Standout Papers
Citation Impact
Citing Papers
A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein
2007 StandoutNobel
Humanized Foxp2 accelerates learning by enhancing transitions from declarative to procedural performance
2014 StandoutNobel
Abolition of Long-Term Stability of New Hippocampal Place Cell Maps by NMDA Receptor Blockade
1998 StandoutScienceNobel
SNOSID, a proteomic method for identification of cysteine S-nitrosylation sites in complex protein mixtures
2006
Control of rat GluR6 glutamate receptor open probability by protein kinase A and calcineurin
1997
Autocrine Nitric Oxide Modulates CD95-induced Apoptosis in γδ T Lymphocytes
1997
Anti-inflammatory glucocorticoids inhibit the induction by endotoxin of nitric oxide synthase in the lung, liver and aorta of the rat
1990
Glutamate receptor ion channels
2005 Standout
Why nitric oxide?
1992
The cardiovascular effects and implications of peroxynitrite
1999
Loss of K+ ATP-Channel-Mediated Vasodilation After Induction of Tachyphylaxis to Peroxynitrite
2005
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
2013 Standout
POLY(ADP-RIBOSE) SYNTHETASE INHIBITION PREVENTS LIPOPOLYSACCHARIDE-INDUCED PEROXYNITRITE MEDIATED DAMAGE IN DIAPHRAGM
2002
Brain nitric oxide synthase is a biopterin‐ and flavin‐containing multi‐functional oxido‐reductase
1991
Calcium‐dependent nitric oxide synthesis in endothelial cytosol is mediated by calmodulin
1990
The physiology and pathophysiology of nitric oxide in the brain
2005
Blockade of quinolinic acid-induced neurotoxicity by pyruvate is associated with inhibition of glial activation in a model of Huntington's disease
2004
Modulation of Iron Regulatory Protein Functions
1996
Acute and Chronic Endothelial Dysfunction: Implications for the Development of Heart Failure
2003
Mitochondrial Nitric-Oxide Synthase: Enzyme Expression, Characterization, and Regulation
2004
Concurrent formation of peroxynitrite with the expression of inducible nitric oxide synthase in the brain during middle cerebral artery occlusion and reperfusion in rats
2002
Aberrant expression of nitric oxide synthase III in Alzheimer’s disease: relevance to cerebral vasculopathy and neurodegeneration
2000
Nitrosation of Uric Acid by Peroxynitrite
1998
Dexras1
2000
Nitration of PPARγ inhibits ligand‐dependent translocation into the nucleus in a macrophage‐like cell line, RAW 264
2002
Cell signaling by reactive nitrogen and oxygen species in atherosclerosis
2000
Mechanisms of regulation and functions of guanylyl cyclases
2005
Phosphorylation and regulation of glutamate receptors by calcium/calmodulin-dependent protein kinase II
1993 Nature
Induction of nitric oxide synthase by cytokines in vascular smooth muscle cells
1990
Myeloperoxidase produces nitrating oxidants in vivo
2002
How does ascorbic acid prevent endothelial dysfunction?
