Citation Impact
Citing Papers
Systematic Genetic Analysis with Ordered Arrays of Yeast Deletion Mutants
2001 StandoutScience
Suppression of Aging in Mice by the Hormone Klotho
2005 StandoutScience
Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces cerevisiae
2000 StandoutScience
Genetic and Functional Studies Implicate HIF1 α as a 14q Kidney Cancer Suppressor Gene
2011 StandoutNobel
The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin
2005 StandoutScience
On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models
2016 StandoutNatureNobel
Topical rapamycin inhibits tuberous sclerosis tumor growth in a nude mouse model
2008
Comprehensive Mutation Analysis of TSC1 and TSC2—and Phenotypic Correlations in 150 Families with Tuberous Sclerosis
1999
mTOR Signaling in Growth Control and Disease
2012 Standout
Retinoic acid receptors: From molecular mechanisms to cancer therapy
2014
Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity
2001
Chromosomal Rearrangements Occur in S. cerevisiae rfa1 Mutator Mutants Due to Mutagenic Lesions Processed by Double-Strand-Break Repair
1998
Replication Protein A Physically Interacts with the Bloom's Syndrome Protein and Stimulates Its Helicase Activity
2000
Tuberous sclerosis complex: linking growth and energy signaling pathways with human disease
2005
Diffusion-Weighted Magnetic Resonance Imaging and Identification of the Epileptogenic Tuber in Patients With Tuberous Sclerosis
2003
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
2001 StandoutNature
Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene
1994 StandoutNature
Essential role of limiting telomeres in the pathogenesis of Werner syndrome
2004
Mutation analysis of the TSC1 and TSC2 genes in Japanese patients with pulmonary lymphangioleiomyomatosis
2002
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
2003 Standout
Tuberous sclerosis complex: Advances in diagnosis, genetics, and management
2007
Mutation in the silencing gene S/R4 can delay aging in S. cerevisiae
1995
The Exonucleolytic and Endonucleolytic Cleavage Activities of Human Exonuclease 1 Are Stimulated by an Interaction with the Carboxyl-terminal Region of the Werner Syndrome Protein
2003
Mosaicism in Tuberous Sclerosis as a Potential Cause of the Failure of Molecular Diagnosis
1999
Telomere Dysfunction Increases Mutation Rate and Genomic Instability
2001 StandoutNobel
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
1997 StandoutNature
Mutational analysis of the TSC1 and TSC2 genes in a diagnostic setting: genotype – phenotype correlations and comparison of diagnostic DNA techniques in Tuberous Sclerosis Complex
2005
Telomeres shorten during ageing of human fibroblasts
1990 StandoutNatureNobel
mTOR Signaling in Growth, Metabolism, and Disease
2017 Standout
TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
2003 Standout
Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family
2011 StandoutNobel
Mutational Analysis in a Cohort of 224 Tuberous Sclerosis Patients Indicates Increased Severity of TSC2, Compared with TSC1, Disease in Multiple Organs
2001
Stimulation of Flap Endonuclease-1 by the Bloom's Syndrome Protein
2004
Autophagy in the Pathogenesis of Disease
2008 Standout
Epilepsy Surgery in Tuberous Sclerosis: A Systematic Review
2007
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
2002 Standout
Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice
1999 StandoutNobel
Tuberous sclerosis
2008 Standout
Consistent Localization of Interictal Epileptiform Activity on EEGs of Patients with Tuberous Sclerosis Complex
2005
Mechanisms of cellular senescence
1997
Insulin signalling and the regulation of glucose and lipid metabolism
2001 StandoutNature
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
2000 StandoutNature
Extrachromosomal rDNA Circles— A Cause of Aging in Yeast
1997
TSC1 and TSC2 mutations in tuberous sclerosis, the associated phenotypes and a model to explain observed TSC1/TSC2 frequency ratios
2002
Structure of the first C2 domain of synaptotagmin I: A novel Ca2+/phospholipid-binding fold
1995 StandoutNobel
Identification of the Epileptogenic Tuber in Patients with Tuberous Sclerosis: A Comparison of High‐resolution EEG and MEG
2006
Klotho converts canonical FGF receptor into a specific receptor for FGF23
2006 StandoutNature
DNA helicases in inherited human disorders
1997
Ras, PI(3)K and mTOR signalling controls tumour cell growth
2006 StandoutNature
The GAP-Related Domain of Tuberin, the Product of the TSC2 Gene, is a Target for Missense Mutations in Tuberous Sclerosis
1997
Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1
1994 Standout
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
2003 StandoutNature
The p66shc adaptor protein controls oxidative stress response and life span in mammals
1999 StandoutNature
Recurrent Lymphangiomyomatosis after Transplantation
2003
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
2010 StandoutNobel
Telomere length predicts replicative capacity of human fibroblasts.
1992 StandoutNobel
Can We Learn about Aging from a Study of Werner's Syndrome?
1982
Topical Review: Intractable Seizures in Tuberous Sclerosis Complex: From Molecular Pathogenesis to the Rationale for Treatment
2005
Structure of the STRA6 receptor for retinol uptake
2016 StandoutScienceNobel
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
Female phenotype and multiple abnormalities in sibs with a Y chromosome and partial X chromosome duplication: H--Y antigen and Xg blood group findings.
1980
Molecular aspects of aging
1985
Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging
2005 StandoutScience
Structure And Evolution Of Calcium-Modulated Protein
1980
The interaction of Ca2+Mg2+ ATPase activator protein and Ca2+ with human erythrocyte membranes
1978
The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae
2002 StandoutNobel
Physiological [Ca2+]i level and pump-leak turnover in intact red cells measured using an incorporated Ca chelator
1982 StandoutNatureNobel
Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction
2000
Nanowire Nanosensors for Highly Sensitive and Selective Detection of Biological and Chemical Species
2001 StandoutScience
Tubulin and calmodulin. Effects of microtubule and microfilament inhibitors on localization in the mitotic apparatus.
