Citation Impact
Citing Papers
Estrogen receptor (ER)-β isoforms: A key to understanding ER-β signaling
2006
De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination
2003 StandoutNobel
Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
2009 StandoutScience
Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
2009 StandoutScience
X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C
2011 StandoutNobel
Gene Expression Preferentially Regulated by Tamoxifen in Breast Cancer Cells and Correlations with Clinical Outcome
2006
Suppression of bone resorption by madindoline A, a novel nonpeptide antagonist to gp130
2002 StandoutNobel
Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA
2011 StandoutScience
Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity
2004 StandoutNobel
Subnuclear Trafficking of Estrogen Receptor-α and Steroid Receptor Coactivator-1
2000
Structure and specificity of nuclear receptor–coactivator interactions
1998
Functional characteristics of a novel murine estrogen receptor-beta isoform, estrogen receptor-beta 2
2000
Different glucocorticoids vary in their genomic and non‐genomic mechanism of action in A549 cells
2002
Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist
1999 Standout
The Orphan Nuclear Receptor SHP Inhibits Agonist-dependent Transcriptional Activity of Estrogen Receptors ERα and ERβ
1999
Selective oestrogen receptor modulators: potential therapeutic applications
1998
Estrogen Receptors: How Do They Signal and What Are Their Targets
2007 Standout
Inflammation and metabolic disorders
2006 StandoutNature
A view on drug resistance in cancer
2019 StandoutNature
Estrogen receptor pathways to AP-1
2000
Cyclical DNA methylation of a transcriptionally active promoter
2008 Nature
Enhancement of Estrogen Receptor Transcriptional Activity by the Coactivator GRIP-1 Highlights the Role of Activation Function 2 in Determining Estrogen Receptor Pharmacology
1998
A comparison of transcriptional activation by ERα and ERβ
1999
Therapeutic potential of selective estrogen receptor modulators
1998
Chromatin Modifications and Their Function
2007 Standout
Incorporation of Prior Phase Information Strengthens Maximum-Likelihood Structure Refinement
1998
Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution
1998 StandoutNature
Estrogen Signaling: A Subtle Balance Between ER and ER
2003
Potentiation of Human Estrogen Receptor α Transcriptional Activation through Phosphorylation of Serines 104 and 106 by the Cyclin A-CDK2 Complex
1999
The nuclear receptor ligand-binding domain: structure and function
1998
Glucocorticoid Ligands Specify Different Interactions with NF-κB by Allosteric Effects on the Glucocorticoid Receptor DNA Binding Domain
2004
Phytoestrogens: a review of the present state of research
2003
The Protective Effects of Estrogen on the Cardiovascular System
1999 Standout
Cloning and Characterization of Human Estrogen Receptor β Isoforms
1998
Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Reveals a Novel Mode of Receptor Dimerization and Coactivator Recognition
2002
Catalysis for fluorination and trifluoromethylation
2011 StandoutNature
Smad4 Inhibits Tumor Growth by Inducing Apoptosis in Estrogen Receptor-α-positive Breast Cancer Cells
2005
Cloning, Sequencing, and Localization of Bovine Estrogen Receptor-β within the Ovarian Follicle1
1999
The Human Estrogen Receptor-α Is a Ubiquitinated Protein Whose Stability Is Affected Differentially by Agonists, Antagonists, and Selective Estrogen Receptor Modulators
2001
Regulation of Hormone-Induced Histone Hyperacetylation and Gene Activation via Acetylation of an Acetylase
1999
Nuclear receptor coactivators
1997
Human nutrition, the gut microbiome and the immune system
2011 StandoutNature
Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha
1998
Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis
2000 Standout
Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ
1998 StandoutNature
Differential Response of Estrogen Receptor α and Estrogen Receptor β to Partial Estrogen Agonists/Antagonists
1998
Molecular determinants of nuclear receptor-corepressor interaction
1999
High-resolution structure prediction and the crystallographic phase problem
2007 StandoutNatureNobel
Co-activators and co-repressors in the integration of transcriptional responses
1998
Mechanism of the nuclear receptor molecular switch
2004
Molecular mechanisms of oestrogen and SERMs in endometrial carcinogenesis
2006
Functional interactions between the gut microbiota and host metabolism
2012 StandoutNature
Epidermal growth factor receptor (EGFR) transactivation by estrogen via the G-protein-coupled receptor, GPR30: a novel signaling pathway with potential significance for breast cancer