2000
Activation of nitric oxide synthase by β2‐adrenoceptors in human umbilical vein endothelium in vitro
1999
Peroxynitrite Induces Covalent Dimerization of Epidermal Growth Factor Receptors in A431 Epidermoid Carcinoma Cells
1998
Nitric oxide, superoxide, and peroxynitrite in myocardial ischaemia‐reperfusion injury and preconditioning
2003
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
1999 StandoutNatureNobel
Nitric oxide-dependent long-term potentiation is blocked by a specific inhibitor of soluble guanylyl cyclase
1995
NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential
2006
Genetic and Pharmacological Evidence for a Novel, Intermediate Phase of Long-Term Potentiation Suppressed by Calcineurin
1998 StandoutNobel
Autocatalytic nitration of P450CAM by peroxynitrite
2000
Nitric oxide synthesis in the CNS, endothelium and macrophages differs in its sensitivity to inhibition by arginine analogues
1991
Purification of a Ca2+/calmodulin‐dependent nitric oxide synthase from porcine cerebellum
1990
Ascorbic Acid Enhances Endothelial Nitric-oxide Synthase Activity by Increasing Intracellular Tetrahydrobiopterin
2000
Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite
2002
Regulatory Interactions between Iron and Nitric Oxide Metabolism for Immune Defense againstPlasmodium falciparumInfection
2001
Reduced Neuronal Injury after Treatment with NG-nitro-L-arginine methyl ester (L-NAME) or 2-sulfo-phenyl-N-tert-butyl nitrone (S-PBN) Following Experimental Brain Contusion
2005
Peroxynitrite reductase activity of bacterial peroxiredoxins
2000 Nature
l-Ascorbic Acid Potentiates Endothelial Nitric Oxide Synthesis via a Chemical Stabilization of Tetrahydrobiopterin
2001
Soluble guanylyl cyclase: Structure and regulation
2005
Heme Oxygenase-1 Mediates Up-Regulation of Adhesion Molecule Expression Induced by Peroxynitrite in Endothelial Cells
2004
Dietary arginine alters time of symptom onset in Huntington’s disease transgenic mice
2000
Unraveling peroxynitrite formation in biological systems
2001
Reaction of tetrahydrobiopterin with superoxide: EPR-kinetic analysis and characterization of the pteridine radical
2001
Protein Nitration in Cardiovascular Diseases
2002
Inducible Nitric Oxide Synthase Mediates Prostaglandin H2 Synthase Nitration and Suppresses Eicosanoid Production
2006
Biology of nitric oxide signaling
2000
Superoxide Generation from Endothelial Nitric-oxide Synthase
1998
Nitric Oxide and Peroxynitrite in Health and Disease
2007 Standout
The role of protein nitration in the inhibition of platelet activation by peroxynitrite
2001
Biological aspects of reactive nitrogen species
1999
Biological chemistry and clinical potential of S-nitrosothiols
2000
Peroxynitrite activates kinases of the src family and upregulates tyrosine phosphorylation signaling
2002
Nitric oxide synthases: structure, function and inhibition
2001 Standout
The nitration of proteins in platelets: significance in platelet function
2002
Human Atherosclerotic Intima and Blood of Patients with Established Coronary Artery Disease Contain High Density Lipoprotein Damaged by Reactive Nitrogen Species
2004
Resistance to endotoxic shock as a consequence of defective NF-kappa B activation in poly (ADP-ribose) polymerase-1 deficient mice
1999
Regulation of β-Adrenergic Receptor Signaling by S-Nitrosylation of G-Protein-Coupled Receptor Kinase 2
2007 StandoutNobel
CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP
1995 StandoutNobel
Localization of nitric oxide synthase indicating a neural role for nitric oxide
1990 StandoutNature
Role of Oxidative Modifications in Atherosclerosis
2004 Standout
Guanabenz-mediated Inactivation and Enhanced Proteolytic Degradation of Neuronal Nitric-oxide Synthase
2000
Nitric Oxide Inhibits Ornithine Decarboxylase viaS-Nitrosylation of Cysteine 360 in the Active Site of the Enzyme
2001 Nobel
Oxygen Reduction by Nitric-oxide Synthases
2001
Protein S-nitrosylation: a physiological signal for neuronal nitric oxide
2001
Neurodegenerative disorders: the role of peroxynitrite
1999
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
Evidence for iNOS-dependent peroxynitrite production in diabetic platelets
1999
Interaction of nitric oxide and cyclic guanosine 3',5'-monophosphate in erythropoietin production.
