Standout Papers
Citation Impact
Citing Papers
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
2003 StandoutScienceNobel
Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney
2006 StandoutNobel
Intrinsic Differences in Adipocyte Precursor Cells From Different White Fat Depots
2012
Effect of rosiglitazone on spontaneous and clomiphene citrate–induced ovulation in women with polycystic ovary syndrome
2003
p300 Interacts with the N- and C-terminal Part of PPARγ2 in a Ligand-independent and -dependent Manner, Respectively
1999
Hallmarks of Cancer: The Next Generation
2011 Standout
Degradation of the Peroxisome Proliferator-activated Receptor γ Is Linked to Ligand-dependent Activation
2000
A role for helix 3of the TRbeta ligand-binding domain in coactivator recruitment identified by characterization of a third cluster of mutations in resistance to thyroid hormone
1998
Capacity for cooperative binding of thyroid hormone (T3) receptor dimers defines wild type T3 response elements.
1992
Thyroid hormone is required for hypothalamic neurons regulating cardiovascular functions
2012
Different functions for the thyroid hormone receptors TRalpha and TRbeta in the control of thyroid hormone production and post-natal development
1999
Polarity-specific activities of retinoic acid receptors determined by a co-repressor
1995 Nature
Thiazolidinediones
2004 Standout
Structure and specificity of nuclear receptor–coactivator interactions
1998
Regulation of the Transcriptional Activity of the Peroxisome Proliferator-activated Receptor α by Phosphorylation of a Ligand-independent trans-Activating Domain
1999
Differential Regulation of Thyroid Hormone Receptor Messenger Ribonucleic Acid Levels by Thyrotropin-Releasing Hormone
1991
An adipogenic cofactor bound by the differentiation domain of PPARgamma
1999
Energy balance regulation by thyroid hormones at central level
2013
Interaction between a peroxisome proliferator-activated receptor gene polymorphism and dietary fat intake in relation to body mass
2003
The Interaction of the Vitamin D Receptor with Nuclear Receptor Corepressors and Coactivators
1998
The Thyrotropin Receptor in Thyroid Diseases
1997
NCoR1 regulates thyroid hormone receptor isoform-dependent adipogenesis
2011
Angiopoietin-like protein 4: health effects, modulating agents and structure–function relationships
2012
Estrogen Receptors: How Do They Signal and What Are Their Targets
2007 Standout
Inflammation and metabolic disorders
2006 StandoutNature
Enhanced angiogenesis in obesity and in response to PPARγ activators through adipocyte VEGF and ANGPTL4 production
2008
Role of peroxisome proliferators-activated receptors in the pathogenesis and treatment of nonalcoholic fatty liver disease
2008
Novel insight from transgenic mice into thyroid hormone resistance and the regulation of thyrotropin
1999
A TATA binding protein-associated factor functions as a coactivator for thyroid hormone receptors.
1996
Adiponectin in health and disease: evaluation of adiponectin-targeted drug development strategies
2009
The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
2000
PPARγ: a Nuclear Regulator of Metabolism, Differentiation, and Cell Growth
2001
The Role of Angiopoietin-Like Proteins in Angiogenesis and Metabolism
2008
Mechanisms That Mediate Negative Regulation of the Thyroid-stimulating Hormone α Gene by the Thyroid Hormone Receptor
1999
Studies of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) gene in relation to insulin sensitivity among glucose tolerant Caucasians
2001
Zfp423 Expression Identifies Committed Preadipocytes and Localizes to Adipose Endothelial and Perivascular Cells
2012
Resistance to Thyroid Hormone Caused by Two Mutant Thyroid Hormone Receptors β, R243Q and R243W, with Marked Impairment of Function That Cannot Be Explained by Alteredin Vitro3,5,3′-Triiodothyroinine Binding Affinity1
1997
Mice deficient in the steroid receptor co-activator 1(SRC-1) are resistant to thyroid hormone
1999
Regulatory T Cells
2000 StandoutNobel
Molecular Mechanisms of Human Hypertension
2001 Standout
Functions of Thyroid Hormone Receptors in Mice
2000
The skinny on fat: lipolysis and fatty acid utilization in adipocytes
2009
Modulating the transcriptional control of adipogenesis
1997
Modulation of RXR function through ligand design
2011
Thyroid Hormone Receptors: Multiple Forms, Multiple Possibilities*
1993
Ligand-Independent Recruitment of SRC-1 to Estrogen Receptor β through Phosphorylation of Activation Function AF-1
1999
Expression of the Mutant Thyroid Hormone Receptor PV in the Pituitary of Transgenic Mice Leads to Weight Reduction
1999
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
Plasma Adiponectin Levels and Risk of Myocardial Infarction in Men
2004 Standout
Impact of the Pro12Ala polymorphism of the PPAR-γ2 gene on serum triacylglycerol response to n−3 fatty acid supplementation
2003
Regulation of Nuclear Receptor Transcriptional Activity by a Novel DEAD Box RNA Helicase (DP97)
2003
Mechanisms by Which Thyroid Hormone Receptor Mutations Cause Clinical Syndromes of Resistance to Thyroid Hormone
1994
