Citation Impact
Citing Papers
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
2018 StandoutScienceNobel
The spatial architecture of protein function and adaptation
2012 Nature
A polybasic domain in aPKC mediates Par6-dependent control of membrane targeting and kinase activity
2020
Surface Sites for Engineering Allosteric Control in Proteins
2008 Science
De novo design of transmembrane β barrels
2021 StandoutScienceNobel
Site-Specific Insertion of 3-Aminotyrosine into Subunit α2 of E. coli Ribonucleotide Reductase: Direct Evidence for Involvement of Y 730 and Y 731 in Radical Propagation
2007
Transposition-Driven Genomic Heterogeneity in the Drosophila Brain
2013 StandoutScienceNobel
Designed protein logic to target cells with precise combinations of surface antigens
2020 StandoutScienceNobel
De novo design of modular and tunable protein biosensors
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Computational design of soluble and functional membrane protein analogues
2024 StandoutNatureNobel
Par complex cluster formation mediated by phase separation
2020
aPKC Phosphorylation of Bazooka Defines the Apical/Lateral Border in Drosophila Epithelial Cells
2010
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
Distinct Binding Specificity of the Multiple PDZ Domains of INADL, a Human Protein with Homology to INAD from Drosophila melanogaster
2001
Antiphase Oscillation of the Left and Right Suprachiasmatic Nuclei
2000 Science
Structure of a mammalian ryanodine receptor
2014 StandoutNatureNobel
Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex
2000
Funnels, pathways, and the energy landscape of protein folding: A synthesis
1995 Standout
Analysis of PDZ Domain-Ligand Interactions Using Carboxyl-terminal Phage Display
2000
RIM Proteins Tether Ca2+ Channels to Presynaptic Active Zones via a Direct PDZ-Domain Interaction
2011 StandoutNobel
Hot Spots for Allosteric Regulation on Protein Surfaces
2011
Molecular mechanisms of nociception
2001 StandoutNatureNobel
How signaling between cells can orient a mitotic spindle
2011
Modular and tunable biological feedback control using a de novo protein switch
2019 StandoutNatureNobel
A mammalian PAR-3–PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity
2000
Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain
2016 StandoutNatureNobel
Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1
2010
What are the dielectric “constants” of proteins and how to validate electrostatic models?
2001
A Buried Polar Interaction Imparts Structural Uniqueness in a Designed Heterodimeric Coiled Coil
1995
Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis
2016 StandoutNobel
Apical–basal polarity and the control of epithelial form and function
2022
The dynamic disulphide relay of quiescin sulphydryl oxidase
2012 StandoutNatureNobel
Photonic structures in biology
2003 StandoutNature
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
Nonmuscle Myosin II Isoforms Coassemble in Living Cells
2014 StandoutNobel
Quantification of PDZ Domain Specificity, Prediction of Ligand Affinity and Rational Design of Super-binding Peptides
2004
Protein folding and misfolding: mechanism and principles
2007
A Bivalent Tarantula Toxin Activates the Capsaicin Receptor, TRPV1, by Targeting the Outer Pore Domain
2010 StandoutNobel
Role of the Biomolecular Energy Gap in Protein Design, Structure, and Evolution
2012 StandoutNobel
Nitric Oxide and Peroxynitrite in Health and Disease
2007 Standout
Rewiring cell signaling: the logic and plasticity of eukaryotic protein circuitry
2004
A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain
2011 StandoutNatureNobel
Rational design of α-helical tandem repeat proteins with closed architectures
2015 StandoutNatureNobel
Voltage-gated ion channels and gating modifier toxins
2006
Membrane protein sequestering by ionic protein–lipid interactions
2011 StandoutNatureNobel
Camguk/CASK Enhances Ether-Á-Go-Go Potassium Current by a Phosphorylation-Dependent Mechanism
2005
Molecular Roots of Degenerate Specificity in Syntenin's PDZ2 Domain
2003
Engineering synthetic signaling proteins with ultrasensitive input/output control
2007
Plasma membrane phosphoinositide organization by protein electrostatics
2005 Nature
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor
2011 StandoutNatureNobel
Synthetic Par polarity induces cytoskeleton asymmetry in unpolarized mammalian cells
2023 StandoutNobel
A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain
2019 StandoutNobel
The structure and function of G-protein-coupled receptors
2009 StandoutNatureNobel
