Citation Impact
Citing Papers
Differential PI3Kδ Signaling in CD4+ T-cell Subsets Enables Selective Targeting of T Regulatory Cells to Enhance Cancer Immunotherapy
2017
A key role for ATF3 in regulating mast cell survival and mediator release
2010
Phosphoinositide 3-kinase γ/δ inhibition limits infarct size after myocardial ischemia/reperfusion injury
2006
Macrophage PI3Kγ Drives Pancreatic Ductal Adenocarcinoma Progression
2016
A sex-biased imbalance between Tfr, Tph, and atypical B cells determines antibody responses in COVID-19 patients
2023 StandoutNobel
Idelalisib given front-line for treatment of chronic lymphocytic leukemia causes frequent immune-mediated hepatotoxicity
2016
PD-1 + regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer
2019 StandoutNobel
Meta-hallmarks of aging and cancer
2023
Human Neuronal Cells Possess Functional Cytoplasmic and TLR-Mediated Innate Immune Pathways Influenced by Phosphatidylinositol-3 Kinase Signaling
2010
MAPK, Phosphatidylinositol 3-Kinase, and Mammalian Target of Rapamycin Pathways Converge at the Level of Ribosomal Protein S6 Phosphorylation to Control Metabolic Signaling in CD8 T Cells
2009
Phosphoproteomic Analyses of Interleukin 2 Signaling Reveal Integrated JAK Kinase-Dependent and -Independent Networks in CD8 + T Cells
2016
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy
2022 StandoutNobel
The Regulation of Class IA PI 3-Kinases by Inter-Subunit Interactions
2010
T cell receptor signalling in the control of regulatory T cell differentiation and function
2016
Elements of cancer immunity and the cancer–immune set point
2017 StandoutNature
Role of the phosphoinositide 3‐kinase p110δ in generation of type 2 cytokine responses and allergic airway inflammation
2007
PI3Kδ and primary immunodeficiencies
2016
Molecular regulation of mast cell activation
2006
A role for phosphoinositol 3–kinase δ in the impairment of glucocorticoid responsiveness in patients with chronic obstructive pulmonary disease
2010
PI3K signalling in inflammation
2014
MAP Kinase Inhibition Promotes T Cell and Anti-tumor Activity in Combination with PD-L1 Checkpoint Blockade
2016
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
Structural, Biochemical, and Biophysical Characterization of Idelalisib Binding to Phosphoinositide 3-Kinase δ
2015
Mammalian phosphoinositide kinases and phosphatases
2009 StandoutNobel
Class I PI3K in oncogenic cellular transformation
2008
Synergy in activating class I PI3Ks
2015
Hallmarks of aging: An expanding universe
2023 Standout
Autophagy fights disease through cellular self-digestion
2008 StandoutNature
Differential Regulation of Protrusion and Polarity by PI(3)K during Neutrophil Motility in Live Zebrafish
2010
Tipping the metabolic scales towards increased longevity in mammals
2015
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils
2005
Binding of Ras to Phosphoinositide 3-Kinase p110α Is Required for Ras- Driven Tumorigenesis in Mice
2007
Targeting the phosphoinositide 3-kinase pathway in cancer
2009 Standout
Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation
2008
Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity
2016 Nature
Phosphoinositide 3‐kinases in cell migration
2008
Mast Cell Chemotaxis – Chemoattractants and Signaling Pathways
2012
Glutamate neurotoxicity and diseases of the nervous system
1988 Standout
PI3Kγ inhibition: towards an 'aspirin of the 21st century'?
2006
Regulation of β-Adrenergic Receptor Signaling by S-Nitrosylation of G-Protein-Coupled Receptor Kinase 2
2007 StandoutNobel
Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation
2006 Nature
The development of allergic inflammation
2008 StandoutNature
Autophagy in the Pathogenesis of Disease
2008 Standout
Lipid signalling in disease
2008
Essential role for the p110 isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia
2005
Potential therapeutic applications of autophagy
2007
Structure of the Novel C-terminal Domain of Vacuolar Protein Sorting 30/Autophagy-related Protein 6 and Its Specific Role in Autophagy
2012 StandoutNobel
Harnessing the plasticity of CD4+ T cells to treat immune-mediated disease
2016
The evolution of checkpoint blockade as a cancer therapy: what's here, what's next?