Effects of Troglitazone on Cellular Differentiation, Insulin Signaling, and Glucose Metabolism in Cultured Human Skeletal Muscle Cells
2001
Effects of Varying the Position of Thyroid Hormone Response Elements within the Rat Growth Hormone Promoter: Implications for Positive and Negative Regulation by 3,5,3′-Triiodothyronine
1991
Interferon-γ-induced Regulation of Peroxisome Proliferator-activated Receptor γ and STATs in Adipocytes
2001
Nuclear-receptor interactions on DNA-response elements
2001
Transcriptional Anti-repression
1999
Multigenic control of thyroid hormone functions in the nervous system
2008
Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARα
2002 Nature
Terminal Differentiation of Human Breast Cancer through PPARγ
1998
A novel cis element mediating ligand-independent activation by c-ErbA: Implications for hormonal regulation
1993
Regulated Production of a Peroxisome Proliferator-activated Receptor-γ Ligand during an Early Phase of Adipocyte Differentiation in 3T3-L1 Adipocytes
2004
Ligand-independent Activation Domain in the N Terminus of Peroxisome Proliferator-activated Receptor γ (PPARγ)
1997
Magnesium Replacement Improves the Metabolic Profile in Obese and Pre-Diabetic Patients with Mild-to-Moderate Chronic Kidney Disease: A 3-Month, Randomised, Double-Blind, Placebo-Controlled Study
2017 Standout
Involvement of Thyroid Hormone and Its α Receptor in Avian Neurulation
1998
Effect of Rosiglitazone on Insulin Sensitivity and Body Composition in Type 2 Diabetic Patients
2002
Lipid‐sensing nuclear receptors in the pathophysiology and treatment of the metabolic syndrome
2011
Animal models of autoimmunity and their relevance to human diseases
2000 StandoutNobel
Thyroid Hormone Response Elements Differentially Modulate the Interactions of Thyroid Hormone Receptors with Two Receptor Binding Domains in the Steroid Receptor Coactivator-1
1998
Rosiglitazone and Retinoic Acid Induce Uncoupling Protein-1 (UCP-1) in a p38 Mitogen-activated Protein Kinase-dependent Manner in Fetal Primary Brown Adipocytes
2002
The retinoid X receptors and their ligands
2011
Endurance training–induced changes in the insulin response to oral glucose are associated with the peroxisome proliferator–activated receptor-γ2 Pro12Ala genotype in men but not in women
2004
PPAR gamma 2 Prevents Lipotoxicity by Controlling Adipose Tissue Expandability and Peripheral Lipid Metabolism
2007
Nuclear receptor coactivators
1997
Potential therapeutic applications of thyroid hormone analogs
2007
PPARgamma agonists in the treatment of type II diabetes: is increased fatness commensurate with long-term efficacy?
2003
The Regulatory Role of Thyroid Hormones in Bone Cell Growth and Differentiation
1995
Nuclear Cytoplasmic Shuttling by Thyroid Hormone Receptors
2001
Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones
2012
Syndromes of reduced sensitivity to thyroid hormone: genetic defects in hormone receptors, cell transporters and deiodination
2007
Multiple sclerosis
2008 Standout
Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change
1995 StandoutNobel
Adiponectin Receptor as a Key Player in Healthy Longevity and Obesity-Related Diseases
2013
Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ
1998 StandoutNature
Thyrotropin Regulation by Thyroid Hormone in Thyroid Hormone Receptor β-Deficient Mice1
1997
PPARs and the complex journey to obesity
2004
Energy balance and food intake: The role of PPARγ gene polymorphisms
2006
A forkhead-domain gene is mutated in a severe speech and language disorder
2001 Nature
STAT6 Transcription Factor Is a Facilitator of the Nuclear Receptor PPARγ-Regulated Gene Expression in Macrophages and Dendritic Cells
2010
A Mutant Thyroid Hormone Receptor α Antagonizes Peroxisome Proliferator-Activated Receptor α Signaling in Vivo and Impairs Fatty Acid Oxidation
2006
Direct Binding of Activated c-Src to the β3-Adrenergic Receptor Is Required for MAP Kinase Activation
2000 StandoutNobel
PPARγ: A Critical Determinant of Body Fat Distribution in Humans and Mice
2005
Molecular and cellular mechanisms of liver fibrosis and its regression
2020
MINIREVIEW: Interactions Among a Subfamily of Nuclear Hormone Receptors: The Regulatory Zipper Model
1990
Molecular determinants of nuclear receptor-corepressor interaction
1999
Defective Release of Corepressor by Hinge Mutants of the Thyroid Hormone Receptor Found in Patients with Resistance to Thyroid Hormone
1998
MECHANISMS OF THYROID HORMONE ACTION
1998
Mechanism of the nuclear receptor molecular switch
2004
Pro12Ala substitution in peroxisome proliferator-activated receptorγ2 is associated with low adiponectin concentrations in young Japanese men
2004
A structural role for hormone in the thyroid hormone receptor
1995 Nature
Increased insulin clearance in peroxisome proliferator-activated receptor γ2 Pro12Ala
2003
Autoimmune disease in first-degree relatives of patients with multiple sclerosis
2000
Ligand-activated thyroid hormone and retinoic acid receptors inhibit growth factor receptor promoter expression
1990
Determinants of coactivator LXXLL motif specificity in nuclear receptor transcriptional activation
1998
