Standout Papers
- Ulcerative colitis (2012)
- IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer (2009)
d - myo -Inositol 1,4,5,6-tetrakisphosphate produced in human intestinal epithelial cells in response to Salmonella invasion inhibits phosphoinositide 3-kinase signaling pathways (1997)- IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer (2004)
- Expanded therapeutic potential in activity space of next-generation 5-nitroimidazole antimicrobials with broad structural diversity (2013)
- Synthesis and Electrochemistry of 2-Ethenyl and 2-Ethanyl Derivatives of 5-Nitroimidazole and Antimicrobial Activity against Giardia lamblia (2009)
- Click Chemistry-Facilitated Structural Diversification of Nitrothiazoles, Nitrofurans, and Nitropyrroles Enhances Antimicrobial Activity against Giardia lamblia (2017)
- Click chemistry-facilitated comprehensive identification of proteins adducted by antimicrobial 5-nitroimidazoles for discovery of alternative drug targets against giardiasis (2020)
Citation Impact
Citing Papers
p50 Nuclear Factor-κB Overexpression in Tumor-Associated Macrophages Inhibits M1 Inflammatory Responses and Antitumor Resistance
2006
Tumor Necrosis Factor-α Promotes Malignant Pleural Effusion
2007
Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan
2003 StandoutScience
STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
2009
MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18
2010
Inflammation and mitochondrial fatty acid β-oxidation link obesity to early tumor promotion
2009
Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement
2006
Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism
2009 StandoutScienceNobel
Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease
2009
Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4
2010
Chronic stimulation of Nod2 mediates tolerance to bacterial products
2007
The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host–microbial interactions
2010
Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum
2010
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer
2013
Yersinia pseudotuberculosis Effector YopJ Subverts the Nod2/RICK/TAK1 Pathway and Activates Caspase-1 to Induce Intestinal Barrier Dysfunction
2012
Conditional Deletion of IkappaB-Kinase-beta Accelerates Helicobacter-Dependent Gastric Apoptosis, Proliferation, and Preneoplasia
2009
Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome
2010
A Functional Role for Nlrp6 in Intestinal Inflammation and Tumorigenesis
2011
Human Intestinal Epithelial Cells Are Broadly Unresponsive to Toll-Like Receptor 2-Dependent Bacterial Ligands: Implications for Host-Microbial Interactions in the Gut
2003
Expression of the Neutrophil Chemokine KC in the Colon of Mice with Enterocolitis and by Intestinal Epithelial Cell Lines: Effects of Flora and Proinflammatory Cytokines
1999
Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice
2011
NLRP3/Cryopyrin Is Necessary for Interleukin-1β (IL-1β) Release in Response to Hyaluronan, an Endogenous Trigger of Inflammation in Response to Injury
2009
Endoplasmic reticulum stress and intestinal inflammation
2009
Hallmarks of Cancer: The Next Generation
2011 Standout
Activated macrophages promote Wnt signalling through tumour necrosis factor-α in gastric tumour cells
2008
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Nitric oxide of human colorectal adenocarcinoma cell lines promotes tumour cell invasion
2002
A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF- B and enhanced IRF-3/STAT1 activation)
2005
Virus-Plus-Susceptibility Gene Interaction Determines Crohn's Disease Gene Atg16L1 Phenotypes in Intestine
2010
A clinical study assessing the tolerability and biological effects of infliximab, a TNF-α inhibitor, in patients with advanced cancer
2008
Tobacco Smoke Promotes Lung Tumorigenesis by Triggering IKKβ- and JNK1-Dependent Inflammation
2010
Inflammation-associated cancer: NF-κB is the lynchpin
2005
Securing the immune tightrope: mononuclear phagocytes in the intestinal lamina propria
2010
Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic Cancer
2011
Essential role of mouse telomerase in highly proliferative organs
1998 StandoutNatureNobel
Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut
2008
