Standout Papers
Citation Impact
Citing Papers
Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro
2006 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Cutaneous Wound Healing
1999 Standout
Inflammation and cancer
2002 StandoutNature
The activation of human [Glu1]plasminogen by human single-chain urokinase
1988
Structural requirements for glycosyl‐phosphatidylinositol‐anchor attachment in the cellular receptor for urokinase plasminogen activator
1992
Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis
1996 Standout
Biological Activation of pro-HGF (Hepatocyte Growth Factor) by Urokinase Is Controlled by a Stoichiometric Reaction
1995
Instability and decay of the primary structure of DNA
1993 StandoutNatureNobel
Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo
1992 StandoutNature
Cancer invasion and tissue remodeling: common themes in proteolytic matrix degradation
1998
Endothelial cell regulation by transforming growth factor‐beta
1991
The Hallmarks of Cancer
2000 Standout
Urokinase and urokinase receptor: A paracrine/autocrine system regulating cell migration and invasiveness
1993
A role for the Drosophila neurogenic genes in mesoderm differentiation
1991 StandoutNobel
The Fibrinolytic System of the Vessel Wall and Its Role in the Control of Thrombosis
1990
The urokinase-type plasminogen activator system in cancer metastasis: A review
1997 Standout
Constitutive Protease-activated Receptor-2-mediated Migration of MDA MB-231 Breast Cancer Cells Requires Both β-Arrestin-1 and -2
2004 StandoutNobel
Sulfation of N-Acetylglucosamine by Chondroitin 6-Sulfotransferase 2 (GST-5)
2000 StandoutNobel
Vascular permeability factor/vascular endothelial growth factor:A multifunctional angiogenic cytokine
1997
Regulation of Ferroptotic Cancer Cell Death by GPX4
2014 Standout
Pathogenesis of tumor stroma generation: a critical role for leaky blood vessels and fibrin deposition
1989
Tumor interactions with the vasculature: angiogenesis and tumor metastasis
1990
A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation
2015 StandoutNobel
The microenvironment of the tumour–host interface
2001 StandoutNature
Immunity, Inflammation, and Cancer
2010 Standout
P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury
2003 StandoutNature
An Antibody Fragment from a Phage Display Library Competes for Ligand Binding to the Low Density Lipoprotein Receptor Family and Inhibits Rhinovirus Infection
1995 StandoutNobel
Cellular Localization of Membrane-type Serine Protease 1 and Identification of Protease-activated Receptor-2 and Single-chain Urokinase-type Plasminogen Activator as Substrates
2000
Loss of Fibrinogen Rescues Mice from the Pleiotropic Effects of Plasminogen Deficiency
1996
Tumor Angiogenesis and Metastasis — Correlation in Invasive Breast Carcinoma
1991 Standout
Stem Cell-derived Neural Stem/Progenitor Cell Supporting Factor Is an Autocrine/Paracrine Survival Factor for Adult Neural Stem/Progenitor Cells
2003 StandoutNobel
Neonatal bleeding in transgenic mice expressing urokinase-type plasminogen activator
1990
Physiological consequences of loss of plasminogen activator gene function in mice
1994 Nature
Functional roles of microglia in the brain
1993
Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation
1991 Standout
Urokinase- and Tissue-Type Plasminogen Activators in Keratinocytes During Wound Reepithelialization In Vivo
1988
Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease
1992 StandoutNature
Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
1996 StandoutNature
Kinetics of inhibition of tissue‐type and urokinase‐type plasminogen activator by plasminogen‐activator inhibitor type 1 and type 2
1988
A matrix metalloproteinase expressed on the surface of invasive tumour cells
1994 StandoutNature
Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
1996 StandoutNature
The pathogenesis of atherosclerosis: a perspective for the 1990s
1993 StandoutNature
Implantation and the placenta: key pieces of the development puzzle
1994 StandoutScience
The effect of polymerised fibrin on the catalytic activities of one-chain tissue-type plasminogen activator as revealed by an analogue resistant to plasmin cleavage
1988
Conformation of one- and two-chain high molecular weight urokinase analyzed by small-angle neutron scattering and vacuum ultraviolet circular dichroism
1991 StandoutNobel
Concomitant secretion of prourokinase and of a plasminogen activator-specific inhibitor by cultured human monocytes-macrophages.