The PPAR‐gamma P12A polymorphism modulates the relationship between dietary fat intake and components of the metabolic syndrome: results from the Québec Family Study
2003
Selective peroxisome proliferator-activated receptor γ (PPARγ) modulation as a strategy for safer therapeutic PPARγ activation
2009
The peroxisome proliferator activated receptorφ2 (PPARφ2) Pro12Ala variant: lack of association with type 2 diabetes in obese and non obese Tunisian patients
2005
The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors
1999 Nature
Five New Families with Resistance to Thyroid Hormone not Caused by Mutations in the Thyroid Hormone Receptor β Gene1
1999
New insights into thyroid hormone action
2007
PAS is a dimerization domain common to Drosophila Period and several transcription factors
1993 StandoutNatureNobel
An immunocytochemical analysis of the expression of thyroid hormone receptor α and β proteins during natural and thyroid hormone‐induced metamorphosis in Xenopus
1997
Mechanisms and Metabolic Implications of Regional Differences among Fat Depots
2013
Hepatic over-expression of peroxisome proliferator activated receptor γ2 in the ob/ob mouse model of non‐insulin dependent diabetes mellitus
2001
More is better: Activators and repressors from the same gene
1992
Influence of Pro12Ala peroxisome proliferator-activated receptor γ2 polymorphism on glucose response to exercise training in type 2 diabetes
2005
Structure of the intact PPAR-γ–RXR-α nuclear receptor complex on DNA
2008 Nature
Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing
2008
PPARγ in the endothelium regulates metabolic responses to high-fat diet in mice
2008
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
2001 StandoutNobel
Plasma Adiponectin Levels in Overweight and Obese Asians
2002
A Dominant Negative Peroxisome Proliferator-activated Receptor-γ Knock-in Mouse Exhibits Features of the Metabolic Syndrome
2005
PPARs at the crossroads of lipid signaling and inflammation
2012
Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors
1991 Standout
Angiogenesis and Vascular Functions in Modulation of Obesity, Adipose Metabolism, and Insulin Sensitivity
2013
Mice Lacking Adiponectin Show Decreased Hepatic Insulin Sensitivity and Reduced Responsiveness to Peroxisome Proliferator-activated Receptor γ Agonists
2005
PPARγ signaling and metabolism: the good, the bad and the future
2013 Standout
Differential SERM Effects on Corepressor Binding Dictate ERα Activity in Vivo
2003
Inflammation in atherosclerosis
2002 StandoutNature
Negative Regulation of the Gene for the Preprothyrotropin-releasing Hormone from the Mouse by Thyroid Hormone Requires Additional Factors in Conjunction with Thyroid Hormone Receptors
1996
The Interaction between Nuclear Receptor Corepressor and Histone Deacetylase 3 Regulates Both Positive and Negative Thyroid Hormone Actionin Vivo
2010
Mechanisms of fatty acid-induced inhibition of glucose uptake.
1994 Standout
The hormone resistin links obesity to diabetes
2001 StandoutNature
Prostaglandins Promote and Block Adipogenesis through Opposing Effects on Peroxisome Proliferator-activated Receptor γ
1998
A Novel Point Mutation in Cluster 3 of the Thyroid Hormone Receptor β Gene (P247L) Causing Mild Resistance to Thyroid Hormone
1999
What We Talk About When We Talk About Fat
2014 Standout
Haplotype analysis of the PPARγ Pro12Ala and C1431T variants reveals opposing associations with body weight
2002
TRAM-1, A Novel 160-kDa Thyroid Hormone Receptor Activator Molecule, Exhibits Distinct Properties from Steroid Receptor Coactivator-1
1997
Lipoatrophy Revisited
2000
Nuclear thyroid hormone receptors.
1990
Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARγ
2004
Negative regulation of the glycoprotein hormone α gene promoter by thyroid hormone: mutagenesis of a proximal receptor binding site preserves transcriptional repression
1993
BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions
2012
Selective Pituitary Resistance to Thyroid Hormone Produced by Expression of a Mutant Thyroid Hormone Receptor β Gene in the Pituitary Gland of Transgenic Mice
1998
The Δ337T mutation on the TRβ causes alterations in growth, adiposity, and hepatic glucose homeostasis in mice
2011
Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases
2010
Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ
2012
Peroxisome Proliferator Activated Receptor γ, CCAAT/ Enhancer-binding Protein α, and Cell Cycle Status Regulate the Commitment to Adipocyte Differentiation
1997
Controlling nuclear receptors: the circular logic of cofactor cycles
2005
Interdomain communication regulating ligand binding by PPAR-γ
1998 Nature
Lipid overload and overflow: metabolic trauma and the metabolic syndrome
2003
An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice
2013
The Hallmarks of Aging
2013 Standout
Thyroid Hormone Export Regulates Cellular Hormone Content and Response
1996
Thyroid Hormone Receptors Form Distinct Nuclear Protein-Dependent and Independent Complexes with a Thyroid Hormone Response Element
1990
Divergent dimerization properties of mutant beta 1 thyroid hormone receptors are associated with different dominant negative activities.
