Citation Impact
Citing Papers
Tryptophan 7-Halogenase (PrnA) Structure Suggests a Mechanism for Regioselective Chlorination
2005 Science
Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation
2015 StandoutNobel
Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist
2004 StandoutNobel
Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble
2018 StandoutNobel
Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ
2003 StandoutScienceNobel
Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life
2016 StandoutScienceNobel
The Human SepSecS-tRNA Sec Complex Reveals the Mechanism of Selenocysteine Formation
2009 StandoutScienceNobel
Computational Thermostabilization of an Enzyme
2005 StandoutScienceNobel
Protein stability promotes evolvability
2006 StandoutNobel
Dimerization of an Inactive Fragment of Huperzine A Produces a Drug with Twice the Potency of the Natural Product
2000
Soft corrugated channel with synergistic exclusive discrimination gating for CO2 recognition in gas mixture
2023 StandoutNobel
Catalytic Subunit of Cyclic AMP-Dependent Protein Kinase
1999
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
2009 StandoutNobel
Mapping the Fluorophilicity of a Hydrophobic Pocket: Synthesis and Biological Evaluation of Tricyclic Thrombin Inhibitors Directing Fluorinated Alkyl Groups into the P Pocket
2006
Bromine K‐edge EXAFS studies of bromide binding to bromoperoxidase from Ascophyllum nodosum
1999
Models for the active site of vanadium-dependent haloperoxidases: insight into the solution structure of peroxo vanadium compounds
2000
Demethylation of 3-Methylthymine in DNA by Bacterial and Human DNA Dioxygenases
2004 StandoutNobel
Identification, Characterization, and Crystal Structure of the Omega Class Glutathione Transferases
2000
The crystal structure of methenyltetrahydromethanopterin cyclohydrolase from the hyperthermophilic archaeon Methanopyrus kandleri
1999
X-ray structure determination of a vanadium-dependent haloperoxidase from Ascophyllum nodosum at 2.0 Å resolution 1 1Edited by R. Huber
1999
Peroxidase and Phosphatase Activity of Active-site Mutants of Vanadium Chloroperoxidase from the Fungus Curvularia inaequalis
2000
Protein Kinase A in Complex with Rho-Kinase Inhibitors Y-27632, Fasudil, and H-1152P
2003 Nobel
Thermophilic Adaptation of Proteins
2001
Combinatorial and computational challenges for biocatalyst design
2001 StandoutNatureNobel
Haloperoxidases and their role in biotransformation reactions
1999
High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site
2002
PKA: a portrait of protein kinase dynamics
2003
Crystal structure and mechanism of a calcium-gated potassium channel
2002 StandoutNatureNobel
Bromoperoxidase activity of vanadate‐substituted acid phosphatases from Shigella flexneri and Salmonella enterica ser. typhimurium
2002
The hyperthermostable indoleglycerol phosphate synthase from Thermotoga maritima is destabilized by mutational disruption of two solvent-exposed salt bridges 1 1Edited by R. Huber
1999
The crystal structure of the tryptophan synthase β2 subunit from the hyperthermophile Pyrococcus furiosus
2004
Syntheses, structures, stability, and insulin-like activities of peroxovanadium(V) complexes with a heteroligand
2001
Oxidation reactions catalyzed by vanadium chloroperoxidase from Curvularia inaequalis
2000
Structural and functional comparisons between vanadium haloperoxidase and acid phosphatase enzymes
2002
Catalysis for fluorination and trifluoromethylation
2011 StandoutNature
The unique role of halogen substituents in the design of modern agrochemicals
2009
Vanadium haloperoxidases
1998
The stability of proteins in extreme environments
1998
Expanding the Enzyme Universe: Accessing Non‐Natural Reactions by Mechanism‐Guided Directed Evolution
2015 StandoutNobel
Peroxo-bridged divanadate as selective bromide oxidant in bromoperoxidation
2002
The Unique Role of Fluorine in the Design of Active Ingredients for Modern Crop Protection
2004 Standout
Analysis of the Catalytic Domain of Phosphatidylinositol 4-Kinase Type II
2002 StandoutNobel
Towards models of vanadate-dependent haloperoxidases: the hydroxyl side chain
2000
Rational design of α-helical tandem repeat proteins with closed architectures
2015 StandoutNatureNobel
Nanoporous Carbohydrate Metal–Organic Frameworks
2011 StandoutNobel
Expanding the Genetic Code
2004
Biocatalytic and biomimetic oxidations with vanadium
2000
Review: Protein function at thermal extremes: balancing stability and flexibility
2001
Crystal structure of dodecameric vanadium-dependent bromoperoxidase from the red algae Corallina officinalis 1 1Edited by R. Huber
2000
Prolegomena to Future Experimental Efforts on Genetic Code Engineering by Expanding Its Amino Acid Repertoire