2002
Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation
1998
A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor
1998
Overexpression, Purification, and Crystal Structure of Native ERα LBD
2001
Super-resolution biomolecular crystallography with low-resolution data
2010 StandoutNatureNobel
Molecular Cloning of an Estrogen Receptor β Subtype from the Goldfish,Carassius auratus
1999
Lessons learnt from structural studies of the oestrogen receptor
2006
DAX-1 Functions as an LXXLL-containing Corepressor for Activated Estrogen Receptors
2000
Osteoclast differentiation and activation
2003 StandoutNature
A structural biologist's view of the oestrogen receptor
2000
The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen
1998 Standout
Activation of Nuclear Receptors
2003
An Additional Region of Coactivator GRIP1 Required for Interaction with the Hormone-binding Domains of a Subset of Nuclear Receptors
1999
Crystal Structure of a Mutant hERα Ligand-binding Domain Reveals Key Structural Features for the Mechanism of Partial Agonism
2001
Combinatorial roles of nuclear receptors in inflammation and immunity
2005
Advances in estrogen receptor biology: prospects for improvements in targeted breast cancer therapy
2003
Differential SERM Effects on Corepressor Binding Dictate ERα Activity in Vivo
2003
Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism
2002
Analysis of Estrogen Receptor Interaction with a Repressor of Estrogen Receptor Activity (REA) and the Regulation of Estrogen Receptor Transcriptional Activity by REA
2000
The Estrogen Receptor β Subtype: A Novel Mediator of Estrogen Action in Neuroendocrine Systems
1998
Interaction of Transcriptional Intermediary Factor 2 Nuclear Receptor Box Peptides with the Coactivator Binding Site of Estrogen Receptor α
2002
Conformational adaptation of agonists to the human nuclear receptor RARγ
1998
Production and Actions of Estrogens
2002 Standout
Controlling nuclear receptors: the circular logic of cofactor cycles
2005
Ligand-Dependent Nuclear Receptor Corepressor LCoR Functions by Histone Deacetylase-Dependent and -Independent Mechanisms
2003
Competition between Thyroid Hormone Receptor-associated Protein (TRAP) 220 and Transcriptional Intermediary Factor (TIF) 2 for Binding to Nuclear Receptors
1999
Asymmetry in the PPARγ/RXRα Crystal Structure Reveals the Molecular Basis of Heterodimerization among Nuclear Receptors
2000
Hormone-independent Transcriptional Activation and Coactivator Binding by Novel Orphan Nuclear Receptor ERR3
1999
Increasing the Complexity of Coactivation in Nuclear Receptor Signaling
1999
Atomic structure of progesterone complexed with its receptor
1998 Nature
Estrogen Receptor-α Directs Ordered, Cyclical, and Combinatorial Recruitment of Cofactors on a Natural Target Promoter
2003
Identification of Ligands with Bicyclic Scaffolds Provides Insights into Mechanisms of Estrogen Receptor Subtype Selectivity
2006
Different positioning of the ligand-binding domain helix 12and the F domain of the estrogen receptor accounts for functional differences between agonists and antagonists
1998
A Nuclear Factor, ASC-2, as a Cancer-amplified Transcriptional Coactivator Essential for Ligand-dependent Transactivation by Nuclear Receptors in Vivo
1999
A Novel Isoform of Rat Estrogen Receptor Beta with 18 Amino Acid Insertion in the Ligand Binding Domain as a Putative Dominant Negative Regulator of Estrogen Action
1998
Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β
1998 Standout
Structural Insights into the Mode of Action of a Pure Antiestrogen
2001
ESR1 ligand-binding domain mutations in hormone-resistant breast cancer
2013
The Octopus vulgaris Estrogen Receptor Is a Constitutive Transcriptional Activator: Evolutionary and Functional Implications
2006
Cofactor Dynamics and Sufficiency in Estrogen Receptor–Regulated Transcription
2000
Understanding the Selectivity of Genistein for Human Estrogen Receptor-β Using X-Ray Crystallography and Computational Methods
2004
Mechanistic Principles in NR Box-Dependent Interaction between Nuclear Hormone Receptors and the Coactivator TIF2
1998
Fluorine in medicinal chemistry
2007 Standout
Antiestrogenic Action of Raloxifene and Tamoxifen: Today and Tomorrow
1998
Estrogen receptor ligands: design and synthesis of new 2-arylindene-1-ones
2005
Coactivator Peptides Have a Differential Stabilizing Effect on the Binding of Estrogens and Antiestrogens with the Estrogen Receptor
1999
Ligand-dependent interactions of coactivators steroid receptor coactivator-1 and peroxisome proliferator-activated receptor binding protein with nuclear hormone receptors can be imaged in live cells and are required for transcription