1994
Modulating nuclear receptor function: may the phos be with you
1999
Sharp, an inducible cofactor that integrates nuclear receptor repression and activation
2001
Direct demonstration of lipid sequestration as a mechanism by which rosiglitazone prevents fatty-acid-induced insulin resistance in the rat: comparison with metformin
2004
TGFα deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice
1993 StandoutNobel
Adiponectin and Leptin Levels in HIV-Infected Subjects With Insulin Resistance and Body Fat Redistribution
2002
Cancer-related inflammation
2008 StandoutNature
Pendred's Syndrome and Genetic Defects in Thyroid Hormone Synthesis
2000
Liver Peroxisome Proliferator-activated Receptor γ Contributes to Hepatic Steatosis, Triglyceride Clearance, and Regulation of Body Fat Mass
2003
Aspects of the regulatory mechanisms of PPAR functions: Analysis of a bidirectional response element and regulation by sumoylation
2006
Transplantation of adipose tissue and stem cells: role in metabolism and disease
2010
Immunosuppressive Drugs for Kidney Transplantation
2004 Standout
A Unique Role of the β-2 Thyroid Hormone Receptor Isoform in Negative Regulation by Thyroid Hormone
1997
Tissue-Specific Actions of Thyroid Hormone: Insights From Animal Models
2000
Alternative mRNA Splicing of Corepressors Generates Variants That Play Opposing Roles in Adipocyte Differentiation
2011
Effect of the Pro12Ala Variant of the Human Peroxisome Proliferator-Activated Receptor γ2 Gene on Adiposity, Fat Distribution, and Insulin Sensitivity in Japanese Men
1998
A Thyroid Hormone Receptor α Gene Mutation (P398H) Is Associated with Visceral Adiposity and Impaired Catecholamine-stimulated Lipolysis in Mice
2003
Molecular evolution of FOXP2, a gene involved in speech and language
2002 StandoutNatureNobel
Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy
2016 StandoutNobel
Genetic Modulation of PPARγ Phosphorylation Regulates Insulin Sensitivity
2003
A Regulatory Role for RIP140 in Nuclear Receptor Activation
1998
Dominant Negative Transcriptional Regulation by a Mutant Thyroid Hormone Receptor-β in a Family with Generalized Resistance to Thyroid Hormone
1990
Retinoid X Receptor Heterodimers in the Metabolic Syndrome
2005
The Human Condition—A Molecular Approach
2014 StandoutNobel
The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function
1997 Nature
Posttranslational Modifications of PPAR‐γ: Fine‐tuning the Metabolic Master Regulator
2009
Isolation and Characterization of a Novel Ligand-dependent Thyroid Hormone Receptor-coactivating Protein
1997
The Pro12Ala polymorphism of PPARγ2 gene and susceptibility to type 2 diabetes mellitus in a Polish population
2003
Thyroid hormone receptors: The challenge of elucidating isotype-specific functions and cell-specific response
2012
The in vivo role of nuclear receptor corepressors in thyroid hormone action
2012
Study of a new PPARγ2 promoter polymorphism and haplotype analysis in a French population
2005
Roles of PPARs in health and disease
2000 StandoutNature
p300 Functions as a Coactivator for the Peroxisome Proliferator-activated Receptor α
1997
Structural Insights into the Mode of Action of a Pure Antiestrogen
2001
Spared bone mass in rats treated with thyroid hormone receptor TRβ-selective compound GC-1
2003
The window of therapeutic opportunity in multiple sclerosis
2005
Graves' Disease
2008
Cofactor Dynamics and Sufficiency in Estrogen Receptor–Regulated Transcription
2000
Thyroid Hormone Regulation of Thyrotropin Gene Expression
1993
Macrophage/Cancer Cell Interactions Mediate Hormone Resistance by a Nuclear Receptor Derepression Pathway
2006
Mechanisms of thyroid hormone action
2012
The Thr92Ala Deiodinase Type 2 ( DIO2 ) Variant Is Not Associated with Type 2 Diabetes or Indices of Insulin Resistance in the Old Order of Amish
2005
Links between Thyroid Hormone Action, Oxidative Metabolism, and Diabetes Risk?
2008
Peroxisome Proliferator–Activated Receptor γ and Metabolic Disease
2001
A novel C-terminal domain in the thyroid hormone receptor selectively mediates thyroid hormone inhibition
1994
Thyroid hormone receptor mutants that cause resistance to thyroid hormone. Evidence for receptor competition for DNA sequences in target genes.
1992
Fibrosis, not cell size, delineates β-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo
2006 StandoutNobel
Evaluation of Liver Function in Type 2 Diabetic Patients During Clinical Trials
2002
Peroxisomal Proliferator-Activated Receptor-γ Upregulates Glucokinase Gene Expression in β-Cells
2002
Novel location and function of a thyroid hormone response element.
1995
Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle
2003
Thyroid hormone resistance syndrome: correlation of dominant negative activity and location of mutations.