Parasite-induced TH1 cells and intestinal dysbiosis cooperate in IFN-γ-dependent elimination of Paneth cells
2012
Hepatocyte Necrosis Induced by Oxidative Stress and IL-1α Release Mediate Carcinogen-Induced Compensatory Proliferation and Liver Tumorigenesis
2008
Epithelial barrier defects in ulcerative colitis: Characterization and quantification by electrophysiological imaging
2001
The immune geography of IgA induction and function
2007
The S100A8–serum amyloid A3–TLR4 paracrine cascade establishes a pre-metastatic phase
2008
Changes of Intestinal Functions in Liver Cirrhosis
2016 Standout
A Novel Mouse Model of Inflammatory Bowel Disease Links Mammalian Target of Rapamycin-Dependent Hyperproliferation of Colonic Epithelium to Inflammation-Associated Tumorigenesis
2009
Role of tumor-associated macrophages in tumor progression and invasion
2006
Expression of IL-10 receptors on epithelial cells from the murine small and large intestine
2000
Innate immune mechanisms of colitis and colitis-associated colorectal cancer
2010
MyD88 signalling plays a critical role in host defence by controlling pathogen burden and promoting epithelial cell homeostasis during Citrobacter rodentium-induced colitis
2007
Phenotype and function of intestinal dendritic cells
2005
Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome
2015 StandoutNature
Fecal Lipocalin 2, a Sensitive and Broadly Dynamic Non-Invasive Biomarker for Intestinal Inflammation
2012
A Crohn's disease–associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1
2009
Tumor Self-Seeding by Circulating Cancer Cells
2009
Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota
2005
Colitis-associated cancer: the role of T cells in tumor development
2009
Differential Regulation of Caspase-1 Activation, Pyroptosis, and Autophagy via Ipaf and ASC in Shigella-Infected Macrophages
2007
Intestinal homeostasis and its breakdown in inflammatory bowel disease
2011 StandoutNature
NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis
2011 Standout
Innate Immunity Gone Awry: Linking Microbial Infections to Chronic Inflammation and Cancer
2006
Human Toll-like receptor 2 mediates induction of the antimicrobial peptide human beta-defensin 2 in response to bacterial lipoprotein
2001
Stat3 Is a Negative Regulator of Intestinal Tumor Progression in ApcMin Mice
2009
Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function
2010
Innate antimicrobial host defense in small intestinal Crohn's disease
2009
Unravelling the pathogenesis of inflammatory bowel disease
2007 StandoutNature
Paneth Cell Defensins and Innate Immunity of the Small Bowel
2001
Toll-Like Receptor 2 Signaling Protects Mice from Tumor Development in a Mouse Model of Colitis-Induced Cancer
2010
IL25 elicits a multipotent progenitor cell population that promotes TH2 cytokine responses
2010 Nature
Toll-like receptor control of the adaptive immune responses
2004 Standout
miR-146a Mediates Protective Innate Immune Tolerance in the Neonate Intestine
2010
Macrophage Migration Inhibitory Factor Promotes Intestinal Tumorigenesis
2005
Cryopyrin activates the inflammasome in response to toxins and ATP
2006 StandoutNature
Smoldering and polarized inflammation in the initiation and promotion of malignant disease
2005 Standout
A cytokine-mediated link between innate immunity, inflammation, and cancer
2007 Standout
TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system
2007
Pathogenic and Protective Roles of MyD88 in Leukocytes and Epithelial Cells in Mouse Models of Inflammatory Bowel Disease
2010
Recognition of microorganisms and activation of the immune response
2007 StandoutNature
IKKβ Couples Hepatocyte Death to Cytokine-Driven Compensatory Proliferation that Promotes Chemical Hepatocarcinogenesis
2005
Inhibition of NF-κB in cancer cells converts inflammation- induced tumor growth mediated by TNFα to TRAIL-mediated tumor regression
2004
The Toll–Interleukin-1 Receptor Member SIGIRR Regulates Colonic Epithelial Homeostasis, Inflammation, and Tumorigenesis
2007
Crohn's disease
2012 Standout
Identification and characterization of an inhibitor of haemopoietic stem cell proliferation
1990 Nature
Blocking TNF-α in mice reduces colorectal carcinogenesis associated with chronic colitis
2008
Toll-like receptors and cancer
2008
Intracellular pattern recognition receptors in the host response
