Citation Impact
Citing Papers
Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro
2003 StandoutNobel
Missense mutations but not allelic variants alter the function of ATM by dominant interference in patients with breast cancer
2002
Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion
2015 StandoutScienceNobel
C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion
2014 StandoutNobel
Circadian oscillation of nucleotide excision repair in mammalian brain
2009 StandoutNobel
Monoclonal Antibodies Generated Against Recombinant ATM Support Kinase Activity
2000
Telomeric Protein Pin2/TRF1 as an Important ATM Target in Response to Double Strand DNA Breaks
2001
Hallmarks of Cancer: The Next Generation
2011 Standout
Immunological disorders and DNA repair
2002
The many substrates and functions of ATM
2000
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
2006 StandoutNature
Ataxia‐telangiectasia, cancer and the pathobiology of the ATM gene
1999
Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1
2000
Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1
2000
Cell cycle checkpoint signaling through the ATM and ATR kinases
2001 Standout
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism
1999
The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein
2000
AMP-Activated Protein Kinase Induces a p53-Dependent Metabolic Checkpoint
2005
Radiation-induced Assembly of Rad51 and Rad52 Recombination Complex Requires ATM and c-Abl
1999 Nobel
Genetic Disorders Associated with Cancer Predisposition and Genomic Instability
1999
Checking in on Cds1 (Chk2): A checkpoint kinase and tumor suppressor
2002
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage
2001
The complexity of p53 modulation: emerging patterns from divergent signals
1998
Reconstitution of an ATM-Dependent Checkpoint that Inhibits Chromosomal DNA Replication following DNA Damage
2000
Chk2 kinase — a busy messenger
2001
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
2000 Nature
Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrest
2002
DNA Damage-dependent and -independent Phosphorylation of the hRad9 Checkpoint Protein
2001
Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response
2000 Nature
ATM and related protein kinases: safeguarding genome integrity
2003 Standout
A role for ATR in the DNA damage-induced phosphorylation of p53
1999
Human Homologs of Schizosaccharomyces pombe Rad1, Hus1, and Rad9 Form a DNA Damage-responsive Protein Complex
1999
ATM Is Activated in Response toN-Methyl-N′-nitro- N-nitrosoguanidine-induced DNA Alkylation
2002
ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response
2000 Nature
Telomere states and cell fates
2000 StandoutNatureNobel
DNA damage checkpoints in mammals
2005
The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53
1999
Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress
2000
ATR: an essential regulator of genome integrity
2008
ATM, a central controller of cellular responses to DNA damage
2001
Cloning and Characterization of a p53-related Protein Kinase Expressed in Interleukin-2-activated Cytotoxic T-cells, Epithelial Tumor Cell Lines, and the Testes
2001
Cancer Risk and the ATM Gene: a Continuing Debate
2000
Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase
2000
MDM2 — master regulator of the p53 tumor suppressor protein
2000
A role for p53 in base excision repair
2001
The Role of ATM in Telomere Structure and Function
2001
The controlling role of ATM in homologous recombinational repair of DNA damage
2000
Mutations in PNKP cause microcephaly, seizures and defects in DNA repair
2010
The Chk2 protein kinase
2004
DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?
