Standout Papers
- Central dopamine receptor agonist and antagonist actions of the enantiomers of 3-PPP (1983)
- 8-hydroxy-2-(di-n-propylamino)tetralin, 8-OH-DPAT, a potent and selective simplified ergot congener with central 5-HT-receptor stimulating activity (1982)
- Effects of a new type of 5-HT receptor agonist on male rat sexual behavior (1981)
- 3-PPP, a new centrally acting DA-receptor agonist with selectivity for autoreceptors (1981)
- A homologous series of N-alkylated cis-(+)-(1 S, 2 R)-5-methoxy-1-methyl-2-aminotetralins: Central dopamine receptor antagonists showing profiles ranging from classical antagonism to selectivity for autoreceptors (1986)
- (+)-UH 232 and (+)-UH 242: Novel stereoselective dopamine receptor antagonists with preferential action on autoreceptors (1986)
Citation Impact
Citing Papers
Agonist and antagonist effects of 3-PPP enantiomers on functional dopamine autoreceptors and postsynaptic dopamine receptors in vitro
1985
Behavioral and biochemical effects of subchronic treatment with (?)3-(3-hydroxyphenyl)-N-n-propylpiperidine in the rat: Dopamine receptor sensitivity and tolerance
1984
Antipsychotic-like profile of combined treatment with raclopride and 8-OH-DPAT in the rat: enhancement of antipsychotic-like effects without catalepsy
1991
Mixed agonist/antagonist properties of NAN-190 at 5-HT1A Receptors: Behavioural and in vivo brain microdialysis studies
1990
5-HT1D Receptors Regulate 5-HT Release in the Rat Raphe Nuclei In Vivo Voltammetry and In Vitro Superfusion Studies
1995
WAY100135: a novel, selective antagonist at presynaptic and postsynaptic 5-HT1A receptors
1993
In vivo dopamine (DA) receptor binding and behavioural effects of the putative DA autoreceptor antagonists (+)-AJ 76 and (+)-UH 232 in rats with a unilateral nigral 6-OH-DA lesion
1988 Nobel
The inhibitory effect of 8-OH-DPAT on the firing activity of dorsal raphe serotoninergic neurons in rats is attenuated by lesion of the frontal cortex
1994
The influence of 5‐HT2and 5‐HT4receptor antagonists to modify drug induced disinhibitory effects in the mouse light/dark test
1997
Behavioral and neurochemical data suggest functional differences between dopamine D2 and D3 receptors
1994 StandoutNobel
Biochemical and pharmacological studies on pramipexole, a potent and selective dopamine D2 receptor agonist
1992
Electrophysiological evidence for a functional differentiation between subtypes of the 5-HT1 receptor
1988
5‐HT1 agonists reduce 5‐hydroxytryptamine release in rat hippocampus in vivo as determined by brain microdialysis
1989
Neural and developmental actions of lithium: A unifying hypothesis
1989 Standout
5-Hydroxytryptamine1 recognition sites in rat brain: Heterogeneity of non-5-hydroxytryptamine1a/1c binding sites revealed by quantitative receptor autoradiography
1993
Further assessment of the antagonist properties of the novel and selective 5-HT1A receptor ligands (+)-WAY 100 135 and SDZ 216–525
1993
Further investigation of the in vivo pharmacological properties of the putative 5-HT1A antagonist, BMY 7378
1990
Partial dopamine receptor agonists reverse behavioral, biochemical and neuroendocrine effects of neuroleptics in the rat: Potential treatment of extrapyramidal side effects
1993 StandoutNobel
Effects of sertraline and citalopram given repeatedly on the responsiveness of 5-HT receptor subpopulations
1992
Network interactions in schizophrenia — therapeutic implications
2000 StandoutNobel
The role of 5-HT1D and 5-HT1A receptors in mediating 5-hydroxytryptophan induced myoclonic jerks in guinea pigs
1995
Immunocytochemical localization of serotonin1A receptors in the rat central nervous system
1996
5-HT1 receptors and behavior
1992
Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics
1990 StandoutNature
Application of brain microdialysis to study the pharmacology of the 5-HT1A autoreceptor
1990
Suppression of neuroleptic-induced persistent abnormal movements in Cebus apella monkeys by enantiomers of 3-PPP
1988
Effects of local application of 5-HT and 8-OH-DPAT into the dorsal and median raphe nuclei on core temperature in the rat
1991
The 5‐HT1B Receptors
1990
Pharmacologic properties of (?)-3PPP (preclamol) in man
1992 StandoutNobel
Neurochemical profile of the selective and silent 5-HT1A receptor antagonist WAY100135: an in vivo microdialysis study