2006 Nature
NLRs join TLRs as innate sensors of pathogens
2005
Downregulation of bactericidal peptides in enteric infections: A novel immune escape mechanism with bacterial DNA as a potential regulator
2001
Inflammatory bowel disease: cause and immunobiology
2007 Standout
Conditional Deletion of IκB-Kinase-β Accelerates Helicobacter-Dependent Gastric Apoptosis, Proliferation, and Preneoplasia
2009
At the Crossroads of Inflammation and Cancer
2004
Inflammatory Bowel Disease
2009 Standout
gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis
2009
Inflammation and colorectal cancer
2009
Inflammation Drives Dysbiosis and Bacterial Invasion in Murine Models of Ileal Crohn’s Disease
2012
Peroxynitrite Inhibits Epidermal Growth Factor Receptor Signaling in Caco-2 Cells
2003
Nitric Oxide and Peroxynitrite in Health and Disease
2007 Standout
Enteric defensins are essential regulators of intestinal microbial ecology
2009
Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis
2006
Macrophage Diversity Enhances Tumor Progression and Metastasis
2010 Standout
Role of the Microbiota in Immunity and Inflammation
2014 Standout
Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis
2008 Nature
Differential Activity of IL-12 and IL-23 in Mucosal and Systemic Innate Immune Pathology
2006
T cell activation causes diarrhea by increasing intestinal permeability and inhibiting epithelial Na+/K+-ATPase
2002
IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection
2011
IL-23 and Th17 cytokines in intestinal homeostasis
2008
Transforming growth factor-β induces development of the TH17 lineage
2006 StandoutNature
Activation-Induced Cytidine Deaminase Links Between Inflammation and the Development of Colitis-Associated Colorectal Cancers
2008 StandoutNobel
Intestinal macrophages: unique effector cells of the innate immune system
2005
Functional consequences of NOD2 (CARD15) mutations
2006
Nuclear factor-κB in cancer development and progression
2006 StandoutNature
Microbial Influences in Inflammatory Bowel Diseases
2008
Pannexin-1-Mediated Recognition of Bacterial Molecules Activates the Cryopyrin Inflammasome Independent of Toll-like Receptor Signaling
2007
Peroxynitrite Is a Potent Inhibitor of NF-κB Activation Triggered by Inflammatory Stimuli in Cardiac and Endothelial Cell Lines
2005
Toll-Like Receptor-4 Promotes the Development of Colitis-Associated Colorectal Tumors
2007
Colitis-Associated Colorectal Cancer Driven by T-bet Deficiency in Dendritic Cells
2009
NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α
2008 Nature
The Role of Microbes in Crohn's Disease
2006
Autophagy genes in immunity
2009
Caspase Functions in Cell Death and Disease
2013 Standout
Transmission of chromosomal instability after plutonium α-particle irradiation
1992 StandoutNature
Recent progress in understanding the phenotype and function of intestinal dendritic cells and macrophages
2008
Intestinal Lamina Propria Dendritic Cell Subsets Have Different Origin and Functions
2009
Signaling Pathways and Genes that Inhibit Pathogen-Induced Macrophage Apoptosis— CREB and NF-κB as Key Regulators
2005
Salmonella typhi uses CFTR to enter intestinal epithelial cells
1998 StandoutNatureNobel
The two NF-κB activation pathways and their role in innate and adaptive immunity
2004 Standout
The Impact of the Gut Microbiota on Human Health: An Integrative View
2012 Standout
A timeline of tumour-associated macrophage biology
2023
Immunity, Inflammation, and Cancer
2010 Standout
Chronic Pancreatitis Is Essential for Induction of Pancreatic Ductal Adenocarcinoma by K-Ras Oncogenes in Adult Mice
2007
Bacterial Flagellin Stimulates Toll‐Like Receptor 5–Dependent Defense against Vancomycin‐Resistant Enterococcus Infection
2010
CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells
2003
Acute Gastroenteritis Is Followed by an Increased Risk of Inflammatory Bowel Disease
2006
The immune response of Drosophila
2003 StandoutNatureNobel
High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn’s disease
2004 Standout
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Nod-like proteins in immunity, inflammation and disease
2006
Immune adaptations that maintain homeostasis with the intestinal microbiota
2010
New genes in inflammatory bowel disease: lessons for complex diseases?