1993
The Nuclear Receptor Corepressor (NCoR) Controls Thyroid Hormone Sensitivity and the Set Point of the Hypothalamic-Pituitary-Thyroid Axis
2011
Current Concepts of the Pathogenesis of the Acute Coronary Syndromes
2001
Rosiglitazone in the Treatment of Haart-Associated Lipodystrophy – a Randomized Double-Blind Placebo-Controlled Study
2003
A Novel Natural Mutation in the Thyroid Hormone Receptor Defines a Dual Functional Domain That Exchanges Nuclear Receptor Corepressors and Coactivators
1998
Improved Glycemic Control and Enhanced Insulin Sensitivity in Type 2 Diabetic Subjects Treated With Pioglitazone
2001
Role of PPARg2 transcription factor in thiazolidinedione-induced insulin sensitization
2011
Ligand-dependent interactions of coactivators steroid receptor coactivator-1 and peroxisome proliferator-activated receptor binding protein with nuclear hormone receptors can be imaged in live cells and are required for transcription
2000 StandoutNobel
Biosynthesis of the Caenorhabditis elegans dauer pheromone
2009 StandoutNobel
Hormone-Dependent Coactivator Binding to a Hydrophobic Cleft on Nuclear Receptors
1998 Science
Structure-function analysis of synthetic and recombinant derivatives of transforming growth factor alpha.
1988
Cardiomyocyte-Specific Knockout and Agonist of Peroxisome Proliferator–Activated Receptor-γ Both Induce Cardiac Hypertrophy in Mice
2005
DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells
2000 StandoutNobel
Effects of Rosiglitazone and Metformin on Liver Fat Content, Hepatic Insulin Resistance, Insulin Clearance, and Gene Expression in Adipose Tissue in Patients With Type 2 Diabetes
2004
A Novel Role for Helix 12 of Retinoid X Receptor in Regulating Repression
1999
Transcriptional regulation of adipogenesis
2000 Standout
Thyroid hormone receptor-beta mutants associated with generalized resistance to thyroid hormone show defects in their ligand-sensitive repression function.
1995
Insulin-Like Growth Factor I Production Is Essential for Anabolic Effects of Thyroid Hormone in Osteoblasts
2000
The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo
2008
The Mechanisms of Action of PPARs
2002 Standout
Abnormal Vascular Function and Hypertension in Mice Deficient in Estrogen Receptor β
2002 StandoutScienceNobel
Kindred S thyroid hormone receptor is an active and constitutive silencer and a repressor for thyroid hormone and retinoic acid responses.
1992
Expression of multiple thyroid hormone receptor isoforms in rat femoral and vertebral bone and in bone marrow osteogenic cultures
1999
PPARG F388L, a Transactivation-Deficient Mutant, in Familial Partial Lipodystrophy
2002
The coregulator exchange in transcriptional functions of nuclear receptors
2000 Standout
Effect of Pioglitazone on Abdominal Fat Distribution and Insulin Sensitivity in Type 2 Diabetic Patients
2002
A shift in the Ligand Responsiveness of Thyroid Hormone Receptor α Induced by Heterodimerization with Retinoid X Receptor α
1996
Fat and Beyond: The Diverse Biology of PPARγ
2008 Standout
Thyronamines—Past, Present, and Future
2011
Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?
1999 Standout
Functional characterization and receptor binding studies of the malic enzyme thyroid hormone response element.
1991
Association Between Adiponectin and Mediators of Inflammation in Obese Women
2003
Peroxisome Proliferator-Activated Receptor γ Recruits the Positive Transcription Elongation Factor b Complex to Activate Transcription and Promote Adipogenesis
2006
PPARγAND GLUCOSE HOMEOSTASIS
2002
A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in Caenorhabditis elegans
2009 StandoutNobel
The Thyroid Hormone Receptor-β Gene Mutation R383H Is Associated with Isolated Central Resistance to Thyroid Hormone1
1999
Alemtuzumab vs. Interferon Beta-1a in Early Multiple Sclerosis
2008
Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice
2008 StandoutNobel
Dose-Response Effect of Pioglitazone on Insulin Sensitivity and Insulin Secretion in Type 2 Diabetes
2002
Genetic Variation in the Peroxisome Proliferator–Activated Receptor-γ2 Gene (Pro12Ala) Affects Metabolic Responses to Weight Loss and Subsequent Weight Regain
2001
Identification of a Negative Regulatory Surface within Estrogen Receptor α Provides Evidence in Support of a Role for Corepressors in Regulating Cellular Responses to Agonists and Antagonists
2002
A detailed functional and structural analysis of a major thyroid hormone inhibitory element in the human thyrotropin beta-subunit gene.
1991
A Transgenic Mouse with a Deletion in the Collagenous Domain of Adiponectin Displays Elevated Circulating Adiponectin and Improved Insulin Sensitivity
2003
Thyroid Hormone Resistance Syndrome Manifests as an Aberrant Interaction between Mutant T3 Receptors and Transcriptional Corepressors
1997
The Conserved Ninth C-Terminal Heptad in Thyroid Hormone and Retinoic Acid Receptors Mediates Diverse Responses by Affecting Heterodimer but Not Homodimer Formation
1993
LIGAND CONTROL OF COREGULATOR RECRUITMENT TO NUCLEAR RECEPTORS
2004
Physiological and Molecular Basis of Thyroid Hormone Action
2001 Standout
A transcriptional corepressor of Stat1 with an essential LXXLL signature motif
2001
Understanding Adipocyte Differentiation
1998 Standout
c-Jun N-Terminal Kinase Phosphorylates Peroxisome Proliferator-Activated Receptor-γ1 and Negatively Regulates Its Transcriptional Activity
1999
Lipodystrophies: Genetic and Acquired Body Fat Disorders
2011
Common polymorphisms of the PPAR-?2 (Pro12Ala) and PGC-1? (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial
2004
Modulation of Circulating and Adipose Tissue Adiponectin Levels by Antidiabetic Therapy
2003
Thyroid hormone receptor dimerization is required for dominant negative inhibition by mutations that cause thyroid hormone resistance
1993
Regulation of myosin heavy chain genes in the heart.
