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Citing Papers
TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo
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Autophagy promotes MHC class II presentation of peptides from intracellular source proteins
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Homeostatic maintenance of natural Foxp3 + CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization
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2001
Analysis of MHC class II DP, DQ and DR alleles in Crohn’s disease
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CD4+ Tregs and immune control
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β-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation
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2012 StandoutNobel
Increased numbers of T cells recognizing multiple myelin basic protein epitopes in multiple sclerosis
1992
Spinal fluid lymphocytes from a subgroup of multiple sclerosis patients respond to mycobacterial antigens
1993
Lack of over-expression of T cell receptor Vβ5.2 in myelin basic protein-specific T cell lines derived from HLA-DR2 positive multiple sclerosis patients and controls
1998
Differences between T‐cell reactivities to major myelin protein‐derived peptides in opticospinal and conventional forms of multiple sclerosis and healthy controls
2001
ICOS co-stimulatory receptor is essential for T-cell activation and function
2001 StandoutNatureNobel
Myelin basic protein-specific T lymphocyte repertoire in multiple sclerosis. Complexity of the response and dominance of nested epitopes due to recruitment of multiple T cell clones.
1993
The Effect of Infections on Susceptibility to Autoimmune and Allergic Diseases
2002 Standout
Migration of Hematogenous Cells Through the Blood‐Brain Barrier and the Initiation of CNS Inflammation
1991
Mechanisms Underlying Inflammation in Neurodegeneration
2010 Standout
Autoreactive T and B cells responding to myelin proteolipid protein in multiple sclerosis and controls
1991
Immunodominance of a low-affinity major histocompatibility complex-binding myelin basic protein epitope (residues 111-129) in HLA-DR4 (B1*0401) subjects is associated with a restricted T cell receptor repertoire.
1997
A new approach for evaluating antigen-specific T cell responses to myelin antigens during the course of multiple sclerosis
2003
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
2003 StandoutNature
Quantitative and qualitative changes in gene expression patterns characterize the activity of plaques in multiple sclerosis
2003
Dual Detection of Fungal Infections in Drosophila via Recognition of Glucans and Sensing of Virulence Factors
2006 StandoutNobel
Regulatory T Cells
2000 StandoutNobel
Recognition of the immunodominant myelin basic protein peptide by autoantibodies and HLA-DR2-restricted T cell clones from multiple sclerosis patients. Identity of key contact residues in the B-cell and T-cell epitopes.
1997
HLA-DR2–restricted responses to proteolipid protein 95-116 peptide cause autoimmune encephalitis in transgenic mice
2000
A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment
2000 Standout
Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells
1993 StandoutNature
TCR repertoire to proteolipid protein (PLP) in multiple sclerosis (MS): homologies between PLP-specific T cells and MS-associated T cells in TCR junctional sequences
1996
The Shaping of the Brain–Specific T Lymphocyte Repertoire in the Thymus
1996
Direct presentation of nonpeptide prenyl pyrophosphate antigens to human γδ T cells
1995
T Lymphocyte Tolerance: From Thymic Deletion to Peripheral Control Mechanisms
1998
Multiple sclerosis candidate autoantigens except myelin oligodendrocyte glycoprotein are transcribed in human thymus
2002
Increased immunoreactivity to two overlapping peptides of myelin proteolipid protein in multiple sclerosis
1997
Identification of a novel T cell epitope of human proteolipid protein (residues 40–60) recognized by proliferative and cytolytic CD4+ T cells from multiple sclerosis patients
1993
CD4+CD28– costimulation-independent T cells in multiple sclerosis
2001
The T‐Cell Repertoire in Myasthenia Gravis Involves Multiple Cholinergic Receptor Epitopes
1992
T cell responses to myelin basic protein in experimental autoimmune encephalomyelitis-resistant BALB/c mice
1993
Human cartilage glycoprotein‐39 as a candidate autoantigen in rheumatoid arthritis
1997
Decreased dependence of myelin basic protein-reactive T cells on CD28-mediated costimulation in multiple sclerosis patients. A marker of activated/memory T cells.
1998
HLA DRB1*1501 and intrathecal inflammation in multiple sclerosis
2000
Multiple sclerosis
2008 Standout
Myasthenia Gravis
1994 Standout
The same TCR (N)Dβ(N)Jβ junctional region is associated with several different vβ13 subtypes in a multiple sclerosis patient at the onset of the disease
2003
Treatment of multiple sclerosis with T–cell receptor peptides: Results of a double–blind pilot trial
1996
Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor
2009 StandoutNobel
Indirect recognition of donor HLA-DR peptides in organ allograft rejection.
1996
Evolving concepts of rheumatoid arthritis
2003 StandoutNature
Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research
2006
Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading
1997
New Approaches and Therapeutics Targeting Apoptosis in Disease
2005
Blood T-cell receptor chain transcriptome in multiple sclerosis. Characterization of the T cells with altered CDR3 length distribution
2004
Myelin basic protein‐specific T‐cell responses in identical twins discordant or concordant for multiple sclerosis
1993
CD4 T‐cell epitopes of human α B‐crystallin
2004
Binding of myelin basic protein peptides to human histocompatibility leukocyte antigen class II molecules and their recognition by T cells from multiple sclerosis patients.
