Standout Papers
Citation Impact
Citing Papers
Structure of the 70 S Ribosome Complexed with mRNA and tRNA
2006 StandoutScienceNobel
Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP
1985 StandoutNatureNobel
Crystal structure of TFIID TATA-box binding protein
1992 Nature
Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase
1988 Standout
Yeast and human TFIID with altered DNA-binding specificity for TATA elements
1992
The HAP2,3,4 transcriptional activator is required for derepression of the yeast citrate synthase gene, CIT1
1994
A Yeast Transcriptional Stimulatory Protein Similar to Human PC4
1996 StandoutNobel
Crystal structure of a yeast TFIIA/TBP/DNA complex
1996 Nature
A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides
1988 StandoutNatureNobel
TFIID binds in the minor groove of the TATA box
1991
Mutants of GAL4 protein altered in an activation function
1987
Isolation of the gene encoding the yeast TATA binding protein TFIID: A gene identical to the SPT15 suppressor of Ty element insertions
1989
Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone
1990 Standout
DNA sequence elements required for transcription initiation of the Schizosaccharomyces pombe ADH gene in Saccharomyces cerevisiae
1990
GAL4 activates gene expression in mammalian cells
1988
Genetic and physical analysis of double-strand break repair and recombination in Saccharomyces cerevisiae.
1989
Elevated recombination rates in transcriptionally active DNA
1989 Standout
Turning ? Cro into a transcriptional activator
1988
The yeast SUA7 gene encodes a homolog of human transcription factor TFIIB and is required for normal start site selection in vivo
1992
GAL4 activates transcription in Drosophila
1988 Nature
A protein conjugation system essential for autophagy
1998 StandoutNatureNobel
Structure and regulation of the isocitrate lyase gene ICL1 from the yeast Saccharomyces cerevisiae
1993
The ubiquitin-like protein Smt3p is activated for conjugation to other proteins by an Aos1p/Uba2p heterodimer
1997
DNA-bound Fos proteins activate transcription in yeast
1988
Cooperativity mutants of the γδ resolvase identify an essential interdimer interaction
1990 StandoutNobel
A highly conserved domain of TFIID displays species specificity in vivo
1991
The degradation signal in a short-lived protein
1989
Identification of functional U1 snRNA-pre-mRNA complexes committed to spliceosome assembly and splicing
1989 StandoutNobel
Function of a yeast TATA element-binding protein in a mammalian transcription system
1988 Nature
The fission yeast gene pmt1+encodes a DNA methyltransferase homologue
1995 StandoutNobel
Interaction of TFIID in the minor groove of the TATA element
1991
General Transcription Factors for RNA Polymerase II1
1997
Cross-Intron Bridging Interactions in the Yeast Commitment Complex Are Conserved in Mammals
1997 StandoutNobel
HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells
2007 StandoutNobel
Functional differences between yeast and human TFIID are localized to the highly conserved region
1991
A Protein Component at the Heart of an RNA Machine: The Importance of Protein L27 for the Function of the Bacterial Ribosome
2005
70K heat shock related proteins stimulate protein translocation into microsomes
1988 StandoutNatureNobel
Identification of a Gl-type cyclin puc1+ in the fission yeast Schizosaccharomyces pombe
1991 StandoutNatureNobel
High level expression of proinsulin in the yeast, Saccharomyces cerevisiae
1987
Characterisation of the gene encoding an unusually divergent TATA-Binding Protein (TBP) from the extremely A+T-rich human malaria parasite Plasmodium falciparum
1993
Dominant negative mutations in yeast TFIID define a bipartite DNA-binding region
1991
1991
How eukaryotic transcriptional activators work
1988 StandoutNature
Isolation and characterization of the Drosophila gene encoding the TATA box binding protein, TFIID
1990
The TATA-binding protein and associated factors are components of pol III transcription factor TFIIIB
1992
Mechanisms of intracellular protein transport
1994 StandoutNatureNobel
A strategy for the generation of conditional mutations by protein destabilization.
1992 StandoutNobel
A bipartite DNA binding domain composed of direct repeats in the TATA box binding factor TFIID.
1992
Mechanisms of protein localization
1983
Cooperative DNA binding of the yeast transcriptional activator GAL4.
1988
Factors involved in specific transcription by mammalian RNA polymerase II: role of transcription factors IIA, IID, and IIB during formation of a transcription-competent complex.
