Standout Papers
- Regulation of Adenylate Cyclase Coupled β-Adrenergic Receptors (1976)
- Negative cooperativity among beta-adrenergic receptors in frog erythrocyte membranes. (1976)
- Gene Substitution/Knockout to Delineate the Role of α2‐Adrenoceptor Subtypes in Mediating Central Effects of Catecholamines and Imidazolines (1999)
- Resolution of beta-adrenergic receptor binding and adenylate cyclase activity by gel exclusion chromatography. (1977)
- Unique uncoupling of the frog erythrocyte adenylate cyclase system by manganese. Loss of hormone and guanine nucleotide-sensitive enzyme activities without loss of nucleotide-sensitive, high affinity agonist binding. (1979)
- Loss of beta-adrenergic receptor-guanine nucleotide regulatory protein interactions accompanies decline in catecholamine responsiveness of adenylate cyclase in maturing rat erythrocytes. (1980)
- Evidence that a beta-adrenergic receptor-associated guanine nucleotide regulatory protein conveys guanosine 5'-O-(3-thiotriphosphate)- dependent adenylate cyclase activity. (1981)
- Agonist-promoted coupling of the beta-adrenergic receptor with the guanine nucleotide regulatory protein of the adenylate cyclase system. (1980)
Citation Impact
Citing Papers
The Binding-Site Crevice of the D4 Dopamine Receptor Is Coupled to Three Distinct Sites of Allosteric Modulation
2001
Adrenergic α2C-Receptors Modulate the Acoustic Startle Reflex, Prepulse Inhibition, and Aggression in Mice
1998 StandoutNobel
The regulation of adenylyl cyclase by receptor-operated G proteins
1991
Cell-type Specific Targeting of the α2c-Adrenoceptor
2000 StandoutNobel
The Role of a Conserved Inter-Transmembrane Domain Interface in Regulating α2a-Adrenergic Receptor Conformational Stability and Cell-Surface Turnover
2001
High-resolution crystal structure of human protease-activated receptor 1
2012 StandoutNatureNobel
G protein-coupled receptor interacting proteins: Emerging roles in localization and signal transduction
2002
Neurexophilin Binding to α-Neurexins
1998 StandoutNobel
The Three α2-Adrenergic Receptor Subtypes Achieve Basolateral Localization in Madin-Darby Canine Kidney II Cells via Different Targeting Mechanisms
1996
Identification of an Allosteric Binding Site for Zn2+on the β2 Adrenergic Receptor
2002 StandoutNobel
Allosteric Modulation of β2-Adrenergic Receptor by Zn2+
2002 StandoutNobel
Gene targeting — homing in on α2-adrenoceptor-subtype function
1997 StandoutNobel
Effect of Cell Type on the Subcellular Localization of the Thyrotropin-Releasing Hormone Receptor
1997
Genetic alteration of the α2-adrenoceptor subtype c in mice affects the development of behavioral despair and stress-induced increases in plasma corticosterone levels
1999 StandoutNobel
Cardiovascular effects of rilmenidine, moxonidine and clonidine in conscious wild‐type and D79N α2A‐adrenoceptor transgenic mice
1999
Substitution of three amino acids switches receptor specificity of Gqα to that of Giα
1993 StandoutNatureNobel
Roles of G protein subunits in transmembrane signalling
1988 Nature
Oligomerization of G-protein-coupled transmitter receptors
2001
Ligand Efficacy and Potency at Recombinant α2 Adrenergic Receptors
1998
Stimulation of Mitogen-activated Protein Kinase by G Protein-coupled α2-Adrenergic Receptors Does Not Require Agonist-elicited Endocytosis
1999
Impaired formation of beta-adrenergic receptor-nucleotide regulatory protein complexes in pseudohypoparathyroidism.
1984 StandoutNobel
Multiple second messenger pathways of alpha-adrenergic receptor subtypes expressed in eukaryotic cells.
1990 StandoutNobel
α2-Adrenergic Receptor Stimulation Mobilizes Intracellular Ca2+ in Human Erythroleukemia Cells
1989
Influence of sodium on the alpha 2-adrenergic receptor system of human platelets. Role for intraplatelet sodium in receptor binding.
