Citation Impact
Citing Papers
Carboplatin dosage: prospective evaluation of a simple formula based on renal function.
1989 Standout
Deoxyuridine triphosphatase (dUTPase) expression and sensitivity to the thymidylate synthase (TS) inhibitor ZD9331
2000
Development and validation of a genetic algorithm for flexible docking 1 1Edited by F. E. Cohen
1997 Standout
Phase I clinical and pharmacokinetic study of the oral platinum analogue JM216 given daily for 14 days
1998
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
2013 StandoutNature
Pharmacokinetic and Pharmacodynamic Analysis of Bis-acetato-ammine-dichloro-cyclohexylamine-platinum(IV) (JM216) Administered Once a Day for Five Consecutive Days: A Phase I Study
2000
Green Chemistry: Principles and Practice
2009 Standout
Reduced drug accumulation as a major mechanism of acquired resistance to cisplatin in a human ovarian carcinoma cell line: circumvention studies using novel platinum (II) and (IV) ammine/amine complexes
1992
Mechanochemistry: opportunities for new and cleaner synthesis
2011 Standout
The resurgence of platinum-based cancer chemotherapy
2007 Standout
Synthesis and biological activity of analogues of diazaquinomycin A, a new thymidylate synthase inhibitor.
1989 StandoutNobel
Ligand-induced distortion of an active site in thymidylate synthase upon binding anticancerdrug 1843U89
1995
Structures of thymidylate synthase with a C-terminal deletion: Role of the C-terminus in alignment of 2'-deoxyuridine 5'-monophosphate and 5,10-methylenetetrahydrofolate
1993
A phase II study
2000
Randomised phase II study of cisplatin-etoposide versus infusional carboplatin in advanced non-small-cell lung cancer and mesothelioma
2000
Human Ku Autoantigen Binds Cisplatin-damaged DNA but Fails to Stimulate Human DNA-activated Protein Kinase
1996
An update on satraplatin: the first orally available platinum anticancer drug
2000
Intracellular metabolism of the orally active platinum drug JM216: influence of glutathione levels
1996
Upstream and downstream of mTOR
2004 Standout
Analysis of apoptosis by laser scanning cytometry
1999
UCSF Chimera—A visualization system for exploratory research and analysis
2004 Standout
Chapter 24 Difficulties and pitfalls in analysis of apoptosis
2001
Association of high molecular weight DNA fragmentation with apoptotic or non‐apoptotic cell death induced by calcium ionophore
1995
Phase II study of iproplatin in advanced ovarian carcinoma.
1988
The relationships between glutathione, glutathione-S-transferase and cytotoxicity of platinum drugs and melphalan in eight human ovarian carcinoma cell lines
1991
Biotransformation of the platinum drug JM216 following oral administration to cancer patients
1996
Clinical development of platinum complexes in cancer therapy: an historical perspective and an update
1998
Interactions with Aromatic Rings in Chemical and Biological Recognition
2003 Standout
Glutathione deficiency produced by inhibition of its synthesis, and its reversal; Applications in research and therapy
1991
Bone marrow stromal cells attenuate sepsis via prostaglandin E2–dependent reprogramming of host macrophages to increase their interleukin-10 production
2008 Standout
5-Fluorouracil: mechanisms of action and clinical strategies
2003 Standout
Structural features of 5,10-dideaza-5,6,7,8-tetrahydrofolate that determine inhibition of mammalian glycinamide ribonucleotide formyltransferase
1991
Pairwise specificity and sequential binding in enzyme catalysis: thymidylate synthase
1990
Clinical Pharmacology of 5-Fluorouracil
1989 Standout
New platinum antitumor complexes
1993
The stress-activated protein kinase pathway mediates cell death following injury induced by cis-platinum, UV irradiation or heat
1996
Recent insights into platinum drug resistance in cancer
1998
In Situ Click Chemistry: Enzyme‐Generated Inhibitors of Carbonic Anhydrase II
2004 StandoutNobel
WR2721 as a modulator of cisplatin-and carboplatin-induced side effects in comparison with other chemoprotective agents: a molecular approach
1993
DNA‐binding properties of novel cis‐ and trans platinum‐based anticancer agents in 2 human ovarian carcinoma cell lines
1995
Inhibition of Papillomavirus Protein Function in Cervical Cancer Cells by Intrabody Targeting
2005 StandoutNobel
Biological properties of ten human ovarian carcinoma cell lines: calibration in vitro against four platinum complexes
1989
Folate status and the safety profile of antifolates
2002
Membrane transport of natural folates and antifolate compounds in murine L1210 leukemia cells: role of carrier- and receptor-mediated transport systems.