1993
Specific Nitration at Tyrosine 430 Revealed by High Resolution Mass Spectrometry as Basis for Redox Regulation of Bovine Prostacyclin Synthase
2003
Contrasting properties of two forms of long-term potentiation in the hippocampus
1995 Nature
Quantitative measurements of NO reaction kinetics with a Clark-type electrode
2005
Regulation of protein function by S‐glutathiolation in response to oxidative and nitrosative stress
2000
Real-Time Patch-Cram Detection of Intracellular cGMP Reveals Long-Term Suppression of Responses to NO and Muscarinic Agonists
1998
Reaction of Neuronal Nitric-oxide Synthase with Oxygen at Low Temperature
1998
Selective inhibition of constitutive nitric oxide synthase by L-NG-nitroarginine
1993
Nitrates and no release: contemporary aspects in biological and medicinal chemistry
2004
Nitric oxide and the regulation of gene expression
2001
Peroxynitrite-Induced Tyrosine Nitration and Phosphorylation in Human Platelets
1997
Dopamine Prevents Nitration of Tyrosine Hydroxylase by Peroxynitrite and Nitrogen Dioxide
2003
The effect of peroxynitrite on the catalytic activity of soluble guanylyl cyclase
2001
Interactions of Peroxynitrite, Tetrahydrobiopterin, Ascorbic Acid, and Thiols
2003
Peroxynitrite reactivity with amino acids and proteins
2003
Nitric Oxide Synthases: Properties and Catalytic Mechanism
1995
Peroxynitrite-induced oxidation and nitration products of guanine and 8-oxoguanine: Structures and mechanisms of product formation
2005
Crystal Structures of Zinc-free and -bound Heme Domain of Human Inducible Nitric-oxide Synthase
1999
Characterization of Endothelium- Dependent Relaxation in Guinea Pig Basilar Artery – Effect of Hypoxia and Role of Cytochrome P<sub>450</sub> Mono-Oxygenase
1998
Tetrahydrobiopterin restores endothelial function in hypercholesterolemia.
1997
Reactive Oxygen Species and Vascular Signal Transduction Mechanisms
1996
Peroxynitrite stimulates vascular smooth muscle cell cyclic GMP synthesis
1995
Immunogenicity of an inflammation-associated product, tyrosine nitrated self-proteins
2004
Tetrahydrobiopterin-dependent Inhibition of Superoxide Generation from Neuronal Nitric Oxide Synthase
1999
Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta.
1990
The Peroxynitrite Reductase Activity of Cytochrome cOxidase Involves a Two-electron Redox Reaction at the Hemea 3-CuB Site
1999
Biological selectivity and functional aspects of protein tyrosine nitration
2003
Nitric oxide is required for the induction and heterosynaptic spread of long‐term potentiation in rat cerebellar slices
2001
Phosphorylation of RIM1α by PKA Triggers Presynaptic Long-Term Potentiation at Cerebellar Parallel Fiber Synapses
2003 StandoutNobel
Peroxynitrite, the Breakdown Product of Nitric Oxide, Is Beneficial in Blood Cardioplegia but Injurious in Crystalloid Cardioplegia
1999
Product formation and kinetic simulations in the pH range 1–14 account for a free-radical mechanism of peroxynitrite decomposition
2003
Quantitative reactivity profiling predicts functional cysteines in proteomes
2010 StandoutNatureNobel
Peroxynitrite irreversibly decreases diastolic and systolic function in cardiac muscle
1999
PPA250 [3-(2,4-Difluorophenyl)-6-{2-[4-(1 H-imidazol-1-ylmethyl) Phenoxy]ethoxy}-2-phenylpyridine], a Novel Orally Effective Inhibitor of the Dimerization of Inducible Nitric-Oxide Synthase, Exhibits an Anti-Inflammatory Effect in Animal Models of Chronic Arthritis
2002
Neuronal Nitric Oxide Synthase Self-inactivates by Forming a Ferrous-Nitrosyl Complex during Aerobic Catalysis
1995 StandoutNobel
Long-Term Potentiation Is Reduced in Mice That Are Doubly Mutant in Endothelial and Neuronal Nitric Oxide Synthase
1996 StandoutNobel
Transforming growth factor β2 inhibits interleukin 1β- and tumour necrosis factor α-induction of nitric oxide synthase in rat renal mesangial cells
1991
Effects of Nitroglycerin on Soluble Guanylate Cyclase
2002
Nitrogen dioxide and carbonate radical anion: two emerging radicals in biology
2002
[41] Examining apoptosis in cultured cells after exposure to nitric oxide and peroxynitrite
1999
Differential Sensitivity of the Tyrosyl Radical of Mouse Ribonucleotide Reductase to Nitric Oxide and Peroxynitrite
1998
Perspectives on Oxygen Sensing
1999 StandoutNobel
The Pathobiochemistry of Nitrogen Dioxide
2002
RIM1α is required for presynaptic long-term potentiation
2002 StandoutNatureNobel
NITRIC OXIDE SYNTHASES: WHY SO COMPLEX?