2004
Temperature adaptation of enzymes: Lessons from laboratory evolution
2001 StandoutNobel
Water and bromide in the active center of vanadate-dependent haloperoxidases
2000
Structure and Catalytic Mechanism of Eukaryotic Selenocysteine Synthase
2007
Refined crystal structure of a superoxide dismutase from the hyperthermophilic archaeon Sulfolobus acidocaldarius at 2.2 Å resolution 1 1Edited by R. Huber
1999
Fluorogenic probes using 4-substituted-2-nitrobenzenesulfonyl derivatives as caging groups for the analysis of human glutathione transferase catalyzed reactions
2013
Reactivity of recombinant and mutant vanadium bromoperoxidase from the red alga Corallina officinalis
2002
Hyperthermophilic Enzymes: Sources, Uses, and Molecular Mechanisms for Thermostability
2001 Standout
CASK Functions as a Mg2+-Independent Neurexin Kinase
2008 StandoutNobel
Cold Adaptation of a Mesophilic Subtilisin-like Protease by Laboratory Evolution
2000 StandoutNobel
Isosteric replacement of sulfur with other chalcogens in peptides and proteins
2005
Molecular Recognition in Chemical and Biological Systems
2015
Quantitative reactivity profiling predicts functional cysteines in proteomes
2010 StandoutNatureNobel
Catalytic promiscuity and the evolution of new enzymatic activities
1999
Exploring protein fitness landscapes by directed evolution
2009 StandoutNobel
Stability and stabilization of globular proteins in solution
2000
Click Chemistry In Situ: Acetylcholinesterase as a Reaction Vessel for the Selective Assembly of a Femtomolar Inhibitor from an Array of Building Blocks
2002 StandoutNobel
Mitogen‐activated protein kinases interacting kinases are autoinhibited by a reprogrammed activation segment
2006
Insulin disrupts β-adrenergic signalling to protein kinase A in adipocytes
2005 StandoutNatureNobel
Selenium incorporation using recombinant techniques
2010
Crystal Structure of a Soluble Form of the Intracellular Chloride Ion Channel CLIC1 (NCC27) at 1.4-Å Resolution
2001
Sulfoxidation mechanism of vanadium bromoperoxidase from Ascophyllum nodosum
2001
A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans
2015 StandoutNobel
Synthesis and Characterization of a Peroxovanadium(V) Complex Containing N-Carboxymethylhistidine as a Model for the Vanadium Haloperoxidase Enzymes
1998
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
Enantioselective Sulfoxidation Catalyzed by Vanadium Haloperoxidases
1998
The medicinal and catalytic potential of model complexes of vanadate-dependent haloperoxidases
2003
Carbon Trifluoromethylation Reactions of Hydrocarbon Derivatives and Heteroarenes
2015
Mechanistic considerations of the vanadium haloperoxidases
1999
Directed Evolution: Bringing New Chemistry to Life
2017 StandoutNobel
Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications
2019 Standout
Synthesis, characterization, and crystal and molecular structures of caesium N-(carbamoylethyl)iminodiacetatooxoperoxovanadate(V) monohydrate
1999
In the light of directed evolution: Pathways of adaptive protein evolution
2009 StandoutNobel
Selectivity of commonly used pharmacological inhibitors for cystathionine β synthase (CBS ) and cystathionine γ lyase (CSE )
2013
Supramolecular interactions of vanadate species: vanadium(V) complexes with N-salicylidenehydrazides as versatile models
2003
Histidine-Containing Bisperoxovanadium(V) Compounds: Insight Into the Solution Structure by an ESI-MS and51V-NMR Comparative Study
1999
Structural studies on the dodecameric vanadium bromoperoxidase from Corallina species
2003
Solids Go Bio: Inorganic Nanoparticles as Enzyme Mimics
2015
X-ray structures of apo and tungstate derivatives of vanadium chloroperoxidase from the fungus Curvularia inaequalis
1998
Towards hydroperoxovanadium complexes: the X-ray crystal structure of a peroxovanadium(v) complex containing a V(O2)(RCO2H)(H2O)2 cluster with hydrogen bond inter-linkages
2001
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Targeted metabolic labeling of yeast N-glycans with unnatural sugars
2010 StandoutNobel
Maintaining Biological Activity by Using Triazoles as Disufide Bond Mimetics
2011 StandoutNobel
Microbial metabolites: 45 years of wandering, wondering and discovering
2011 StandoutNobel
Mass spectrometry-based proteomics
2003 StandoutNature
Towards New Protein Engineering: In Vivo Building and Folding of Protein Shuttles for Drug Delivery and Targeting by the Selective Pressure Incorporation (SPI) Method
2000
Fluorine in Pharmaceuticals: Looking Beyond Intuition
2007 StandoutScience
Unlocking Reactivity of TrpB: A General Biocatalytic Platform for Synthesis of Tryptophan Analogues
2017 StandoutNobel
