Standout Papers
- Organ distribution of erythropoietin messenger RNA in normal and uremic rats (1991)
- Production of Erythropoietin by Liver Cells in Vivo and in Vitro (1994)
- Expression of hypoxia-inducible factors-1alpha and-2alpha in hypoxic and ischemic rat kidneys (2002)
Citation Impact
Citing Papers
Differentiation Stage-Specific Requirement in Hypoxia-Inducible Factor-1α–Regulated Glycolytic Pathway during Murine B Cell Development in Bone Marrow
2009 StandoutNobel
Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia
2010
Hypoxia-inducible factor 2α (HIF-2α) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension
2011 StandoutNobel
High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq
2011 StandoutNobel
Widespread, hypoxia‐inducible expression of HIF‐2α in distinct cell populations of different organs
2002 StandoutNobel
Treatment of kidney cancer
2009 StandoutNobel
Loss of Hypoxia-Inducible Factor Prolyl Hydroxylase Activity in Cardiomyocytes Phenocopies Ischemic Cardiomyopathy
2010 StandoutNobel
Regulation of Type II Transmembrane Serine Proteinase TMPRSS6 by Hypoxia-inducible Factors
2010 StandoutNobel
Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases
2016 StandoutNobel
The use of in situ hybridization to study erythropoietin gene expression in murine kidney and liver
1993 StandoutNobel
EGFR Antagonists in Cancer Treatment
2008 Standout
Ischemia and reperfusion—from mechanism to translation
2011 Standout
Identification of the renal erythropoietin-producing cells using transgenic mice
1993 StandoutNobel
Preconditional Activation of Hypoxia-Inducible Factors Ameliorates Ischemic Acute Renal Failure
2006
The von Hippel–Lindau tumour suppressor protein: O2 sensing and cancer
2008 StandoutNobel
Elevated level of erythropoietin in congestive heart failure Relationship to renal perfusion and plasma renin
1993
Transactivation and Inhibitory Domains of Hypoxia-inducible Factor 1α
1997 StandoutNobel
Age-dependent expression of the erythropoietin gene in rat liver and kidneys.
1992 StandoutNobel
Angiogenesis and antiangiogenic therapy in hematologic malignancies
2006
Immunohistochemical Detection of Hypoxia-Inducible Factor-1α in Human Renal Allograft Biopsies
2006
Cellular sites of extrarenal and renal erythropoietin production in anaemic rats
1992
Sites of erythropoietin production
1997 StandoutNobel
Oxygen sensing by HIF hydroxylases
2004 StandoutNobel
The interstitial response to renal injury: Fibroblast–like cells show phenotypic changes and have reduced potential for erythropoietin gene expression
1997 StandoutNobel
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
2007 Standout
Cellular oxygen sensing in health and disease
2007 StandoutNobel
Erythropoietin production in rats with post-ischemic acute renal failure
1996
Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer
2013 StandoutNobel
Immunohistochemical colocalization of the α-subunit of neutrophil NADPH oxidase and ecto-5′-nucleotidase in kidney and liver
1997
Molecular biology of erythropoietin
1993 StandoutNobel
Dimerization, DNA Binding, and Transactivation Properties of Hypoxia-inducible Factor 1
1996 StandoutNobel
Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α
1999 StandoutNobel
Selection of Mutant CHO Cells with Constitutive Activation of the HIF System and Inactivation of the von Hippel-Lindau Tumor Suppressor
2001 StandoutNobel
Hypoxia-inducible Factor-1 Deficiency Results in Dysregulated Erythropoiesis Signaling and Iron Homeostasis in Mouse Development
2006 StandoutNobel
Regulation of the Erythropoietin Gene
1989
Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
2008 StandoutNobel
Hypoxia-inducible factor–2 (HIF-2) regulates hepatic erythropoietin in vivo
2007
Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2
2013 StandoutNobel
Rapid oxygen-dependent changes in erythropoietin mRNA in perfused rat kidneys: Evidence against mediation by cAMP
1992 StandoutNobel
Tumor Angiogenesis
2008 Standout
Selective Inhibition of Hypoxia-Inducible Factor (HIF) Prolyl-Hydroxylase 1 Mediates Neuroprotection against Normoxic Oxidative Death via HIF- and CREB-Independent Pathways
2009 StandoutNobel
Anemia of Chronic Disease
2005 Standout
Lack of angiotensin II–facilitated erythropoiesis causes anemia in angiotensin-converting enzyme–deficient mice
2000 StandoutNobel
Clinical iron deficiency disturbs normal human responses to hypoxia
2016 StandoutNobel
Triggering of erythropoietin production by hypoxia is inhibited by respiratory and metabolic acidosis
1990
Renal innervation plays no role in oxygen-dependent control of erythropoietin mRNA levels
1992 StandoutNobel
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
1995 StandoutNobel
Comparison of the human and mouse erythropoietin genes shows extensive homology in the flanking regions
1993 StandoutNobel
Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain
2001 StandoutNobel
Hypoxia-inducible Factor-1 Mediates Transcriptional Activation of the Heme Oxygenase-1 Gene in Response to Hypoxia
1997 StandoutNobel
Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPα
2008
Embryonal Carcinoma P19 Cells Produce Erythropoietin Constitutively But Express Lactate Dehydrogenase in an Oxygen-Dependent Manner
1998 StandoutNobel
Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2
2012 StandoutNobel
Regulation of Erythropoietin Production: New Insights Into Molecular Mechanisms of Oxygen Homeostasis
1994 StandoutNobel
Expression of a homologously recombined erythopoietin-SV40 T antigen fusion gene in mouse liver: evidence for erythropoietin production by Ito cells
1994 StandoutNobel
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.
1992 StandoutNobel
Inhibition of Prolyl Hydroxylases Increases Erythropoietin Production in ESRD
2010
A Nuclear Factor Induced by Hypoxia via De Novo Protein Synthesis Binds to the Human Erythropoietin Gene Enhancer at a Site Required for Transcriptional Activation
1992 StandoutNobel
Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer.
1994 StandoutNobel
Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure
2007 StandoutNobel
HIF-2α regulates murine hematopoietic development in an erythropoietin-dependent manner
2004
Regulation of the Erythropoietin Gene
1999
Role of the hypoxic bone marrow microenvironment in 5T2MM murine myeloma tumor progression.
2005
Quantitative assessment of erythropoiesis and functional classification of anemia based on measurements of serum transferrin receptor and erythropoietin
1993
Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1
1996 StandoutNobel
Polycythemic responses to hypoxia: molecular and genetic mechanisms of chronic mountain sickness
1998
Nitric oxide prevents axonal degeneration by inducing HIF-1–dependent expression of erythropoietin
2011 StandoutNobel
Treatment of erythropoietin deficiency in mice with systemically administered siRNA
2012 StandoutNobel
Effect of inflammatory cytokines on hypoxia-induced erythropoietin production
1992
In vivo and in vitro regulation of erythropoietin mRNA: measurement by competitive polymerase chain reaction
1993
Works of K-U Eckardt being referenced
Expression of hypoxia-inducible factors-1alpha and-2alpha in hypoxic and ischemic rat kidneys
2002 StandoutNobel
Activation of the HIF pathway in childhood ALL, prognostic implications of VEGF
2004
Erythropoietin in health and disease
1989
Organ distribution of erythropoietin messenger RNA in normal and uremic rats
1991 StandoutNobel
Role of excretory graft function for erythropoietin formation after renal transplantation
1990
Role of excretory graft function for erythropoietin formation after renal transplantation
1990