Citation Impact
Citing Papers
A Tlr7 translocation accelerates systemic autoimmunity in murine lupus
2006
Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus
2009 StandoutNobel
Autoreactive B Cell Responses to RNA-Related Antigens Due to TLR7 Gene Duplication
2006 Science
Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7
2021 StandoutNobel
The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins
2019 StandoutNobel
A Distinct Signaling Pathway Used by the IgG-Containing B Cell Antigen Receptor
2002 Science
Modulation of immune cell reactivity with cis -binding Siglec agonists
2021 StandoutNobel
Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche
2011
Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils
2007
Photocrosslinkers illuminate interactions in living cells
2008
Evidence for Genes in Addition to Tlr7 in the Yaa Translocation Linked with Acceleration of Systemic Lupus Erythematosus
2008
Immune privilege of the CNS is not the consequence of limited antigen sampling
2014
Initial clinical trial of epratuzumab (humanized anti-CD22 antibody) for immunotherapy of systemic lupus erythematosus
2006
Siglecs: A journey through the evolution of sialic acid-binding immunoglobulin-type lectins
2018
In Situ trans Ligands of CD22 Identified by Glycan-Protein Photocross-linking-enabled Proteomics
2010
CD22: A Multifunctional Receptor That Regulates B Lymphocyte Survival and Signal Transduction
2005
Siglec-mediated regulation of immune cell function in disease
2014
Glycopolymer probes of signal transduction
2013
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
2009 StandoutNobel
Siglecs and their roles in the immune system
2007 Standout
Activation-Induced Cytidine Deaminase Deficiency Causes Organ-Specific Autoimmune Disease
2008
Molecular diversity and evolution of the Siglec family of cell-surface lectins
2006
Control of Toll-like Receptor 7 Expression Is Essential to Restrict Autoimmunity and Dendritic Cell Proliferation
2007
The lectin Siglec-G inhibits dendritic cell cross-presentation by impairing MHC class I–peptide complex formation
2016
CD72-Deficient Mice Reveal Nonredundant Roles of CD72 in B Cell Development and Activation
1999
CD22 regulates B lymphocyte function in vivo through both ligand-dependent and ligand-independent mechanisms
2004
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Marginal-zone B cells
2002
Accelerated Systemic Autoimmunity in the Absence of Somatic Hypermutation in 564Igi: A Mouse Model of Systemic Lupus with Knocked-In Heavy and Light Chain Genes
2017 StandoutNobel
Thymus, innate immunity and autoimmune arthritis: Interplay of gene and environment
2011 StandoutNobel
A Small Region of the Natural Killer Cell Receptor, Siglec-7, Is Responsible for Its Preferred Binding to α2,8-Disialyl and Branched α2,6-Sialyl Residues
2002
I-type lectins
2002
Unravelling the pathogenesis of inflammatory bowel disease
2007 StandoutNature
Homomultimeric complexes of CD22 in B cells revealed by protein-glycan cross-linking
2005
CD33 recruitment inhibits IgE-mediated anaphylaxis and desensitizes mast cells to allergen
2019
Homing of antibody secreting cells
2003
Ablation of CD22 in ligand-deficient mice restores B cell receptor signaling
2005
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors
2005
Protein-glycan interactions in the control of innate and adaptive immune responses
2008
Siglec-8 as a drugable target to treat eosinophil and mast cell-associated conditions
2012
Molecular basis of human CD22 function and therapeutic targeting
2017
Role of siglecs and related glycan-binding proteins in immune responses and immunoregulation
2015
Antigenic liposomes displaying CD22 ligands induce antigen-specific B cell apoptosis
2013
Sialoside Specificity of the Siglec Family Assessed Using Novel Multivalent Probes
2003