1993
Inflammatory Bowel Disease
2002 Standout
CTLA-4 dysregulation in the activation of myelin basic protein reactive T cells may distinguish patients with multiple sclerosis from healthy controls
2003
Decreases in Interleukin-4 Secretion by Invariant CD4−CD8−Vα24JαQ T Cells in Peripheral Blood of Patients with Relapsing–Remitting Multiple Sclerosis
2001
Cross‐reactivity with myelin basic protein and human herpesvirus‐6 in multiple sclerosis
2003
T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development
2012 StandoutNobel
Oligoclonal expansion of memory CD8+ T cells in cerebrospinal fluid from multiple sclerosis patients
2002
Critical regulation of CD4+ T cell survival and autoimmunity by β-arrestin 1
2007
Encephalitogenic potential of the myelin basic protein peptide (amino acids 83–99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand
2000
Selective activation and accumulation of oligoclonal V beta-specific T cells in active pulmonary sarcoidosis.
1994
Superantigens: Mechanism of T-Cell Stimulation and Role in Immune Responses
1991
Ex vivo detection of myelin basic protein‐reactive T cells in multiple sclerosis and controls using specific TCR oligonucleotide probes
2004
Regulatory T cells in transplantation tolerance
2003 StandoutNobel
Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria
2011 Standout
T cell vaccination in multiple sclerosis: results of a preliminary study
2002
Sarcoidosis
1997 Standout
T cell receptor repertoire of T lymphocytes recovered from the lung and blood of patients with sarcoidosis.
1994
Limited heterogeneity of biased T‐cell receptor Vβ gene usage in lung but not blood T cells in active pulmonary sarcoidosis
1996
Identification of a second T cell epitore of human proteolipid protein (residues 89–106) recognized by proliferative and cytolytic CD4+ T cells from multiple sclerosis patients
1994
FOXP3+ regulatory T cells in the human immune system
2010 StandoutNobel
BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1
2003 StandoutNobel
A novel and rapid cloning method for the T-cell receptor variable region sequences
1991
High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice
1994 Nobel
A functional and structural basis for TCR cross-reactivity in multiple sclerosis
2002
PD-1 ligands, negative regulators for activation of naïve, memory, and recently activated human CD4+ T cells
2004
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
T Cell Immunoglobulin Mucin-3 Crystal Structure Reveals a Galectin-9-Independent Ligand-Binding Surface
2007 StandoutNobel
T cell response to myelin basic protein in the context of the multiple sclerosis-associated HLA-DR15 haplotype: peptide binding, immunodominance and effector functions of T cells
1997
HLA-DR2 Dose Effect on Susceptibility to Multiple Sclerosis and Influence on Disease Course
2003
Skewed T-cell receptor repertoire in genetically identical twins correlates with multiple sclerosis
1993 Nature
HLA-DP: A Class II Restriction Molecule Involved in Epitope Spreading During the Development of Multiple Sclerosis
1998
Sarcoidosis
2007 Standout
Molecular tracking of antigen-specific T cell clones in neurological immune-mediated disorders
2002
Innate and adaptive immune requirements for induction of autoimmune demyelinating disease by molecular mimicry
2003
Animal models
1994
Biomarkers in multiple sclerosis
2015
Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein
1995
The immunopathogenesis of sepsis
2002 StandoutNature
Pembrolizumab versus Chemotherapy for PD-L1–Positive Non–Small-Cell Lung Cancer
2016 Standout
Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones.
1994
Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis
1994 StandoutScience
Dysregulated T cell expression of TIM3 in multiple sclerosis
2006
Compartmentalization of T lymphocytes to the site of disease: intrahepatic CD4+ T cells specific for the protein NS4 of hepatitis C virus in patients with chronic hepatitis C.
1993 StandoutNobel
Expansion of Autoreactive T Cells in Multiple Sclerosis Is Independent of Exogenous B7 Costimulation
1998
CD4+CD25high Regulatory Cells in Human Peripheral Blood
2001 Standout
Efficient Presentation of Phagocytosed Cellular Fragments on the Major Histocompatibility Complex Class II Products of Dendritic Cells
1998 StandoutNobel
Autoreactive CD8+ T-cell responses to human myelin protein-derived peptides.
1994
Recognition of Stress-Induced MHC Molecules by Intestinal Epithelial γδ T Cells
1998 StandoutScience
CD28 Costimulation Is Crucial for the Development of Spontaneous Autoimmune Encephalomyelitis
1999 Nobel
TLR4 Contributes to Disease-Inducing Mechanisms Resulting in Central Nervous System Autoimmune Disease
2004
Multiple Sclerosis
2018 Standout
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
Immunological Aspects of Demyelinating Diseases
1992
TYPE I INTERFERONS (α/β) IN IMMUNITY AND AUTOIMMUNITY
2004 StandoutNobel
Selective anergy of V beta 8+ T cells in human immunodeficiency virus-infected individuals.