1984
Plasmin-catalysed cleavage of single chain tissue-type plasminogen activator in fibrin clots
1989
Vascular Permeability Factor, an Endothelial Cell Mitogen Related to PDGF
1989 StandoutScience
Activation of pro-urokinase and plasminogen on human sarcoma cells: a proteolytic system with surface-bound reactants.
1989
Fibrinogen influx and accumulation of cross-linked fibrin in mouse carcinomas.
1988
Circadian rhythms in Neurospora crassa: a mutation affecting temperature compensation.
1982
Prourokinase activation on the surface of human rhabdomyosarcoma cells: localization and inactivation of newly formed urokinase-type plasminogen activator by recombinant class 2 plasminogen activator inhibitor.
1990
Inhibition by human recombinant tissue inhibitor of metalloproteinases of human amnion invasion and lung colonization by murine B16-F10 melanoma cells.
1988
Production of large amounts of hydrogen peroxide by human tumor cells.
1991 Standout
Cloning and sequence of a cDNA coding for the human beta-migrating endothelial-cell-type plasminogen activator inhibitor.
1986
Internalization of the urokinase-plasminogen activator inhibitor type-1 complex is mediated by the urokinase receptor.
1992
Advances in skin grafting and treatment of cutaneous wounds
2014 StandoutScience
Regulation of the endothelial cell urokinase-type plasminogen activator receptor. Evidence for cyclic AMP-dependent and protein kinase C-dependent pathways.
1993 StandoutNobel
Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol
1991
Functional rafts in cell membranes
1997 StandoutNature
Impaired wound healing in mice with a disrupted plasminogen gene
1996
Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.
1995 Standout
A cellular binding site for the Mr 55,000 form of the human plasminogen activator, urokinase.
1985
Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis
1997 StandoutScience
A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor.
1991
PER Protein Interactions and Temperature Compensation of a Circadian Clock in Drosophila
1995 StandoutScienceNobel
Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.
1992
Serpin reactive center loop mobility is required for inhibitor function but not for enzyme recognition.
1994
Plasminogen activators in tissue remodeling and invasion: mRNA localization in mouse ovaries and implanting embryos.
1989
A Perspective on Cancer Cell Metastasis
2011 StandoutScience
From legumes to leukocytes: biological roles for sulfated carbohydrates
1996
92-kD type IV collagenase mediates invasion of human cytotrophoblasts.
1991
Surface receptors for urokinase plasminogen activator
1988
Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor is an hepatic receptor for tissue-type plasminogen activator.
1992
The human receptor for urokinase plasminogen activator. NH2-terminal amino acid sequence and glycosylation variants.
1990
Wound Healing--Aiming for Perfect Skin Regeneration
1997 StandoutScience
Cancer Treatment by Targeted Drug Delivery to Tumor Vasculature in a Mouse Model
1998 StandoutScience
Determinants of binding and internalization of tissue-type plasminogen activator by human vascular smooth muscle and endothelial cells
1993
A genetically clamped renin transgene for the induction of hypertension
2002 StandoutNobel
The receptor-binding sequence of urokinase. A biological function for the growth-factor module of proteases.
1987
Interaction of single-chain urokinase-type plasminogen activator with human endothelial cells.
1990 StandoutNobel
Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product
1991 StandoutScience
Liver Regeneration
1997 StandoutScience
Endocytosis of urokinase-plasminogen activator inhibitor type 1 complexes bound to a chimeric transmembrane urokinase receptor.
1994 StandoutNobel
Angiogenic Factors
1987 StandoutScience
Receptor-mediated internalization and degradation of urokinase is caused by its specific inhibitor PAI-1.