2001
A unified view of the DNA-damage checkpoint
2002
Autophosphorylation of p110delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases invitro and invivo
1999
Telomeres Do D-Loop–T-Loop
1999 StandoutNobel
TopBP1 activates ATR through ATRIP and a PIKK regulatory domain
2008
Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm
2000 StandoutNobel
Functional Link between BLM Defective in Bloom's Syndrome and the Ataxia-telangiectasia-mutated Protein, ATM
2002
The Fanconi anaemia/BRCA pathway
2003
Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts
2000
ATM Mediates Phosphorylation at Multiple p53 Sites, Including Ser46, in Response to Ionizing Radiation
2002
ATM: Genome stability, neuronal development, and cancer cross paths
2001
Chromosomal breakage syndromes
1999
Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage
2002
Regulation of the p53 Tumor Suppressor Protein
1999
ATM Is Required for IκB Kinase (IKK) Activation in Response to DNA Double Strand Breaks
2001
Convergence of the Fanconi Anemia and Ataxia Telangiectasia Signaling Pathways
2002
Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products
2000 Nature
Recombinational DNA repair and human disease
2002
Interaction of c-Abl and p73α and their collaboration to induce apoptosis
1999 Nature
Nuclear Retention of ATM at Sites of DNA Double Strand Breaks
2001
A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage
2000 Nature
p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis
1999 StandoutNobel
Switching and Signaling at the Telomere
2001 StandoutNobel
Protein kinase CK1 is a p53‐threonine 18 kinase which requires prior phosphorylation of serine 15
1999
A Critical Role for Pin2/TRF1 in ATM-dependent Regulation
2002
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
The DNA damage response: putting checkpoints in perspective
2000 StandoutNature
Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks
2002
Signaling to p53
1998
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
2003 StandoutNature
The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability
2001 StandoutNobel
A DNA Damage–Induced p53 Serine 392 Kinase Complex Contains CK2, hSpt16, and SSRP1
2001
Substrate Specificities and Identification of Putative Substrates of ATM Kinase Family Members
1999
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
Short Dysfunctional Telomeres Impair Tumorigenesis in the INK4aΔ2/3 Cancer-Prone Mouse
1999 StandoutNobel
Mechanisms of switching on p53: a role for covalent modification?
1999
ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses
2001 Nature
Utilization of Oriented Peptide Libraries to Identify Substrate Motifs Selected by ATM
2000
Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability
2016 StandoutNobel
Caffeine Abolishes the Mammalian G2/M DNA Damage Checkpoint by Inhibiting Ataxia-Telangiectasia-mutated Kinase Activity
2000
Exploring complex networks
2001 StandoutNature
The DNA-dependent protein kinase
1999
ATM-dependent phosphorylation of nibrin in response to radiation exposure
2000
Loss of ATM sensitizes against O6-methylguanine triggered apoptosis, SCEs and chromosomal aberrations
2004
Caretaker tumour suppressor genes that defend genome integrity
2002
DNA Ligase IV Deficiency in Mice Leads to Defective Neurogenesis and Embryonic Lethality via the p53 Pathway
2000
Post-translational modification of p53 in tumorigenesis
2004
A role for casein kinase 2α in the Drosophila circadian clock
2002 StandoutNatureNobel
A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase
1999
ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK
1999
Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53
1999
Repair of and checkpoint response to topoisomerase I-mediated DNA damage
2003
Purification and Characterization of ATM from Human Placenta
2000
SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint
2002
The first 30 years of p53: growing ever more complex
2009 Standout
Cancer Risk in ATM Heterozygotes: A Model of Phenotypic and Mechanistic Differences between Missense and Truncating Mutations
1999
ATP Activates Ataxia-Telangiectasia Mutated (ATM) in Vitro
2003
ATM and ATR: networking cellular responses to DNA damage
2001
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
Multiple roles of ATM in monitoring and maintaining DNA integrity
2010
DNA Damage-Induced Activation of p53 by the Checkpoint Kinase Chk2
2000 Science
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
2011 StandoutNobel
Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells
2001 StandoutNobel
Purification and characterization of human DNA damage checkpoint Rad complexes
2001 StandoutNobel
Chk1 is an essential kinase that is regulated by Atr and required for the G2/M DNA damage checkpoint
2000
The scaffold protein Nde1 safeguards the brain genome during S phase of early neural progenitor differentiation
2014
Synthesis and Function of 3-Phosphorylated Inositol Lipids
2001 Standout
Reconstitution of a human ATR-mediated checkpoint response to damaged DNA
2007 StandoutNobel
eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation
2016 StandoutNatureNobel
Molecular Interaction Map of the Mammalian Cell Cycle Control and DNA Repair Systems
1999 Nobel
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures
2000
Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling
2010 StandoutNobel
Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase
2002
The Protein Kinase Complement of the Human Genome
2002 StandoutScience
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro
2000
CHK1 and CHK2 are differentially involved in mismatch repair–mediated 6-thioguanine-induced cell cycle checkpoint responses
2004
Ataxia telangiectasia mutated (Atm) is not required for telomerase-mediated elongation of short telomeres
2006 StandoutNobel
p53- and ATM-Dependent Apoptosis Induced by Telomeres Lacking TRF2
1999 Science
Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion
2000
Chk2/hCds1 functions as a DNA damage checkpoint in G1by stabilizing p53
2000
The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae
2002 StandoutNobel
THE GENETIC DEFECT IN ATAXIA-TELANGIECTASIA
1997
Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation.
