of Smoothened Mediated by ß-Arrestin 2 and GRK2
2004 StandoutScienceNobel
The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
2013 StandoutScienceNobel
Regulation of the Cell Cycle at the G1–S Transition by Proteolysis of Cyclin E and p27Kip1
2001
Tumor Induction and Tissue Atrophy in Mice Lacking E2F-1
1996
Hallmarks of Cancer: The Next Generation
2011 Standout
PPARγ induces cell cycle withdrawal: inhibition of E2F/DP DNA-binding activity via down-regulation of PP2A
1997
E2F and Cell Proliferation: A World Turned Upside Down
1996
Recent Insights into the Functions of the Retinoblastoma Susceptibility Gene Product
1997 StandoutNobel
The retinoblastoma gene family in differentiation and development
1999
The RB and p53 pathways in cancer
2002 Standout
Regulation of cell proliferation by the E2F transcription factors
1998
Role for the p53 homologue p73 in E2F-1-induced apoptosis
2000 StandoutNatureNobel
Involvement of Reactive Oxygen Species in Cytokine and Growth Factor Induction of c-fos Expression in Chondrocytes
1995 Standout
Control of pRB phosphorylation
1998
DNA synthesis control in yeast: An evolutionarily conserved mechanism for regulating DNA synthesis genes?
1992
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins
1997
Minimal regions of chromosomal imbalance in retinoblastoma detected by comparative genomic hybridization
2001
Expression of transcription factor E2F1 induces quiescent cells to enter S phase
1993 Nature
E2F target genes and cell-cycle checkpoint control
1999
A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F
1992
c-Myc-regulated microRNAs modulate E2F1 expression
2005 StandoutNature
Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth
1998 StandoutNobel
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
The Novel ATM-Related Protein TRRAP Is an Essential Cofactor for the c-Myc and E2F Oncoproteins
1998
Exogenous E2F expression is growth inhibitory before, during, and after cellular transformation
2000
Elite and stochastic models for induced pluripotent stem cell generation
2009 StandoutNatureNobel
Phosphorylation of E2F-1 modulates its interaction with the retinoblastoma gene product and the adenoviral E4 19 kDa protein
1994
Expression patterns of the E2F family of transcription factors during mouse nervous system development
1997
The retinoblastoma gene family: cousins with overlapping interests
1998
The retinoblastoma gene product protects E2F-1 from degradation by the ubiquitin-proteasome pathway.
1996
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties
1992 StandoutNobel
Molecular characterization of the retinoblastoma susceptibility gene
1993
Amplification of the E2F1 transcription factor gene in the HEL erythroleukemia cell line
1995
The C. elegans E2F- and DP-Related Proteins Are Required for Embryonic Asymmetry and Negatively Regulate Ras/MAPK Signaling
2001
A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting
1998
Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage
2003 StandoutNatureNobel
Myb DNA binding inhibited by phosphorylation at a site deleted during oncogenic activation
1990 StandoutNatureNobel
The Hallmarks of Cancer
2000 Standout
Apoptosis induced in mammalian cells by small peptides that functionally antagonize the Rb-regulated E2F transcription factor
1997
The E2F transcription factor is a cellular target for the RB protein
1991 Standout
Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint
1995
A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex
1992
A Long Twentieth Century of the Cell Cycle and Beyond
2000 StandoutNobel
Role of the retinoblastoma protein in the pathogenesis of human cancer.
1997 StandoutNobel
Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/−) mice
1998
dpl-1 DP and efl-1 E2F Act with lin-35 Rb to Antagonize Ras Signaling in C. elegans Vulval Development
2001 StandoutNobel
The Chk2 protein kinase
2004
The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein
1991 StandoutNobel
KLF4, p21 and context-dependent opposing forces in cancer
2005
DNA-binding activity of the adenovirus-induced E4F transcription factor is regulated by phosphorylation.
1989
The regulation of E2F by pRB-family proteins
1998 Standout
Adenoviral delivery of E2F-1 directs cell cycle reentry and p53-independent apoptosis in postmitotic adult myocardium in vivo.
