Citation Impact
Citing Papers
Programmable RNA recognition using a CRISPR-associated Argonaute
2018 StandoutNobel
Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis
2006 StandoutScience
Transferrin receptor targeting by de novo sheet extension
2021 StandoutNobel
Caenorhabditis elegans ADAR editing and the ERI-6/7/MOV10 RNAi pathway silence endogenous viral elements and LTR retrotransposons
2020 StandoutNobel
Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo
2003
Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis
2014
Structure-based inhibitors of amyloid beta core suggest a common interface with tau
2019
Alzheimer's disease: synapses gone cold
2011
Estimating the reproducibility of psychological science
2015 StandoutScience
Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2
2014
The generation and function of soluble apoE receptors in the CNS
2006
Interactions between APP secretases and inflammatory mediators
2008
The future of genetic research on neurodegeneration
2010
Genetics of cerebral amyloid angiopathy: systematic review and meta-analysis
2013
Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy
2009
Synapses and Alzheimer's Disease
2012 StandoutNobel
ApoE Promotes the Proteolytic Degradation of Aβ
2008
The benefits and limitations of animal models for translational research in neurodegenerative diseases
2010
Dynamic O-Glycosylation of Nuclear and Cytosolic Proteins
2001
Presenilins are essential for regulating neurotransmitter release
2009 StandoutNatureNobel
Inflammation and metabolic disorders
2006 StandoutNature
Aberrant Excitatory Neuronal Activity and Compensatory Remodeling of Inhibitory Hippocampal Circuits in Mouse Models of Alzheimer's Disease
2007
Single-cell sequencing-based technologies will revolutionize whole-organism science
2013
Imbalance between GABAergic and Glutamatergic Transmission Impairs Adult Neurogenesis in an Animal Model of Alzheimer's Disease
2009
APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy
2005
Mitochondria are a direct site of Aβ accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression
2006
The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
2008 Standout
Replication of past candidate loci for common diseases and phenotypes in 100 genome-wide association studies
2010
Channel opening and gating mechanism in AMPA-subtype glutamate receptors
2017 StandoutNatureNobel
Mechanisms Underlying Inflammation in Neurodegeneration
2010 Standout
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Loss of γ-Secretase Function Impairs Endocytosis of Lipoprotein Particles and Membrane Cholesterol Homeostasis
2008
Fyn Kinase Induces Synaptic and Cognitive Impairments in a Transgenic Mouse Model of Alzheimer's Disease
2005
The mTOR pathway and its role in human genetic diseases
2008
Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by β-amyloid fibrils
2003
Somatic APP gene recombination in Alzheimer’s disease and normal neurons
2018 Nature
Modeling familial Alzheimer's disease with induced pluripotent stem cells
2011 StandoutNobel
Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta
2013
Alzheimer's disease
2011 Standout
A Presenilin-1 Mutation Identified in Familial Alzheimer Disease with Cotton Wool Plaques Causes a Nearly Complete Loss of γ-Secretase Activity
2010
Problems and Solutions in the Genetic Analysis of Late-Onset Alzheimer’s Disease
2004
TREM2 variants: new keys to decipher Alzheimer disease pathogenesis
2016
apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain
2008
Diabetes Mellitus and Risk of Alzheimer Disease and Decline in Cognitive Function
2004
A Hundred Years of Alzheimer's Disease Research
2006
Reduced Hippocampal Insulin-Degrading Enzyme in Late-Onset Alzheimer's Disease Is Associated with the Apolipoprotein E-ε4 Allele
2003
Current status on Alzheimer disease molecular genetics: from past, to present, to future
2010
Low‐density lipoprotein receptor‐related protein‐1: a serial clearance homeostatic mechanism controlling Alzheimer’s amyloid β‐peptide elimination from the brain
2010
The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid β‐protein level in vivo
2008
Zinc takes the center stage: its paradoxical role in Alzheimer’s disease
2003
Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3
2017 StandoutNatureNobel
The Genetics of Alzheimer Disease
2012
Immunotherapeutic Approaches for Alzheimer’s Disease
2015
The Role of Insulin, Insulin Growth Factor, and Insulin‐Degrading Enzyme in Brain Aging and Alzheimer′s Disease
2005
Genome-wide Analysis of Genetic Loci Associated With Alzheimer Disease
2010
Clearance of Alzheimer's Aβ Peptide
2004
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