1983
G z -Mediated Hormonal Inhibition of Cyclic AMP accumulation
1992 Science
Activation of alpha 1-adrenoceptors, protein kinase C, or treatment with intracellular free Ca2+ elevating agents increases pineal phospholipase A2 activity. Evidence that protein kinase C may participate in Ca2+-dependent alpha 1-adrenergic stimulation of pineal phospholipase A2 activity.
1987
Role of Ni in coupling angiotensin receptors to inhibition of adenylate cyclase in hepatocytes.
1985
Cloning, sequence analysis, and permanent expression of a human α2-adrenergic receptor in Chinese hamster ovary cells
1989
Adenylate cyclase permanently uncoupled from hormone receptors in a novel variant of S49 mouse lymphoma cells.
1977 StandoutNobel
Drug Efficacy at G Protein–Coupled Receptors
2002
Resolution of some components of adenylate cyclase necessary for catalytic activity.
1977 StandoutNobel
Coupling of opiate receptors to adenylate cyclase: requirement for Na+ and GTP.
1979
Molecular Mechanisms of Coupling in Hormone Receptor‐Adenylate Cyclase Systems
1982 StandoutNobel
Purification and characterization of the human platelet alpha 2-adrenergic receptor.
1986 StandoutNobel
In vitro and in vivo down-regulation of human platelet? 2-adrenoceptors by clonidine
1982
Resolution, reconstitution and kinetics of the primary action of a hormone receptor
1980 Nature
Effects of phospholipase A2 and filipin on the activation of adenylate cyclase
1979 StandoutNobel
Intracellular targeting and trafficking of thrombin receptors. A novel mechanism for resensitization of a G protein-coupled receptor.
1994 StandoutNobel
Guanine nucleotide-binding regulatory proteins and dual control of adenylate cyclase.
1984 StandoutNobel
Heterogeneity of radioligand binding to alpha-adrenergic receptors. Analysis of guanine nucleotide regulation of agonist binding in relation to receptor subtypes.
1980 StandoutNobel
A Point Mutation of the α 2 -Adrenoceptor that Blocks Coupling to Potassium but not Calcium Currents
1992 Science
Reciprocal modulation of agonist and antagonist binding to muscarinic cholinergic receptor by guanine nucleotide.
1982 StandoutNobel
Mammalian beta-adrenergic receptors. Structural differences in beta 1 and beta 2 subtypes revealed by peptide maps.
1983 StandoutNobel
G Proteins and Regulation of Adenylyl Cyclase
1989 StandoutNobel
Hormonal inhibition of adenylate cyclase. alpha 2 Adrenergic receptors promote release of [3H]guanylylimidodiphosphate from platelet membranes.
1982 StandoutNobel
Identification of the subunit-binding site of alpha 2-adrenergic receptors using [3H]phenoxybenzamine.
1984 StandoutNobel
Recombinant Gq alpha. Mutational activation and coupling to receptors and phospholipase C.
1992
Preferential uncoupling by manganese of alpha adrenergic receptor mediated inhibition of adenylate cyclase in human platelets
1981 StandoutNobel
Heterozygous α 2A -adrenergic receptor mice unveil unique therapeutic benefits of partial agonists
2002 StandoutNobel
Deficient activity of guanine nucleotide regulatory protein in erythrocytes from patients with pseudohypoparathyroidism
1980
The hamster adipocyte adenylate cyclase system I. Regulation of enzyme stimulation and inhibition by manganese and magnesium ions
1981
Structure of the turkey erythrocyte adenylate cyclase system.
1981 StandoutNobel
Hypothyroidism modulates beta adrenergic receptor adenylate cyclase interactions in rat reticulocytes.
1981 StandoutNobel
Correlation of beta-adrenergic receptor-stimulated [3H]GDP release and adenylate cyclase activation. Differences between frog and turkey erythrocyte membranes.