2006
Gut Commensal Bacteria Direct a Protective Immune Response against Toxoplasma gondii
2009
GRIM-19 Interacts with Nucleotide Oligomerization Domain 2 and Serves as Downstream Effector of Anti-bacterial Function in Intestinal Epithelial Cells
2005
Expression of activation-induced cytidine deaminase in human hepatocytes via NF-κB signaling
2007 StandoutNobel
Promotion of Lung Carcinogenesis by Chronic Obstructive Pulmonary Disease–Like Airway Inflammation in a K-ras–Induced Mouse Model
2008
DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice
2008
Reduced α-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn’s disease
2008
Mechanisms of Disease: pathogenesis of Crohn's disease and ulcerative colitis
2006
Anti-Inflammatory Role for Intracellular Dimeric Immunoglobulin A by Neutralization of Lipopolysaccharide in Epithelial Cells
2003
STATs in cancer inflammation and immunity: a leading role for STAT3
2009 Standout
Cellular mechanisms of tumour suppression by the retinoblastoma gene
2008
The role of mitochondrial nitric oxide synthase in inflammation and septic shock
2002
Gut flora in health and disease
2003 Standout
The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental Colitis
2010
Innate Immune Sensing of Microbes by Nod Proteins
2006
Inflammatory stimuli from macrophages and cancer cells synergistically promote tumor growth and angiogenesis
2007
The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis
2007
Th17 and Regulatory T Cells in Mediating and Restraining Inflammation
2010
Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer
2009
Paradoxical roles of the immune system during cancer development
2006 Standout
Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression
2010
The Inflammasomes
2010 Standout
Inflammation and Cancer: Is the Link as Simple as We Think?
2005
Interleukin 23 Production by Intestinal CD103+CD11b+ Dendritic Cells in Response to Bacterial Flagellin Enhances Mucosal Innate Immune Defense
2012
Paneth Cell α-Defensin Synthesis and Function
2006
Dendritic cells in intestinal immune regulation
2008
Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms
2013 Standout
A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses
2009
Control of pathogens and pathobionts by the gut microbiota
2013
Commensal DNA Limits Regulatory T Cell Conversion and Is a Natural Adjuvant of Intestinal Immune Responses
2008
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Molecular pathogenesis of inflammatory bowel disease: Genotypes, phenotypes and personalized medicine
2007
The Genetics of Inflammatory Bowel Disease
2007
The Key Role of Segmented Filamentous Bacteria in the Coordinated Maturation of Gut Helper T Cell Responses
2009
Tumour necrosis factor and cancer
2009
XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease
2008 Standout
Epithelial NEMO links innate immunity to chronic intestinal inflammation
2007 Nature
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
2006 Standout
Inflammatory bowel disease: Etiology and pathogenesis
1998 Standout
NF-κB functions as a tumour promoter in inflammation-associated cancer
2004 StandoutNature
Signalling pathways and molecular interactions of NOD1 and NOD2
2005
Intracellular NOD-like Receptors in Host Defense and Disease
2007
The Role of Autophagy in Alpha-1-Antitrypsin Deficiency: A Specific Cellular Response in Genetic Diseases Associated with Aggregation-Prone Proteins
2006
CD14-dependent Lipopolysaccharide-induced β-Defensin-2 Expression in Human Tracheobronchial Epithelium
2000
NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis
2010
Cancer-related inflammation
2008 StandoutNature
Antimicrobial peptides of multicellular organisms
2002 StandoutNature
Toll-like receptors in inflammatory bowel diseases: A decade later
2010
Salmonella enterica Serovar Typhimurium Exploits Inflammation to Compete with the Intestinal Microbiota
2007
Microbiota-mediated colonization resistance against intestinal pathogens
2013
Recent advances in the growth and isolation of primitive human haemopoietic progenitor cells
1992
Yersinia pseudotuberculosis disrupts intestinal barrier integrity through hematopoietic TLR-2 signaling
2012
De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent
2005
Development of intestinal M cells
2005
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
Interplay of commensal and pathogenic bacteria, genetic mutations, and immunoregulatory defects in the pathogenesis of inflammatory bowel diseases
2008
Tumors as Organs: Complex Tissues that Interface with the Entire Organism
2010
Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability
2009 Standout
Deletion of TLR5 results in spontaneous colitis in mice
2007
Cancer related inflammation: The macrophage connection
2008
Communicable Ulcerative Colitis Induced by T-bet Deficiency in the Innate Immune System
2007
Heterogeneous expression of Wnt/β‐catenin target genes within colorectal cancer
2007
A Role for Erbin in the Regulation of Nod2-dependent NF-κB Signaling
2005
Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria
2006
Inflammasomes in health and disease
2012 StandoutNature
Fen1 mutations result in autoimmunity, chronic inflammation and cancers
2007
Regulation of the Antimicrobial Response by NLR Proteins
2011
Overexpression of Interleukin-1β Induces Gastric Inflammation and Cancer and Mobilizes Myeloid-Derived Suppressor Cells in Mice
2008
Macrophage/Cancer Cell Interactions Mediate Hormone Resistance by a Nuclear Receptor Derepression Pathway
2006
Recent insights into the mucosal reactions associated with Giardia lamblia infections
2005
Predominant T helper type 2‐inflammatory responses promote murine colon cancers
2005
Current status of genetics research in inflammatory bowel disease
2005
Mechanisms of cross hyporesponsiveness to toll-like receptor bacterial ligands in intestinal epithelial cells☆
2004
NF-κB: linking inflammation and immunity to cancer development and progression
2005 Standout
Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease
2009
Interleukin-23 drives innate and T cell–mediated intestinal inflammation
2006
Natural Aryl Hydrocarbon Receptor Ligands Control Organogenesis of Intestinal Lymphoid Follicles
2011 Science
Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
2006 StandoutScience
Inducible Expression of Human β-Defensin 2 byFusobacterium nucleatumin Oral Epithelial Cells: Multiple Signaling Pathways and Role of Commensal Bacteria in Innate Immunity and the Epithelial Barrier
2000
TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis
2009
CXCL10 Promotes Invasion-Related Properties in Human Colorectal Carcinoma Cells
2007
Induction of a proinflammatory program in normal human thyrocytes by the RET/PTC1 oncogene
2005
Ovarian cancer cell–derived migration inhibitory factor enhances tumor growth, progression, and angiogenesis
2007 Standout
Prokaryotic Regulation of Epithelial Responses by Inhibition of IκB-α Ubiquitination
2000 Science
The Inflammatory Cytokine Tumor Necrosis Factor-α Regulates Chemokine Receptor Expression on Ovarian Cancer Cells
2005
Abnormally Differentiated Subsets of Intestinal Macrophage Play a Key Role in Th1-Dominant Chronic Colitis through Excess Production of IL-12 and IL-23 in Response to Bacteria