1993
Region-selective activation of brain monoamine synthesis by sexual activity in the male rat
1987 StandoutNobel
An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior
2005 StandoutNobel
Antipsychotic Properties of the Partial Dopamine Agonist (−)-3-(3-Hydroxyphenyl)-N-n-Propylpiperidine (Preclamol) in Schizophrenia
1998 StandoutNobel
Direct evidence for an important species difference in the mechanism of 8‐OH‐DPAT‐induced hypothermia
1991
A review of central 5-HT receptors and their function
1999 Standout
Neurotransmitter interactions in schizophrenia—therapeutic implications
1999 StandoutNobel
Dopamine (DA) autoreceptor efficacy of 3-PPP enantiomers after short-term synaptic DA deprivation
1988
Review: D1 dopamine receptor—the search for a function: A critical evaluation of the D1/D2 dopamine receptor classification and its functional implications
1987
The genomic clone G-21 which resembles a β-adrenergic receptor sequence encodes the 5-HT1A receptor
1988 StandoutNatureNobel
8-hydroxy-2-(di-N-propylamino) tetralin, a selective serotonin1A receptor agonist, blocks haloperidol-induced catalepsy by an action on raphe nuclei medianus and dorsalis
1988
Effects of MDL 73005EF on central pre- and postsynaptic 5-HT1A receptor function in the rat in vivo
1990
Electrophysiological, biochemical, neurohormonal and behavioural studies with WAY-100635, a potent, selective and silent 5-HT1A receptor antagonist
1995
Differential agonist profile of the enantiomers of 3‐PPP at striatal dopamine autoreceptors: Dependence on extracellular dopamine
1991
Effects of 8‐OHDPAT and 5‐HT1A antagonists WAY100135 and WAY100635, on guinea‐pig behaviour and dorsal raphe 5‐HT neurone firing
1996
The 5-HT1A receptor antagonist (S)-UH-301 blocks the (R)-8-OH-DPAT-induced inhibition of serotonergic dorsal raphe cell firing in the rat
1994
Molecular Basis of Buspirone's Anxiolytic Action
1991
Dopaminergic Supersensitivity in G Protein-Coupled Receptor Kinase 6-Deficient Mice
2003 StandoutNobel
Ultrastructural localization of 5-hydroxytryptamine1A receptors in the rat brain
1996
Differential effects of dopamine D2 and D3 receptor antagonists in regard to dopamine release, in vivo receptor displacement and behaviour
1994 StandoutNobel
Differential Regulation of Dopamine D1A Receptor Responsiveness by Various G Protein-coupled Receptor Kinases
1996 StandoutNobel
In vivo receptor binding, neurochemical and functional studies with the dopamine D-1 receptor antagonist SCH 23390
1988 StandoutNobel
Sigma-1 Receptor Chaperones at the ER- Mitochondrion Interface Regulate Ca2+ Signaling and Cell Survival
2007 Standout
Behavioural and biochemical consequences following activation of 5HT1-like and GABA receptors in the dorsal raphé nucleus of the rat
1988
Molecular Characterization of a Functional cDNA Encoding the Serotonin 1c Receptor
1988 StandoutScienceNobel
Pharmacological Specificity of Conditioned Avoidance Response Inhibition in Rats: Inhibition by Neuroleptics and Correlation to Dopamine Receptor Blockade
1982
Effects of B‐HT 920 and B‐HT 933 on Dopamine and Noradrenaline Autoreceptors in the Rat Brain
1983
Is inhibitio of striatal synaptosomal tyrosine hydroxylation by dopamine agonists a measure of dopamine autoreceptor function?
1985
The effects of SCH 23390, YM 09151-2, (+)- and (−)-3-PPP and some classical neuroleptics on D-1 and D-2 receptors in rat neostriatum in vitro
1984
The putatively selective dopamine autoreceptor antagonists (+)-AJ 76 and (+)-UH 232 stimulate prolactin release in rats
1986 StandoutNobel
Is 3-PPP a potential antipsychotic agent? Evidence from animal behavioural studies
1982 StandoutNobel
Catalytic decomposition of diazomethane as a general method for the methylenation of chemical compounds
1993
The yawning-penile erection syndrome as a model for putative dopamine autoreceptor activity
1984
Central dopaminergic properties of HW-165 and its enantiomers; Trans-octahydrobenzo(f)quinoline congeners of 3-PPP
1986 StandoutNobel
Effects of (-)3-PPP on acquisition and retention of a conditioned avoidance response in the rat
1984
A review of the biochemical and neuropharmacological actions of lithium
1987
An efficient resolution of 3-PPP and assignment of the absolute configuration.