High Resolution Crystal Structures of Siglec-7
2003
Antigen Delivery to Macrophages Using Liposomal Nanoparticles Targeting Sialoadhesin/CD169
2012
Fcγ receptors as regulators of immune responses
2007 Standout
Direct conversion of human fibroblasts to multilineage blood progenitors
2010 Nature
Cloning, Characterization, and Phylogenetic Analysis of Siglec-9, a New Member of the CD33-related Group of Siglecs
2000
Biological roles of glycans
2016 Standout
Structural and functional features of central nervous system lymphatic vessels
2015 StandoutNature
Rho GTPases in cell biology
2002 StandoutNature
Cell surface biology mediated by low affinity multivalent protein–glycan interactions
2004
Photocrosslinking of glycoconjugates using metabolically incorporated diazirine-containing sugars
2009
Functional groups of sialic acids involved in binding to siglecs (sialoadhesins) deduced from interactions with synthetic analogues
1998
Mouse Siglec-F and human Siglec-8 are functionally convergent paralogs that are selectively expressed on eosinophils and recognize 6′-sulfo-sialyl Lewis X as a preferred glycan ligand
2005
Loss of N-Glycolylneuraminic Acid in Human Evolution
2000
Characterization of Siglec-5 (CD170) expression and functional activity of anti–Siglec-5 antibodies on human phagocytes
2003
The Glycoscience of Immunity
2018
Siglecs: sialic-acid-binding immunoglobulin-like lectins in cell–cell interactions and signalling
2002
FcγRIIB Ile232Thr transmembrane polymorphism associated with human systemic lupus erythematosus decreases affinity to lipid rafts and attenuates inhibitory effects on B cell receptor signaling
2005
Therapeutic Targeting of Siglecs using Antibody- and Glycan-Based Approaches
2015
Siglecs, sialic acids and innate immunity
2001
CD22 as a target of passive immunotherapy
2003
Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction
2011
The clinical impact of glycobiology: targeting selectins, Siglecs and mammalian glycans
2021 StandoutNobel
Siglec-5 (CD170) Can Mediate Inhibitory Signaling in the Absence of Immunoreceptor Tyrosine-based Inhibitory Motif Phosphorylation
2005
Siglec-G represses DAMP-mediated effects on T cells
2017
A uniquely human consequence of domain-specific functional adaptation in a sialic acid-binding receptor
2003
Activating and inhibitory FcγRs in autoimmune disorders
2006
Structure-Guided Design of Sialic Acid-Based Siglec Inhibitors and Crystallographic Analysis in Complex with Sialoadhesin
2003
Click and Pick: Identification of Sialoside Analogues for Siglec‐Based Cell Targeting
2012
OB-BP1/Siglec-6
1999
Synthesis and biological evaluation of 9-N-oxamyl sialosides as Siglec-7 ligands
2015
Comparison of CD22 binding to native CD45 and synthetic oligosaccharide
2002
Siglec-7 Undergoes a Major Conformational Change When Complexed with the α(2,8)-Disialylganglioside GT1b
2006
Negative Regulation of T Cell Receptor Signaling by Siglec-7 (p70/AIRM) and Siglec-9
2004
Deletion of SHIP or SHP-1 Reveals Two Distinct Pathways for Inhibitory Signaling
1997
A Dominant Complement Fixation Pathway for Pneumococcal Polysaccharides Initiated by SIGN-R1 Interacting with C1q
2006 StandoutNobel
Constitutive repressor activity of CD33 on human monocytes requires sialic acid recognition and phosphoinositide 3‐kinase‐mediated intracellular signaling
2004
Glycan Array Screening Reveals a Candidate Ligand for Siglec-8*
2004
Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases
2008 StandoutNobel
Role of B cell inhibitory receptor polymorphisms in systemic lupus erythematosus: a negative times a negative makes a positive
2006
Siglecs in innate immunity
2005
Macrophage biology in development, homeostasis and disease
2013 StandoutNature
Interaction of CD22 with α2,6-linked sialoglycoconjugates: innate recognition of self to dampen B cell autoreactivity?