1997
Inhibition of cell proliferation by an RNA ligand that selectively blocks E2F function
1996
Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants
2005 StandoutNatureNobel
E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex
2002
The cell cycle and the retinoblastoma protein family
1994
DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control
1994
Intrinsic tumour suppression
2004 Nature
Retinoblastoma-repression of E2F-dependent transcription depends on the ability of the retinoblastoma protein to interact with E2F and is abrogated by the adenovirus E1A oncoprotein
1992
E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APCCdh1
2002
E1A signaling to p53 involves the p19ARFtumor suppressor
1998
Coordination of Growth and Cell Division in the Drosophila Wing
1998
E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation
1996 StandoutNobel
Cellular mechanisms of tumour suppression by the retinoblastoma gene
2008
The role of E2F in the mammalian cell cycle
1993
p73 is a human p53-related protein that can induce apoptosis
1997 StandoutNatureNobel
Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression
2000 StandoutNobel
Sibling rivalry in the E2F family
2002
Growth Regulation by the E2F and DP Transcription Factor Families
1998
The fission yeast cdc18+ gene product couples S phase to START and mitosis
1993 StandoutNobel
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex
2004 StandoutNatureNobel
Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A
1991
Short Dysfunctional Telomeres Impair Tumorigenesis in the INK4aΔ2/3 Cancer-Prone Mouse
1999 StandoutNobel
Domains of the adenovirus E1A protein required for oncogenic activity are also required for dissociation of E2F transcription factor complexes.
1991
Induction of hepatocyte proliferation and liver hyperplasia by the targeted expression of cyclin E and skp2
2001
A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
2000 StandoutNatureNobel
Cancer-related inflammation
2008 StandoutNature
Evolutionarily Conserved Multisubunit RBL2/p130 and E2F4 Protein Complex Represses Human Cell Cycle-Dependent Genes in Quiescence
2007
lin-35 and lin-53, Two Genes that Antagonize a C. elegans Ras Pathway, Encode Proteins Similar to Rb and Its Binding Protein RbAp48
1998 StandoutNobel
Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: A novel mechanism for E1A trans-activation
1990
Molecular evolution of FOXP2, a gene involved in speech and language
2002 StandoutNatureNobel
Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex
2004
Transcriptional regulation during the mammalian cell cycle
1995
E2F-1 Potentiates Cell Death by Blocking Antiapoptotic Signaling Pathways
1999
The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F
1991
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
Overexpression of the E2F-1 transcription factor gene mediates cell transformation.
1995
Cellular Targets for Activation by the E2F1 Transcription Factor Include DNA Synthesis- and G1/S-Regulatory Genes
1995
Cloning and characterization of E2F-2, a Novel Protein with the Biochemical Properties of Transcription Factor E2F
1993
Genetic analysis of the adenovirus E4 6/7 trans activator: interaction with E2F and induction of a stable DNA-protein complex are critical for activity
1991
Functional Inactivation of the Retinoblastoma Protein Requires Sequential Modification by at Least Two Distinct Cyclin-cdk Complexes
1998
Cell Cycle Regulation of the Murine Cyclin E Gene Depends on an E2F Binding Site in the Promoter
1996
E2F and Its Developmental Regulation inXenopus laevis
1994
The adenovirus early region 4 open reading frame 6/7 protein regulates the DNA binding activity of the cellular transcription factor, E2F, through a direct complex.
1989
Heterodimerization of the transcription factors E2F-1 and DP-1 is required for binding to the adenovirus E4 (ORF6/7) protein
1994
Nuclear accumulation of the E2F heterodimer regulated by subunit composition and alternative splicing of a nuclear localization signal
1996
The role of cellular transcription factor E2F in the regulation of cdc2 mRNA expression and cell cycle control of human hematopoietic cells
1994
Phosphorylation-dependent activation of the adenovirus-inducible E2F transcription factor in a cell-free system.
1989
An adenovirus E4 gene product trans-activates E2 transcription and stimulates stable E2F binding through a direct association with E2F.
1990
Functional Interaction between DP-1 and p53
1996
A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites.
1995 StandoutNobel
Binding of the von Hippel-Lindau Tumor Suppressor Protein to Elongin B and C
1995 StandoutScienceNobel
A role for E2F1 in the induction of ARF, p53, and apoptosis during thymic negative selection.
1999
Association of cdk2 Kinase with the Transcription Factor E2F During S Phase
1992 Science
Cloning, Chromosomal Location, and Characterization of Mouse E2F1
1994 StandoutNobel
Skp2 is oncogenic and overexpressed in human cancers
2001
Functional properties of a Drosophila homolog of the E2F1 gene.
1994
An E2F-binding site mediates cell-cycle regulated repression of mouse B-myb transcription.
1993
E2F-1 Cooperates with Topoisomerase II Inhibition and DNA Damage To Selectively Augment p53-Independent Apoptosis
1997
Rb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular Senescence
2003 Standout
Regions of the retinoblastoma gene product required for its interaction with the E2F transcription factor are necessary for E2 promoter repression and pRb-mediated growth suppression.
