Citation Impact
Citing Papers
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
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High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
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A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
2012 StandoutScienceNobel
Crystal Structure of Argonaute and Its Implications for RISC Slicer Activity
2004 Science
Comparative genomics in acid mine drainage biofilm communities reveals metabolic and structural differentiation of co-occurring archaea
2013
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
2018 StandoutScienceNobel
Cisplatin- and UV-damaged DNA lure the basal transcription factor TFIID/TBP
1997
The structure of bacteriorhodopsin at 3.0 Å resolution based on electron crystallography: implication of the charge distribution 1 1Edited by R. Huber
1999
Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA
1998
G protein coupled receptor structure and activation
2006 StandoutNobel
Projection structure of rhodopsin
1993 StandoutNatureNobel
Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA
2014 Standout
The TRPC3 Channel Has a Large Internal Chamber Surrounded by Signal Sensing Antennas
2006
Crystal structure of the human β2 adrenergic G-protein-coupled receptor
2007 StandoutNatureNobel
Structure of the 30S ribosomal subunit
2000 StandoutNatureNobel
Instability and decay of the primary structure of DNA
1993 StandoutNatureNobel
Rapid gating and anion permeability of an intracellular aquaporin
1999 StandoutNatureNobel
New CRISPR–Cas systems from uncultivated microbes
2016 StandoutNatureNobel
The three-dimensional structure of aquaporin-1
1997 StandoutNatureNobel
Structure of the recA protein–ADP complex
1992 StandoutNatureNobel
The homing endonuclease I-CreI uses three metals, one of which is shared between the two active sites.
2001
DNA damage recognition during nucleotide excision repair in mammalian cells
1999
A novel nuclease-ATPase (Nar71) from archaea is part of a proposed thermophilic DNA repair system
2004
A three-dimensional view of the molecular machinery of RNA interference
2008 StandoutNatureNobel
Structure and activity of the Cas3 HD nuclease MJ0384, an effector enzyme of the CRISPR interference
2011
The Topodynamics of Incision of UV-irradiated Covalently Closed DNA by the Escherichia coli Uvr(A)BC Endonuclease
1996
Crystal structure of Thermus aquaticus DNA polymerase
1995 StandoutNatureNobel
Structural determinants of water permeation through aquaporin-1
2000 StandoutNatureNobel
Two-dimensional crystallization of membrane proteins
1992
Binding of Activated Cyclosome to p13
1997 StandoutNobel
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
2017 StandoutNatureNobel
Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor
2010 StandoutNatureNobel
The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA
2016 StandoutNatureNobel
Crystal Structures of RNase H Bound to an RNA/DNA Hybrid: Substrate Specificity and Metal-Dependent Catalysis
2005
On/off blinking and switching behaviour of single molecules of green fluorescent protein
1997 StandoutNatureNobel
The coming of age of de novo protein design
2016 StandoutNatureNobel
DNA Binding and Cleavage by the HNH Homing Endonuclease I-HmuI
2004
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
Programmable RNA recognition and cleavage by CRISPR/Cas9
2014 StandoutNatureNobel
Recombining the structures of HIV integrase, RuvC and RNase H
1995 StandoutNobel
Purified Argonaute2 and an siRNA form recombinant human RISC
2005
RNA-guided genetic silencing systems in bacteria and archaea
2012 StandoutNatureNobel
Properties of Cloned and Expressed Human RNase H1
1999
Design, Activity, and Structure of a Highly Specific Artificial Endonuclease
2002 StandoutNobel
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
2013 StandoutNatureNobel
Conformational control of DNA target cleavage by CRISPR–Cas9
2015 StandoutNatureNobel
CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition
1995
Crystal structure of RuvC resolvase in complex with Holliday junction substrate
2013
Homing endonucleases: structural and functional insight into the catalysts of intron/intein mobility
2001
DNA glycosylases
1997
Structures of the Human Rad17-Replication Factor C and Checkpoint Rad 9-1-1 Complexes Visualized by Glycerol Spray/Low Voltage Microscopy
2002 StandoutNobel
HIV reverse transcriptase structure-function relationships
1991
Structural asymmetry in the Thermus thermophilus RuvC dimer suggests a basis for sequential strand cleavages during Holliday junction resolution
2012
Structure of a β1-adrenergic G-protein-coupled receptor
2008 StandoutNatureNobel
Mutations altering the cleavage specificity of a homing endonuclease
2002
X-ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity
2002 StandoutNatureNobel
Crystal structure of T4 endonuclease VII resolving a Holliday junction
2007 Nature
Xeroderma Pigmentosum Group C Protein Complex Is the Initiator of Global Genome Nucleotide Excision Repair
1998
Nucleases: diversity of structure, function and mechanism
2010
Cut2 proteolysis required for sister-chromatid separation in fission yeast
1996 StandoutNatureNobel
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
Molecular mechanism of nucleotide excision repair
1999
Activity, specificity and structure of I-Bth0305I: a representative of a new homing endonuclease family
2011
Universal control mechanism regulating onset of M-phase
1990 StandoutNatureNobel
The Complete Atomic Structure of the Large Ribosomal Subunit at 2.4 Å Resolution
2000 StandoutScienceNobel
A specific subdomain in φ29 DNA polymerase confers both processivity and strand-displacement capacity
2005 StandoutNobel
Tyrosine 264 in the recA protein from Escherichia coli is the site of modification by the photoaffinity label 8-azidoadenosine 5'-triphosphate.