1994
Isoforms of nitric oxide synthase Characterization and purification from different cell types
1991 StandoutNobel
Supplementation with tetrahydrobiopterin prevents the cardiovascular effects of angiotensin II-induced oxidative and nitrosative stress
2005
Cancer-related inflammation
2008 StandoutNature
Immunohistochemical evidence for the myeloperoxidase/H2O2/halide system in human atherosclerotic lesions
2000
Nitric oxide synthase expression reveals compartments of cerebellar granule cells and suggests a role for mossy fibers in their development
1994
A Novel Protein-Protein Interaction between a G Protein-coupled Receptor and the Phosphatase SHP-2 Is Involved in Bradykinin-induced Inhibition of Cell Proliferation
2002
Peroxynitrite Formed by Simultaneous Nitric Oxide and Superoxide Generation Causes Cyclosporin‐A‐Sensitive Mitochondrial Calcium Efflux and Depolarisation
1995
Oxidative stress in diabetes-induced endothelial dysfunction involvement of nitric oxide and protein kinase C
2003
The pathogenesis of atherosclerosis: a perspective for the 1990s
1993 StandoutNature
Selective pharmacological inhibition of distinct nitric oxide synthase isoforms
1996
Thiols Protect the Inhibition of Myocardial Aconitase by Peroxynitrite
1998
Glutathione Protects Against Myocardial Ischemia–reperfusion Injury by Detoxifying Peroxynitrite
2000
Mammalian nitric oxide synthases
1999
The basic chemistry of nitrogen monoxide and peroxynitrite
1998
Peroxynitrite affects exocytosis and SNARE complex formation and induces tyrosine nitration of synaptic proteins
2002
Oxidation of tetrahydrobiopterin by biological radicals and scavenging of the trihydrobiopterin radical by ascorbate
2002
Radical causes of cancer
2003
Peroxynitrite inhibits leukocyte-endothelial cell interactions and protects against ischemia-reperfusion injury in rats.
1997
Synergies and Coincidence Requirements between NO, cGMP, and Ca2+ in the Induction of Cerebellar Long-Term Depression
1997 StandoutNobel
The role of lipid peroxidation and antioxidants in oxidative modification of LDL
1992 Standout
3-Nitrotyrosine in Atherosclerotic Blood Vessels
2003
Interactions of Homocysteine, Nitric Oxide, Folate and Radicals in the Progressively Damaged Endothelium
2003
[35] Using peroxynitrite as oxidant with low-density lipoprotein
1996
The nitric oxide-cyclic GMP signalling pathway in rat brain
1993
L-Arginine Stimulates Cyclic Guanosine 3′,5′- Monophosphate Formation in Rat Islets of Langerhans and RINm5F Insulinoma Cells: Evidence for LArgininerNitric Oxide Synthase*
1991
S-Nitrosothiol Signaling in Respiratory Biology
2006
Oxidative Stress and Endothelial Nitric Oxide Bioactivity
2003
Long-Term Potentiation in the Hippocampal CA1 Region of Mice Lacking cGMP-Dependent Kinases Is Normal and Susceptible to Inhibition of Nitric Oxide Synthase
1999
Nitric oxide-induced cytostasis and cell cycle arrest of a human breast cancer cell line (MDA-MB-231): Potential role of cyclin D1
2001
Effect of Nitric Oxide Donors on Oxygen-Dependent Cytotoxic Responses Mediated by Neutrophils
1999
A Neural Substrate of Prediction and Reward
1997 StandoutScience
Formation and Properties of Peroxynitrite as Studied by Laser Flash Photolysis, High-Pressure Stopped-Flow Technique, and Pulse Radiolysis
1997
A selective role of calcineurin Aα in synaptic depotentiation in hippocampus
1999 StandoutNobel
Altered Tetrahydrobiopterin Metabolism in Atherosclerosis
2002
Peroxynitrite disables the tyrosine phosphorylation regulatory mechanism: Lymphocyte-specific tyrosine kinase fails to phosphorylate nitrated cdc2(6-20)NH2 peptide.
1996
Vitamin E protects against impairment of endothelium-mediated relaxations in cholesterol-fed rabbits.