2005
Lack of interleukin 10 regulation of antigen presentation‐associated molecules expressed on colonic epithelial cells
1999
The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer
2010
ANTIGEN SAMPLING ACROSS EPITHELIAL BARRIERS AND INDUCTION OF MUCOSAL IMMUNE RESPONSES
1996
Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense againstSalmonella
2010
IFN Regulatory Factor 3-Dependent Induction of Type I IFNs by Intracellular Bacteria Is Mediated by a TLR- and Nod2-Independent Mechanism
2004
Intestinal Bacteria and the Regulation of Immune Cell Homeostasis
2010
Interactions Between the Microbiota and the Immune System
2012 StandoutScience
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production
2008 StandoutNature
Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation
2006
TNF-α inhibits asbestos-induced cytotoxicity via a NF-κB-dependent pathway, a possible mechanism for asbestos-induced oncogenesis
2006
Chronic lymphocytic leukemia of Eμ-TCL1 transgenic mice undergoes rapid cell turnover that can be offset by extrinsic CD257 to accelerate disease progression
2009
“Re-educating” tumor-associated macrophages by targeting NF-κB
2008
Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury
2011
Common themes in microbial pathogenicity revisited.
1997
IFNγ-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice
2006
Requirement of Mip-1α for an Inflammatory Response to Viral Infection
1995 StandoutScienceNobel
Chemokine Receptor CCR6 Expression Level and Liver Metastases in Colorectal Cancer
2006
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria
2008 Standout
Membrane-permeant Esters of Phosphatidylinositol 3,4,5-Trisphosphate
1998 StandoutNobel
Common themes in microbial pathogenicity revisited
1997 Standout
Links between α-catenin, NF-κB, and squamous cell carcinoma in skin
2006
Toll-Like Receptor–Gut Microbiota Interactions: Perturb at Your Own Risk!
2011
Inflammatory Bowel Disease
2010 Standout
Metagenomics of the Human Body
2010
Selective Suppression of IL-12 Production by Chemoattractants
2000
Ovarian Cancer Cells Polarize Macrophages Toward A Tumor-Associated Phenotype
2006
Cutting Edge: Bacterial Flagellin Activates Basolaterally Expressed TLR5 to Induce Epithelial Proinflammatory Gene Expression
2001
Differential Alteration in Intestinal Epithelial Cell Expression of Toll-Like Receptor 3 (TLR3) and TLR4 in Inflammatory Bowel Disease
2000
Host-microbiota interactions in inflammatory bowel disease
2012
An essential amino acid induces epithelial β-defensin expression
2000
Interleukin-10 and the Interleukin-10 Receptor
2001 Standout
The Inflammasomes: Guardians of the Body
2009 Standout
Signal Sequence Trap: a Cloning Strategy for Secreted Proteins and Type I Membrane Proteins
1993 StandoutScienceNobel
Microbe sampling by mucosal dendritic cells is a discrete, MyD88-independent stepin ΔinvG S. Typhimurium colitis
2008
Pseudomonas aeruginosa invasion of and multiplication within corneal epithelial cells in vitro
1995
Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice
2010
Rapid Infection of Oral Mucosal-Associated Lymphoid Tissue with Simian Immunodeficiency Virus
1999 StandoutScienceNobel
Regulation of Adaptive Immunity by the Innate Immune System
2010 StandoutScience
Chemokine ReceptorCXCR4Expression in Colorectal Cancer Patients Increases the Risk for Recurrence and for Poor Survival
2005
Transforming growth factor beta: is it a downregulator of stem cell inhibition by macrophage inflammatory protein 1 alpha?