1985
Crystallization of 70 S ribosomes and 30 S ribosomal subunits from Thermus thermophilus
1987
Crystal Structure at 3.5 Å Resolution of HIV-1 Reverse Transcriptase Complexed with an Inhibitor
1992 StandoutScience
G Protein–Coupled Receptor Oligomerization
2004
Quality Control by DNA Repair
1999 StandoutScienceNobel
The C-Terminal Domain of the Adenine-DNA Glycosylase MutY Confers Specificity for 8-Oxoguanine·Adenine Mispairs and May Have Evolved from MutT, an 8-Oxo-dGTPase
1999
TATA Binding Protein Discriminates between Different Lesions on DNA, Resulting in a Transcription Decrease
1998
The chemistry of Cas9 and its CRISPR colleagues
2017 StandoutNobel
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Mammalian growth-associated H1 histone kinase: a homolog of cdc2+/CDC28 protein kinases controlling mitotic entry in yeast and frog cells.
1989 StandoutNobel
A yeast splicing factor is localized in discrete subnuclear domains.
1992 StandoutNobel
Structure of the GDP Domain of EF-Tu and Location of the Amino Acids Homologous to ras Oncogene Proteins
1985 Science
Programmed DNA destruction by miniature CRISPR-Cas14 enzymes
2018 StandoutScienceNobel
Proteolytic release and crystallization of the RNase H domain of human immunodeficiency virus type 1 reverse transcriptase
1991
Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p.
1996
The product of the spindle formation gene sad1+ associates with the fission yeast spindle pole body and is essential for viability.
1995
Crystal Structure of the Ribonuclease H Domain of HIV-1 Reverse Transcriptase
1991 Science
Phenotypic Change Caused by Transcriptional Bypass of Uracil in Nondividing Cells
1999 Science
Atomic Structure of the DNA Repair [4Fe-4S] Enzyme Endonuclease III
1992 Science
Crystal Structure of DNA Photolyase from Escherichia coli
1995 StandoutScienceNobel
Crystal structure of a suicidal DNA repair protein: the Ada O6-methylguanine-DNA methyltransferase from E. coli.
1994
Structure, Recognition, and Processing of Cisplatin−DNA Adducts
1999 Standout
Bypassing anaphase by fission yeast cut9 mutation: requirement of cut9+ to initiate anaphase.
1994
DNA glycosylases in the base excision repair of DNA
1997
MOLECULAR MECHANISM OF 7TM RECEPTOR ACTIVATION—A GLOBAL TOGGLE SWITCH MODEL
2006
Structural details of the binding of guanosine diphosphate to elongation factor Tu from E. coli as studied by X-ray crystallography.
1985
Probing Individual Molecules with Confocal Fluorescence Microscopy
1994 Science
Crystal Structure of the Catalytic Domain of HIV-1 Integrase: Similarity to Other Polynucleotidyl Transferases
1994 Science
De Novo Computational Design of Retro-Aldol Enzymes
2008 StandoutScienceNobel
Helicase dissociation and annealing of RNA-DNA hybrids by Escherichia coli Cas3 protein
2011
Enzymatic Processing of Radiation-Induced Free Radical Damage in DNA
1998
Protein Radicals in Enzyme Catalysis
1998 Standout
Structural Basis for Double-Stranded RNA Processing by Dicer
2006 StandoutScienceNobel
G PROTEIN MECHANISMS: Insights from Structural Analysis
1997
Cell cycle-dependent specific positioning and clustering of centromeres and telomeres in fission yeast.