1994
A new form of cerebellar long-term potentiation is postsynaptic and depends on nitric oxide but not cAMP
2002 StandoutNobel
An activity in rat tissues that modifies nitrotyrosine-containing proteins
1998 StandoutNobel
Reduced cGMP signaling associated with neointimal proliferation and vascular dysfunction in late-stage atherosclerosis
2004
Endothelial Nitric Oxide Synthase in Vascular Disease
2006 Standout
Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells.
1990
Inhibition of cGMP Breakdown Promotes the Induction of Cerebellar Long-Term Depression
1996
Mechanism and Thermochemistry of Peroxynitrite Decomposition in Water
1999
Postsynaptic Membrane Fusion and Long-Term Potentiation
1998 StandoutScienceNobel
Dopaminergic Modulation of NMDA-Induced Whole Cell Currents in Neostriatal Neurons in Slices: Contribution of Calcium Conductances
1998
Nitric oxide and the immune response
2001 Standout
Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptor
2004 StandoutNobel
The predictive brain: temporal coincidence and temporal order in synaptic learning mechanisms.
1994
All-or-none potentiation at CA3-CA1 synapses
1998 StandoutNobel
Endothelial NO synthase as a source of NO and superoxide
2005
Regulation of Nitric Oxide-Sensitive Guanylyl Cyclase
2003
Peroxynitrite mediates calcium‐dependent mitochondrial dysfunction and cell death via activation of calpains
2004
Peroxynitrite-mediated vasorelaxation: evidence against the formation of circulatingS-nitrosothiols
1998
Tests of the roles of two diffusible substances in long-term potentiation: evidence for nitric oxide as a possible early retrograde messenger.
1991 StandoutNobel
Cytokine-Mediated Apoptosis in Cardiac Myocytes
1999
Hydroxyl Radical Formation by O−O Bond Homolysis in Peroxynitrous Acid
2003
Inhibition of cGMP breakdown promotes the induction of cerebellar long-term depression.
1996
Differential Association of Syntrophin Pairs with the Dystrophin Complex
1997
Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly
1996 Standout
Superoxide generation by endothelial nitric oxide synthase: The influence of cofactors
1998
Isoforms of nitric oxide synthase
1995
Pharmacological and immunohistochemical evidence for a functional nitric oxide synthase system in rat peritoneal eosinophils
1997 StandoutNobel
Nitration of succinyl-CoA:3-oxoacid CoA-transferase in rats after endotoxin administration
2001 Nobel
Regulation of biosynthesis of nitric oxide.
1994
Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase
2003
Nitration of Unsaturated Fatty Acids by Nitric Oxide-Derived Reactive Nitrogen Species Peroxynitrite, Nitrous Acid, Nitrogen Dioxide, and Nitronium Ion
1998
Mechanism of transfer of NO from extracellular S -nitrosothiols into the cytosol by cell-surface protein disulfide isomerase
2001
The Glutamate Receptor Ion Channels
1999 Standout
L-arginine and calmodulin regulation of the heme iron reactivity in neuronal nitric oxide synthase.
1994
Nitric oxide regulates endocytosis by S -nitrosylation of dynamin
2006
Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: comparison with enzymatically formed nitric oxide from L-arginine.
1993 StandoutNobel
Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death.
1995 StandoutNobel
N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine.
1991
Spatiotemporal dynamics of guanosine 3′,5′-cyclic monophosphate revealed by a genetically encoded, fluorescent indicator
2001 StandoutNobel
Nitric oxide, oxidants, and protein tyrosine nitration
2004
Endothelial NOS and the Blockade of LTP by NOS Inhibitors in Mice Lacking Neuronal NOS
1994 StandoutScienceNobel
Formation of free nitric oxide from l-arginine by nitric oxide synthase: direct enhancement of generation by superoxide dismutase.
1994 StandoutNobel
Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells.
1991 StandoutNobel
Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning
2011 StandoutNobel
Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat
1990
Formation of the NO donors glyceryl mononitrate and glyceryl mononitrite from the reaction of peroxynitrite with glycerol
1997
An alternative Ca 2+ ‐dependent mechanism of neuroprotection by the metalloporphyrin class of superoxide dismutase mimetics
2005
Intrinsic and Extrinsic Modulation of Nitric Oxide Synthase Activity
2002
Heme coordination of NO in NO synthase.