2001
Hypoxia Links ATR and p53 through Replication Arrest
2002
An ATR- and Chk1-Dependent S Checkpoint Inhibits Replicon Initiation following UVC-Induced DNA Damage
2002
ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1
2001
Regulation of p53 Function and Stability by Phosphorylation
1999
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
Chk2 Activation Dependence on Nbs1 after DNA Damage
2001
Two Molecularly Distinct G2/M Checkpoints Are Induced by Ionizing Irradiation
2002
Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks
1999 Science
Surfing the p53 network
2000 StandoutNature
Purification and DNA binding properties of the ataxia-telangiectasia gene product ATM
1999
Mdm2: The Ups and Downs
1999
Regulation of p53 stability
1999
Cancer Genome Landscapes
2013 StandoutScience
ATM-dependent Phosphorylation of Human Rad9 Is Required for Ionizing Radiation-induced Checkpoint Activation
2001
A DNA Damage-Regulated BRCT-Containing Protein, TopBP1, Is Required for Cell Survival
2002
Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage
1999
P53 Binding Protein 1 (53bp1) Is an Early Participant in the Cellular Response to DNA Double-Strand Breaks
2000
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
2003 StandoutNobel
Pie1, a Protein Interacting with Mec1, Controls Cell Growth and Checkpoint Responses in Saccharomyces cerevisiae
2001
A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferation
2001 StandoutNobel
Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage
1999
Toward Maintaining the Genome: DNA Damage and Replication Checkpoints
2002
The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
2000
Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system
2000
Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair
2008 StandoutNobel
High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6
2001 StandoutNobel
Analysis of p53-regulated gene expression patterns using oligonucleotide arrays
2000
Identification and Characterization of a Novel and Specific Inhibitor of the Ataxia-Telangiectasia Mutated Kinase ATM
2004
Human DNA Repair Genes
2001 StandoutScienceNobel
DNA Damage Responses: Mechanisms and Roles in Human Disease
2008
Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase
2010 StandoutNobel
Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G 1 /S checkpoint activation in response to DNA damage
2001
hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage
1999 StandoutNobel
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination
2014 StandoutNobel
The human Rad9–Rad1–Hus1 checkpoint complex stimulates flap endonuclease 1
2004 StandoutNobel
Mdm2: the ups and downs.
1999
Preferential binding of ATR protein to UV-damaged DNA
2002 StandoutNobel
Repair of DNA–polypeptide crosslinks by human excision nuclease
2006 StandoutNobel
ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response
2001
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
2004 StandoutNobel
ATAXIA-TELANGIECTASIA AND THE NIJMEGEN BREAKAGE SYNDROME: Related Disorders But Genes Apart
1997
A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage
1999
Works of L. Chessa being referenced
True
2000
Modulation of radiation-induced chromosomal damage by inhibitors of DNA repair and flow cytometric analysis in ataxia telangiectasia cells with ‘intermediate radiosensitivity’
1995
The novel human gene aprataxin is directly involved in DNA single-strand-break repair
2005
Heterogeneity in ataxia‐telangiectasia: Classical phenotype associated with intermediate cellular radiosensitivity
1992
Localization of an ataxia-telangiectasia locus to a 3-cM interval on chromosome 11q23: linkage analysis of 111 families by an international consortium.
1991
Localization of an ataxia-telangiectasia gene to an approximately 500-kb interval on chromosome 11q23.1: linkage analysis of 176 families by an international consortium.
1995
A variant of the Nijmegen breakage syndrome with unusual cytogenetic features and intermediate cellular radiosensitivity.
1997
Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage
1998 StandoutScience
Radiosensitivity of ataxia-telangiectasia, X-linked agammaglobulinemia, and related syndromes using a modified colony survival assay.
1994