1993
Colon Epithelial Cell Death in 2,4,6-Trinitrobenzenesulfonic Acid-Induced Colitis Is Associated with Increased Inducible Nitric-Oxide Synthase Expression and Peroxynitrite Production
2001
Role of lipopolysaccharide in signaling to subepithelial polymorphonuclear leukocytes
1997
Effector Memory T Cells, Early Metastasis, and Survival in Colorectal Cancer
2005 Standout
γδ intraepithelial lymphocytes are essential mediators of host–microbial homeostasis at the intestinal mucosal surface
2011
MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands
2010 StandoutNobel
V. Polarized compartmentalization of antigen processing and Toll-like receptor signaling in intestinal epithelial cells
2002
Hyperplastic Gastric Tumors with Spasmolytic Polypeptide–Expressing Metaplasia Caused by Tumor Necrosis Factor-α–Dependent Inflammation in Cyclooxygenase-2/Microsomal Prostaglandin E Synthase-1 Transgenic Mice
2005
Macrophages Induce Invasiveness of Epithelial Cancer Cells Via NF-κB and JNK
2005
Discovery of a Viral NLR Homolog that Inhibits the Inflammasome
2011 Science
Increased Susceptibility to Colitis-Associated Cancer of Mice Lacking TIR8, an Inhibitory Member of the Interleukin-1 Receptor Family
2007
Immune Therapy for Cancer
2008
Induction of antiviral immunity requires Toll-like receptor signaling in both stromal and dendritic cell compartments
2004
Lipopolysaccharide Activates Distinct Signaling Pathways in Intestinal Epithelial Cell Lines Expressing Toll-Like Receptors
2000
Citrobacter rodentiumInfection in Mice Elicits a Mucosal Th1 Cytokine Response and Lesions Similar to Those in Murine Inflammatory Bowel Disease
1999
The Innate Immune Receptor Nod1 Protects the Intestine from Inflammation-Induced Tumorigenesis
2008
Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term Foe
2009
Aberrant plasmacytoid dendritic cell distribution and function in patients with Crohn's disease and ulcerative colitis
2011
The gut flora as a forgotten organ
2006 Standout
Dual Roles for Immunity in Gastrointestinal Cancers
2010
The Antibacterial Lectin RegIIIγ Promotes the Spatial Segregation of Microbiota and Host in the Intestine
2011 Science
Works of Lars Eckmann being referenced
Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells
2007
Nod2 Mutation in Crohn's Disease Potentiates NF-κB Activity and IL-1ß Processing
2005 Science
Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface
2008
A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion.
1995
IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer
2004 Standout
Chemokine receptor expression by human intestinal epithelial cells
1999
Nod2 regulates the host response towards microflora by modulating T cell function and epithelial permeability in mouse Peyer's patches
2009
Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis
2007 Nature
Nuclear factor-kappa B in intestinal protection and destruction
2009
Epithelial cells as sensors for microbial infection.
1997
The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4
2004 Nature
Toll-like receptor 9–induced type I IFN protects mice from experimental colitis
2005
Innate immune defenses in the intestinal tract
2007
Infection of human intestinal epithelial cells with invasive bacteria upregulates apical intercellular adhesion molecule-1 (ICAM)-1) expression and neutrophil adhesion.
1996
Regulated production of interferon-inducible T-cell chemoattractants by human intestinal epithelial cells
2001
Cyclic AMP Promotes cAMP-responsive Element-binding Protein-dependent Induction of Cellular Inhibitor of Apoptosis Protein-2 and Suppresses Apoptosis of Colon Cancer Cells through ERK1/2 and p38 MAPK
2004
Nod2 Mediates Susceptibility to Yersinia pseudotuberculosis in Mice
2008
Chemokine receptor CCR6 transduces signals that activate p130Cas and alter cAMP-stimulated ion transport in human intestinal epithelial cells
2004
Intestinal epithelial cells as watchdogs for the natural immune system
1995
NOD2 and Crohn’s Disease: Loss or Gain of Function?