1981 StandoutNobel
Molecular and Regulatory Properties of Adrenergic Receptors
1987 StandoutNobel
In Vitro Desensitization of Beta Adrenergic Receptors in Human Neutrophils. ATTENUATION BY CORTICOSTEROIDS
1983 StandoutNobel
Mammalian beta-adrenergic receptors. Distinct glycoprotein populations containing high mannose or complex type carbohydrate chains.
1984 StandoutNobel
Biophysical characterization of the purified alpha 1-adrenergic receptor and identification of the hormone binding subunit.
1982
Substitution of a mutant α 2a -adrenergic receptor via “hit and run” gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo
1997
Differential regulation of the α2-adrenergic receptor by Na+ and guanine nucleotides
1980 StandoutNatureNobel
Tentative identification of β-adrenoreceptor subunits
1978 Nature
Adrenergic receptors. Models for the study of receptors coupled to guanine nucleotide regulatory proteins.
1988 StandoutNobel
Mutation of the α2A-Adrenoceptor Impairs Working Memory Performance and Annuls Cognitive Enhancement by Guanfacine
2002 StandoutNobel
The disaggregation theory of signal transduction revisited: further evidence that G proteins are multimeric and disaggregate to monomers when activated.
1993 StandoutNobel
Decreased Lymphocyte Beta-Adrenergic-Receptor Density in Patients with Heart Failure and Tolerance to the Beta-Adrenergic Agonist Pirbuterol
1981
Isolation of adenylate cyclase-free, beta-adrenergic receptor from turkey erythrocyte membranes by affinity chromatography.
1977
Hydrodynamic properties of the beta-adrenergic receptor and adenylate cyclase from wild type and varient S49 lymphoma cells.
1977 StandoutNobel
Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family.
1994 StandoutNobel
Central Hypotensive Effects of the α 2a -Adrenergic Receptor Subtype
1996 Science
Molecular comparison of alpha 1- and alpha 2-adrenergic receptors suggests that these proteins are structurally related "isoreceptors".
1985
Mechanisms Regulating the Cell Surface Residence Time of the α2A-Adrenergic Receptor
2000
Catecholamine-specific desensitization of adenylate cyclase. Evidence for a multistep process.
1980
Mechanisms of Membrane-Receptor Regulation
1984 StandoutNobel
Functional reconstitution of beta-adrenergic receptors and the stimulatory GTP-binding protein of adenylate cyclase.
1982
Reconstitution of catecholamine-sensitive adenylate cyclase activity: interactions of solubilized components with receptor-replete membranes.
1977 StandoutNobel
A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.
1980 StandoutNobel
Allosteric activation of the CaR by l -amino acids
2000 StandoutNobel
Activation of adenylate cyclase in hepatic membranes involves interactions of the catalytic unit with multimeric complexes of regulatory proteins.
1979 StandoutNobel
Cloning, Sequencing, and Expression of the Gene Coding for the Human Platelet α 2 -Adrenergic Receptor
1987 StandoutScienceNobel
The guanine nucleotide activating site of the regulatory component of adenylate cyclase. Identification by ligand binding.
1982 StandoutNobel
Molecular mechanism of mitogen action: Processing of receptor induced by epidermal growth factor
1978
Reconstitution of catecholamine-sensitive adenylate cyclase. Reconstitution of the uncoupled variant of the S40 lymphoma cell.
1979 StandoutNobel
A point mutation in the seventh hydrophobic domain of the alpha 2 adrenergic receptor increases its affinity for a family of beta receptor antagonists
1991 StandoutNobel
β-Adrenoreceptors determine affinity but not intrinsic activity of adenylate cyclase stimulants
1979 StandoutNatureNobel
A Point Mutation (D79N) of the α2A Adrenergic Receptor Abolishes the Antiepileptogenic Action of Endogenous Norepinephrine
1998
Relationship between the beta-adrenergic receptor and adenylate cyclase.
1977 StandoutNobel
Atypical characteristics of frog and chick erythrocyte β-adrenoceptors
1981
The Binding Site of Aminergic G Protein–Coupled Receptors: The Transmembrane Segments and Second Extracellular Loop
2002
Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase. Structural alterations in the beta-adrenergic receptor revealed by photoaffinity labeling.