1991
Evidence for a functional defect in the translocation of the methotrexate transport carrier in a methotrexate-resistant murine L1210 leukemia cell line.
1988
Biochemical effects of a quinazoline inhibitor of thymidylate synthetase, N-(4-(N-((2-amino-4-hydroxy-6-quinazolinyl)methyl)prop-2-ynylamino)benzoyl)-l-glutamic acid (CB3717), on human lymphoblastoid cells
1983
The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs
2016 Standout
Biochemical Modulation of Cisplatin Mechanisms of Action: Enhancement of Antitumor Activity and Circumvention of Drug Resistance
2003 Standout
Molecular Recognition of Protein−Ligand Complexes: Applications to Drug Design
1997 Standout
The Stress Kinase Mitogen-Activated Protein Kinase Kinase (Mkk)7 Is a Negative Regulator of Antigen Receptor and Growth Factor Receptor–Induced Proliferation in Hematopoietic Cells
2001 StandoutNobel
Bioorganometallic Chemistry of Ferrocene
2004 Standout
Acquired methotrexate resistance in lymphoblasts resulting from altered kinetic properties of dihydrofoltate reductase
1977
Pharmaceuticals, Hormones, and Other Organic Wastewater Contaminants in U.S. Streams, 1999−2000: A National Reconnaissance
2002 Standout
Multiple membrane transport systems for the uptake of folate-based thymidylate synthase inhibitors.
1990
Calculating Structures and Free Energies of Complex Molecules: Combining Molecular Mechanics and Continuum Models
2000 Standout
In Situ Click Chemistry: Enzyme Inhibitors Made to Their Own Specifications
2004 StandoutNobel
Apoptosis: A Review of Programmed Cell Death
2007 Standout
Phase III Study of Pemetrexed in Combination With Cisplatin Versus Cisplatin Alone in Patients With Malignant Pleural Mesothelioma
2003 Standout
Kinetics and mechanism for reduction of oral anticancer platinum(IV) dicarboxylate compounds by L-ascorbate ions †
2000
Insights into Mechanisms of Cisplatin Resistance and Potential for Its Clinical Reversal
1996
The response in vitro, of continuous cultures of human lymphoblasts (CCRF-CEM cells) to chemotherapeutic agents
1967
Current Status of Platinum-Based Antitumor Drugs
1999 Standout
Glide: A New Approach for Rapid, Accurate Docking and Scoring. 1. Method and Assessment of Docking Accuracy
2004 Standout
Synthesis and Characterization of Novel Axial Dichloroplatinum(IV) Cisplatin Analogues: Crystal Structure of an Axial Dichloro Complex [Pt(cis-1,4-DACH)(trans-Cl2)(CBDCA)]·1/2MeOH
1997
Current status of trans-platinum compounds in cancer therapy
2001
Additions to Metal-Activated Organonitriles
2002 Standout
Asymmetric Catalysis by Architectural and Functional Molecular Engineering: Practical Chemo- and Stereoselective Hydrogenation of Ketones
2001 StandoutNobel
Dynamic Combinatorial Chemistry
2006 Standout
Theoretical Studies Suggest a New Antifolate as a More Potent Inhibitor of Thymidylate Synthase
2000
Diazaquinomycin A, a new antifolate antibiotic, inhibits thymidylate synthase.
1985 StandoutNobel
Iterative in Situ Click Chemistry Assembles a Branched Capture Agent and Allosteric Inhibitor for Akt1
2011 StandoutNobel
The development of anticancer ruthenium(ii ) complexes: from single molecule compounds to nanomaterials
2017 Standout
The events that occur when cisplatin encounters cells
1996
Cytotoxicity of 5-fluoro-2'-deoxyuridine: requirement for reduced folate cofactors and antagonism by methotrexate.
1978
Insertion of an intracisternal A particle within the 5'-regulatory region of a gene encoding folate-binding protein in L1210 leukemia cells in response to low folate selection. Association with increased protein expression.
