Standout Papers
Citation Impact
Citing Papers
Genetically Encoding Fluorosulfate- l -tyrosine To React with Lysine, Histidine, and Tyrosine via SuFEx in Proteins in Vivo
2018
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
2019 StandoutNobel
Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade
2017 Standout
In vivo aspects of protein folding and quality control
2016 Science
Sulfur [ 18 F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis
2021 StandoutNobel
Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors
2022 StandoutNobel
Bifluoride Ion Mediated SuFEx Trifluoromethylation of Sulfonyl Fluorides and Iminosulfur Oxydifluorides
2019 StandoutNobel
Global metabolomics reveals metabolic dysregulation in ischemic retinopathy
2015
Arteriovenous Blood Metabolomics: A Readout of Intra-Tissue Metabostasis
2015
Silicon‐Free SuFEx Reactions of Sulfonimidoyl Fluorides: Scope, Enantioselectivity, and Mechanism
2020
Targeting microbial biofilms: current and prospective therapeutic strategies
2017 Standout
The Unfolded Protein Response and Cell Fate Control
2017
Mechanisms, regulation and functions of the unfolded protein response
2020 Standout
Modular click chemistry libraries for functional screens using a diazotizing reagent
2019 StandoutNatureNobel
Regulation and Functions of the ER-Associated Nrf1 Transcription Factor
2022 StandoutNobel
IRE1α-XBP1s pathway promotes prostate cancer by activating c-MYC signaling
2019
Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease
2019 Standout
Pharmacological targeting of endoplasmic reticulum stress in disease
2021
Hallmarks of aging: An expanding universe
2023 Standout
A lifetime of stress: ATF6 in development and homeostasis
2018
Biomedical applications of biodegradable polymers
2011 Standout
SuFExable polymers with helical structures derived from thionyl tetrafluoride
2021 StandoutNobel
Selective C H bond functionalization with engineered heme proteins: new tools to generate complexity
2018 StandoutNobel
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
2020 Standout
Click Chemistry in Proteomic Investigations
2020
Metabolomics: beyond biomarkers and towards mechanisms
2016 Standout
PROTAC targeted protein degraders: the past is prologue
2022 Standout
Metabolism Links Bacterial Biofilms and Colon Carcinogenesis
2015
Gut microbiota, metabolites and host immunity
2016 Standout
A Pragmatic Guide to Enrichment Strategies for Mass Spectrometry–Based Glycoproteomics
2020 StandoutNobel
A new era in functional genomics screens
2021
The UPR Activator ATF6 Responds to Proteotoxic and Lipotoxic Stress by Distinct Mechanisms
2018
Current approaches and challenges for the metabolite profiling of complex natural extracts
2014
The proteostasis network and its decline in ageing
2019
Discovery and resupply of pharmacologically active plant-derived natural products: A review
2015 Standout
MetaboAnalyst 3.0—making metabolomics more meaningful
2015 Standout
Using sulfuramidimidoyl fluorides that undergo sulfur(vi) fluoride exchange for inverse drug discovery
2020 StandoutNobel
Proteostasis control by the unfolded protein response
2015
Protein Sequence Editing of SKN-1A/Nrf1 by Peptide:N-Glycanase Controls Proteasome Gene Expression
2019 StandoutNobel
Targeting the Endoplasmic Reticulum Unfolded Protein Response to Counteract the Oxidative Stress‐Induced Endothelial Dysfunction
2018
Nitric Oxide: A Key Mediator of Biofilm Dispersal with Applications in Infectious Diseases
2014
Modeling neurodevelopmental disorder-associated humanAGO1mutations inCaenorhabditis elegansArgonautealg-1
2024 StandoutNobel
SuFEx‐Based Polysulfonate Formation from Ethenesulfonyl Fluoride–Amine Adducts
2017 StandoutNobel
METLIN: A Technology Platform for Identifying Knowns and Unknowns
2018
Micelle-Encapsulated Quantum Dot-Porphyrin Assemblies as in Vivo Two-Photon Oxygen Sensors
2015 StandoutNobel
Coping with Protein Quality Control Failure
2017
Age-Associated mRNA and miRNA Expression Changes in the Blood-Brain Barrier
2019 StandoutNobel
SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization
2018 StandoutNobel
Defining the Functional Targets of Cap‘n’collar Transcription Factors NRF1, NRF2, and NRF3
2020
Ion Mobility Derived Collision Cross Sections to Support Metabolomics Applications
2014
A New Portal to SuFEx Click Chemistry: A Stable Fluorosulfuryl Imidazolium Salt Emerging as an “F−SO2+” Donor of Unprecedented Reactivity, Selectivity, and Scope
2017 StandoutNobel
Effect of Nitroxides on Swarming Motility and Biofilm Formation, Multicellular Behaviors in Pseudomonas aeruginosa
2013
X13CMS: Global Tracking of Isotopic Labels in Untargeted Metabolomics
2014
Interactive XCMS Online: Simplifying Advanced Metabolomic Data Processing and Subsequent Statistical Analyses
2014
Regioselective Synthesis of Fluorosulfonyl 1,2,3-Triazoles from Bromovinylsulfonyl Fluoride
2018
Multidimensional SuFEx Click Chemistry: Sequential Sulfur(VI) Fluoride Exchange Connections of Diverse Modules Launched From An SOF4 Hub
2017 StandoutNobel
Two-Photon Oxygen Sensing with Quantum Dot-Porphyrin Conjugates
2013 StandoutNobel
Sulfonyl Fluorides (SFs): More Than Click Reagents?
