Citation Impact
Citing Papers
Intermittent Administration of MEK Inhibitor GDC-0973 plus PI3K Inhibitor GDC-0941 Triggers Robust Apoptosis and Tumor Growth Inhibition
2011
Two-Step Synthesis of Carbohydrates by Selective Aldol Reactions
2004 Science
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
Pharmacokinetics of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Locally Advanced or Metastatic Solid Tumors: the Role of Alpha-1-Acid Glycoprotein Binding
2011
Hedgehog Signaling Is a Novel Therapeutic Target in Tamoxifen-Resistant Breast Cancer Aberrantly Activated by PI3K/AKT Pathway
2012
Efficacy and Safety of Vismodegib in Advanced Basal-Cell Carcinoma
2012 Standout
Itraconazole and Arsenic Trioxide Inhibit Hedgehog Pathway Activation and Tumor Growth Associated with Acquired Resistance to Smoothened Antagonists
2013
GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas
2013 Nature
Vismodegib
2012
Smarter drugs emerging in pancreatic cancer therapy
2014
Combined Vemurafenib and Cobimetinib in BRAF -Mutated Melanoma
2014 Standout
The mechanisms of Hedgehog signalling and its roles in development and disease
2013 Standout
[6] Properties of solid supports
1997 StandoutNobel
1,4‐Thienodiazepine‐2,5‐diones via MCR (II): Scaffold Hopping by Gewald and Ugi‐Deprotection‐Cyclization Strategy
2010
Inhibition of cruzipain visualized in a fluorescence quenched solid-phase inhibitor library assay.D-Amino Acid Inhibitors for cruzipain, cathepsin B and cathepsin L
1998 StandoutNobel
Reaching for high-hanging fruit in drug discovery at protein–protein interfaces
2007 StandoutNature
Medulloblastomics: the end of the beginning
2012
Nonpeptide glycoprotein IIb/IIIa inhibitors: Substituted quinazolinediones and quinazolinones as potent fibrinogen receptor antagonists
1998
De novo protein design. I. in search of stability and specificity
1999 StandoutNobel
Mechanochemistry: opportunities for new and cleaner synthesis
2011 Standout
Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer
2015 StandoutNature
A computationally engineered RAS rheostat reveals RAS–ERK signaling dynamics
2016 StandoutNobel
The Hedgehog's tale: developing strategies for targeting cancer
2011
α-helix mimicry of a β-turn
1998
The Molecular Signatures Database Hallmark Gene Set Collection
2015 Standout
The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence
2015 Standout
Influence of tumour micro-environment heterogeneity on therapeutic response
2013 StandoutNature
Molybdenum and Tungsten Imido Alkylidene Complexes as Efficient Olefin‐Metathesis Catalysts
2003 StandoutNobel
The recent impact of solid-phase synthesis on medicinally relevant benzoannelated nitrogen heterocycles
2002
Targeting protein–protein interactions for cancer therapy
2005
Glucocorticoid Compounds Modify Smoothened Localization and Hedgehog Pathway Activity
2012
Peptidomimetic design
1998
RGD modified polymers: biomaterials for stimulated cell adhesion and beyond
2003 Standout
Antagonists of protein–protein interactions
2000
Unraveling the therapeutic potential of the Hedgehog pathway in cancer
2013 Standout
The Diels-Alder Reaction in Total Synthesis
2002 Standout
NMR structure of a complex between MDM2 and a small molecule inhibitor
2004
Small molecule modulation of HH-GLI signaling: Current leads, trials and tribulations
2010
RosettaLigand Docking with Full Ligand and Receptor Flexibility
2008 StandoutNobel
Neutrophils in cancer: neutral no more
2016 Standout
The Organic Approach to Asymmetric Catalysis
2006 StandoutScienceNobel
Integrins
2002 Standout
Synthesis and evaluation of RGD peptidomimetics aimed at surface bioderivatization of polymer substrates
1998
Small Molecule Antagonists in Distinct Binding Modes Inhibit Drug-Resistant Mutant of Smoothened
2011
Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling
2014
Protein–protein interactions as targets for small molecule drug discovery
2006
Copper-Mediated Coupling Reactions and Their Applications in Natural Products and Designed Biomolecules Synthesis
2008 Standout