1993
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
Molecular mechanisms of E2F-dependent activation and pRB-mediated repression
2004
Basic fibroblast growth factor-stimulated endothelial cell movement is mediated by a pertussis toxin-sensitive pathway regulating phospholipase A2 activity.
1994
CDC25A Phosphatase Is a Target of E2F and Is Required for Efficient E2F-Induced S Phase
1999
E2F and its developmental regulation in Xenopus laevis.
1994
p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein.
1994
Regulation of Plasma Cholesterol by Lipoprotein Receptors
1981 StandoutScienceNobel
The retinoblastoma protein binds to a family of E2F transcription factors.
1993
Cyclin A Expression Is under Negative Transcriptional Control during the Cell Cycle
1996
Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F.
1992
Expression of the E2F-1/DP-1 transcription factor in murine development.
1996
E2F-5, a New E2F Family Member That Interacts with p130 In Vivo
1995
A role for the adenovirus inducible E2F transcription factor in a proliferation dependent signal transduction pathway.
1990
Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation.
1994
E2F-4 Switches from p130 to p107 and pRB in Response to Cell Cycle Reentry
1996
Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members
1996
The HIP1 binding site is required for growth regulation of the dihydrofolate reductase gene promoter.
1992
The Transcription Factor E2F-1 Is a Downstream Target of RB Action
1995 StandoutNobel
The adenovirus E4 17-kilodalton protein complexes with the cellular transcription factor E2F, altering its DNA-binding properties and stimulating E1A-independent accumulation of E2 mRNA
1990
The HIP1 Binding Site Is Required for Growth Regulation of the Dihydrofolate Reductase Gene Promoter
1992
Transcription factor E2F binds DNA as a heterodimer.
1993
Distinct gene expression phenotypes of cells lacking Rb and Rb family members.
2003
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
1998
Transcription of the E2F-1 Gene Is Rendered Cell Cycle Dependent by E2F DNA-Binding Sites within Its Promoter
1994 StandoutNobel
Cloning, chromosomal location, and characterization of mouse E2F1.
1994 StandoutNobel
Specific Regulation of E2F Family Members by Cyclin-Dependent Kinases
1997
Differential regulation of E2F transactivation by cyclin/cdk2 complexes.
1994
A Role for a Bent DNA Structure in E2F-Mediated Transcription Activation
1996
Pocket Protein Complexes Are Recruited to Distinct Targets in Quiescent and Proliferating Cells
2005
DNA-binding and trans-activation properties of Drosophila E2F and DP proteins.
1994
E2F-1:DP-1 Induces p53 and Overrides Survival Factors To Trigger Apoptosis
1995
E2F-4, a new member of the E2F transcription factor family, interacts with p107.
1994
Regions of the Retinoblastoma Gene Product Required for its Interaction with the E2F Transcription Factor are Necessary for E2 Promoter Repression and pRb-Mediated Growth Suppression
1993
Retinoblastoma Protein Contains a C-terminal Motif That Targets It for Phosphorylation by Cyclin-cdk Complexes
1999 StandoutNobel
Cyclin A/CDK2 Binds Directly to E2F-1 and Inhibits the DNA-Binding Activity of E2F-1/DP-1 by Phosphorylation
1994
E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity.
1995
Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F.
1993
Cyclin E-induced S phase without activation of the pRb/E2F pathway.
1997
Regulation of E2F through ubiquitin–proteasome-dependent degradation: Stabilization by the pRB tumor suppressor protein
1997
The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E.
1993
E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction.
1997
A protein synthesis-dependent increase in E2F1 mRNA correlates with growth regulation of the dihydrofolate reductase promoter.
1993 StandoutNobel
Expression of Dominant-Negative Mutant DP-1 Blocks Cell Cycle Progression in G1
1996
E2f3 is critical for normal cellular proliferation
2000
Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression.
1995
E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis
1995
Regulation of the cyclin E gene by transcription factor E2F1.
1995
Molecular characterization of Xenopus laevis DP proteins.
1994
Association of p107 with Sp1: Genetically Separable Regions of p107 Are Involved in Regulation of E2F- and Sp1-Dependent Transcription
1995
The Developmental Biology of Brain Tumors
2001
In Vivo Association of E2F and DP Family Proteins
1995
Cell Cycle Analysis of E2F in Primary Human T Cells Reveals Novel E2F Complexes and Biochemically Distinct Forms of Free E2F
1993
E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo.
1994
Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation.
1993
Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells
1998
Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression.