2018
SuFEx Chemistry of Thionyl Tetrafluoride (SOF4) with Organolithium Nucleophiles: Synthesis of Sulfonimidoyl Fluorides, Sulfoximines, Sulfonimidamides, and Sulfonimidates
2018 StandoutNobel
Endoplasmic reticulum-associated SKN-1A/Nrf1 mediates a cytoplasmic unfolded protein response and promotes longevity
2019 StandoutNobel
Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release
2016 Standout
Emerging roles of ER stress in the etiology and pathogenesis of Alzheimer's disease
2017
Quantitative and Orthogonal Formation and Reactivity of SuFEx Platforms
2018 StandoutNobel
Biofilm infections, their resilience to therapy and innovative treatment strategies
2012
Endoplasmic reticulum proteostasis impairment in aging
2017
Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF4)‐Derived Connective Hubs for Bioconjugation to DNA and Proteins
2019 StandoutNobel
Bioinformatics: The Next Frontier of Metabolomics
2014
Structural Characterization of a Conserved, Calcium-Dependent Periplasmic Protease from Legionella pneumophila
2012
Cyclic di-GMP: the First 25 Years of a Universal Bacterial Second Messenger
2013 Standout
Photo-ribonucleotide reductase β2 by selective cysteine labeling with a radical phototrigger
2011
Oxygen Activation and Radical Transformations in Heme Proteins and Metalloporphyrins
2017
The STRING database in 2023: protein–protein association networks and functional enrichment analyses for any sequenced genome of interest
2022 Standout
Identification of simple arylfluorosulfates as potent agents against resistant bacteria
2021 StandoutNobel
Differential Incorporation of Glucose into Biomass during Warburg Metabolism
2014
The growing applications of SuFEx click chemistry
2019
Multidimensional SuFEx Click Chemistry: Sequential Sulfur(VI) Fluoride Exchange Connections of Diverse Modules Launched From An SOF4 Hub
2017 StandoutNobel
Reactive Oxygen Species (ROS)-Based Nanomedicine
2019 Standout
SuFEx Chemistry of Thionyl Tetrafluoride (SOF4) with Organolithium Nucleophiles: Synthesis of Sulfonimidoyl Fluorides, Sulfoximines, Sulfonimidamides, and Sulfonimidates
2018 StandoutNobel
Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2‐Substituted‐Alkynyl‐1‐Sulfonyl Fluoride (SASF) Hubs
2020 StandoutNobel
A Heck–Matsuda Process for the Synthesis of β‐Arylethenesulfonyl Fluorides: Selectively Addressable Bis‐electrophiles for SuFEx Click Chemistry
2016 StandoutNobel
Fluorosulfuryl Isocyanate Enabled SuFEx Ligation of Alcohols and Amines
2021 StandoutNobel
Systemic amyloidosis: novel therapies and role of biomarkers
2016
SuFEx in Metal–Organic Frameworks: Versatile Postsynthetic Modification Tool
2018
A Heck–Matsuda Process for the Synthesis of β‐Arylethenesulfonyl Fluorides: Selectively Addressable Bis‐electrophiles for SuFEx Click Chemistry
2016 StandoutNobel
Brain Region Mapping Using Global Metabolomics
2014
Palladium‐Catalyzed Fluorosulfonylvinylation of Organic Iodides
2017 StandoutNobel
Chemical Tagging in Mass Spectrometry for Systems Biology
2018
Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry
2020 StandoutNobel
Design of Heme Enzymes with a Tunable Substrate Binding Pocket Adjacent to an Open Metal Coordination Site
2023 StandoutNobel
Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF4)‐Derived Connective Hubs for Bioconjugation to DNA and Proteins
2019 StandoutNobel
A New Portal to SuFEx Click Chemistry: A Stable Fluorosulfuryl Imidazolium Salt Emerging as an “F−SO2+” Donor of Unprecedented Reactivity, Selectivity, and Scope
2017 StandoutNobel
Pharmacological targeting of the unfolded protein response for disease intervention
2019
New Electrophiles and Strategies for Mechanism-Based and Targeted Covalent Inhibitor Design
2019
Liquid phase condensation in cell physiology and disease
2017 StandoutScience
MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights
2021 Standout
1-Bromoethene-1-sulfonyl fluoride (BESF) is another good connective hub for SuFEx click chemistry
2018
Works of Lars Plate being referenced
Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming
2020
Regulating Secretory Proteostasis through the Unfolded Protein Response: From Function to Therapy
2017
Nitric oxide-sensing H-NOX proteins govern bacterial communal behavior
2013
Nitric Oxide Modulates Bacterial Biofilm Formation through a Multicomponent Cyclic-di-GMP Signaling Network
2012
Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis
2019
Toward ‘Omic Scale Metabolite Profiling: A Dual Separation–Mass Spectrometry Approach for Coverage of Lipid and Central Carbon Metabolism
2013
Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation
2016
Methodology To Probe Subunit Interactions in Ribonucleotide Reductases
2008
Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chain
2014
Hyaluronan-Tethered Opioid Depots: Synthetic Strategies and Release KineticsIn VitroandIn Vivo
2008
Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins
2018
The unfolded protein response regulator ATF6 promotes mesodermal differentiation
2018
Deconvoluting Stress-Responsive Proteostasis Signaling Pathways for Pharmacologic Activation Using Targeted RNA Sequencing
2019
Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether
2019
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue
2016 StandoutNobel
“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates
2017 StandoutNobel