Site-specific chemical modification of recombinant proteins produced in mammalian cells by using the genetically encoded aldehyde tag
2009 StandoutNobel
Discovery of aminoacyl-tRNA synthetase activity through cell-surface display of noncanonical amino acids
2006 StandoutNobel
De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures
2017 StandoutNobel
Dimerization of an Inactive Fragment of Huperzine A Produces a Drug with Twice the Potency of the Natural Product
2000
The Chemistry and Biochemistry of Vanadium and the Biological Activities Exerted by Vanadium Compounds
2004 Standout
Toward the experimental codon reassignment in vivo : protein building with an expanded amino acid repertoire
1999 Nobel
A structural view of evolutionary divergence
1999 StandoutNobel
Mass Spectrometry as a Tool for Protein Crystallography
2001
Ultrafast Dynamics of Flavins in Five Redox States
2008 StandoutNobel
Protein Design: Toward Functional Metalloenzymes
2014
Complementary roles of gasotransmitters CO and H2S in sleep apnea
2017 StandoutNobel
Networks of electrostatic and hydrophobic interactions modulate the complex folding free energy surface of a designed βα protein
2019 StandoutNobel
Synthesis, characterization, crystal structure and reactivity of the vanadium(V) monoperoxo complex with tetradentate N-(carbamoylethyl)iminodiacetate as heteroligand
1998
Modeling the Catalytic Site of Vanadium Bromoperoxidase: Synthesis and Structural Characterization of Intramolecularly H-bonded Vanadium(V) Oxoperoxo Complexes, [VO(O2)(NH2pyg2)]K and [VO(O2)(BrNH2pyg2)]K
2001
Improving the Catalytic Performance of an Artificial Metalloenzyme by Computational Design
2015 StandoutNobel
Design and Structure−Activity Relationship of a New Class of Potent VEGF Receptor Tyrosine Kinase Inhibitors
1999
Enzymatic aminoacylation of tRNA with unnatural amino acids
2006 StandoutNobel
Prolegomena zum experimentellen Engineering des genetischen Codes durch Erweiterung seines Aminosäurerepertoires
2004
Asymmetric sulfoxidation catalyzed by a vanadium bromoperoxidase: Substrate requirements of the catalyst
1998
Reactivity of Dioxovanadium(V) Complexes with Hydrogen Peroxide: Implications for Vanadium Haloperoxidase
1998
Catalytic oxidations by vanadium complexes
2003
New Aspects for Modeling Supramolecular Interactions in Vanadium Haloperoxidases: β‐Cyclodextrin Inclusion Compounds of cis‐Dioxovanadium(V) Complexes
2007
The coordination chemistry of vanadium as related to its biological functions
1999
Ribosomal Synthesis of Unnatural Peptides
2005 StandoutNobel
Enzymatic Halogenation and Dehalogenation Reactions: Pervasive and Mechanistically Diverse
2017
Probing the scope of the sulfoxidation activity of vanadium bromoperoxidase from Ascophyllum nodosum
1999
Die Erweiterung des genetischen Codes
2004
“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates
2017 StandoutNobel
Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design
2011 Standout
Biological and medicinal aspects of vanadium
2003
Works of Lars Prade being referenced
Structures of class pi glutathione S-transferase from human placenta in complex with substrate, transition-state analogue and inhibitor
1997
Implications for the Catalytic Mechanism of the Vanadium-Containing Enzyme Chloroperoxidase from the Fungus Curvularia inaequalis by X-Ray Structures of the Native and Peroxide Form
1997
Replacement of Isobutyl by Trifluoromethyl in Pepstatin A Selectively Affects Inhibition of Aspartic Proteinases
2005
X-ray Structure of Plasmepsin II Complexed with a Potent Achiral Inhibitor
2005
Staurosporine-induced conformational changes of cAMP-dependent protein kinase catalytic subunit explain inhibitory potential
1997 Nobel
Achiral, Cheap, and Potent Inhibitors of Plasmepsins I, II, and IV
2006
Lactate dehydrogenase from the hyperthermophilic bacterium Thermotoga maritima: the crystal structure at 2.1 å resolution reveals strategies for intrinsic protein stabilization
1998 Nobel
Crystal structrure of herbicide-detoxifying maize glutathione S-transferase-I in complex with lactoylglutathione: evidence for an induced-fit mechanism
1997
Bioincorporation of telluromethionine into proteins: a promising new approach for X-ray structure analysis of proteins 1 1Edited by K. Nagai
1997 Nobel
Three-dimensional structure of glutathione S-transferase from Arabidopsis thaliana at 2.2 Å resolution: Structural characterization of herbicide-conjugating plant glutathione S-transferases and a novel active site architecture
1996 Nobel
Crystal structure of Escherichia coli cystathionine γ-synthase at 1.5 Å resolution
1998
Rack-induced metal binding vs. flexibility: Met121His azurin crystal structures at different pH
1998 Nobel
Ein enzymgebundener Disubstrathybrid-Inhibitor der Adenylsuccinat-Synthetase
1999