1990
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
SHI, a new yeast gene affecting the spacing between TATA and transcription initiation sites.
1991
Nucleotide sequence of the transcriptional initiation region of the yeastGAL7gene
1983
[8] Searching for clones with open reading frames
1987 Nobel
Primary Structure of the Saccharomyces cerevisiae GAL4 Gene
1984
Green Fluorescent Protein as a Marker for Gene Expression
1994 StandoutScienceNobel
A comparison of yeast ribosomal protein gene DNA sequences
1984 StandoutNobel
Deletion analysis of GAL4 defines two transcriptional activating segments
1987
An Assay for Circulating Antibodies to a Major Etiologic Virus of Human Non-A, Non-B Hepatitis
1989 StandoutScienceNobel
Requirement for acidic amino acid residues immediately N-terminal to the conserved domain of Saccharomyces cerevisiae TFIID.
1991
The isolation, characterization, and sequence of the pyruvate kinase gene of Saccharomyces cerevisiae.
1983
RNA Polymerase II Initiation Factor Interactions and Transcription Start Site Selection
1994 StandoutScienceNobel
Isolation of Two Genes That Encode Subunits of the Yeast Transcription Factor IIA
1992 Science
Specific DNA binding of GAL4, a positive regulatory protein of yeast
1985
The yeast MUD2 protein: an interaction with PRP11 defines a bridge between commitment complexes and U2 snRNP addition.
1994 StandoutNobel
Resolution of factors required for the initiation of transcription by yeast RNA polymerase II.
1990 StandoutNobel
The sua8 suppressors of Saccharomyces cerevisiae encode replacements of conserved residues within the largest subunit of RNA polymerase II and affect transcription start site selection similarly to sua7 (TFIIB) mutations.
1994
Oxygen Sensing and the Transcriptional Regulation of Oxygen-Responsive Genes in Yeast
1998
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Interaction Between PRP11 and SPP91 Yeast Splicing Factors and Characterization of a PRP9-PRP11-SPP91 Complex
1993 Science
ARD1 and NAT1 proteins form a complex that has N-terminal acetyltransferase activity.
1992 StandoutNobel
Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic Scale
1997 StandoutScience
An MF alpha 1-SUC2 (alpha-factor-invertase) gene fusion for study of protein localization and gene expression in yeast.
1983 StandoutNobel
The fission yeast Cdc1 protein, a homologue of the small subunit of DNA polymerase delta, binds to Pol3 and Cdc27.
1996 StandoutNobel
Crystal structure of yeast TATA-binding protein and model for interaction with DNA.
1993 StandoutNobel
Correction: Identification of a Gl-type cyclin puc+ in the fission yeast Schizosaccharomyces pombe
1991 StandoutNatureNobel
Evidence for the biochemical role of an internal sequence in yeast nuclear mRNA introns: Implications for U1 RNA and metazoan mRNA splicing
1983 StandoutNobel
Regulation of expression of the galactose gene cluster in Saccharomyces cerevisiae
1983
Interactions between PRP9 and SPP91 splicing factors identify a protein complex required in prespliceosome assembly.
1993
REGULATORY PROTEINS IN YEAST
1987
Initiation by Yeast RNA Polymerase II at the Adenoviral Major Late Promoter in Vitro
1989 StandoutScienceNobel
Saccharomyces cerevisiae GAL1-GAL10 divergent promoter region: location and function of the upstream activating sequence UASG.
1984
Expression of a beta-galactosidase gene containing the ribosomal protein 51 intron is sensitive to the rna2 mutation of yeast.
1983 StandoutNobel
A possible role for the yeast TATA-element-binding protein in DNA replication.
1993
In Vivo DNA-Binding Properties of a Yeast Transcription Activator Protein
1987
Identification of two proteins encoded by the Saccharomyces cerevisiae GAL4 gene.
1984
Transcription factor TFIID induces DNA bending upon binding to the TATA element.
1992
Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles
1983
Constitutive and inducible Saccharomyces cerevisiae promoters: evidence for two distinct molecular mechanisms.
1986
Uses of lac fusions for the study of biological problems
1985
A GAL family of upstream activating sequences in yeast: roles in both induction and repression of transcription.
1986 StandoutNobel
A quantitative analysis of the effects of 5′ junction and TACTAAC box mutants and mutant combinations on yeast mRNA splicing
1985 StandoutNobel
Sequences distal to the mitochondrial targeting sequences are necessary for the maturation of the F1-ATPase beta-subunit precursor in mitochondria.