Nitric Oxide and Peroxynitrite in Health and Disease
2007 Standout
Genetics of Alzheimer disease in the pre- and post-GWAS era
2010
No association between APOE epsilon 4 allele and multiple sclerosis susceptibility: A meta-analysis from 5472 cases and 4727 controls
2011
Human neprilysin is capable of degrading amyloid β peptide not only in the monomeric form but also the pathological oligomeric form
2003
TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia
2016
O-GlcNAc cycling: Implications for neurodegenerative disorders
2009
Super-Enhancers in the Control of Cell Identity and Disease
2013 Standout
Perceived information gain from randomized trials correlates with publication in high–impact factor journals
2012
Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice
2006
Genetics, environmental factors and the emerging role of epigenetics in neurodegenerative diseases
2008
Linking Aβ and Tau in Late-Onset Alzheimer's Disease: A Dual Pathway Hypothesis
2008
A role of PIEZO1 in iron metabolism in mice and humans
2021 StandoutNobel
Defining Molecular Targets to Prevent Alzheimer Disease
2005
A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior
2008 StandoutNobel
Insulin, insulin-degrading enzyme and amyloid-β peptide in Alzheimer's disease: review and hypothesis
2005
The Amyloid Precursor Protein Locus and Very-Late-Onset Alzheimer Disease
2001
Power failure: why small sample size undermines the reliability of neuroscience
2013 Standout
β-Amyloid-induced Dynamin 1 Degradation Is Mediated by N-Methyl-D-Aspartate Receptors in Hippocampal Neurons
2006
Cathepsin D—Many functions of one aspartic protease
2008
The Role of Apolipoprotein E in Alzheimer's Disease
2009
Clearing the Brain's Amyloid Cobwebs
2001
Alzheimer's Disease
2010 Standout
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
2006 StandoutNature
Increased brain atrophy rates in cognitively normal older adults with low cerebrospinal fluid Aβ1‐42
2010
α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy body disease
2016
Role of toll-like receptor signalling in A uptake and clearance
2006
The role of GSK3 in Alzheimer disease
2009
Partial volume effect-corrected FDG PET and grey matter volume loss in patients with mild Alzheimer’s disease
2007
Accelerating progress in induced pluripotent stem cell research for neurological diseases
2012
Reduced Spine Density in Specific Regions of CA1 Pyramidal Neurons in Two Transgenic Mouse Models of Alzheimer's Disease
2011
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
2011 StandoutNatureNobel
Publication and other reporting biases in cognitive sciences: detection, prevalence, and prevention
2014
Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs
2004
Evaluation of Excess Statistical Significance in Meta-analyses of 98 Biomarker Associations with Cancer Risk
2012
Activation of β2-adrenergic receptor stimulates γ-secretase activity and accelerates amyloid plaque formation
2006
Apolipoprotein E as a Therapeutic Target in Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence
2016
The Pathobiology of Vascular Dementia
2013 Standout
Sorting through the Cell Biology of Alzheimer's Disease: Intracellular Pathways to Pathogenesis
2006
Meta-analysis of MTHFR gene variants in schizophrenia, bipolar disorder and unipolar depressive disorder: Evidence for a common genetic vulnerability?
2010
Innate immunity in Alzheimer's disease
2015
Enhanced Proteolysis of β-Amyloid in APP Transgenic Mice Prevents Plaque Formation, Secondary Pathology, and Premature Death
2003
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Gene expression profiles of transcripts in amyloid precursor protein transgenic mice: up-regulation of mitochondrial metabolism and apoptotic genes is an early cellular change in Alzheimer's disease
2004
A network dysfunction perspective on neurodegenerative diseases
2006 Nature
Synaptic AMPA receptor composition in development, plasticity and disease
2016
Excess Significance Bias in the Literature on Brain Volume Abnormalities
2011
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
Why Most Discovered True Associations Are Inflated
2008
Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders
2011 Standout
Genetically engineered mouse models of neurodegenerative diseases
2002
Cellular senescence: from physiology to pathology
2014 Standout
Amyloid-β/Fyn–Induced Synaptic, Network, and Cognitive Impairments Depend on Tau Levels in Multiple Mouse Models of Alzheimer's Disease
2011
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
2010 StandoutNobel
Elucidation of AMPA receptor–stargazin complexes by cryo–electron microscopy
2016 StandoutScienceNobel
Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?