1994
Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis.
1994
E1A-dependent trans-activation of the human MYC promoter is mediated by the E2F factor.
1989
Disruption of RB/E2F-1 interaction by single point mutations in E2F-1 enhances S-phase entry and apoptosis.
1996
DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1.
1994
Control of Cell Cycle Exit and Entry by Protein Kinase B-Regulated Forkhead Transcription Factors
2002
The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting
2003
pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.
1997
E2F Activity Is Regulated by Cell Cycle-Dependent Changes in Subcellular Localization
1997
Regulation of cholesterol synthesis by low density lipoprotein in isolated human lymphocytes
1977
Functional conservation of the cell cycle-regulating transcription factor DRTF1/E2F and its pathway of control in Drosophila melanogaster
1995
A genetic analysis of the E2F1 gene distinguishes regulation by Rb, p107, and adenovirus E4.
1993
A role for E2F1 in the induction of apoptosis during thymic negative selection.
2000
Effect of apoproteins on hepatic uptake of triglyceride emulsions in the rat.
1980
Ectopic expression of dE2F and dDP induces cell proliferation and death in the Drosophila eye.
1996
Targeted disruption of p107: functional overlap between p107 and Rb.
1996
Coordinated repression of cell cycle genes by KDM5A and E2F4 during differentiation
2012 StandoutNobel
Induction of S-Phase Entry by E2F Transcription Factors Depends on Their Nuclear Localization
1997
Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes.
1993
Differential Roles of Two Tandem E2F Sites in Repression of the Human p107 Promoter by Retinoblastoma and p107 Proteins
1995
Subunit Composition Determines E2F DNA-Binding Site Specificity
1997
Regulation of the Ets-Related Transcription Factor Elf-1 by Binding to the Retinoblastoma Protein
1993 StandoutScienceNobel
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Transcription Factor E2F Is Required for Efficient Expression of the Hamster Dihydrofolate Reductase Gene In Vitro and In Vivo
1989
Protein domains governing interactions between E2F, the retinoblastoma gene product, and human papillomavirus type 16 E7 protein.
1993
Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins.
1996
Identification of Positively and Negatively Acting Elements Regulating Expression of the E2F2 Gene in Response to Cell Growth Signals
1997
E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins
1992 Science
Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression
2000
Overexpression of E2F-1 in rat embryo fibroblasts leads to neoplastic transformation.
1994
Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site.
1995
The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F.
1992
Expression of the HsOrc1 Gene, a Human ORC1 Homolog, Is Regulated by Cell Proliferation via the E2F Transcription Factor
1996
RB and hbrm cooperate to repress the activation functions of E2F1
1997
Another p53 Doppelgänger?
1998 StandoutScienceNobel
E2F-1 Blocks Terminal Differentiation and Causes Proliferation in Transgenic Megakaryocytes
1996
A Matter of Life and Cell Death
1998 Science
Works of Laszlo Jakoi being referenced
Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F
1997 Nature
Identification and Characterization of E2F7, a Novel Mammalian E2F Family Member Capable of Blocking Cellular Proliferation
2003
Loss of E2F4 Activity Leads to Abnormal Development of Multiple Cellular Lineages
2000
E2F4 and E2F5 Play an Essential Role in Pocket Protein–Mediated G1 Control
2000
E2F3 activity is regulated during the cell cycle and is required for the induction of S phase
1998
Role of the Rb/E2F pathway in cell growth control
1997
Identification of a Novel E2F3 Product Suggests a Mechanism for Determining Specificity of Repression by Rb Proteins
2000
A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation.
1996
The Induction of Hepatic Cholesterol Synthesis in the Rat by Lecithin Mesophase Infusions
1974
Interactions of the p107 and Rb proteins with E2F during the cell proliferation response.
1993
Functional analysis of E2F transcription factor
1997
The adenovirus-inducible factor E2F stimulates transcription after specific DNA binding.
1989
The Adenovirus-Inducible Factor E2F Stimulates Transcription after Specific DNA Binding
1989
The Accumulation of an E2F-p130 Transcriptional Repressor Distinguishes a G0 Cell State From a G1 Cell State
1996
E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2.
1998
The heterogeneity of rat high density lipoproteins
1978
Collaborative role of E2F transcriptional activity and G 1 cyclindependent kinase activity in the induction of S phase
1999
Oncogenic capacity of the E2F1 gene.
1994
Role of a guanine nucleotide regulatory protein in the activation of phospholipase C by different chemoattractants.
1987
Distinct roles for E2F proteins in cell growth control and apoptosis
1997