1992 StandoutNobel
Modification of Platinum(II) Antitumor Complexes with Sulfur Ligands. 1. Synthesis, Structure, and Spectroscopic Properties of Cationic Complexes of the Types [PtCl(diamine)(L)]NO3and [{PtCl(diamine)}2(L-L)](NO3)2(L = Monofunctional Thiourea Derivative; L-L = Bifunctional Thiourea Derivative)
1998
Structure-Based Strategies for Drug Design and Discovery
1992 Science
Methotrexate-induced misincorporation of uracil into DNA
1980
Paclitaxel plus platinum-based chemotherapy versus conventional platinum-based chemotherapy in women with relapsed ovarian cancer: the ICON4/AGO-OVAR-2.2 trial
2003 Standout
A new folate antimetabolite, 5,10-dideaza-5,6,7,8-tetrahydrofolate is a potent inhibitor of de novo purine synthesis
1989
Structure, Recognition, and Processing of Cisplatin−DNA Adducts
1999 Standout
Carbon Nanomaterials for Biological Imaging and Nanomedicinal Therapy
2015 Standout
Targeted Single-Wall Carbon Nanotube-Mediated Pt(IV) Prodrug Delivery Using Folate as a Homing Device
2008
Ischemic Cell Death in Brain Neurons
1999 Standout
The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures
2003 Standout
Reactive Oxygen Species (ROS)-Based Nanomedicine
2019 Standout
Rapamycin enhances apoptosis and increases sensitivity to cisplatin in vitro.
1995
Enhanced 5-Fluorouracil Nucleotide Formation After Methotrexate Administration: Explanation for Drug Synergism
1979 Science
5-fluorouracil modulation of dihydrofolate reductase RNA levels in methotrexate-resistant KB cells.
1983
Recent advances in solventless organic reactions: towards benign synthesis with remarkable versatility.
2001
In Situ Selection of Lead Compounds by Click Chemistry: Target-Guided Optimization of Acetylcholinesterase Inhibitors
2005 StandoutNobel
Site-directed ligand discovery
2000
Gene amplification in a leukemic patient treated with methotrexate.
1984
5-Substituted quinazoline antifolates
1980
Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas
2003 StandoutNobel
Dendrimers Designed for Functions: From Physical, Photophysical, and Supramolecular Properties to Applications in Sensing, Catalysis, Molecular Electronics, Photonics, and Nanomedicine
2010 Standout
Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy
2016 Standout
The effects on 4-aminoantifolates on 5-formyltetrahydrofolate metabolism in L1210 cells. A biochemical basis of the selectivity of leucovorin rescue.
1987
Cisplatin Sensitizes Cancer Cells to Ionizing Radiation via Inhibition of Nonhomologous End Joining
2005
Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation
2001 Standout
A Non-Cross-Linking Platinum−Acridine Agent with Potent Activity in Non-Small-Cell Lung Cancer
2008
Irreversible Inhibitors of Serine, Cysteine, and Threonine Proteases
2002 Standout
DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSα/hMutSβ ratio and reduces the efficiency of base–base mismatch repair
1997 StandoutNobel
Structure-based drug design (SBDD): Every structure tells a story...
1993
5-fluorouracil and methotrexate combination chemotherapy: The effect of drug scheduling
1981
Characterization of two cDNAs encoding folate-binding proteins from L1210 murine leukemia cells. Increased expression associated with a genomic rearrangement.
1991 StandoutNobel
Works of K.R. Harrap being referenced
Lack of neurotoxicity of oral bisacetatoamminedichlorocyclohexylamine-platinum(IV) in comparison to cisplatin and tetraplatin in the rat.
1994
Historical aspects of glutathione and cancer chemotherapy
1991
Evaluation of novel ammine/amine platinum (IV) dicarboxylates in L1210 murine leukaemia cells sensitive and resistant to cisplatin, tetraplatin or carboplatin
1994
Thymidylate synthase: A target for anticancer drug design
1989
Phase I trial of ZD1694, a new folate-based thymidylate synthase inhibitor, in patients with solid tumors.
1996
Cisplatin Induces Apoptosis in a Human Ovarian Carcinoma Cell Line without Concomitant Internucleosomal Degradation of DNA
1994
Mechanism of action of an orally administered platinum complex [ammine bis butyrato cyclohexylamine dichloroplatinum (IV) (JM221)] in intrinsically cisplatin-resistant human ovarian carcinoma in vitro
1994
Future possibilities for the development of treatments of leukemia.
1965
Combination chemotherapy: The interaction of methotrexate and 5-fluorouracil
1973
Structure-activity relationships of the antitumor platinum coordination complexes.
1980
Quinazoline antifolates with dual biochemical loci of action. Biochemical and biological studies directed towards overcoming methotrexate resistance
1980
A potent antitumour quinazoline inhibitor of thymidylate synthetase: Synthesis, biological properties and therapeutic results in mice
1981
Studies with a mathematical model of folate metabolism
1973
Initiatives with platinum- and quinazoline-based antitumor molecules--Fourteenth Bruce F. Cain Memorial Award Lecture.
1995
Phase I studies with carboplatin at the Royal Marsden Hospital
1985