2005
The Hexosamine Signaling Pathway: Deciphering the "O-GlcNAc Code"
2005
Metabolic cross-talk allows labeling of O-linked β- N -acetylglucosamine-modified proteins via the N -acetylgalactosamine salvage pathway
2011 StandoutNobel
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function
2009 StandoutNobel
Exosomal cellular prion protein drives fibrillization of amyloid beta and counteracts amyloid beta‐mediated neurotoxicity
2015
Common Pathological Processes and Transcriptional Pathways in Alzheimer's Disease and Type 2 Diabetes
2009
Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals
2022 StandoutNobel
Linkage of Plasma Aβ42 to a Quantitative Locus on Chromosome 10 in Late-Onset Alzheimer's Disease Pedigrees
2000 Science
Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome
2008
Microglia Function in the Central Nervous System During Health and Neurodegeneration
2017 Standout
A chemical approach for identifying O -GlcNAc-modified proteins in cells
2003 StandoutNobel
Regulation of Caenorhabditis elegans neuronal polarity by heterochronic genes
2019 StandoutNobel
TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques
2016
Alzheimer's Disease: Genes, Proteins, and Therapy
2001 Standout
The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
2011 Standout
The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
2011 Standout
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
Hypometabolism exceeds atrophy in presymptomatic early-onset familial Alzheimer's disease.
2006
Subacute Ischemic Stroke Is Associated With Focal 11 C PiB Positron Emission Tomography Retention But Not With Global Neocortical Aβ Deposition
2012
Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans -Golgi network
2012 StandoutNobel
Alzheimer'S Disease: Advances In Genetics, Molecular And Cellular Biology
2007
Amyloidogenic processing of β-amyloid precursor protein in intracellular compartments
2006
The Emerging Significance of O-GlcNAc in Cellular Regulation
2002
Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation
2013 StandoutNobel
Alzheimer's disease‐associated TREM2 variants exhibit either decreased or increased ligand‐dependent activation
2016
The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins
2004 StandoutNobel
Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model
2007 StandoutScience
Clarifications on the application and interpretation of the test for excess significance and its extensions
2013
Sampling the conformational space of the catalytic subunit of human γ-secretase
2015
Metabolic labeling enables selective photocrosslinking of O-GlcNAc-modified proteins to their binding partners
2012 StandoutNobel
Chemical Glycoproteomics
2016 StandoutNobel
Mouse neurexin-1α deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments
2009 StandoutNobel
Development of biomarkers to chart all Alzheimer's disease stages: The royal road to cutting the therapeutic Gordian Knot
2012
Works of Lars Bertram being referenced
Serum Iron Levels and the Risk of Parkinson Disease: A Mendelian Randomization Study
2013
Rare autosomal copy number variations in early-onset familial Alzheimer’s disease
2013
The future of Alzheimer's disease: The next 10 years
2011
Association of GSK3B With Alzheimer Disease and Frontotemporal Dementia
2008
Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database
2006
Decreased Catalytic Activity of the Insulin-degrading Enzyme in Chromosome 10-Linked Alzheimer Disease Families
2007
Partial Loss-of-Function Mutations in Insulin-Degrading Enzyme that Induce Diabetes also Impair Degradation of Amyloid β-Protein
2004
Genome-wide association studies in Alzheimer's disease
2009
Alzheimer's disease: one disorder, too many genes?
2004
The role of genetics for biomarker development in neurodegeneration
2011
The genetic epidemiology of neurodegenerative disease
2005
Evaluation of the Potential Excess of Statistically Significant Findings in Published Genetic Association Studies: Application to Alzheimer's Disease
2008
The Genetics of Alzheimer Disease: Back to the Future
2010
The Genetics of Alzheimer's Disease
2012
New Frontiers in Alzheimer's Disease Genetics
2001
Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses
2008
Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database
2008
Candidate genes showing no evidence for association or linkage with Alzheimer's disease using family-based methodologies
2000
Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease
2007
Somatic Mutation Profiles of MSI and MSS Colorectal Cancer Identified by Whole Exome Next Generation Sequencing and Bioinformatics Analysis
2010
Comprehensive Field Synopsis and Systematic Meta-analyses of Genetic Association Studies in Cutaneous Melanoma
2011
The pursuit of susceptibility genes for Alzheimer's disease: progress and prospects
2010
Quantifying Selective Reporting and the Proteus Phenomenon for Multiple Datasets with Similar Bias
2011
Twenty Years of the Alzheimer’s Disease Amyloid Hypothesis: A Genetic Perspective
2005
The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk
2014
Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD
2005
Alzheimer's Disease Neuroimaging Initiative biomarkers as quantitative phenotypes: Genetics core aims, progress, and plans
2010
New light on an old CLU
2010
Evidence for Genetic Linkage of Alzheimer's Disease to Chromosome 10q
2000 Science
PEN2 is not a genetic risk factor for Alzheimer’s disease in a large family sample
2004