Citation Impact
Citing Papers
CD4+ Count–Guided Interruption of Antiretroviral Treatment
2006 Standout
Bifluoride Ion Mediated SuFEx Trifluoromethylation of Sulfonyl Fluorides and Iminosulfur Oxydifluorides
2019 StandoutNobel
Novel therapeutic strategies targeting HIV integrase
2012
Aminothienopyridazines and Methylene Blue Affect Tau Fibrillization via Cysteine Oxidation
2013
Magnesium-cationic Dummy Atom Molecules Enhance Representation of DNA Polymerase β in Molecular Dynamics Simulations: Improved Accuracy in Studies of Structural Features and Mutational Effects
2006 StandoutNobel
Understanding organofluorine chemistry. An introduction to the C–F bond
2007 Standout
Visible light photoredox catalysis: applications in organic synthesis
2010 Standout
Modifying enzyme activity and selectivity by immobilization
2012 Standout
X-Ray Structure of Acid-Sensing Ion Channel 1–Snake Toxin Complex Reveals Open State of a Na+-Selective Channel
2014 StandoutNobel
The role of autophagy in neurodegenerative disease
2013 Standout
Fragment-based approaches to enzyme inhibition
2007
Amiloride Docking to Acid-sensing Ion Channel-1
2010
Frequent hitters: nuisance artifacts in high-throughput screening
2020
Sphingolipids and their metabolism in physiology and disease
2017 Standout
Coupling between endocytosis and sphingosine kinase 1 recruitment
2014
Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse
2016
Catalysis for fluorination and trifluoromethylation
2011 StandoutNature
Introduction of Fluorine and Fluorine‐Containing Functional Groups
2013 Standout
Principles of bioactive lipid signalling: lessons from sphingolipids
2008 Standout
Trifluoroacetamides from Amino Alcohols as Nucleophilic Trifluoromethylating Reagents
2003
Inflammation and insulin resistance
2006 Standout
Enantioselective rhodium-catalyzed addition of arylboronic acids to trifluoromethyl ketones
2006 StandoutNobel
Inhibition of Tumor Necrosis Factor-induced Cell Death in MCF7 by a Novel Inhibitor of Neutral Sphingomyelinase
2002
Newly approved integrase inhibitors for clinical treatment of AIDS
2014
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
2013 Standout
The Structures of Antibiotics Bound to the E Site Region of the 50 S Ribosomal Subunit of Haloarcula marismortui: 13-Deoxytedanolide and Girodazole
2007 StandoutNobel
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
2019 Standout
Signalling sphingomyelinases: which, where, how and why?11With the participation of Nathalie Andrieu-Abadie, Nathalie Augé, Bruno Ségui, Emmanuelle Uro-Coste, Robert Salvayre, INSERM Unit 466, Laboratoire de Biochimie, Maladies Métaboliques, Institut Louis Bugnard, Bât. L3, C.H.U. Rangueil, 1 Avenue Jean Poulhès, E 9910 Toulouse Cedex 4, France, and Christine Bezombes, Véronique Mansat-De Mas, INSERM CJF 9503, Institut Claudius Régaud, Toulouse, France.
1999
Structures of phi29 DNA polymerase complexed with substrate: the mechanism of translocation in B‐family polymerases
2007 StandoutNobel
Sphingomyelinase, an Enzyme Implicated in Atherogenesis, Is Present in Atherosclerotic Lesions and Binds to Specific Components of the Subendothelial Extracellular Matrix
1999
Development of potent B-RafV600E inhibitors containing an arylsulfonamide headgroup
2011
HIV Drug Resistance
2004
Fluorine Interactions at the Thrombin Active Site: Protein Backbone Fragments HCαCO Comprise a Favorable CF Environment and Interactions of CF with Electrophiles
2004
Structure and mechanism of DNA polymerases
2005
Membrane lipids: where they are and how they behave
2008 Standout
RosettaLigand Docking with Full Ligand and Receptor Flexibility
2008 StandoutNobel
Molecular mechanisms of necroptosis: an ordered cellular explosion
2010 Standout
The Lys103Asn mutation of HIV-1 RT: a novel mechanism of drug resistance
2001
Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia
2012
Acid and neutral sphingomyelinases: roles and mechanisms of regulation
2004
Atherosclerosis
2000 StandoutNature
Drug–target residence time: critical information for lead optimization
2010
Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication
2018 Standout
Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): A Novel Pharmacological Group of Drugs with Broad Clinical Applications
2010
Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processes
2014
Sphingosine-1-phosphate: an enigmatic signalling lipid
2003 Standout
Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry
2014 StandoutNobel
Induction of Apoptosis through B-cell Receptor Cross-linking Occurs via de Novo Generated C16-Ceramide and Involves Mitochondria
2001
Towards Enantioselective Nucleophilic Trifluoromethylation
2004
Recent advances in Sonogashira reactions
2011 Standout
Structure and Dynamics of a Processive Brownian Motor: The Translating Ribosome
2010 StandoutNobel
Monofluorination of Organic Compounds: 10 Years of Innovation
2015 Standout
Fluorine in medicinal chemistry
2007 Standout
Relationship Between Insulin Sensitivity and Sphingomyelin Signaling Pathway in Human Skeletal Muscle
2004
Enantioselective Trifluoromethylation of Ketones with (Trifluoromethyl)trimethylsilane Catalyzed by Chiral Quaternary Ammonium Phenoxides
2007
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