2002
Multifarious roles of sialic acids in immunity
2012
Lectin Domains of Polypeptide GalNAc Transferases Exhibit Glycopeptide Binding Specificity
2011 StandoutNobel
Flexible ordering of antibody class switch and V(D)J joining during B-cell ontogeny
2013
Sialic Acid Mimetics to Target the Sialic Acid–Siglec Axis
2016
The Human Condition—A Molecular Approach
2014 StandoutNobel
The ST6Gal I Sialyltransferase Selectively ModifiesN-Glycans on CD45 to Negatively Regulate Galectin-1-induced CD45 Clustering, Phosphatase Modulation, and T Cell Death
2003
Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec‐7‐dependent and ‐independent mechanisms
2003
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Vav Is Required for Cyclin D2 Induction and Proliferation of Mouse B Lymphocytes Activated via the Antigen Receptor
2001
Notch2 Is Preferentially Expressed in Mature B Cells and Indispensable for Marginal Zone B Lineage Development
2003
Siglecs—the major subfamily of I-type lectins
2005
A Case for Regulatory B Cells
2006
Carboxy-terminal domain of AID required for its mRNA complex formation in vivo
2009 StandoutNobel
Siglecs as Immune Cell Checkpoints in Disease
2020
A point mutation in the murine Hem1 gene reveals an essential role for Hematopoietic Protein 1 in lymphopoiesis and innate immunity
2008 StandoutNobel
Inhibitory Coreceptors Activated by Antigens But Not by Anti-Ig Heavy Chain Antibodies Install Requirement of Costimulation Through CD40 for Survival and Proliferation of B Cells
2003
Siglec receptors impact mammalian lifespan by modulating oxidative stress
2015
CD33 responses are blocked by SOCS3 through accelerated proteasomal-mediated turnover
2006
Boron Nitride Nanotubes Are Noncytotoxic and Can Be Functionalized for Interaction with Proteins and Cells
2009 StandoutNobel
Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function
2009 StandoutNobel
Expression of an anti‐RNA autoantibody in a mouse model of SLE increases neutrophil and monocyte numbers as well as IFN ‐I expression
2013
The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide ofStreptococcus pneumoniaein the marginal zone of mouse spleen
2003 StandoutNobel
Interactions Between the Microbiota and the Immune System
2012 StandoutScience
Two distinctive pathways for recruitment of naïve and primed IgM+B cells to the gut lamina propria
2005 StandoutNobel
Chemical Approaches to Glycobiology
2010
B Cell Antigen Receptor and CD40 Differentially Regulate CD22 Tyrosine Phosphorylation
2006
AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination
2009 StandoutNobel
Sialic acid binding receptors (siglecs) expressed by macrophages
1999
A Self-Assembled Multivalent Pseudopolyrotaxane for Binding Galectin-1
2004 StandoutNobel
Viewing Siglecs through the lens of tumor immunology
2017
Photoaffinity Probes for Studying Carbohydrate Biology
2012
The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination
2009 StandoutNobel
CD24 and Siglec-10 Selectively Repress Tissue Damage–Induced Immune Responses
2009 Science
Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger
2008 StandoutNobel
Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells
2012 StandoutNobel
Sialylated multivalent antigens engage CD22in transand inhibit B cell activation
2009
Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors
2006
The B Cell Coreceptor CD22 Associates with AP50, a Clathrin-Coated Pit Adapter Protein, Via Tyrosine-Dependent Interaction
2003
Siglec‐7 tetramers characterize B‐cell subpopulations and leukemic blasts
2012
Enhanced T Cell Function in a Mouse Model of Human Glycosylation
2013
Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling
2007 StandoutNobel
Chemically tunable mucin chimeras assembled on living cells
2015 StandoutNobel
Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1α-deficient chimeric mice