Solvent-Free Heterocyclic Synthesis
2009
Solid-Phase Intramolecular N-Acyliminium Pictet−Spengler Reactions as Crossroads to Scaffold Diversity
2004 StandoutNobel
Multicomponent Reactions with Isocyanides
2000 Standout
Chemistry of Polyvalent Iodine
2008 Standout
Synthesis and reactions of lithio derivatives of 1‐allenylbenzotriazole
1995
Metal-Initiated Amination of Alkenes and Alkynes
1998 Standout
Stereocontrolled cyclofunctionalizations of double bonds through heterocyclic intermediates
1990
Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design
2018 Standout
Oligosaccharide Mimetics Obtained by Novel, Rapid Screening of Carboxylic Acid Encoded Glycopeptide Libraries
1998 StandoutNobel
The magnitude of the stereodirecting effect of an allylic alkoxy-substituent in an amidomercuration cyclization
1990
Hydroamination: Direct Addition of Amines to Alkenes and Alkynes
2008 Standout
CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2006-2010
2013 Standout
Samarium(II)-Iodide-Mediated Cyclizations in Natural Product Synthesis
2004 Standout
The Organocatalytic Approach to Enantiopure 2H‐ and 3H‐Pyrroles: Inhibitors of the Hedgehog Signaling Pathway
2016 StandoutNobel
Novel applications of resin bound α-amino acids for the synthesis of benzodiazepines (via Wang resin) and ketopiperazines (via hydroxymethyl resin)
2000
Combinatorial Synthesis of Small Organic Molecules
1996
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Total Syntheses of (±)- and (−)-Stemoamide
2000
Novel applications of ethyl glyoxalate with the Ugi MCR
1999
Recent Developments in Isocyanide Based Multicomponent Reactions in Applied Chemistry
2005 Standout
Electrophilicity Index
2006 Standout
Oncogenic RAS pathway activation promotes resistance to anti-VEGF therapy through G-CSF–induced neutrophil recruitment
2013
Precise Modulation of CO2 Sorption in Ti8Ce2–Oxo Clusters: Elucidating Lewis Acidity of the Ce Metal Sites and Structural Flexibility
2024 StandoutNobel
Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies
2012
Palladium catalysed aryl enol ether synthesis from vinyl triflatesElectronic supplementary information (ESI) available: experimental. See http://www.rsc.org/suppdata/cc/b3/b307574e/
2003
A Unified Approach to Differentially Linked β-C-Disaccharides by Ring-Closing Metathesis
2001
A Remarkable Two-Step Synthesis of Diverse 1,4-Benzodiazepine-2,5-diones Using the Ugi Four-Component Condensation
1996
Olefin Metathesis and Beyond
2000 Standout
Diverse, High-Quality Test Set for the Validation of Protein−Ligand Docking Performance
2007
Aryl−Aryl Bond Formation by Transition-Metal-Catalyzed Direct Arylation
2007 Standout
Direct visualization of enzyme inhibitors using a portion mixing inhibitor library containing a quenched fluorogenic peptide substrate. Part 1. Inhibitors for subtilisin Carlsberg
1995 StandoutNobel
Convergent preparation of 1,6-linked C-disaccharides via olefin metathesis
1999
High chemoselectivity of CS dipolarophile in 1,3‐dipolar cycloaddition of nitrilimines and 1,2,4‐triazepin‐5‐one derivatives: experimental, theoretical and X‐ray study
2005
Hedgehog pathway inhibition and the race against tumor evolution
2012
Ring closing metathesis as an efficient approach to branched cyclitols and aminocyclitols: a short synthesis of valiolamine
1999
Mechanistic Diversity of Cytokine Receptor Signaling Across Cell Membranes
2004
A Field Guide to Foldamers
2001 Standout
Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model
2012
The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures
2003 Standout
A novel and efficient iodine(III)-mediated access to 1,4-benzodiazepin-2-ones
2002
Properties and Synthetic Utility ofN-Substituted Benzotriazoles
1998 Standout
Advances in Synthetic Applications of Hypervalent Iodine Compounds
2016 Standout
Solid-Phase Library Synthesis, Screening, and Selection of Tight-Binding Reduced Peptide Bond Inhibitors of a RecombinantLeishmaniamexicanaCysteine Protease B
2002 StandoutNobel
An Olefin Metathesis Route for the Preparation of (1→6)-Linked C-Disaccharide Glycals. A Convergent and Flexible Approach to C-Saccharide Synthesis