1979
The Tuberous Sclerosis Complex and its Highly Variable Manifestations
2003
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
Oxidative Stress, Caloric Restriction, and Aging
1996 StandoutScience
Requirement for Three Novel Protein Complexes in the Absence of the Sgs1 DNA Helicase in Saccharomyces cerevisiae
2001
Calmodulin pharmacology
1981
Positional Cloning of the Werner's Syndrome Gene
1996 Science
Human 67-kDa calelectrin contains a duplication of four repeats found in 35-kDa lipocortins.
1988 StandoutNobel
c-Ha-ras-1 proto-oncogene amplification and overexpression during the limited replicative life span of normal human fibroblasts.
1985
Werner syndrome protein interacts functionally with translesion DNA polymerases
2007
Mismatch repair in extracts of Werner syndrome cell lines.
1997
Aging, life span, and senescence
1998 StandoutNobel
Mutations in the tuberous sclerosis complex geneTSC2are a cause of sporadic pulmonary lymphangioleiomyomatosis
2000
Evidence for a relationship between longevity of mammalian species and life spans of normal fibroblasts in vitro and erythrocytes in vivo
1981
Rapid disassembly of cold-stable microtubules by calmodulin.
1981 StandoutNobel
Cellular Senescence revisited: a review
1987
Reversible shift between two states of Ca2+-ATPase in human erythrocytes mediated by Ca2+ and a membrane-bound activator
1978
Regulation of microtubule cold stability by calmodulin-dependent and -independent phosphorylation.
1983 StandoutNobel
The Molecular Genetics of Cancer
1987 StandoutScienceNobel
Sequence homology of the Ca2+-dependent regulator of cyclic nucleotide phosphodiesterase from rat testis with other Ca2+-binding proteins.
1978
Three-dimensional structure of calmodulin
1985 StandoutNature
Accelerated Aging and Nucleolar Fragmentation in Yeast sgs1 Mutants
1997 Science
Behavioral and Cognitive Aspects of Tuberous Sclerosis Complex
2004
Purification of the Ca2+-stimulated ATPase activator from human erythrocytes. Its membership in the class of Ca2+-binding modulator proteins
1978
Purification and characterization of sheep brain cold-stable microtubules.
1983 StandoutNobel
Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair
2008 StandoutNobel
Mutation-causing mutations
1996 Nature
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Epilepsy Surgery for Children With Tuberous Sclerosis Complex
2004
Calmodulin
1982
Surface Enhanced Raman Spectroscopy of Individual Rhodamine 6G Molecules on Large Ag Nanocrystals
1999 StandoutNobel
Calmodulin. Development and application of a sensitive radioimmunoassay.
1979
Calmodulin Plays a Pivotal Role in Cellular Regulation
1980 StandoutScience
Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase
2001
Human platelet myosin light chain kinase requires the calcium-binding protein calmodulin for activity.
1979
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
1998 StandoutScience
Control of microtubule assembly-disassembly by calcium-dependent regulator protein.
1978
Works of Kit Sing Au being referenced
Hypoglycemia associated with lipid accumulation in primary hepatocellular carcinoma
1973
Genotype/phenotype correlation in 325 individuals referred for a diagnosis of tuberous sclerosis complex in the United States
2007
COL5a1: fine genetic mapping and exclusion as candidate gene in families with nail-patella syndrome, tuberous sclerosis 1, hereditary hemorrhagic telangiectasia, and Ehlers—Danlos syndrome type II
1995
On the Surgical Treatment of Refractory Epilepsy in Tuberous Sclerosis Complex
1997
Mutations and polymorphisms in the tuberous sclerosis complex gene on chromosome 16
1997
Germ-Line Mosaicism in Tuberous Sclerosis: How Common?
1999
Identification of 54 large deletions/duplications in TSC1 and TSC2 using MLPA, and genotype-phenotype correlations
2007
Association of retinoic acid receptor genes with meningomyelocele
2010
Germ-Line Mutational Analysis of the TSC2 Gene in 90 Tuberous-Sclerosis Patients
1998
Systematic growth studies, cocultivation, and cell hybridization studies of Werner syndrome cultured skin fibroblasts
1981
Studies on an endogenous protein activator of pig erythrocyte membrane (Ca2+ + Mg2+)-ATPase
1978
Variegated translocation mosaicism in human skin fibroblast cultures
1975
An endogenous inhibitor of erythrocyte membrane (Ca2+ + Mg2+)-ATPase
1978
Effects of radical-scavenging enzymes and reduced oxygen exposure on growth and chromosome abnormalities of Werner syndrome cultured skin fibroblasts
1981
Evidence of clonal attenuation, clonal succession, and clonal expansion in mass cultures of aging Werner’s syndrome skin fibroblasts
1981
An endogenous inhibitor of erythrocyte membrane (Ca+ + Mg2+)-ATPase involved in calcium transport
1980
Purification of an activator of human erythrocyte membrane (Ca2++Mg2+)ATPase
1977
Molecular Genetic Basis of Tuberous Sclerosis Complex: From Bench to Bedside
2004
Tissue-specific differences in cultured human diploid fibroblasts
1977
Cytogenetics of Werner’s syndrome cultured skin fibroblasts: variegated translocation mosaicism
1981
Differences in human X isochromosomes.
1975