TRPV1 structures in distinct conformations reveal activation mechanisms
2013 StandoutNatureNobel
Overview of Molecular Relationships in the Voltage-Gated Ion Channel Superfamily
2005
Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer
2009
PDZ domains – glue and guide
2003
aPKC Inhibition by Par3 CR3 Flanking Regions Controls Substrate Access and Underpins Apical-Junctional Polarization
2016
Light‐Directed Protein Binding of a Biologically Relevant β‐Sheet
2009
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action
2016 StandoutNatureNobel
Mitotic Spindle Orientation in Asymmetric and Symmetric Cell Divisions during Animal Development
2011
De novo design of bioactive protein switches
2019 StandoutNatureNobel
Characterization of Three Full-length Human Nonmuscle Myosin II Paralogs
2013
Structural snapshots of TRPV1 reveal mechanism of polymodal functionality
2021 StandoutNobel
Allosteric Switches: Remote Controls for Proteins
2009
Modular peptide binding: From a comparison of natural binders to designed armadillo repeat proteins
2013
An RNAi Screen in a Novel Model of Oriented Divisions Identifies the Actin-Capping Protein Z β as an Essential Regulator of Spindle Orientation
2017
Different WASP family proteins stimulate different Arp2/3 complex-dependent actin-nucleating activities
2001
CASK Functions as a Mg2+-Independent Neurexin Kinase
2008 StandoutNobel
Photocontrol of Contracting Muscle Fibers
2011
Solution Structure of the RIM1α PDZ Domain in Complex with an ELKS1b C-terminal Peptide
2005 StandoutNobel
Nck and Phosphatidylinositol 4,5-Bisphosphate Synergistically Activate Actin Polymerization through the N-WASP-Arp2/3 Pathway
2001
A surprising simplicity to protein folding
2000 StandoutNatureNobel
Programmable design of orthogonal protein heterodimers
2018 StandoutNatureNobel
Coupled oscillators control morning and evening locomotor behaviour of Drosophila
2004 StandoutNatureNobel
Computational design of ligand-binding proteins with high affinity and selectivity
2013 StandoutNatureNobel
hCASK and hDlg Associate in Epithelia, and Their Src Homology 3 and Guanylate Kinase Domains Participate in Both Intramolecular and Intermolecular Interactions
2000
Structural Brain Mutants: Mushroom Body Defect (Mud): A Case Study
2009
Cellular Motility Driven by Assembly and Disassembly of Actin Filaments
2003 Standout
A Photocontrolled β‐Hairpin Peptide
2005
The organization of INAD-signaling complexes by a multivalent PDZ domain protein in Drosophila photoreceptor cells ensures sensitivity and speed of signaling
1999
The crosstalk between microtubules, actin and membranes shapes cell division
2020
Oxidative Protein Folding and the Quiescin–Sulfhydryl Oxidase Family of Flavoproteins
2010
Synaptic transmission regulated by a presynaptic MALS/Liprin-α protein complex
2006
Macrophage podosomes assemble at the leading lamella by growth and fragmentation
2003
Remote control of therapeutic T cells through a small molecule–gated chimeric receptor
2015 Science
Activation by Cdc42 and Pip2 of Wiskott-Aldrich Syndrome Protein (Wasp) Stimulates Actin Nucleation by Arp2/3 Complex
2000
Proline Rich Motifs as Drug Targets in Immune Mediated Disorders
2012
Organization of Signaling Complexes by PDZ-Domain Scaffold Proteins
2003
Regulation of Actin Filament Network Formation Through ARP2/3 Complex: Activation by a Diverse Array of Proteins
2001
Dynein–Dynactin–NuMA clusters generate cortical spindle-pulling forces as a multi-arm ensemble
2018
Neuronal IP33-Kinase is an F-actin–bundling Protein: Role in Dendritic Targeting and Regulation of Spine Morphology
2009
Molecular Mechanisms Controlling Actin Filament Dynamics in Nonmuscle Cells
2000
PIP2and Proteins: Interactions, Organization, and Information Flow
2002
De novo design of protein homo-oligomers with modular hydrogen-bond network–mediated specificity
2016 StandoutScienceNobel
Regulation of GPCRs by Endocytic Membrane Trafficking and Its Potential Implications
2007
LOVely enzymes – towards engineering light‐controllable biocatalysts
2009
Assembly of Cell Regulatory Systems Through Protein Interaction Domains
2003 Science
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Rewiring MAP Kinase Pathways Using Alternative Scaffold Assembly Mechanisms
2003 Science
Progress in Modeling of Protein Structures and Interactions
2005 StandoutScienceNobel
Computational design of mechanically coupled axle-rotor protein assemblies
2022 StandoutScienceNobel
Mechanism and role of PDZ domains in signaling complex assembly
2001
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
PDZ Domain Proteins: Plug and Play!