2000
Selective Identification of Hedgehog Pathway Antagonists By Direct Analysis of Smoothened Ciliary Translocation
2012
Preparation of C-1 Glycals via Olefin Metathesis. A Convergent and Flexible Approach to C-Glycoside Synthesis1
1999
Initial Assessment of Tumor Regrowth After Vismodegib in Advanced Basal Cell Carcinoma
2012
Transition-Metal-Catalyzed Reactions in Heterocyclic Synthesis
2004 Standout
An architectonic macrolide library based on a C2-symmetric macrodiolide toward pharmaceutical compositions
2015 StandoutNobel
Dibenzo-1,5-diazocine-2,6-dione, 2-iminoindolin-3-one and N-(carbamoylmethyl)-aminobenzoic acid ester from aminobenzoic acid by multicomponent reactions
1998
Samarium(II) iodide mediated transformations of carbohydrate derived alkenyl iodides
1997
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
Palladium- and Copper-Catalyzed Synthesis of Medium- and Large-Sized Ring-Fused Dihydroazaphenanthrenes and 1,4-Benzodiazepine-2,5-diones. Control of Reaction Pathway by Metal-Switching
2004
Asymmetric Enamine Catalysis
2007 StandoutNobel
Total Synthesis of Carba-d -fructofuranose via a Novel Metathesis Reaction
1999
Platelet Glycoprotein IIb-IIIa Antagonists as Prototypical Integrin Blockers: Novel Parenteral and Potential Oral Antithrombotic Agents
2000
SPOCC: A Resin for Solid-Phase Organic Chemistry and Enzymatic Reactions on Solid Phase
1999 StandoutNobel
Solid phase synthesis of 1,4-benzodiazepine-2,5-diones
1996
An expeditious route to the synthesis of highly functionalized chiral oxepines from monosaccharides
1998
Works of Kirk Robarge being referenced
Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance
2010
A Selective, Slow Binding Inhibitor of Factor VIIa Binds to a Nonstandard Active Site Conformation and Attenuates Thrombus Formation in Vivo
2005
Preclinical assessment of the absorption, distribution, metabolism and excretion of GDC-0449 (2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide), an orally bioavailable systemic Hedgehog signalling pathway inhibitor
2009
Preclinical disposition and pharmacokinetics-pharmacodynamic modeling of biomarker response and tumour growth inhibition in xenograft mouse models of G-573, a MEK inhibitor
2010
Preclinical Disposition of GDC-0973 and Prospective and Retrospective Analysis of Human Dose and Efficacy Predictions
2012
Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479
2014
Preparation and biological activity of novel tricyclic GPIIb/IIIa antagonists
1998
ChemInform Abstract: From Peptide to Non‐Peptide. Part 2. The de novo Design of Potent, Non‐ Peptidal Inhibitors of Platelet Aggregation Based on a Benzodiazepinedione Scaffold.
1994
Stereoselectivity in the electrophile-mediated cyclization of 2,3,5-tri-O-benzyl-1,2-dideoxy-d-arabino-hex-1-enitol. A stereocontrolled synthesis of 1-amino-2,5-anhydro-3,4,6-tri-O-benzyl-1-deoxy-d-glucitol
1987
From Peptide to Non-Peptide. 2. The de Novo Design of Potent, Non-peptidal Inhibitors of Platelet Aggregation Based on a Benzodiazepinedione Scaffold
1994
Mono-N-alkylation of anthranilamides via quinazolinones. An efficient synthesis of G5598, a benzodiazepine dione gpIIbIIIa antagonist
1994
Stereoselectivity in electrophile-mediated intramolecular cyclizations of hept-2-enitols
1989
Electrophile-mediated cyclizations in carbohydrate chemistry: synthesis of highly functionalized ribofuranose and ribopyranose compounds
1985
From Peptide to Non-Peptide. 3. Atropisomeric GPIIbIIIa Antagonists Containing the 3,4-Dihydro-1H-1,4-benzodiazepine-2,5-dione Nucleus
1997
Accelerated inverse electron demand Diels-Alder reactions of 1-oxa-1,3-butadienes: [4 + 2] cycloaddition reactions of .beta.,.gamma.-unsaturated .alpha.-keto esters
1988
Divergent de novo synthesis of carbohydrates based on an accelerated inverse electron demand Diels-Alder reaction of 1-oxa-1,3-butadienes
1988
Epimerization at C-2 during the Wittig reaction of 2,3,5-tri-O-benzyl-d-ribose and methylidenetriphenylphosphorane
1986