1983
Is TL-99 a selective presynaptic dopamine receptor agonist?
1982
In vitro effect of the racemic mixture and the (?)enantiomer of N-n-propyl-3-(3-hydroxyphenyl)-piperidine (3-PPP) on postsynaptic dopamine receptors and on a presynaptic dopamine autoreceptor
1983
Differential effects of the enantiomers of 3-(3-hydroxyphenyl)-N-n-propylpiperidine (3-PPP) at dopamine receptors sites
1983
Characterization of dopamine autoreceptor and [3H]spiperone binding sites in vitro with classical and novel dopamine receptor agonists
1983
Dopamine agonist activity of EMD 23,448
1985
Effects of apomorphine, TL-99 and 3-PPP on yawning in rats
1984
Anticonflict effect of the putative serotonin receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)
1984 StandoutNobel
Pharmacological analysis of the behavioural and thermoregulatory effects of the putative 5-HT1 receptor agonist, RU 24969, in the rat
1986
5-HT1c receptor is a prominent serotonin receptor subtype in the central nervous system.
1989 StandoutNobel
Serotonin receptors in the human brain. I. Characterization and autoradiographic localization of 5-HT1A recognition sites. Apparent absence of 5-HT1B recognition sites
1986
Further functional in vitro comparison of pre- and postsynaptic dopamine receptors in the rabbit caudate nucleus
1983
Serotonin receptors in the human brain. II. Characterization and autoradiographic localization of 5-HT1C and 5-HT2 recognition sites
1986
Molecular pharmacology of 5-HT1 and 5-HT2 recognition sites in rat and pig brain membranes: Radioligand binding studies with [3H]5-HT, [3H]8-OH-DPAT, (−)[125I]iodocyanopindolol, [3H]mesulergine and [3H]Ketanserin
1985
Dopamine receptor agonistic and antagonistic effects of 3-PPP enantiomers
1983
The Pharmacological Characterization of a Novel Selective 5-Hydroxytryptamine1A Receptor Antagonist, NAD-299
1997
Effect of 8-hydroxy-2-(di-n-propylamino) tetralin on rat prolactin secretion
1984
Stereoselectivity and generality of the palladium-catalysed cyclopropanation of α,β-unsaturated carboxylic acids derivatized with Oppolzer's sultam
1994
Nervous system distribution of the serotonin 5-HT3 receptor mRNA.
1993 StandoutNobel
Antidyskinetic action of 3-PPP, a selective dopaminergic autoreceptor agonist, in Cebus monkeys with persistent neuroleptic-induced dyskinesias
1983 StandoutNobel
Presynaptic dopaminergic agonists modify brain glucose metabolism in a way similar to the neuroleptics
1984
Dopamine D2 receptors in brain and anterior pituitary recognize agonist and antagonist actions of (?)-3-PPP
1985
Dopamine autoreceptor antagonists: Effects on sleep-wake activity in the rat
1987 StandoutNobel
Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors
1985 Standout
Dopamine autoreceptors and the effects of drugs on locomotion and dopamine synthesis
1985 StandoutNobel
Rat brain serotonin: Biochemical and functional evidence for a sex difference
1985 StandoutNobel
Stereoselective Cyclopropanation Reactions
2003 Standout
Interaction of (+)- and (−)-3-PPP with the dopamine receptor in the anterior pituitary gland
1984
Is pindolol a mixed agonist-antagonist at central serotonin (5-HT) receptors?
1986 StandoutNobel
Distribution and cellular localization of mRNA coding for 5-HT1A receptor in the rat brain: correlation with receptor binding
1992
Catalytic Cyclopropanation of Alkenes Using Diazo Compounds Generated in Situ. A Novel Route to 2-Arylcyclopropylamines
2001
Dopamine Synthesis in Synaptosomes: Relation of Autoreceptor Functioning to pH, Membrane Depolarization, and Intrasynaptosomal Dopamine Content
1984
Avoidance and ICSS behavioral models dissociate TL-99 and 3-PPP from dopamine receptor antagonists
1983
The 5HT2 receptor defines a family of structurally distinct but functionally conserved serotonin receptors.