1993
In Vivo Interaction of Steroid Receptor Coactivator (SRC)-1 and the Activation Function-2 Domain of the Thyroid Hormone Receptor (TR) β in TRβ E457A Knock-In and SRC-1 Knockout mice
2009
Novel Pathway for Thyroid Hormone Receptor Action through Interaction with jun and fos Oncogene Activities
1991
Distinct Properties and Advantages of a Novel Peroxisome Proliferator-Activated Protein γ Selective Modulator
2003
Resistin / Fizz3 Expression in Relation to Obesity and Peroxisome Proliferator–Activated Receptor-γ Action in Humans
2001
The Effect of Thiazolidinediones on Plasma Adiponectin Levels in Normal, Obese, and Type 2 Diabetic Subjects
2002
Thyroid Hormone Regulation of Metabolism
2014 Standout
Pioglitazone Reduces Hepatic Fat Content and Augments Splanchnic Glucose Uptake in Patients With Type 2 Diabetes
2003
The Effects of Rosiglitazone on Insulin Sensitivity, Lipolysis, and Hepatic and Skeletal Muscle Triglyceride Content in Patients With Type 2 Diabetes
2002
PPARs and Lipid Ligands in Inflammation and Metabolism
2011
Positive and negative modulation of Jun action by thyroid hormone receptor at a unique AP1 site.
1993
Muscle-specific PPARγ-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones
2003
The Peroxisome Proliferator-Activated Receptor-γ2 Pro12Ala Polymorphism
2002
Peroxisome Proliferator-Activated Receptors and Retinoic Acid Receptors Differentially Control the Interactions of Retinoid X Receptor Heterodimers with Ligands, Coactivators, and Corepressors
1997
Analysis of the Functional Role of Steroid Receptor Coactivator-1 in Ligand-Induced Transactivation by Thyroid Hormone Receptor
1997
Clinical Phenotype of a New Type of Thyroid Hormone Resistance Caused by a Mutation of the TRα1 Receptor: Consequences of LT4 Treatment
2013
Resistance to thyroid hormone is modulated in vivo by the nuclear receptor corepressor (NCOR1)
2011
Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling
2007 StandoutNobel
Unliganded thyroid hormone receptor inhibits formation of a functional preinitiation complex: implications for active repression.
1993
Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway
2000
Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives
2020
Nuclear Receptor Coregulators: Cellular and Molecular Biology*
1999 Standout
Different causes of Reduced Sensitivity to Thyroid Hormone: Diagnosis and Clinical management
2013
Augmented Hepatic and Skeletal Thyromimetic Effects of Tiratricol in Comparison with Levothyroxine
1997
Studies on the repression of basal transcription (silencing) by artificial and natural human thyroid hormone receptor-beta mutants.
1995
Sodium butyrate selectively alters thyroid hormone receptor gene expression in GH3 cells.
1990
Two Separate NCoR (Nuclear Receptor Corepressor) Interaction Domains Mediate Corepressor Action on Thyroid Hormone Response Elements
1998
Adiponectin – journey from an adipocyte secretory protein to biomarker of the metabolic syndrome
2005
Heterodimer Formation by Retinoid X Receptor: Regulation by Ligands and by the Receptor's Self-Association Properties
1998
Estradiol modulates thyroid hormone regulation of the human glycoprotein hormone alpha subunit gene.
1993
Induction of Adiponectin, a Fat-Derived Antidiabetic and Antiatherogenic Factor, by Nuclear Receptors
2003
Functional Regulation of Thyroid Hormone Receptor Variant TRα2 by Phosphorylation
1995
Implications of nonshivering thermogenesis for energy balance regulation in humans
2011
Hypoxic retinal Müller cells promote vascular permeability by HIF-1–dependent up-regulation of angiopoietin-like 4
2013 StandoutNobel
Direct Interactions between Corepressors and Coactivators Permit the Integration of Nuclear Receptor-Mediated Repression and Activation
2002
Lack of Coactivator Interaction Can Be a Mechanism for Dominant Negative Activity by Mutant Thyroid Hormone Receptors
1998
Peroxisome Proliferator-Activated Receptors: Nuclear Control of Metabolism*
1999 Standout
Dominant inheritance of resistance to thyroid hormone not linked to defects in the thyroid hormone receptor alpha or beta genes may be due to a defective cofactor.
1996
The Molecular Basis of Thyroid Hormone Action
1994
AP-1 antagonizes thyroid hormone receptor action on the thyrotropin beta-subunit gene.