1987
Mutants of the catabolite activator protein of Escherichia coli that are specifically deficient in the gene-activation function.
1987
Cloning of the gene encoding the yeast protein BTF1Y, which can substitute for the human TATA box-binding factor.
1989
Crystal Structure of a CAP-DNA Complex: the DNA Is Bent by 90°
1991 StandoutScienceNobel
Yeast and human TATA-binding proteins have nearly identical DNA sequence requirements for transcription in vitro.
1990
Accurate initiation at RNA polymerase II promoters in extracts from Saccharomyces cerevisiae.
1987 StandoutNobel
Mitochondrial protein import: Nucleoside triphosphates are involved in conferring import-competence to precursors
1987
Yeast genes fused to beta-galactosidase in Escherichia coli can be expressed normally in yeast.
1981
A eukaryotic transcriptional activator bearing the DNA specificity of a prokaryotic repressor
1985
Crystal Structure of the Yeast TFIIA/TBP/DNA Complex
1996 Science
Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins
1989 StandoutScience
TFIIA induces conformational changes in TFIID via interactions with the basic repeat.
1992
TRANSCRIPTION OF EUKARYOTIC PROTEIN-CODING GENES
2000
Separation of DNA Binding from the Transcription-Activating Function of a Eukaryotic Regulatory Protein
1986 Science
Repressor structure and the mechanism of positive control
1983
The Karyopherin Kap122p/Pdr6p Imports Both Subunits of the Transcription Factor Iia into the Nucleus
1999 StandoutNobel
Regulation of HIS4-lacZ Fusions in Saccharomyces cerevisiae
1982
The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins
1988 StandoutScience
Construction of a plasmid that overproduces the large proteolytic fragment (Klenow fragment) of DNA polymerase I of Escherichia coli.
1983
TFIID can be rate limiting in vivo for TATA-containing, but not TATA-lacking, RNA polymerase II promoters.
1992
TFIIA Induces Conformational Changes in TFIID via Interactions with the Basic Repeat
1992
Normal stoichiometry of histone dimer sets is necessary for high fidelity of mitotic chromosome transmission
1986 StandoutNobel
A Highly Conserved Domain of RNA Polymerase II Shares a Functional Element with Acidic Activation Domains of Upstream Transcription Factors
1994
Identification of Two Proteins Encoded by the Saccharomyces cerevisiae GAL4 Gene
1984
The relationship between the "TATA" sequence and transcription initiation sites at the HIS4 gene of Saccharomyces cerevisiae.
1985
DNA sequences bound specifically by glucocorticoid receptor in vitro render a heterologous promoter hormone responsive in vivo
1983
Yeast and Human TATA-Binding Proteins Have Nearly Identical DNA Sequence Requirements for Transcription In Vitro
1990
Sequences That Regulate the Divergent GAL1-GAL10 Promoter in Saccharomyces cerevisiae
1984
The recognition component of the N-end rule pathway.
1990
Mutations in a conserved region of RNA polymerase II influence the accuracy of mRNA start site selection.
1991
Some cis- and trans-acting mutants for splicing target pre-mRNA to the cytoplasm
1989 StandoutNobel
Identification of a sequence responsible for periodic synthesis of yeast histone 2A mRNA.
1982
Saccharomyces cerevisiae GAL1-GAL10 Divergent Promoter Region: Location and Function of the Upstream Activating Sequence UASG
1984
Structural Basis of Transcription: RNA Polymerase II at 2.8 Ångstrom Resolution
2001 StandoutScienceNobel
Use of lacZ fusions to delimit regulatory elements of the inducible divergent GAL1-GAL10 promoter in Saccharomyces cerevisiae.
1984
A fission yeast RCC1-related protein is required for the mitosis to interphase transition.
1994 StandoutNobel
The yeast general transcription factor TFIIA is composed of two polypeptide subunits.
1991
Specific protein binding to far upstream activating sequences in polymerase II promoters.
1985 StandoutNobel
Drosophila maternal and embryo mRNAs transcribed from a single transcription unit use alternate combinations of exons.
1984 StandoutNobel
β-Arrestin: a Protein that Regulates β-adrenergic Receptor Function
1990 StandoutScienceNobel
Simple derivation of TFIID-dependent RNA polymerase II transcription systems from Schizosaccharomyces pombe and other organisms, and factors required for transcriptional activation.