1982 StandoutNobel
Characterization of α1-and α2-Adrenergic Receptors
1983
A high affinity agonist . beta-adrenergic receptor complex is an intermediate for catecholamine stimulation of adenylate cyclase in turkey and frog erythrocyte membranes.
1980 StandoutNobel
Parallel modulation of catecholamine activation of adenylate cyclase and formation of the high-affinity agonist.cntdot.receptor complex in turkey erythrocyte membranes by temperature and cis-vaccenic acid
1980 StandoutNobel
Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts
1982 Standout
Immunoprecipitation of alpha 2a-adrenergic receptor-GTP-binding protein complexes using GTP-binding protein selective antisera. Changes in receptor/GTP-binding protein interaction following agonist binding.
1992
Reconstitution of hormone-sensitive adenylate cyclase activity with resolved components of the enzyme.
1978 StandoutNobel
The Human 5-HT1A Receptor Expressed in HeLa Cells Stimulates Sodium-dependent Phosphate Uptake via Protein Kinase C
1989 StandoutNobel
Characterization of transducin from bovine retinal rod outer segments. I. Separation and reconstitution of the subunits.
1983
Agonist-induced increase in apparent β-adrenergic receptor size
1978 StandoutNobel
Gene targeting — homing in on α2-adrenoceptor-subtype function
1997 StandoutNobel
Sites in the third intracellular loop of the alpha 2A-adrenergic receptor confer short term agonist-promoted desensitization. Evidence for a receptor kinase-mediated mechanism.
1992 StandoutNobel
Activation and desensitization of beta-adrenergic receptor-coupled GTPase and adenylate cyclase of frog and turkey erythrocyte membranes.
1980 StandoutNobel
Differential effects of GTP on the coupling of β-adrenergic receptors to adenylate cyclase from frog and turkey erythrocytes application of new methods for the analysis of receptor-effector coupling
1979 StandoutNobel
125I-labeled p-azidobenzylcarazolol, a photoaffinity label for the beta-adrenergic receptor. Characterization of the ligand and photoaffinity labeling of beta 1- and beta 2-adrenergic receptors.
1982 StandoutNobel
Affinity chromatography of the beta-adrenergic receptor.
1979 StandoutNobel
Hormone-sensitive adenylate cyclase. Delineation of a trypsin-sensitive site in the pathway of receptor-mediated inhibition.
1982 StandoutNobel
Affinity chromatography of human platelet α 2 -adrenergic receptors
1982 StandoutNobel
Pertussis toxin substrate, the putative Ni component of adenylyl cyclases, is an alpha beta heterodimer regulated by guanine nucleotide and magnesium.
1983
Desensitization of the beta-adrenergic receptor of frog erythrocytes. Recovery and characterization of the down-regulated receptors in sequestered vesicles.
1983 StandoutNobel
Works of L E Limbird being referenced
Monovalent cation and amiloride analog modulation of adrenergic ligand binding to the unglycosylated alpha 2B-adrenergic receptor subtype.
1991
Sodium ion modulates agonist and antagonist interactions with the human platelet alpha 2-adrenergic receptor in membrane and solubilized preparations.
1982
Summary of the ASPET-sponsored Colloquium: Alpha-2 adrenergic receptors: structure, function, and therapeutic implications, October 25-27, 1995.
1996
EXPRESSION OF α 2 -ADRENERGIC RECEPTOR SUBTYPES IN THE MOUSE BRAIN: EVALUATION OF SPATIAL AND TEMPORAL INFORMATION IMPARTED BY 3 kb OF 5′ REGULATORY SEQUENCE FOR THE α 2A AR-RECEPTOR GENE IN TRANSGENIC ANIMALS
1996
In Vivo Mutation of the α2A-Adrenergic Receptor by Homologous Recombination Reveals the Role of This Receptor Subtype in Multiple Physiological Processes
1997
Evidence that human platelet alpha-adrenergic receptors coupled to inhibition of adenylate cyclase are not associated with the subunit of adenylate cyclase ADP-ribosylated by cholera toxin.