2002 StandoutNobel
Photoactivatable Crosslinking Sugars for Capturing Glycoprotein Interactions
2008
Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease
2014 StandoutScienceNobel
Precision glycocalyx editing as a strategy for cancer immunotherapy
2016 StandoutNobel
PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine
2001 StandoutNobel
Cell surface sialic acids do not affect primary CD22 interactions with CD45 and surface IgM nor the rate of constitutive CD22 endocytosis
2004
Nuclear repartitioning of galectin-1 by an extracellular glycan switch regulates mammary morphogenesis
2016 StandoutNobel
High-Affinity Ligand Probes of CD22 Overcome the Threshold Set by cis Ligands to Allow for Binding, Endocytosis, and Killing of B Cells
2006
Graded Attenuation of TCR Signaling Elicits Distinct Autoimmune Diseases by Altering Thymic T Cell Selection and Regulatory T Cell Function
2010 StandoutNobel
Production of IgG autoantibody requires expression of activation‐induced deaminase in early‐developing B cells in a mouse model of SLE
2014
ST6Gal-I Restrains CD22-Dependent Antigen Receptor Endocytosis and Shp-1 Recruitment in Normal and Pathogenic Immune Signaling
2006
Clusters, bundles, arrays and lattices: novel mechanisms for lectin–saccharide-mediated cellular interactions
2002
Inactivation of CMP- N -acetylneuraminic acid hydroxylase occurred prior to brain expansion during human evolution
2002 StandoutNobel
Interfacing Carbon Nanotubes with Living Cells
2006 StandoutNobel
Mechanism and Regulation of Class Switch Recombination
2008
Masking and unmasking of the sialic acid-binding lectin activity of CD22 (Siglec-2) on B lymphocytes
1998
Masking of CD22 by cis ligands does not prevent redistribution of CD22 to sites of cell contact
2004
Protein Glycoengineering Enabled by the Versatile Synthesis of Aminooxy Glycans and the Genetically Encoded Aldehyde Tag
2011 StandoutNobel
Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b β2-integrin–dependent signaling
2013
The structure of siglec-7 in complex with sialosides: leads for rational structure-based inhibitor design
2006
Enhancement and suppression of signaling by the conserved tail of IgG memory–type B cell antigen receptors
2007
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination
2014 StandoutNobel
Cutting Edge Commentary: Origins of B-1 Cells
2001
Overexpression of TLR7 promotes cell-intrinsic expansion and autoantibody production by transitional T1 B cells
2013
Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry
2020 StandoutNobel
Sialic acid binding immunoglobulin‐like lectins may regulate innate immune responses by modulating the life span of granulocytes
2006
Chemical Diversity in the Sialic Acids and Related α-Keto Acids: An Evolutionary Perspective
2002
Steering Siglec–Sialic Acid Interactions on Living Cells using Bioorthogonal Chemistry
2017
Metabolic labeling enables selective photocrosslinking of O-GlcNAc-modified proteins to their binding partners
2012 StandoutNobel
Chemical Glycoproteomics
2016 StandoutNobel
Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes
2014 StandoutNobel
Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti–CTLA-4 antibody
2018 StandoutNobel
Antibody Fusion Proteins: Anti-CD22 Recombinant Immunotoxin Moxetumomab Pasudotox
2011
Works of Lars Nitschke being referenced
Nanoscale organization and dynamics of the siglec CD 22 cooperate with the cytoskeleton in restraining BCR signalling
2015
The Guanine-Nucleotide Exchange Factor Vav Is a Crucial Regulator of B Cell Receptor Activation and B Cell Responses to Nonrepetitive Antigens
1999
CD22 × Siglec-G Double-Deficient Mice Have Massively Increased B1 Cell Numbers and Develop Systemic Autoimmunity
2010
New Functions for the Sialic Acid‐Binding Adhesion Molecule CD22, a Member of the Growing Family of Siglecs