Functional Nucleic Acid Sensors
2009 Standout
Room-Temperature Ionic Liquids: Solvents for Synthesis and Catalysis. 2
2011 Standout
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
Asymmetric Trifluoromethylation of Ketones with (Trifluoromethyl)trimethylsilane Catalyzed by Chiral Quaternary Ammonium Phenoxides
2007
Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals
2014 Standout
CHARMM‐GUI: A web‐based graphical user interface for CHARMM
2008 Standout
Synthesis, Anti-HIV Activity, and Metabolic Stability of New Alkenyldiarylmethane HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors
2005
Comprehensive Review in Current Developments of Imidazole-Based Medicinal Chemistry
2013
The Sonogashira Reaction: A Booming Methodology in Synthetic Organic Chemistry
2007 Standout
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Stereoselective Enzymatic Synthesis of Heteroatom-Substituted Cyclopropanes
2018 StandoutNobel
Biochemical Properties of Mammalian Neutral Sphingomyelinase2 and Its Role in Sphingolipid Metabolism
2003
Nucleophilic trifluoromethylation
2005
Synthesis and Anti‐HIV‐1 Evaluation of New Sonogashira‐Modified Emivirine (MKC‐442) Analogues
2009
Cloning and characterization of the mammalian brain-specific, Mg 2+ -dependent neutral sphingomyelinase
2000
Carbamoyl Pyridone HIV-1 Integrase Inhibitors. 2. Bi- and Tricyclic Derivatives Result in Superior Antiviral and Pharmacokinetic Profiles
2013
Sphingomyelin Hydrolysis to Ceramide during the Execution Phase of Apoptosis Results from Phospholipid Scrambling and Alters Cell-Surface Morphology
2000
Molecular modeling of organic and biomolecular systems using BOSS and MCPRO
2005
Diverse, High-Quality Test Set for the Validation of Protein−Ligand Docking Performance
2007
Fluorine in Pharmaceuticals: Looking Beyond Intuition
2007 StandoutScience
Electrophilic Trifluoromethylation by Use of Hypervalent Iodine Reagents
2014 Standout
Advances in Catalytic Enantioselective Fluorination, Mono-, Di-, and Trifluoromethylation, and Trifluoromethylthiolation Reactions
2014
Recent advances in enantioselective trifluoromethylation reactions
2008
How to Reach Stereogenic Trifluoromethylated Carbon? En Route to the “Grail” of the Asymmetric Trifluoromethylation Reaction
2006
The “Cyclopropyl Fragment” is a Versatile Player that Frequently Appears in Preclinical/Clinical Drug Molecules
2016
High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations
2008
Cellular and Molecular Dissection of Reperfusion Injury
2000 StandoutNobel
Functional Aptamers and Aptazymes in Biotechnology, Diagnostics, and Therapy
2007
Catalytic Mechanism and Performance of Computationally Designed Enzymes for Kemp Elimination
2008 StandoutNobel
Activatable Photosensitizers for Imaging and Therapy
2010 Standout
Electrogenerated Chemiluminescence and Its Biorelated Applications
2008 Standout
Aromatic Trifluoromethylation with Metal Complexes
2011 Standout
ADMETlab 2.0: an integrated online platform for accurate and comprehensive predictions of ADMET properties
2021 Standout
Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant reverse transcriptases resistant to other nonnucleoside inhibitors
2004 StandoutNobel
A Coupled Protein and Probe Engineering Approach for Selective Inhibition and Activity-Based Probe Labeling of the Caspases
2013
Efficient synthesis of benzophenone derivatives in Lewis acid ionic liquids
2007
“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates
2017 StandoutNobel
Regulation of Mammalian Autophagy in Physiology and Pathophysiology
2010 Standout
Rapid Activation of Neutral Sphingomyelinase by Hypoxia-Reoxygenation of Cardiac Myocytes
2000
Works of Kurt Weaver being referenced
Crystallization of protein–ligand complexes
2006
Purification and Characterization of a Membrane Bound Neutral pH Optimum Magnesium-dependent and Phosphatidylserine-stimulated Sphingomyelinase from Rat Brain
1998
Crystal Structures of HIV-1 Reverse Transcriptases Mutated at Codons 100, 106 and 108 and Mechanisms of Resistance to Non-nucleoside Inhibitors
2004
Structural Basis for the Resilience of Efavirenz (DMP-266) to Drug Resistance Mutations in HIV-1 Reverse Transcriptase
2000
Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors 1 1Edited by J. Karn
2001
Expression, Preparation, and High-Throughput Screening of Caspase-8: Discovery of Redox-Based and Steroid Diacid Inhibition
2002
An intrinsic ATPase activity of phospho-MEK-1 uncoupled from downstream ERK phosphorylation
2007
Relationship of Potency and Resilience to Drug Resistant Mutations for GW420867X Revealed by Crystal Structures of Inhibitor Complexes for Wild-Type, Leu100Ile, Lys101Glu, and Tyr188Cys Mutant HIV-1 Reverse Transcriptases
2007
Rational Design of Potent Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase
2012
Potent Inhibitors of HIV-1 Integrase Display a Two-Step, Slow-Binding Inhibition Mechanism Which Is Absent in a Drug-Resistant T66I/M154I Mutant
2009
Dolutegravir (S/GSK1349572) Exhibits Significantly Slower Dissociation than Raltegravir and Elvitegravir from Wild-Type and Integrase Inhibitor-Resistant HIV-1 Integrase-DNA Complexes
2011
Novel Benzophenones as Non-nucleoside Reverse Transcriptase Inhibitors of HIV-1
2004