1982
Solubilization of human platelet alpha-adrenergic receptors: evidence that agonist occupancy of the receptor stabilizes receptor--effector interactions.
1981
Mutational analysis of the ligand binding domain of the low density lipoprotein receptor.
1988 Nobel
GTP and Na+ modulate receptor-adenyl cyclase coupling and receptor-mediated function
1984
Purification of the alpha 2-adrenergic receptor from porcine brain using a yohimbine-agarose affinity matrix.
1987
Negative cooperativity among beta-adrenergic receptors in frog erythrocyte membranes.
1976 StandoutNobel
Regulation of Adenylate Cyclase Coupled β-Adrenergic Receptors
1976 StandoutNobel
Coupling of the alpha 2A-adrenergic receptor to multiple G-proteins. A simple approach for estimating receptor-G-protein coupling efficiency in a transient expression system.
1994
Agonist-promoted coupling of the beta-adrenergic receptor with the guanine nucleotide regulatory protein of the adenylate cyclase system.
1980 StandoutNobel
Activation and attenuation of adenylate cyclase. The role of GTP-binding proteins as macromolecular messengers in receptor–cyclase coupling
1981
Mutation of an aspartate residue highly conserved among G-protein-coupled receptors results in nonreciprocal disruption of alpha 2-adrenergic receptor-G-protein interactions. A negative charge at amino acid residue 79 forecasts alpha 2A-adrenergic receptor sensitivity to allosteric modulation by monovalent cations and fully effective receptor/G-protein coupling.
1994
Unique uncoupling of the frog erythrocyte adenylate cyclase system by manganese. Loss of hormone and guanine nucleotide-sensitive enzyme activities without loss of nucleotide-sensitive, high affinity agonist binding.
1979 StandoutNobel
The alpha 2A-adrenergic receptor is targeted directly to the basolateral membrane domain of Madin-Darby canine kidney cells independent of coupling to pertussis toxin-sensitive GTP-binding proteins
1993
Mutations of the alpha 2A-adrenergic receptor that eliminate detectable palmitoylation do not perturb receptor-G-protein coupling.
1993
Evidence that Na+/H+ exchange regulates receptor-mediated phospholipase A2 activation in human platelets.
1986
Genetic evidence for involvement of multiple effector systems in alpha 2A-adrenergic receptor inhibition of stimulus-secretion coupling.
1996
Regulation of porcine brain alpha 2-adrenergic receptors by Na+,H+ and inhibitors of Na+/H+ exchange.
1987
Alpha 2-adrenergic receptors accelerate Na+/H+ exchange in neuroblastoma X glioma cells.
1987
Unique structural features important for stabilization versus polarization of the alpha 2A-adrenergic receptor on the basolateral membrane of Madin-Darby canine kidney cells.
1994
Loss of beta-adrenergic receptor-guanine nucleotide regulatory protein interactions accompanies decline in catecholamine responsiveness of adenylate cyclase in maturing rat erythrocytes.
1980 StandoutNobel
Cloning, sequencing, and expression of the gene encoding the porcine alpha 2-adrenergic receptor. Allosteric modulation by Na+, H+, and amiloride analogs.
1990
Inhibitors of Na+/H+ exchange block epinephrine- and ADP-induced stimulation of human platelet phospholipase C by blockade of arachidonic acid release at a prior step.
1986
The alpha(2a)-adrenergic receptor plays a protective role in mouse behavioral models of depression and anxiety.
2001
The hydrophobic tryptic core of the porcine alpha 2-adrenergic receptor retains allosteric modulation of binding by Na+, H+, and 5-amino-substituted amiloride analogs.
1990
Evidence that a beta-adrenergic receptor-associated guanine nucleotide regulatory protein conveys guanosine 5'-O-(3-thiotriphosphate)- dependent adenylate cyclase activity.
1981 StandoutNobel
Resolution of beta-adrenergic receptor binding and adenylate cyclase activity by gel exclusion chromatography.
1977 StandoutNobel
An aspartate conserved among G-protein receptors confers allosteric regulation of alpha 2-adrenergic receptors by sodium.
1990