2015
Regulatory T cells in cancer immunotherapy
2016 StandoutNobel
Regulatory T Cells: Molecular and Cellular Basis for Immunoregulation
2017
Emerging Biological Principles of Metastasis
2017 Standout
The emerging mechanisms of isoform-specific PI3K signalling
2010
Methods in Mammalian Autophagy Research
2010 Standout
Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy
2017 Standout
A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling
2006
Myocardial Reperfusion Injury
2007 Standout
PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting
2014
Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells
2008
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy
2017
New developments in FcεRI regulation, function and inhibition
2007
AKT/PKB Signaling: Navigating the Network
2017 Standout
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
The role of senescent cells in ageing
2014 StandoutNature
Geroscience: Linking Aging to Chronic Disease
2014 Standout
The Hallmarks of Aging
2013 Standout
Immune cell promotion of metastasis
2015
PI3Kδ inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model
2014
The PI3K Pathway in Human Disease
2017 Standout
Targeting PI3K signalling in cancer: opportunities, challenges and limitations
2009 Standout
VEGF in Signaling and Disease: Beyond Discovery and Development
2019 Standout
A selective inhibitor of the p110δ isoform of PI 3-kinase inhibits AML cell proliferation and survival and increases the cytotoxic effects of VP16
2006
Integrated signalling pathways for mast-cell activation
2006 Standout
The phosphoinositide 3-kinase pathway and therapy resistance in cancer
2015
Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer
2019 StandoutNobel
Chaperone-mediated Autophagy Targets Hypoxia-inducible Factor-1α (HIF-1α) for Lysosomal Degradation
2013 StandoutNobel
Roles of regulatory T cells in cancer immunity
2016
Regulatory T Cells and Human Disease
2020 StandoutNobel
Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses
2011 StandoutNobel
The PI3K Isoforms p110α and p110δ Are Essential for Pre–B Cell Receptor Signaling and B Cell Development
2010
Targeting Treg cells in cancer immunotherapy
2019 StandoutNobel
Ultrasensitive and absolute quantification of the phosphoinositide 3-kinase/Akt signal transduction pathway by mass spectrometry
2006
Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model
2016 StandoutNobel
PI3K signalling in B- and T-lymphocytes: new developments and therapeutic advances
2012
Dialogue between E. coli free radical pathways and the mitochondria of C. elegans
2015 StandoutNobel
PI3K p110δ regulates T-cell cytokine production during primary and secondary immune responses in mice and humans
2010
Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II–III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas
2016 Standout
Inhibition of Class I Phosphoinositide 3-Kinase Activity Impairs Proliferation and Triggers Apoptosis in Acute Promyelocytic Leukemia without Affecting Atra-Induced Differentiation
2009
Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2
2012 StandoutNobel
The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways
2022 StandoutNobel
Spermidine in health and disease
2018 StandoutScience
Chimeric Antigen Receptor Therapy
2018 Standout
Proenkephalin+regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function
2020 StandoutNobel
Signaling by the Phosphoinositide 3-Kinase Family in Immune Cells
2013
Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation
2020 StandoutNobel
Role of β-adrenergic receptor signaling and desensitization in heart failure: new concepts and prospects for treatment
2006
Mouse Models to Disentangle the Hallmarks of Human Aging
2018
Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells
2021 StandoutNobel
Targeting PI3K in Cancer: Impact on Tumor Cells, Their Protective Stroma, Angiogenesis, and Immunotherapy
2016
Tissue-specific contributions of Tmem79 to atopic dermatitis and mast cell-mediated histaminergic itch
2018 StandoutNobel
PI3K, Rho, and ROCK play a key role in hypoxia-induced ATP release and ATP-stimulated angiogenic responses in pulmonary artery vasa vasorum endothelial cells
2009
Inflammation and metabolism in tissue repair and regeneration
2017 StandoutScience
Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells
2016
The Pten/PI3K pathway governs the homeostasis of Vα14iNKT cells
2006 StandoutNobel
Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti–CTLA-4 antibody
2018 StandoutNobel
Works of Khaled Ali being referenced
Antigen receptor signalling: a distinctive role for the p110δ isoform of PI3K
2007
Isoform-Specific Functions of Phosphoinositide 3-Kinases: p110δ but Not p110γ Promotes Optimal Allergic Responses In Vivo
2008
Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer
2014 Nature
Essential role for the p110δ phosphoinositide 3-kinase in the allergic response
2004 Nature
Signalling by PI3K isoforms: insights from gene-targeted mice
2005
Engineered IL-21 Cytokine Muteins Fused to Anti-PD-1 Antibodies Can Improve CD8+ T Cell Function and Anti-tumor Immunity
2020
Long‐term p110α PI3K inactivation exerts a beneficial effect on metabolism
2013
Btk-dependent Rac activation and actin rearrangement following FcεRI aggregation promotes enhanced chemotactic responses of mast cells
2010