1994
Mechanisms of cardioprotection by peroxynitrite in myocardial ischemia and reperfusion injury
1998
Expression of Inducible Nitric Oxide Synthase Depresses β-Adrenergic–Stimulated Calcium Release From the Sarcoplasmic Reticulum in Intact Ventricular Myocytes
2001
Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite
2002
Syntrophin-dependent expression and localization of Aquaporin-4 water channel protein
2001 StandoutNobel
The glutamate receptor ion channels.
1999
Myeloperoxidase produces nitrating oxidants in vivo
2002
Endothelial cell activation by endotoxin involves superoxide/NO‐mediated nitration of prostacyclin synthase and thromboxane receptor stimulation
2003
Nitric oxide inhibits neuronal nitric oxide synthase by interacting with the heme prosthetic group. Role of tetrahydrobiopterin in modulating the inhibitory action of nitric oxide.
1994 StandoutNobel
Nitric Oxide Inhibition of Lipid Peroxidation: Kinetics of Reaction with Lipid Peroxyl Radicals and Comparison with α-Tocopherol
1997
Ca2+/calmodulin-dependent formation of hydrogen peroxide by brain nitric oxide synthase
1992
Attenuation of vascular relaxation after development of tachyphylaxis to peroxynitrite in vivo
1998
Dimerization: An Emerging Concept for G Protein–Coupled Receptor Ontogeny and Function
2002
S-nitrosylation of endothelial nitric oxide synthase is associated with monomerization and decreased enzyme activity
2004
Calmodulin controls neuronal nitric-oxide synthase by a dual mechanism. Activation of intra- and interdomain electron transfer.
1994
Two closely linked but separable promoters for human neuronal nitric oxide synthase gene transcription.
1995 StandoutNobel
Existence of nitric oxide synthase in rat hippocampal pyramidal cells.
1994 StandoutNobel
Native Low-Density Lipoprotein Increases Endothelial Cell Nitric Oxide Synthase Generation of Superoxide Anion
1995
Peroxynitrite aggravates myocardial reperfusion injury in the isolated perfused rat heart
1997
Post-Translational Control of Endothelial Nitric Oxide Synthase: Why Isn't Calcium/Calmodulin Enough?
2001
Effect of •NO on the Decomposition of Peroxynitrite: Reaction of N2O3 with ONOO-
1999
Reversing cerebellar long-term depression
2003 StandoutNobel
RIM1α phosphorylation at serine-413 by protein kinase A is not required for presynaptic long-term plasticity or learning
2008 StandoutNobel
Heme coordination and structure of the catalytic site in nitric oxide synthase.
1993
Calmodulin-dependent nitric-oxide synthase. Mechanism of inhibition by imidazole and phenylimidazoles
1993
Arginine metabolism: nitric oxide and beyond
1998 Standout
Electrochemical Analysis of Protein Nitrotyrosine and Dityrosine in the Alzheimer Brain Indicates Region-Specific Accumulation
1998
Elevated blood pressures in mice lacking endothelial nitric oxide synthase
1996 StandoutNobel
Hydroxyl Radical Formation during Peroxynitrous Acid Decomposition
1999
Genetic evidence for a protein-kinase-A-mediated presynaptic component in NMDA-receptor-dependent forms of long-term synaptic potentiation
2005 StandoutNobel
Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase.
1991 StandoutNobel
Response : Nitric Oxide and Arginine-Evoked Insulin Secretion
1992 StandoutScienceNobel
Effects of ATP and bradykinin on endothelial cell Ca2+ homeostasis and formation of cGMP and prostacyclin
1993
Nitric oxide synthases in mammals
1994 Standout
Works of Kurt Schmidt being referenced
Characterization of endothelial cell amino acid transport systems involved in the actions of nitric oxide synthase inhibitors.
1993
Novel guanylyl cyclase inhibitor potently inhibits cyclic GMP accumulation in endothelial cells and relaxation of bovine pulmonary artery.