1990 StandoutNobel
8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site
1983
Effect of dopaminergic drugs on striatal acetylcholine concentration
1985
Differential effects of the enantiomers of 3-PPP on dopamine D1-receptors of isolated rabbit retina
1984
Similarities of the effects of apomorphine and 3-PPP on serotonin neurons
1983
Blockade of the central 5-HT autoreceptor by β-adrenoceptor antagonists
1986
Differential behavioural effects of dopamine agonists in developing rats: A study of 3-PPP enantiomers
1983
The binding of serotonergic ligands to the porcine choroid plexus: Characterization of a new type of serotonin recognition site
1984
Sub-chronic administration of (?)-3-PPP and central dopamine receptor sensitivity changes
1985 StandoutNobel
Anxiolytic-like action of the 3-PPP enantiomers in the Vogel conflict paradigm
1987 StandoutNobel
Stimulation of presynaptic dopamine autoreceptors by 4-(2-di-n-propylaminoethyl) indole (DPAI)
1984
trans-N-n-propyl-7-hydroxy-octahydrobenzo(f)quinoline, a rigid 3-PPP analogue with greater potency but lack of selectivity for dopamine autoreceptors
1983
Pharmacological profiles of the putative dopamine autoreceptor agonists 3-PPP and TL-99
1981
Perspectives on the Discovery of Central Monoaminergic Neurotransmission
1987 StandoutNobel
Differential effects of the stereoisomers of 3PPP in dopaminergic and cholinergic neurotransmission in superfused slices of the corpus striatum
1984
Psychotomimetic opiate receptors labeled and visualized with (+)-[3H]3-(3-hydroxyphenyl)-N-(1-propyl)piperidine.
1984
Dopamine-receptor agonists: Mechanisms underlying autoreceptor selectivity
1985 StandoutNobel
Action of putative dopamine receptor agonists, TL-99, 3-PPP and RDS-127 on substantia nigra neurons
1984
The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.
1986 Standout
Modifications of sleep parameters in the rat by (+)- and (-)-3-PPP
1985
Failure of 3-PPP to activate dopamine autoreceptors in vitro
1983
Dopamine receptors involved in prolactin secretion pharmacologically characterized by means of 3-PPP enantiomers
1983 StandoutNobel
Receptor mechanisms in antipsychotic drug action: focus on sigma receptors
1989
Differential electrophysiological effects of 3-PPP and its enantiomers on dopamine autoreceptors and postsynaptic receptors
1986
Enantioselective synthesis of chiral cyclopropane compounds through microbial transformations of trans-2-arylcyclopropanecarbonitriles
2000
Dopamine receptor agonists: Intrinsic activity vs. state of receptor
1983 StandoutNobel
Assessment of dopamine autoreceptor agonist properties of apomorphine, (+)-3-PPP and (−)-3-PPP by recording of yawning behaviour in rats
1984
Effect of 3-PPP, a putative dopamine autoreceptor agonist, on rat serum prolactin levels
1981
Neuroscience: Breaking Down Scientific Barriers to the Study of Brain and Mind
2000 StandoutScienceNobel
(+)- and (−)-3-PPP exhibit different intrinsic activity at striatal dopamine autoreceptors controlling dopamine synthesis
1984 StandoutNobel
The effect of the enantiomers of 3-PPP on conditioned avoidance responding in the rat
1983 StandoutNobel
Thermoregulatory responses to serotonin (5-HT) receptor stimulation in the rat
1986
Antagonism by haloperidol of the suppression of exploratory locomotor activity induced by the local application of(−)3-(3-hydroxyphenyl)-N-n-propylpiperidine into the nucleus accumbens of the rat
1984
Complete Field Guide to Asymmetric BINOL-Phosphate Derived Brønsted Acid and Metal Catalysis: History and Classification by Mode of Activation; Brønsted Acidity, Hydrogen Bonding, Ion Pairing, and Metal Phosphates
2014 Standout
A Paradigm Shift in Brain Research
2001 ScienceNobel
Effect of COMT Val 108/158 Met genotype on frontal lobe function and risk for schizophrenia
2001 Standout
The involvement of subtypes of the 5-HT1 receptor and of catecholaminergic systems in the behavioural response to 8-hydroxy-2-(di-n-Propylamino) tetralin in the rat
1984
Dopamine-receptor agonist with apparent selectivity for autoreceptors: a new principle for antipsychotic action?
1982 StandoutNobel
Pharmacological Properties of Presynaptic Dopamine Receptor Agonists
1985 StandoutNobel
Characterization of the 5-HTIB recognition site in rat brain: Binding studies with (−)[125I]Iodocyanopindolol
1985
Stereoselective palladium-catalyzed cyclopropanation of α,β-unsaturated carboxylic acids derivatized with oppolzer's sultam
1991
Regioselective synthesis of 3-aryl substituted pyrrolidines via palladium catalyzed arylation: pharmacological evaluation for central dopaminergic and serotonergic activity.