1993
Secretion of Angiogenic and Antiapoptotic Factors by Human Adipose Stromal Cells
2004 Standout
Large-scale analysis of the human and mouse transcriptomes
2002 StandoutNobel
Molecular Aspects of Thyroid Hormone Actions
2010
Thyroid hormone receptor-induced bending of specific DNA sequences is modified by an accessory factor.
1993
Lack of Coactivator Interaction Can Be a Mechanism for Dominant Negative Activity by Mutant Thyroid Hormone Receptors**This work was supported by the March of Dimes Foundation.
1998
Allosteric Effects of Pit-1 DNA Sites on Long-Term Repression in Cell Type Specification
2000 Science
Recessive resistance to thyroid hormone in mice lacking thyroid hormone receptor beta: evidence for tissue-specific modulation of receptor function.
1996
Association Between Peroxisome Proliferator–Activated Receptor γ Haplotypes and the Metabolic Syndrome in French Men and Women
2005
Triiodothyronine (T3) decreases binding to DNA by T3-receptor homodimers but not receptor-auxiliary protein heterodimers.
1992
Increased Lipolysis and Decreased Leptin Production by Human Omental as Compared With Subcutaneous Preadipocytes
2002
The Syndromes of Resistance to Thyroid Hormone*
1993
PPAR-γ
2010
Do clinical manifestations of resistance to thyroid hormone correlate with the functional alteration of the corresponding mutant thyroid hormone-beta receptors?
1995
Peroxisome Proliferator-Activated Receptor Gamma Activators Inhibit Gene Expression and Migration in Human Vascular Smooth Muscle Cells
1998
Selective antagonism of thyroid hormone action by retinoic acid.
1992
Cloning and Characterization of Mouse RIP140, a Corepressor for Nuclear Orphan Receptor TR2
1998
Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults--The Evidence Report. National Institutes of Health.
1998 Standout
Nuclear Receptor Corepressors Activate Rather than Suppress Basal Transcription of Genes That Are Negatively Regulated by Thyroid Hormone
1997
Alpha and beta thyroid hormone receptors bind immediately adjacent to the rat growth hormone gene TATA box in a negatively hormone-responsive promoter region.
1990
Fast detection of liver fibrosis with collagen-binding single-nanometer iron oxide nanoparticles via T 1 -weighted MRI
2023 StandoutNobel
daf-12encodes a nuclear receptor that regulates the dauer diapause and developmental age inC. elegans
2000
The Dawn of the SPPARMs?
2002
Regional Differences in the Response of Human Pre-Adipocytes to PPARγ and RXRα Agonists
2002
Dysregulation of the Peroxisome Proliferator-Activated Receptor Target Genes by XPD Mutations
2005
Nuclear Corepressors Enhance the Dominant Negative Activity of Mutant Receptors That Cause Resistance to Thyroid Hormone*
1998
Works of Krishna Chatterjee being referenced
Energy Expenditure and Adaptive Responses to an Acute Hypercaloric Fat Load in Humans with Lipodystrophy
2005
Epidermal growth factor in blood
1986
Does peroxisome proliferator-activated receptor γ genotype (Pro12ala) modify the association of physical activity and dietary fat with fasting insulin level?
2003
Repression of the Human Glycoprotein Hormone α-Subunit Gene by Glucocorticoids: Evidence for Receptor Interactions with Limiting Transcriptional Activators
1991
Hypothalamic mTOR pathway mediates thyroid hormone‐induced hyperphagia in hyperthyroidism
2012
International Union of Pharmacology. LXI. Peroxisome Proliferator-Activated Receptors
2006
Negative and Positive Transcriptional Regulation by Thyroid Hormone Receptor Isoforms
1990
Peroxisome Proliferator-activated Receptor γ Induces a Phenotypic Switch from Activated to Quiescent Hepatic Stellate Cells
2004
A Dominant Negative Human Peroxisome Proliferator-Activated Receptor (PPAR)α Is a Constitutive Transcriptional Corepressor and Inhibits Signaling through All PPAR Isoforms
2005
Activators of peroxisome proliferator-activated receptor gamma have depot-specific effects on human preadipocyte differentiation.
1997
Chromatin Remodeling by the Thyroid Hormone Receptor in Regulation of the Thyroid-stimulating Hormone α-Subunit Promoter
2001
Genetic analysis of 29 kindreds with generalized and pituitary resistance to thyroid hormone. Identification of thirteen novel mutations in the thyroid hormone receptor beta gene.
1994
The Structural Basis for the Specificity of Retinoid-X Receptor-selective Agonists: New Insights Into the Role of Helix H12
2002
Two Novel Mutations in the Thyrotropin (TSH) Receptor Gene in a Child with Resistance to TSH1
1997
A Dominant-negative Peroxisome Proliferator-activated Receptor γ (PPARγ) Mutant Is a Constitutive Repressor and Inhibits PPARγ-mediated Adipogenesis
2000
Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension
1999 Nature
Resistance to Thyroid Hormone
1997
Retardation of post-natal development caused by a negatively acting thyroid hormone receptor α1
2002
Thyroid hormone resistance syndrome. Inhibition of normal receptor function by mutant thyroid hormone receptors.