2001
Constitutively unmasked CD22 on B cells of ST6Gal I knockout mice: novel sialoside probe for murine CD22
2002
Reduction of marginal zone B cells in CD22-deficient mice
2002
A novel subset of murine B cells that expresses unmasked forms of CD22 is enriched in the bone marrow: implications for B‐cell homing to the bone marrow
2000
B Cell Siglecs–News on Signaling and Its Interplay With Ligand Binding
2018
B Cell-Specific Deletion of Protein-Tyrosine Phosphatase Shp1 Promotes B-1a Cell Development and Causes Systemic Autoimmunity
2007
Absence of Siglec-H in MCMV Infection Elevates Interferon Alpha Production but Does Not Enhance Viral Clearance
2013
CD22 is a negative regulator of B-cell receptor signalling
1997 Nobel
Naïve CD8 T-cells initiate spontaneous autoimmunity to a sequestered model antigen of the central nervous system
2008
The role of CD22 and Siglec-G in B-cell tolerance and autoimmune disease
2014
Siglec-G is a B1 cell–inhibitory receptor that controls expansion and calcium signaling of the B1 cell population
2007
Novel mouse mutants with primary cellular immunodeficiencies generated by genome-wide mutagenesis
2007
Regulation of B cell development and B cell signalling by CD22 and its ligands α2,6-linked sialic acids
2006
SIGLEC-G deficiency increases susceptibility to develop B-cell lymphoproliferative disorders
2014
The murine inhibitory receptor mSiglec‐E is expressed broadly on cells of the innate immune system whereas mSiglec‐F is restricted to eosinophils
2004
CD22 and Siglec‐G: B‐cell inhibitory receptors with distinct functions
2009
CD22 and Siglec-G regulate inhibition of B-cell signaling by sialic acid ligand binding and control B-cell tolerance
2014
Molecular interactions regulate BCR signal inhibition by CD22 and CD72
2004
Human CD 22 cannot fully substitute murine CD 22 functions in vivo, as shown in a new knockin mouse model
2012
Suppressing the Antibody Response with Siglec Ligands
2013
IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Igα/β
2007
Sialic Acid Ligand Binding of CD22 and Siglec-G Determines Distinct B Cell Functions but Is Dispensable for B Cell Tolerance Induction
2018
Identification of CD22 Ligands on Bone Marrow Sinusoidal Endothelium Implicated in CD22-dependent Homing of Recirculating B Cells
1999
Targeting of CD 22‐positive B ‐cell lymphoma cells by synthetic divalent sialic acid analogues
2012
2012
The Ligand-binding Domain of CD22 Is Needed for Inhibition of the B Cell Receptor Signal, as Demonstrated by a Novel Human CD22-specific Inhibitor Compound
2002
The role of CD22 and other inhibitory co-receptors in B-cell activation
2005
B Cell–specific Transgenic Expression of Bcl2 Rescues Early B Lymphopoiesis but Not B Cell Responses in BOB.1/OBF.1-deficient Mice
2003
CD22 ligand-binding and signaling domains reciprocally regulate B-cell Ca 2+ signaling
2013
Regulation of B Cell Functions by the Sialic Acid-Binding Receptors Siglec-G and CD22
2012
A Critical Role for FcγRIIB in the Induction of Rheumatoid Factors
2004
The Ligand-Binding Domain of Siglec-G Is Crucial for Its Selective Inhibitory Function on B1 Cells
2014
Siglec-G Deficiency Leads to More Severe Collagen-Induced Arthritis and Earlier Onset of Lupus-like Symptoms in MRL/lpr Mice
2014
Effect of Transmembrane and Cytoplasmic Domains of IgE on the IgE Response
1997 Science
Design, Synthesis, and Biological Evaluation of Small, High-Affinity Siglec-7 Ligands: Toward Novel Inhibitors of Cancer Immune Evasion
2017
Discovery of Multifold Modified Sialosides as Human CD22/Siglec-2 Ligands with Nanomolar Activity on B-Cells
2014
Siglec-G Deficiency Leads to Autoimmunity in Aging C57BL/6 Mice
2015
Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling
2001
The Yaa Mutation Promoting Murine Lupus Causes Defective Development of Marginal Zone B Cells
2003