1997 StandoutNobel
SEROTONIN 1A RECEPTORS ARE EXPRESSED BY A SUBPOPULATION OF CHOLINERGIC NEURONS IN THE RAT MEDIAL SEPTUM AND DIAGONAL BAND OF BROCA—A DOUBLE IMMUNOCYTOCHEMICAL STUDY
1996
Serotonin receptor knockouts: A moody subject
1998 StandoutNobel
Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region
1996 StandoutScience
Effects of putative dopamine autoreceptor agonists in pharmacological models related to dopaminergic and neuroleptic activity
1982
The pharmacology of the hypothermic response in mice to 8-hydroxy-2-(DI-n-propylamino)tetralin (8-OH-DPAT)
1985
Postsynaptic dopamine agonistic effects of 3-PPP enantiomers revealed by bilateral 6-hydroxy-dopamine lesions and by chronic reserpine treatment in rats
1984
Involvement of extrapyramidal motor mechanisms in the suppression of locomotor activity by antipsychotic drugs: A comparison between the effects produced by pre- and post-synaptic inhibition of dopaminergic neurotransmission
1986
[3H]8‐Hydroxy‐2‐(Di‐n‐Propylamino)Tetralin Binding to Pre‐ and Postsynaptic 5‐Hydroxytryptamine Sites in Various Regions of the Rat Brain
1985
Stereocontrolled cyclopropanation of α,β-unsaturated carboxamides derived from bicyclic amino alcohols
1994
An electrophysiological analysis of the actions of the 3-PPP enantiomers on the nigrostriatal dopamine system
1985 StandoutNobel
Stereoselective inhibition of prolactin secretion by (−)-HW-165, a novel 3-PPP congener; further support for similarities between central DA autoreceptors and pituitary lactotroph DA receptors
1986
The putative dopamine autoreceptor agonist B-HT 920 decreases nigral dopamine cell firing rate and prolactin release in rat
1985
Selective stimulation of dopamine and noradrenaline autoreceptors by B-HT 920 and B-HT 933, respectively
1982
(+)-AJ 76 and (+)-UH 232: Central stimulants acting as preferential dopamine autoreceptor antagonists
1986 StandoutNobel
Lack of functional evidence for the involvement of sigma opiate receptors in the actions of the 3-PPP enantiomers on central dopaminergic systems: Discrepancies between and observations
1985 StandoutNobel
Electrophysiological effects of the enantiomers of 3-PPP on neurons in the locus coeruleus of the rat
1986
Effects of dopamine agonists, catecholamine depletors, and cholinergic and GABAergic drugs on acute dyskinesias in squirrel monkeys
1983
Suppression of exploratory locomotor activity in the rat by the local application of 3-PPP enantiomers into the nucleus accumbens
1983
Biphasic effects of some dopamine agonists on striatal acetylcholine concentrations
1983
Dopamine receptor-mediated hypothermia induced in rats by (+)-, but not by (—)-3-PPP
1985 StandoutNobel
Characterisation of the mechanisms by which purported dopamine agonists reduce spontaneous locomotor activity of mice
1981
Works of L. -E. Arvidsson being referenced
N,N-Dialkylated monophenolic trans-2-phenylcyclopropylamines: novel central 5-hydroxytryptamine-receptor agonists
1988
Intrinsic activity of enantiomers of 8-hydroxy-2-(di-n-propylamino)tetralin and its analogs at 5-hydroxytryptamine1A receptors that are negatively coupled to adenylate cyclase.
1991
Cardiovascular effects in the Sprague-Dawley rat of 8−hydroxy−2(di- N-propylamino) tetralin, a selective 5−hydroxytryptamine receptor agonist
1985
Effects of a new type of 5-HT receptor agonist on male rat sexual behavior
1981 StandoutNobel
(+)-UH 232 and (+)-UH 242: Novel stereoselective dopamine receptor antagonists with preferential action on autoreceptors
1986 StandoutNobel
A homologous series of N-alkylated cis-(+)-(1 S, 2 R)-5-methoxy-1-methyl-2-aminotetralins: Central dopamine receptor antagonists showing profiles ranging from classical antagonism to selectivity for autoreceptors
1986 StandoutNobel
8-hydroxy-2-(di-n-propylamino)tetralin, 8-OH-DPAT, a potent and selective simplified ergot congener with central 5-HT-receptor stimulating activity
1982 StandoutNobel
3-PPP, a new centrally acting DA-receptor agonist with selectivity for autoreceptors
1981 StandoutNobel
Central dopamine receptor agonist and antagonist actions of the enantiomers of 3-PPP
1983 StandoutNobel