2003
Reconstruction of Par-dependent polarity in apolar cells reveals a dynamic process of cortical polarization
2019
A Localized Wnt Signal Orients Asymmetric Stem Cell Division in Vitro
2013 StandoutScienceNobel
Reprogramming Control of an Allosteric Signaling Switch Through Modular Recombination
2003 Science
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
De novo design of protein logic gates
2020 StandoutScienceNobel
Sara endosomes and the asymmetric division of intestinal stem cells
2014
Works of Kenneth E. Prehoda being referenced
Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6–aPKC
2007
Partitioning-defective Protein 6 (Par-6) Activates Atypical Protein Kinase C (aPKC) by Pseudosubstrate Displacement
2012
A Polybasic Motif Allows N-WASP to Act as a Sensor of PIP2 Density
2005
A spindle-independent cleavage furrow positioning pathway
2010 Nature
Polarization of Drosophila Neuroblasts During Asymmetric Division
2009
Effects of amino acid substitutions on the pressure denaturation of staphylococcal nuclease as monitored by fluorescence and nuclear magnetic resonance spectroscopy
1993
Structure of the SH3-Guanylate Kinase Module from PSD-95 Suggests a Mechanism for Regulated Assembly of MAGUK Scaffolding Proteins
2001
Establishment of Par-Polarized Cortical Domains via Phosphoregulated Membrane Motifs
2015
Calcium Channel Function Regulated by the SH3-GK Module in β Subunits
2004
Cdc42 Regulates the Par-6 PDZ Domain through an Allosteric CRIB-PDZ Transition
2004
Identification of an Aurora-A/PinsLINKER/ Dlg Spindle Orientation Pathway using Induced Cell Polarity in S2 Cells
2009
The Fz-Dsh Planar Cell Polarity Pathway Induces Oriented Cell Division via Mud/NuMA in Drosophila and Zebrafish
2010
Multiple WASP-interacting Protein Recognition Motifs Are Required for a Functional Interaction with N-WASP
2007
Hydrogen exchange in unligated and ligated staphylococcal nuclease
1993
aPKC Phosphorylates Miranda to Polarize Fate Determinants during Neuroblast Asymmetric Cell Division
2009
A Conserved PDZ-Binding Motif in aPKC Interacts with Par-3 and Mediates Cortical Polarity
2020
Structure of the Enabled/VASP Homology 1 Domain–Peptide Complex
1999
Structure of the N-WASP EVH1 Domain-WIP Complex
2002
Gαi generates multiple Pins activation states to link cortical polarity and spindle orientation in Drosophila neuroblasts
2007
Unexpected Modes of PDZ Domain Scaffolding Revealed by Structure of nNOS-Syntrophin Complex
1999 Science
Multiple tail domain interactions stabilize nonmuscle myosin II bipolar filaments
2010
Binding of Crumbs to the Par-6 CRIB-PDZ Module Is Regulated by Cdc42
2016
Microscopic pKa Values of Escherichia coli Thioredoxin
1997
Integration of Multiple Signals Through Cooperative Regulation of the N-WASP-Arp2/3 Complex
2000 Science
The CXXC Motif: A Rheostat in the Active Site
1997
Asymmetric recruitment and actin-dependent cortical flows drive the neuroblast polarity cycle
2019