1994 StandoutNobel
Immune Tolerance After Delivery of Dying Cells to Dendritic Cells In Situ
2002 StandoutNobel
Cytotoxic T lymphocyte antigen-4 (CTLA-4) limits the expansion of encephalitogenic T cells in experimental autoimmune encephalomyelitis (EAE)-resistant BALB/c mice
2002 StandoutNobel
IMMUNOLOGY OF MULTIPLE SCLEROSIS
2005 Standout
Double-Blind Pilot Trial of Oral Tolerization with Myelin Antigens in Multiple Sclerosis
1993 Science
CD4+regulatory cells as a potential immunotherapy
2005 StandoutNobel
CD4+ Tregs and immune control
2004 StandoutNobel
Oral administration of lipopolysaccharides activates B-1 cells in the peritoneal cavity and lamina propria of the gut and induces autoimmune symptoms in an autoantibody transgenic mouse.
1994 StandoutNobel
A myelin basic protein peptide is recognized by cytotoxic T cells in the context of four HLA-DR types associated with multiple sclerosis.
1991
Complementarity-Determining Region 3 Spectratyping Analysis of the TCR Repertoire in Multiple Sclerosis
2003
Multiple sclerosis
2004
Naive regulatory T cells: a novel subpopulation defined by resistance toward CD95L-mediated cell death
2006
Dual Role for Fas Ligand in the Initiation of and Recovery from Experimental Allergic Encephalomyelitis
1999
Regulatory CD4+ T Cells Expressing Endogenous T Cell Receptor Chains Protect Myelin Basic Protein–specific Transgenic Mice from Spontaneous Autoimmune Encephalomyelitis
1998
Efficient Targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen Presentation on Major Histocompatibility Complex Class I Products and Peripheral CD8+ T Cell Tolerance
2002 StandoutNobel
Myelin-Associated Oligodendrocytic Basic Protein: Identification of an Encephalitogenic Epitope and Association with Multiple Sclerosis
2000
Increased CD8+ Cytotoxic T Cell Responses to Myelin Basic Protein in Multiple Sclerosis
2004
Unique Clinical and Pathological Features in HLA-DRB1*0401–restricted MBP 111–129–specific Humanized TCR Transgenic Mice
2004
CD4+CD28– costimulation-independent T cells in multiple sclerosis
2001
Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions.
1995
Expansion and Functional Relevance of High-Avidity Myelin-Specific CD4+ T Cells in Multiple Sclerosis
2004
Preferential T-cell receptor beta-chain variable gene use in myelin basic protein-reactive T-cell clones from patients with multiple sclerosis.
1991
High prevalence of autoreactive, neuroantigen-specific CD8+ T cells in multiple sclerosis revealed by novel flow cytometric assay
2004
Visualization of Myelin Basic Protein (Mbp) T Cell Epitopes in Multiple Sclerosis Lesions Using a Monoclonal Antibody Specific for the Human Histocompatibility Leukocyte Antigen (Hla)-Dr2–Mbp 85–99 Complex
2000
Restricted T-cell receptor V beta gene usage by myelin basic protein-specific T-cell clones in multiple sclerosis: predominant genes vary in individuals.
1991
Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain
2011 StandoutNobel
Thymus and Autoimmunity: Production of CD25+CD4+ Naturally Anergic and Suppressive T Cells as a Key Function of the Thymus in Maintaining Immunologic Self-Tolerance
1999 StandoutNobel
The T-cell-receptor repertoire in the synovial fluid of a patient with rheumatoid arthritis is polyclonal.
1991
Bacterial pyrogenic exotoxins as superantigens
1995
High Immunogenicity of Intracellular Myelin Oligodendrocyte Glycoprotein Epitopes
2002
Direct Ex Vivo Analysis of Activated, Fas-sensitive Autoreactive T Cells in Human Autoimmune Disease
1997
Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple-sclerosis patients and healthy donors.
1990
Effects of Breeding Environments on Generation and Activation of Autoreactive B-1 Cells in Anti-red Blood Cell Autoantibody Transgenic Mice
1997 StandoutNobel
Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis
2004
Works of Kohei Ota being referenced
T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis
1990 Nature
Microarray analysis identifies interferon β-regulated genes in multiple sclerosis
2003
Two subtypes of optic-spinal form of multiple sclerosis in Japan: clinical and laboratory features
2007
Increased Fas antigen on T cells in multiple sclerosis
1996
Microarray analysis identifies an aberrant expression of apoptosis and DNA damage-regulatory genes in multiple sclerosis
2005
Shared Human T Cell Receptor V β Usage to Immunodominant Regions of Myelin Basic Protein
1990 Science