2000 StandoutNobel
MULTIPROTEIN-DNA COMPLEXES IN TRANSCRIPTIONAL REGULATION
1999
Hormone-Dependent Coactivator Binding to a Hydrophobic Cleft on Nuclear Receptors
1998 Science
Orphan Nuclear Receptors: From Gene to Function*
1999
Estrogen Receptor Domains E and F: Role in Dimerization and Interaction with Coactivator RIP-140
1999
DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells
2000 StandoutNobel
Peptide Antagonists of the Human Estrogen Receptor
1999 Science
Synthesis of Functionalized Porphyrins as Oxygen Ligand Receptors
2003 StandoutNobel
[Selective estrogen receptor modulators (SERM): new substances for hormone replacement therapy].
1999
Hypoxia-inducible factor 1α protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations
2000 StandoutNobel
Ligand-independent activation of the estrogen receptors alpha and beta by mutations of a conserved tyrosine can be abolished by antiestrogens.
1998
Bone Resorption by Osteoclasts
2000 StandoutScience
Abnormal Vascular Function and Hypertension in Mice Deficient in Estrogen Receptor β
2002 StandoutScienceNobel
Selective Estrogen Receptor Modulators
2004
Delineation of a unique protein–protein interaction site on the surface of the estrogen receptor
2005
The coregulator exchange in transcriptional functions of nuclear receptors
2000 Standout
Crystallographic comparison of the estrogen and progesterone receptor’s ligand binding domains
1998
Estrogen receptor (ER) modulators each induce distinct conformational changes in ER α and ER β
1999
Basic Guide to the Mechanisms of Antiestrogen Action
1998
Structure-Based Design of Estrogen Receptor-β Selective Ligands
2004
Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?
1999 Standout
Raloxifene: Magic bullet for heart and bone?
1998
Quantum Dot-Based Multiplexed Fluorescence Resonance Energy Transfer
2005 StandoutNobel
Various Phosphorylation Pathways, Depending on Agonist and Antagonist Binding to Endogenous Estrogen Receptor α (ERα), Differentially Affect ERα Extractability, Proteasome-Mediated Stability, and Transcriptional Activity in Human Breast Cancer Cells
2003
The Estrogen Receptor Enhances AP-1 Activity by Two Distinct Mechanisms with Different Requirements for Receptor Transactivation Functions
1999
Direct Visualization of the Human Estrogen Receptor α Reveals a Role for Ligand in the Nuclear Distribution of the Receptor
1999
Identification of a Negative Regulatory Surface within Estrogen Receptor α Provides Evidence in Support of a Role for Corepressors in Regulating Cellular Responses to Agonists and Antagonists
2002
LIGAND CONTROL OF COREGULATOR RECRUITMENT TO NUCLEAR RECEPTORS
2004
Physiological and Molecular Basis of Thyroid Hormone Action
2001 Standout
ERβ Ligands. 3. Exploiting Two Binding Orientations of the 2-Phenylnaphthalene Scaffold To Achieve ERβ Selectivity
2005
Cell Cycle Progression Stimulated by Tamoxifen-Bound Estrogen Receptor-α and Promoter-Specific Effects in Breast Cancer Cells Deficient in N-CoR and SMRT
2005
Mechanisms of Estrogen Action
2001 Standout
A Negative Coregulator for the Human ER
2002
Design and Synthesis of Aryl Diphenolic Azoles as Potent and Selective Estrogen Receptor-β Ligands
2004
Structural Basis for an Unexpected Mode of SERM-Mediated ER Antagonism
2005
Connections and Regulation of the Human Estrogen Receptor
2002 Science
The Molecular Pharmacology of SERMs
1999
X-ray Crystal Structure of the Novel Enhanced-Affinity Glucocorticoid Agonist Fluticasone Furoate in the Glucocorticoid Receptor−Ligand Binding Domain
2008
Molecular Determinants of the Estrogen Receptor-Coactivator Interface
1999
A New Series of Estrogen Receptor Modulators That Display Selectivity for Estrogen Receptor β
2002
Coregulator Function: A Key to Understanding Tissue Specificity of Selective Receptor Modulators
2004
Molecular Determinants for the Tissue Specificity of SERMs
2002 Science
Light-Activated Gene Expression
2000
Antiinflammatory Action of Glucocorticoids — New Mechanisms for Old Drugs
2005 Standout
Boron in Drug Discovery: Carboranes as Unique Pharmacophores in Biologically Active Compounds
2011
Selective Estrogen Receptor Modulators with Conformationally Restricted Side Chains. Synthesis and Structure−Activity Relationship of ERα-Selective Tetrahydroisoquinoline Ligands
2004
Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor–coactivator interactions
2003
A second binding site for hydroxytamoxifen within the coactivator-binding groove of estrogen receptor β
2006
Expression of nuclear receptor interacting proteins TIF-1, SUG-1, receptor interacting protein 140, and corepressor SMRT in tamoxifen-resistant breast cancer.