1991
Mechanism of corepressor binding and release from nuclear hormone receptors
1999
Mutation of the gene encoding human TTF-2 associated with thyroid agenesis, cleft palate and choanal atresia
1998
Thyroid Hormone-mediated Enhancement of Heterodimer Formation between Thyroid Hormone Receptor β and Retinoid X Receptor
1997
Resistance to thyroid hormone is associated with raised energy expenditure, muscle mitochondrial uncoupling, and hyperphagia
2010
Resistance to thyroid hormone mediated by defective thyroid hormone receptor alpha
2013
Clinical and Hormonal Outcome After Two Years of Triiodothyroacetic Acid Treatment in a Child with Thyroid Hormone Resistance
1997
The Variable Clinical Phenotype in Thyroid Hormone Resistance Syndrome
1994
A dynamic mechanism of nuclear receptor activation and its perturbation in a human disease
2003
Nomenclature of thyroid hormone receptor-β gene mutations in resistance to thyroid hormone: consensus statement from the First Workshop on Thyroid Hormone Resistance, 10–11th July 1993, Cambridge, UK
1994
Nomenclature of thyroid hormone receptor ß gene mutations in resistance to thyroid hormone First Workshop on Thyroid Hormone Resistance, July 10–11, 1993, Cambridge, U.K.
1994
The expression of thyroid hormone receptors in human bone
1997
The Localization of Thyroid Hormone Receptor mRNAs in Human Bone
2000
The Metabolic Syndrome: Peroxisome Proliferator-Activated Receptor γ and Its Therapeutic Modulation
2003
Transcriptional Activation by Peroxisome Proliferator-activated Receptor γ Is Inhibited by Phosphorylation at a Consensus Mitogen-activated Protein Kinase Site
1997
A Novel TRβ Mutation (R383H) in Resistance to Thyroid Hormone Syndrome Predominantly Impairs Corepressor Release and Negative Transcriptional Regulation
1998
Functional properties of a novel mutant thyroid hormone receptor in a family with generalized thyroid hormone resistance syndrome
1992
HIV protease inhibitors block human preadipocyte differentiation, but not via the PPARgamma/RXR heterodimer
2000
Human Metabolic Syndrome Resulting From Dominant-Negative Mutations in the Nuclear Receptor Peroxisome Proliferator-Activated Receptor-γ
2003
Induction of Adipocyte Complement-Related Protein of 30 Kilodaltons by PPARγ Agonists: A Potential Mechanism of Insulin Sensitization
2002
A natural transactivation mutation in the thyroid hormone β receptor: Impaired interaction with putative transcriptional mediators
1997
Negative regulation of the thyroid-stimulating hormone alpha gene by thyroid hormone: receptor interaction adjacent to the TATA box.
1989
PPARγ regulates the function of human dendritic cells primarily by altering lipid metabolism
2007
Influences of Age, Gender, Smoking, and Family History on Autoimmune Thyroid Disease Phenotype
2006
2 Thyroid hormone resistance
1994
Thyroid Hormone Resistance Syndrome Manifests as an Aberrant Interaction between Mutant T3 Receptors and Transcriptional Corepressors
1997
Fatty Acid Metabolism in Patients with PPARγ Mutations
2008
Leptin Deficiency Unmasks the Deleterious Effects of Impaired Peroxisome Proliferator–Activated Receptor γ Function (P465L PPARγ) in Mice
2006
Thyroid hormone receptors and their role in development.
1992
Schilddrüsen-Hormon-Resistenz: unterschiedlicher klinischer Ausprägungsgrad bei fünf Patienten
1997
Elevated Plasma Adiponectin in Humans with Genetically Defective Insulin Receptors
2006
Nomenclature of thyroid hormone receptor beta-gene mutations in resistance to thyroid hormone: consensus statement from the first workshop on thyroid hormone resistance, July 10-11, 1993, Cambridge, United Kingdom.
1994
Paracrine Regulation of Angiogenesis and Adipocyte Differentiation During In Vivo Adipogenesis
2003
Rosiglitazone Increases Indexes of Stearoyl-CoA Desaturase Activity in Humans
2005
Resistance to thyroid hormone, and peroxisome-proliferator-activated receptor γ resistance
2001
Resistance to thyroid hormone--an uncommon cause of thyroxine excess and inappropriate TSH secretion.
1994
Tyrosine Agonists Reverse the Molecular Defects Associated with Dominant-Negative Mutations in Human Peroxisome Proliferator-Activated Receptor γ
2003
Dominant-negative mutant thyroid hormone receptors prevent transcription from Xenopus thyroid hormone receptor beta gene promoter in response to thyroid hormone in Xenopus tadpoles in vivo.
1996
Evidence for Gene-Nutrient Interaction at the PPARγ Locus
2001
Pulsed monoclonal antibody treatment and autoimmune thyroid disease in multiple sclerosis
1999
Functional analysis of a transactivation domain in the thyroid hormone beta receptor.
1994
Evidence for the secretion of thyrotropin with enhanced bioactivity in syndromes of thyroid hormone resistance.
1994
Spectrum of transcriptional, dimerization, and dominant negative properties of twenty different mutant thyroid hormone beta-receptors in thyroid hormone resistance syndrome.
1994