Citation Impact
Citing Papers
Non-Identity-Mediated CRISPR-Bacteriophage Interaction Mediated via the Csy and Cas3 Proteins
2011
Global analysis of protein folding using massively parallel design, synthesis, and testing
2017 StandoutScienceNobel
Transferrin receptor targeting by de novo sheet extension
2021 StandoutNobel
A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation–Driven Colorectal Tumor Growth
2013
Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality
2020 StandoutNobel
Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma
2010 StandoutScience
Sulfur [ 18 F]Fluoride Exchange Click Chemistry Enabled Ultrafast Late-Stage Radiosynthesis
2021 StandoutNobel
Designed protein logic to target cells with precise combinations of surface antigens
2020 StandoutScienceNobel
PARP inhibitors: Synthetic lethality in the clinic
2017 StandoutScience
Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism
2009 StandoutNobel
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
Bump-and-Hole Engineering Identifies Specific Substrates of Glycosyltransferases in Living Cells
2020 StandoutNobel
The Spring α-Helix Coordinates Multiple Modes of HCV (Hepatitis C Virus) NS3 Helicase Action
2016 StandoutNobel
PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage
2013
Structural Insights into RNA Recognition by RIG-I
2011
A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export
2011 Nature
Can we safely target the WNT pathway?
2014
LRRTM2 Functions as a Neurexin Ligand in Promoting Excitatory Synapse Formation
2009 StandoutNobel
MUT-14 and SMUT-1 DEAD Box RNA Helicases Have Overlapping Roles in Germline RNAi and Endogenous siRNA Formation
2014 StandoutNobel
Structure and mechanism of bacterial dehalogenases: different ways to cleave a carbon–halogen bond
2003
Protein–protein interactions: General trends in the relationship between binding affinity and interfacial buried surface area
2013
Enhancement of the Rate of Pyrophosphate Hydrolysis by Nonenzymatic Catalysts and by Inorganic Pyrophosphatase
2011
Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3
2015 StandoutNobel
Determinants of BH3 Binding Specificity for Mcl-1 versus Bcl-xL
2010
Multi-input chemical control of protein dimerization for programming graded cellular responses
2019 StandoutNobel
Forces stabilizing proteins
2014
Neurexins Physically and Functionally Interact with GABAA Receptors
2010 StandoutNobel
A buried lysine that titrates with a normal pKa: Role of conformational flexibility at the protein–water interface as a determinant of pKavalues
2008
Hallmarks of aging: An expanding universe
2023 Standout
Evolutionarily Conserved Roles of the Dicer Helicase Domain in Regulating RNA Interference Processing
2014 StandoutNobel
The ups and downs of Poly(ADP-ribose) Polymerase-1 inhibitors in cancer therapy–Current progress and future direction
2020
Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing
2012 StandoutNobel
Cancer stem cells revisited
2017 Standout
From unwinding to clamping — the DEAD box RNA helicase family
2011
Contribution of Hydrophobic Interactions to Protein Stability
2011
Wnt signaling pathway in aging-related tissue fibrosis and therapies
2020
The diverse roles and clinical relevance of PARPs in DNA damage repair: Current state of the art
2012
A Computationally Designed Inhibitor of an Epstein-Barr Viral Bcl-2 Protein Induces Apoptosis in Infected Cells
2014 StandoutNobel
Mcl‐1–Bim complexes accommodate surprising point mutations via minor structural changes
2010
The widespread regulation of microRNA biogenesis, function and decay
2010 Standout
RNA-guided genetic silencing systems in bacteria and archaea
2012 StandoutNatureNobel
Adenosyl Radical: Reagent and Catalyst in Enzyme Reactions
2010
PARP-1 Activation Requires Local Unfolding of an Autoinhibitory Domain
2015
De novo design of bioactive protein switches
2019 StandoutNatureNobel
Enzymatic functionalization of carbon–hydrogen bonds
2010 StandoutNobel
A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers
2012
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
2013 Standout
A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation
2015 Standout
A Genome-wide CRISPR Screen Identifies ZCCHC14 as a Host Factor Required for Hepatitis B Surface Antigen Production
2019
PHENIX: a comprehensive Python-based system for macromolecular structure solution
2010 Standout
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies
2013 StandoutNobel
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
Are Acidic and Basic Groups in Buried Proteins Predicted to be Ionized?