1996
A New Pathway of Nitric Oxide/Cyclic GMP Signaling InvolvingS-Nitrosoglutathione
1998
Kinetics and Mechanism of Tetrahydrobiopterin-induced Oxidation of Nitric Oxide
1995
Interference of Carboxy-PTIO with Nitric Oxide- and Peroxynitrite-Mediated Reactions
1997
Release of nitric oxide from donors with known half-life: a mathematical model for calculating nitric oxide concentrations in aerobic solutions
1997
Molecular Mechanisms Involved in the Synergistic Activation of Soluble Guanylyl Cyclase by YC-1 and Nitric Oxide in Endothelial Cells
2001
Effect of calcium on endothelium-derived relaxing factor formation and cGMP levels in endothelial cells
1989
Is the bradykinin-induced Ca2+ influx and the formation of endothelium-derived relaxing factor mediated by a G protein?
1992
Characterization of Recombinant Human Endothelial Nitric-oxide Synthase Purified from the Yeast Pichia pastoris
1999
The protein inhibitor of neuronal nitric oxide synthase (PIN): characterization of its action on pure nitric oxide synthases
1998
Electrochemistry of Pterin Cofactors and Inhibitors of Nitric Oxide Synthase
2001
Interaction of Endothelial and Neuronal Nitric-oxide Synthases with the Bradykinin B2 Receptor
2000
Electrochemical Determination ofS-Nitrosothiols with a Clark-Type Nitric Oxide Electrode
1998
Selective stimulation of L-arginine uptake contributes to shear stress-induced formation of nitric oxide
1999
Biosynthesis of endothelium-derived relaxing factor: A cytosolic enzyme in porcine aortic endothelial cells Ca2+-dependently converts L-arginine into an activator of soluble guanylyl cyclase
1989
Inhibition of nitric oxide synthesis by methylene blue
1993
Peroxynitrite-induced Accumulation of Cyclic GMP in Endothelial Cells and Stimulation of Purified Soluble Guanylyl Cyclase
1995
Reaction of Peroxynitrite with HEPES or MOPS Results in the Formation of Nitric Oxide Donors
1998
Dityrosine Formation Outcompetes Tyrosine Nitration at Low Steady-state Concentrations of Peroxynitrite
2000
A Synthetic Peptide Corresponding to the Putative Dihydrofolate Reductase Domain of Nitric Oxide Synthase Inhibits Uncoupled NADPH Oxidation
1997
Characterization of Neuronal Amino Acid Transporters: Uptake of Nitric Oxide Synthase Inhibitors and Implication for Their Biological Effects
1995
Lack of involvement of extracellular signal-regulated kinase (ERK) in the agonist-induced endothelial nitric oxide synthesis
2002
Activation of Neuronal Nitric-oxide Synthase by the 5-Methyl Analog of Tetrahydrobiopterin
1999
Activation of soluble guanylate cyclase by nitrovasodilators is inhibited by oxidized low-density lipoprotein
1990
High-density lipoprotein antagonizes the inhibitory effects of oxidized low-density lipoprotein and lysolecithin on soluble guanylyl cyclase
1992
Molecular mechanisms of inhibition of porcine brain nitric oxide synthase by the antinociceptive drug 7-nitro-indazole
1994
Nitric oxide-induced autoinhibition of neuronal nitric oxide synthase in the presence of the autoxidation-resistant pteridine 5-methyltetrahydrobiopterin
2000
Inhibition of nitric oxide synthesis by NG‐nitro‐L‐arginine methyl ester (L‐NAME): requirement for bioactivation to the free acid, NG‐nitro‐L‐arginine
1996
Nitric Oxide Synthase-Catalyzed Activation of Oxygen and Reduction of Cytochromes: Reaction Mechanisms and Possible Physiological Implications
1992
Activation of Soluble Guanylyl Cyclase by the Nitrovasodilator 3-Morpholinosydnonimine Involves Formation ofS-Nitrosoglutathione
1998
Molecular Actions of a Mn(III)Porphyrin Superoxide Dismutase Mimetic and Peroxynitrite Scavenger: Reaction with Nitric Oxide and Direct Inhibition of NO Synthase and Soluble Guanylyl Cyclase
1998
Metabolic Fate of Peroxynitrite in Aqueous Solution
1997
Regulation of Neuronal Nitric Oxide and Cyclic GMP Formation by Ca2+
1992
Protein Tyrosine Nitration in Cytokine-activated Murine Macrophages
2001
Role of Bound Zinc in Dimer Stabilization but Not Enzyme Activity of Neuronal Nitric-oxide Synthase
2000
Stimulation of Soluble Guanylate Cyclase by Endothelium-Derived Relaxing Factor Is Antagonized by Oxidized Low-Density Lipoprotein
1991
Comparison of neuronal and endothelial isoforms of nitric oxide synthase in stably transfected HEK 293 cells
2001
Increases in endothelial cyclic AMP levels amplify agonist-induced formation of endothelium-derived relaxing factor (EDRF)
1992
Stimulation of Soluble Guanylate Cyclase by Endothelium-Derived Relaxing Factor Is Antagonized by Oxidized Low-Density Lipoprotein
1991
Thiols and Neuronal Nitric Oxide Synthase: Complex Formation, Competitive Inhibition, and Enzyme Stabilization
1997
Expression of rat brain nitric oxide synthase in baculovirus-infected insect cells and characterization of the purified enzyme
1994
Multiple catalytic functions of brain nitric oxide synthase. Biochemical characterization, cofactor-requirement, and the role of N omega-hydroxy-L-arginine as an intermediate
1993
Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase.