1999
Peptide blockade of HIFα degradation modulates cellular metabolism and angiogenesis
2002 StandoutNobel
Simulations of the Estrogen Receptor Ligand-Binding Domain: Affinity of Natural Ligands and Xenoestrogens
2000
The Orphan Nuclear Receptor SHP Utilizes Conserved LXXLL-Related Motifs for Interactions with Ligand-Activated Estrogen Receptors
2000
De Novo Carborane-Containing Macrocyclic Peptides Targeting Human Epidermal Growth Factor Receptor
2019 StandoutNobel
Estrogen Receptor Subtype-Selective Ligands: Asymmetric Synthesis and Biological Evaluation of cis- and trans-5,11-Dialkyl- 5,6,11,12-tetrahydrochrysenes
1999
Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis
2013 Standout
Multiplexed microsphere-based flow cytometric assays
2002
Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment
2022 StandoutNobel
A Transmembrane Intracellular Estrogen Receptor Mediates Rapid Cell Signaling
2005 StandoutScience
Phosphorylation of Human Estrogen Receptor α by Protein Kinase A Regulates Dimerization
1999
Identification of Tamoxifen-Induced Coregulator Interaction Surfaces within the Ligand-Binding Domain of Estrogen Receptors
2004
Photopharmacology: Beyond Proof of Principle
2014 StandoutNobel
Differential regulation by estrogens of growth and prolactin synthesis in pituitary cells suggests that only a small pool of estrogen receptors is required for growth
1998
The selective oestrogen receptor modulation: evolution and clinical applications
1999
Novel Ligands that Function as Selective Estrogens or Antiestrogens for Estrogen Receptor-α or Estrogen Receptor-β*
1999
Preferential binding of ATR protein to UV-damaged DNA
2002 StandoutNobel
Estrogen Receptor Modulators: Identification and Structure−Activity Relationships of Potent ERα-Selective Tetrahydroisoquinoline Ligands
2003
Identification of a Nuclear Receptor for Bile Acids
1999 StandoutScience
Nonnuclear Actions of Estrogen
2002
An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens
1999
The Interplay between the Glucocorticoid Receptor and Nuclear Factor-κB or Activator Protein-1: Molecular Mechanisms for Gene Repression
2003
Acetylation of Nuclear Hormone Receptor-Interacting Protein RIP140 Regulates Binding of the Transcriptional Corepressor CtBP
2001
Therapeutic Approaches to Bone Diseases
2000 Science
P/CAF associates with cyclin D1 and potentiates its activation of the estrogen receptor
1999
The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease
2006 StandoutScience
Estrogen inhibits the vascular injury response in estrogen receptor β-deficient female mice
1999 StandoutNobel
Molecular mechanisms of steroid hormone action
1998
Works of Lars Öhman being referenced
The Three-dimensional Structures of Antagonistic and Agonistic Forms of the Glucocorticoid Receptor Ligand-binding Domain
2003
Molecular basis of agonism and antagonism in the oestrogen receptor
1997 StandoutNature