1990
Ultrastructural localization of plasma membrane-associated urokinase-type plasminogen activator at focal contacts.
1988
Proteolytic cleavage of single-chain pro-urokinase induces conformational change which follows activation of the zymogen and reduction of its high affinity for fibrin.
1985
In vivo patterns of expression of urokinase and its inhibitor PAI-1 suggest a concerted role in regulating physiological angiogenesis.
1992
Better reception for urokinase
1990 Nature
Growth Factors and Cancer
1991 StandoutScience
Matrix Metalloproteinase Inhibitors and Cancer—Trials and Tribulations
2002 StandoutScience
The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes.
1990
Purification and characterization of recombinant single-chain urokinase produced in Escherichia coli
1986
Differentiation-enhanced binding of the amino-terminal fragment of human urokinase plasminogen activator to a specific receptor on U937 monocytes.
1985
Proteolytic activation of latent transforming growth factor-beta from fibroblast-conditioned medium.
1988 Standout
Accessibility of receptor-bound urokinase to type-1 plasminogen activator inhibitor.
1989
Proteolysis and physiological regulation
1987
Role of transforming growth factor-beta in the development of the mouse embryo.
1987
Requirement of Vascular Integrin α v β 3 for Angiogenesis
1994 StandoutScience
Matrix Metalloproteinases: A Review
1993 Standout
Tumors: Wounds That Do Not Heal
1986 Standout
Invasiveness of human glioma cell lines in vitro: Relation to tumorigenicity in athymic mice
1987
Regions involved in binding of urokinase-type-1 inhibitor complex and pro-urokinase to the endocytic alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Evidence that the urokinase receptor protects pro-urokinase against binding to the endocytic receptor.
1994
Genes Expressed in Human Tumor Endothelium
2000 StandoutScience
Control of Angiogenesis in Fibroblasts by p53 Regulation of Thrombospondin-1
1994 StandoutScience
Urokinase-type plasminogen activator: proenzyme, receptor, and inhibitors
1987
Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis.
1990
The role of fragment X polymers in the fibrin enhancement of tissue plasminogen activator-catalyzed plasmin formation.
1990 StandoutNobel
Identification and primary sequence of an unspliced human urokinase poly(A)+ RNA.
1984
Works of Lars Skriver being referenced
Inactive proenzyme to tissue-type plasminogen activator from human melanoma cells, identified after affinity purification with a monoclonal antibody.
1984
Distribution of urokinase-type plasminogen activator immunoreactivity in the mouse.
1984
Plasminogen Activators, Tissue Degradation, and Cancer
1985 Standout
Enzyme-Linked Immunosorbent Assay for Human Urokinase-Type Plasminogen Activator and its Proenzyme Using a Combination of Monoclonal and Polyclonal Antibodies
1986
Immunocytochemical localization of urokinase-type plasminogen activator in Lewis lung carcinoma.
1984
Plasminogen Activator Released as Inactive Proenzyme from Murine Cells Transformed by Sarcoma Virus
1982
One-chain urokinase-type plasminogen activator from human sarcoma cells is a proenzyme with little or no intrinsic activity.
1988
Plasminogen activator inhibitor from human fibrosarcoma cells binds urokinase-type plasminogen activator, but not its proenzyme.
1986
Proenzyme to urokinase‐type plasminogen activator in the mouse in vivo
1985
Plasminogen activators catalyse conversion of inhibitor from fibrosarcoma cells to an inactive form with a lower apparent molecular mass
1986
Monoclonal antibody to human 66,000 molecular weight plasminogen activator from melanoma cells. Specific enzyme inhibition and one-step affinity purification.
1983
Purification of zymogen to plasminogen activator from human glioblastoma cells by affinity chromatography with monoclonal antibody
1982
Molecular control of membrane properties during temperature acclimation. Fatty acid desaturase regulation of membrane fluidity in acclimating Tetrahymena cells
1976