1996
Pteridine biosynthesis in human endothelial cells. Impact on nitric oxide-mediated formation of cyclic GMP.
1993
Protein tyrosine nitration in mouse peritoneal macrophages activated in vitro and in vivo: evidence against an essential role of peroxynitrite
2001
Overexpression of neuronal nitric oxide synthase in insect cells reveals requirement of haem for tetrahydrobiopterin binding
1996
The pteridine binding site of brain nitric oxide synthase. Tetrahydrobiopterin binding kinetics, specificity, and allosteric interaction with the substrate domain.
1994
Hypercholesterolemia is associated with a reduced response of smooth muscle guanylyl cyclase to nitrovasodilators.
1993
Structural analysis of porcine brain nitric oxide synthase reveals a role for tetrahydrobiopterin and L-arginine in the formation of an SDS-resistant dimer.
1995
Dopamine modulates the kinetics of ion channels gated by excitatory amino acids in retinal horizontal cells.
1990
Effects of pH on the structure and function of neuronal nitric oxide synthase
1998
Identification of the 4-amino analogue of tetrahydrobiopterin as a dihydropteridine reductase inhibitor and a potent pteridine antagonist of rat neuronal nitric oxide synthase
1996
Novel actions of methylene blue.
1993
Reaction of peroxynitrite with oxyhaemoglobin: interference with photometrical determination of nitric oxide
1994
Characterization of bovine endothelial nitric oxide synthase as a homodimer with down-regulated uncoupled NADPH oxidase activity: tetrahydrobiopterin binding kinetics and role of haem in dimerization
1997
Uptake of nitric oxide synthase inhibitors by macrophage RAW 264.7 cells
1994
Brain nitric oxide synthase is a haemoprotein
1992
Tetrahydrobiopterin-Free Neuronal Nitric Oxide Synthase: Evidence for Two Identical Highly Anticooperative Pteridine Binding Sites
1996
Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one.
1995 Standout
Dopamine alters glutamate receptor desensitization in retinal horizontal cells of the perch (Perca fluviatilis).
1994
Haem insertion, dimerization and reactivation of haem-free rat neuronal nitric oxide synthase
1998
Tetrahydrobiopterin-dependent formation of endothelium-derived relaxing factor (nitric oxide) in aortic endothelial cells
1992
Inhibitors of brain nitric oxide synthase. Binding kinetics, metabolism, and enzyme inactivation.
1994
Contrasting effects of N5-substituted tetrahydrobiopterin derivatives on phenylalanine hydroxylase, dihydropteridine reductase and nitric oxide synthase
2000
Allosteric modulation of rat brain nitric oxide synthase by the pterin-site enzyme inhibitor 4-aminotetrahydrobiopterin
1997
Tetrahydrobiopterin Binding to Macrophage Inducible Nitric Oxide Synthase: Heme Spin Shift and Dimer Stabilization by the Potent Pterin Antagonist 4-Amino-Tetrahydrobiopterin
1997
Nitric oxide-induced autoinhibition of neuronal nitric oxide synthase in the presence of the autoxidation-resistant pteridine 5-methyltetrahydrobiopterin
2000