1992 StandoutNobel
Transcription Factor IID Mutants Defective for Interaction with Transcription Factor IIA
1992 Science
The Conserved Carboxy-Terminal Domain of Saccharomyces cerevisiae TFIID Is Sufficient To Support Normal Cell Growth
1991
Nutrient Availability and the RAS/Cyclic AMP Pathway Both Induce Expression of Ribosomal Protein Genes in Saccharomyces cerevisiae but by Different Mechanisms
1995
In vivo DNA-binding properties of a yeast transcription activator protein.
1987
The period clock locus of D. melanogaster codes for a proteoglycan
1986 StandoutNobel
Interaction of GAL4 and GAL80 gene regulatory proteins in vitro.
1987 StandoutNobel
Two Types of TATA Elements for the CYC1 Gene of the Yeast Saccharomyces cerevisiae
1991
A Carbon Source-Responsive Promoter Element Necessary for Activation of the Isocitrate Lyase Gene ICL1 Is Common to Genes of the Gluconeogenic Pathway in the Yeast Saccharomyces cerevisiae
1994
Works of L Guarente being referenced
Striking conservation of TFIID in Schizosaccharomyces pombe and Saccharomyces cerevisiae
1990 Nature
Evidence that TUP1/SSN6 has a positive effect on the activity of the yeast activator HAP1.
1994
Communication Between Mitochondria and the Nucleus in Regulation of Cytochrome Genes in the Yeast Saccharomyces cerevisiae
1989
A GAL10-CYC1 hybrid yeast promoter identifies the GAL4 regulatory region as an upstream site.
1982
Cloning and molecular analysis of the HAP2 locus: a global regulator of respiratory genes in Saccharomyces cerevisiae.
1985
Yeast TATA-binding protein TFIID binds to TATA elements with both consensus and nonconsensus DNA sequences.
1989
Fusion of Escherichia coli lacZ to the cytochrome c gene of Saccharomyces cerevisiae.
1981
Yeast SUB1 is a suppressor of TFIIB mutations and has homology to the human co-activator PC4.
1996
Mutations in yeast HAP2/HAP3 define a hybrid CCAAT box binding domain.
1993
HAP1 positive control mutants specific for one of two binding sites.
1992
Identification of a yeast protein homologous in function to the mammalian general transcription factor, TFIIA.
1989
Mitochondrial and nonmitochondrial citrate synthases in Saccharomyces cerevisiae are encoded by distinct homologous genes.
1986
The nine amino-terminal residues of delta-aminolevulinate synthase direct beta-galactosidase into the mitochondrial matrix.
1986
Mutational analysis of upstream activation sequence 2 of the CYC1 gene of Saccharomyces cerevisiae: a HAP2-HAP3-responsive site.
1988
Sequence and nuclear localization of the Saccharomyces cerevisiae HAP2 protein, a transcriptional activator.
1987
Transcription by RNA polymerase II induces changes of DNA topology in yeast.
1988
Saccharomyces cerevisiae contains two functional citrate synthase genes.
1986
In vitro construction and characterization of phoA-lacZ gene fusions in Escherichia coli
1983
Isolation, sequence, and regulation by oxygen of the yeast HEM13 gene coding for coproporphyrinogen oxidase.
1988
The HAP3 regulatory locus of Saccharomyces cerevisiae encodes divergent overlapping transcripts.
1988
Each of three "TATA elements" specifies a subset of the transcription initiation sites at the CYC-1 promoter of Saccharomyces cerevisiae.
1985
The C6 zinc cluster dictates asymmetric binding by HAP1.
1996
Improved methods for maximizing expression of a cloned gene: a bacterium that synthesizes rabbit β-globin
1980
Identification and characterization of HAP4: a third component of the CCAAT-bound HAP2/HAP3 heteromer.
1989
Regulation of the yeast CYT1 gene encoding cytochrome c1 by HAP1 and HAP2/3/4.
1991
A single Saccharomyces cerevisiae upstream activation site (UAS1) has two distinct regions essential for its activity.
1986
Organization of the regulatory region of the yeast CYC7 gene: multiple factors are involved in regulation.
1987
Open reading frame cloning: identification, cloning, and expression of open reading frame DNA.
1982 StandoutNobel
Mutant lambda phage repressor with a specific defect in its positive control function.
1982