2005
Surprises and pitfalls arising from (pseudo)symmetry
2007
Structural Insights into a Unique Dimeric DEAD-Box Helicase CshA that Promotes RNA Decay
2017
A Key Role for Poly(ADP-Ribose) Polymerase 3 in Ectodermal Specification and Neural Crest Development
2011
Using sulfuramidimidoyl fluorides that undergo sulfur(vi) fluoride exchange for inverse drug discovery
2020 StandoutNobel
PARP inhibition: PARP1 and beyond
2010
Proteome-wide Profiling of Clinical PARP Inhibitors Reveals Compound-Specific Secondary Targets
2016
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
2017 Standout
ATP-Dependent Effector-like Functions of RIG-I-like Receptors
2015 StandoutNobel
Serine/Threonine Phosphatases: Mechanism through Structure
2009
In vivo 3′-to-5′ exoribonuclease targetomes of Streptococcus pyogenes
2018 StandoutNobel
Quantitative exploration of the molecular origin of the activation of GTPase
2013 StandoutNobel
Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors
2016
Molecular Determinants of Bim(BH3) Peptide Binding to Pro-Survival Proteins
2012
Polymorphisms in melanoma differentiation‐associated gene 5 link protein function to clearance of hepatitis C virus
2014 StandoutNobel
New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs
2012
Eukaryote-Like Serine/Threonine Kinases and Phosphatases in Bacteria
2011
ATP-independent diffusion of double-stranded RNA binding proteins
2012 StandoutNobel
Roles of mutation and recombination in the evolution of protein thermodynamics
2002 StandoutNobel
Osmosensory signaling in Mycobacterium tuberculosis mediated by a eukaryotic-like Ser/Thr protein kinase
2013 StandoutNobel
On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1
2012 Standout
Mutational analysis of the neurexin/neuroligin complex reveals essential and regulatory components
2008
Azine Activation via Silylium Catalysis
2021 StandoutNobel
De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures
2017 StandoutNobel
Inositol hexakisphosphate suppresses excitatory neurotransmission via synaptotagmin-1 C2B domain in the hippocampal neuron
2012 StandoutNobel
Engineering Orthogonal Polypeptide GalNAc-Transferase and UDP-Sugar Pairs
2019 StandoutNobel
DEAD-Box Helicases: Sensors, Regulators, and Effectors for Antiviral Defense
2020
Targeting Wnt signaling in colorectal cancer. A Review in the Theme: Cell Signaling: Proteins, Pathways and Mechanisms
2015
C–H Functionalization of Azines
2017
Progress in Ab Initio QM/MM Free-Energy Simulations of Electrostatic Energies in Proteins: Accelerated QM/MM Studies of pKa, Redox Reactions and Solvation Free Energies
2008 StandoutNobel
Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells
2015
The mechanism of ATP-dependent RNA unwinding by DEAD box proteins
2009
Dynamic Kinetic Resolution of Racemic β-Haloalcohols: Direct Access to Enantioenriched Epoxides
2008 StandoutNobel
Quantifying the Mechanism of Phosphate Monoester Hydrolysis in Aqueous Solution by Evaluating the Relevant Ab Initio QM/MM Free-Energy Surfaces
2013 StandoutNobel
DEAD-box helicases: the Yin and Yang roles in viral infections
2018
Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression
2011
ADMETlab 2.0: an integrated online platform for accurate and comprehensive predictions of ADMET properties
2021 Standout
Engineering the Substrate Specificity of ADP-Ribosyltransferases for Identifying Direct Protein Targets
2014
The Mononuclear Molybdenum Enzymes
2014 Standout
Peptide Ligands for Pro-survival Protein Bfl-1 from Computationally Guided Library Screening
2013
Structural basis for Zika envelope domain III recognition by a germline version of a recurrent neutralizing antibody
2020 StandoutNobel
Works of L. Lehtiö being referenced
Structure-based design, synthesis and evaluation in vitro of arylnaphthyridinones, arylpyridopyrimidinones and their tetrahydro derivatives as inhibitors of the tankyrases
2015
Structural Basis and Selectivity of Tankyrase Inhibition by a Wnt Signaling Inhibitor WIKI4
2013
Comparative Structural Analysis of Human DEAD-Box RNA Helicases
2010
PARP-3 Is a Mono-ADP-ribosylase That Activates PARP-1 in the Absence of DNA
2010
Buried Charged Surface in Proteins
2000
The DEXD/H-box RNA Helicase DDX19 Is Regulated by an α-Helical Switch
2009
Zinc Binding Catalytic Domain of Human Tankyrase 1
2008
The structure of Pseudomonas P51 Cl‐muconate lactonizing enzyme: Co‐evolution of structure and dynamics with the dehalogenation function
2003
Structure of Streptococcus agalactiae serine/threonine phosphatase
2007
Completing the family portrait of the anti‐apoptotic Bcl‐2 proteins: Crystal structure of human Bfl‐1 in complex with Bim
2008
Unusual twinning in an acetyl coenzyme A synthetase (ADP-forming) fromPyrococcus furiosus
2005
A Trimetal Site and Substrate Distortion in a Family II Inorganic Pyrophosphatase
2006
Crystal Structure of a Glycyl Radical Enzyme from Archaeoglobus fulgidus
2006
Small-Molecule Chemical Probe Rescues Cells from Mono-ADP-Ribosyltransferase ARTD10/PARP10-Induced Apoptosis and Sensitizes Cancer Cells to DNA Damage
2016
Tankyrases: Structure, Function and Therapeutic Implications in Cancer
2014
Structural Basis for Inhibitor Specificity in Human Poly(ADP-ribose) Polymerase-3
2009
Tankyrases as drug targets
2013
Evaluation and Structural Basis for the Inhibition of Tankyrases by PARP Inhibitors
2013
Structural Basis of Selective Inhibition of Human Tankyrases
2012
Crystal Structure of the N-terminal NC4 Domain of Collagen IX, a Zinc Binding Member of the Laminin-Neurexin-Sex Hormone Binding Globulin (LNS) Domain Family
2007