1993
Examination of the LeafScan 45, a line-illuminating micro-densitometer, for its use in electron crystallography
1997
The Structure of Aquaporin-1 at 4.5-Å Resolution Reveals Short α-Helices in the Center of the Monomer
1999 StandoutNobel
Repair of DNA–polypeptide crosslinks by human excision nuclease
2006 StandoutNobel
Critical Analysis of Antibody Catalysis
2000
bimA encodes a member of the tetratricopeptide repeat family of proteins and is required for the completion of mitosis in Aspergillus nidulans
1991
Structure of Ribonuclease H Phased at 2 Å Resolution by MAD Analysis of the Selenomethionyl Protein
1990 Science
Structure and Function of DNA Photolyase and Cryptochrome Blue-Light Photoreceptors
2003 StandoutNobel
Design of ordered two-dimensional arrays mediated by noncovalent protein-protein interfaces
2015 StandoutScienceNobel
Works of Kosuke Morikawa being referenced
Implications of the zinc‐finger motif found in the DNA‐binding domain of the human XPA protein
1996
Solution structure of the DNA- and RPA-binding domain of the human repair factor XPA
1998
X-Ray and Biochemical Anatomy of an Archaeal XPF/Rad1/Mus81 Family Nuclease
2003
PI-PfuI and PI-Pfull, intein-coded homing endonucleases from Pyrococcus furiosus. II. Characterization of the binding and cleavage abilities by site-directed mutagenesis
1999
Precluding uracil from DNA
1996
Structural models of ribonuclease H domains in reverse transcriptases from retroviruses
1991
A structural basis for transition-state stabilization in antibody-catalyzed hydrolysis: crystal structures of an abzyme at 1.8 Å resolution
1998
Crystal Structure of the RuvA-RuvB Complex
2002
Crystal Structure of the Archaeal Holliday Junction Resolvase Hjc and Implications for DNA Recognition
2001
Structure of the metabotropic glutamate receptor
2003
Atomic structure of the RuvC resolvase: A holliday junction-specific endonuclease from E. coli
1994
Crystal Structure of an Archaeal Intein-encoded Homing Endonuclease PI-PfuI
2000
Crystal structure of a pyrimidine dimer-specific excision repair enzyme from bacteriophage T4: Refinement at 1.45 Å and X-ray analysis of the three active site mutants
1995
Hexameric Ring Structure of the ATPase Domain of the Membrane-Integrated Metalloprotease FtsH from Thermus thermophilus HB8
2002
Recognition of a TG Mismatch
1999
Atomic Structure of the Clamp Loader Small Subunit from Pyrococcus furiosus
2001
Structure of the Whole Cytosolic Region of ATP-Dependent Protease FtsH
2006
Structural details of ribonuclease H from Escherichia coli as refined to an atomic resolution
1992
Nuclear magnetic resonance study of the interaction of T4 endonuclease V with DNA
1994
Structure and function of nucleases in DNA repair: shape, grip and blade of the DNA scissors
2002
Three-dimensional structural views of damaged-DNA recognition: T4 endonuclease V, E. coli Vsr protein, and human nucleotide excision repair factor XPA
2000
Three-Dimensional Electron Microscopy of the Clamp Loader Small Subunit from Pyrococcus furiosus
2001
Crystal structure of Escherichia coli RNase HI in complex with Mg2+ at 2.8 Å resolution: Proof for a single Mg2+‐binding site
1993
Snap helix with knob and hole: Essential repeats in S. pombe nuclear protein nuc2 +
1990
The clamp-loading complex for processive DNA replication
2004
Three-dimensional structure of ribonuclease H from E. coli
1990 Nature
PI-Pful and PI-PfuII, intein-coded homing endonucleases from Pyrococcus furiosus. I. Purification and identification of the homing-type endonuclease activities
1999
Atomic model of a pyrimidine dimer excision repair enzyme complexed with a dna substrate: Structural basis for damaged DNA recognition
1995
The nucleotide sequence of the fission yeast DNA topoisomerase II gene: structural and functional relationships to other DNA topoisomerases.
1986
Identification of four acidic amino acids that constitute the catalytic center of the RuvC Holliday junction resolvase.
1995
Development of a superfluid helium stage for high-resolution electron microscopy
1991
A Holliday junction resolvase from Pyrococcus furiosus : Functional similarity to Escherichia coli RuvC provides evidence for conserved mechanism of homologous recombination in Bacteria, Eukarya, and Archaea
1999
Crystallization and preliminary X‐ray diffraction study of 5 S rRNA from Thermus thermophilus HB8
1982
X-Ray Structure of T4 Endonuclease V: an Excision Repair Enzyme Specific for a Pyrimidine Dimer
1992 Science
Structural features of the GDP binding site of elongation factor Tu from Escherichia coli as determined by X‐ray diffraction
1981
Visualization of Individual DNA Molecules in Solution by Light Microscopy: DAPI Staining Method1
1981
Overproduction and preliminary crystallographic study of ribonuclease H from Escherichia coli
1989
Crystal structure of the Holliday junction DNA in complex with a single RuvA tetramer
2000
High resolution X-ray crystallographic analysis of a modified form of the elongation factor Tu:Guanosine diphosphate complex
1978
How does RNase H recognize a DNA.RNA hybrid?
1991
Structural views of the ligand-binding cores of a metabotropic glutamate receptor complexed with an antagonist and both glutamate and Gd 3+
2002