2005
Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells
2006
Innate immunity and mucosal bacterial interactions in the intestine
2004
Differential and regulated expression of C-X-C, C-C, and C-chemokines by human colon epithelial cells
1997
NF-κB Is a Negative Regulator of IL-1β Secretion as Revealed by Genetic and Pharmacological Inhibition of IKKβ
2007
Role of intestinal epithelial cells in the host secretory response to infection by invasive bacteria. Bacterial entry induces epithelial prostaglandin h synthase-2 expression and prostaglandin E2 and F2alpha production.
1997
Ubiquitous production of macrophage migration inhibitory factor by human gastric and intestinal epithelium
2002
IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer
2009 Standout
Mucosal defences against Giardia
2003
Apoptosis of human intestinal epithelial cells after bacterial invasion.
1998
Cytokines in host defense against
2001
Animal Models of Inflammatory Bowel Disease
2006
Analysis by High Density cDNA Arrays of Altered Gene Expression in Human Intestinal Epithelial Cells in Response to Infection with the Invasive Enteric BacteriaSalmonella
2000
NF-kappa B is a central regulator of the intestinal epithelial cell innate immune response induced by infection with enteroinvasive bacteria.
1999
Human hepatocytes express an array of proinflammatory cytokines after agonist stimulation or bacterial invasion
1997
Nitric Oxide Production by Human Intestinal Epithelial Cells and Competition for Arginine as Potential Determinants of Host Defense Against the Lumen-Dwelling Pathogen Giardia lamblia
2000
Expression and Regulation of the Human β-Defensins hBD-1 and hBD-2 in Intestinal Epithelium
1999
Expression of the Salmonella virulence plasmid gene spvB in cultured macrophages and nonphagocytic cells
1993
NF-κB Is a Central Regulator of the Intestinal Epithelial Cell Innate Immune Response Induced by Infection with Enteroinvasive Bacteria
1999
Regulated MIP-3α/CCL20 production by human intestinal epithelium: mechanism for modulating mucosal immunity
2001
The effect of stem cell proliferation regulators demonstrated with an in vitro assay
1988
1997 StandoutNobel
How bile acids confer gut mucosal protection against bacteria
2006
IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer
2009
Epithelial cells secrete the chemokine interleukin-8 in response to bacterial entry
1993
Opposing functions of IKKβ during acute and chronic intestinal inflammation
2008
Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium.
1999
Enteroinvasive bacteria directly activate expression of iNOS and NO production in human colon epithelial cells
1998
A NOD2–NALP1 complex mediates caspase-1-dependent IL-1β secretion in response to Bacillus anthracis infection and muramyl dipeptide
2008
Synergistic interactions allow colony formation in vitro by murine haemopoietic stem cells
1990
Toll-like receptor 9–induced type I IFN protects mice from experimental colitis
2005
Polymeric Immunoglobulin Receptor in Intestinal Immune Defense against the Lumen-Dwelling Protozoan ParasiteGiardia
2006
Genetically resistant (Ityr) and susceptible (Itys) congenic mouse strains show similar cytokine responses following infection with Salmonella dublin
1996
Colonic epithelial cell lines as a source of interleukin-8: stimulation by inflammatory cytokines and bacterial lipopolysaccharide.
1994
Microbes and Microbial Toxins: Paradigms for Microbial- Mucosal Interactions I. Pathophysiological aspects of enteric infections with the lumen-dwelling protozoan pathogenGiardia lamblia
2001
IκB-kinaseβ-dependent NF-κB activation provides radioprotection to the intestinal epithelium
2004
Cathelicidin Mediates Innate Intestinal Defense against Colonization with Epithelial Adherent Bacterial Pathogens
2005
Clearance ofCitrobacter rodentiumRequires B Cells but Not Secretory Immunoglobulin A (IgA) or IgM Antibodies
2004
Tumor promotion by caspase-resistant retinoblastoma protein
2005
Central Importance of Immunoglobulin A in Host Defense againstGiardiaspp
2002
Importance of Interleukin-10 in Genetic Susceptibility of Mice toCoccidioides immitis
1998