Citation Impact
Citing Papers
LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF
2003
Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF
2005
Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus
2009 StandoutNobel
Crystal Structure of Human Toll-Like Receptor 3 (TLR3) Ectodomain
2005 Science
Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA
2004 StandoutScience
Bifurcation of Toll-Like Receptor 9 Signaling by Adaptor Protein 3
2010 Science
A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis
2021 StandoutScienceNobel
Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity
2006
IFN-regulatory factor 3-dependent gene expression is defective in Tbk1 -deficient mouse embryonic fibroblasts
2003
Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway
2003 StandoutScience
The molecular structure of the Toll-like receptor 3 ligand-binding domain
2005
Small Interfering RNAs Mediate Sequence-Independent Gene Suppression and Induce Immune Activation by Signaling through Toll-Like Receptor 3
2004 StandoutNobel
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3
2003
The MyD88-Dependent, but Not the MyD88-Independent, Pathway of TLR4 Signaling Is Important in Clearing Nontypeable Haemophilus influenzae from the Mouse Lung
2005 StandoutNobel
Forward genetic dissection of afferent immunity: the role of TIR adapter proteins in innate and adaptive immune responses
2004 StandoutNobel
UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes
2008 Nature
Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections
2005 StandoutNatureNobel
LPS-Induced Upregulation of SHIP Is Essential for Endotoxin Tolerance
2004
RNA recognition and signal transduction by RIG‐I‐like receptors
2008
SEC14L2 enables pan-genotype HCV replication in cell culture
2015 StandoutNatureNobel
The Forward Genetic Dissection of Afferent Innate Immunity
2008 StandoutNobel
IKKε and TBK1 are essential components of the IRF3 signaling pathway
2003 Standout
mRNA Is an Endogenous Ligand for Toll-like Receptor 3
2004 StandoutNobel
Toll-like receptor pathways in the immune responses to mycobacteria
2004
Completion of the entire hepatitis C virus life cycle in genetically humanized mice
2013 StandoutNatureNobel
A robust cell culture system supporting the complete life cycle of hepatitis B virus
2017 StandoutNobel
Type I Interferons in Host Defense
2006
Toll-like Receptor Signaling
2003
Toll-like receptor control of the adaptive immune responses
2004 Standout
ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance
2004
TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway
2003
SINTBAD, a novel component of innate antiviral immunity, shares a TBK1‐binding domain with NAP1 and TANK
2007
Saturated Fatty Acid Activates but Polyunsaturated Fatty Acid Inhibits Toll-like Receptor 2 Dimerized with Toll-like Receptor 6 or 1
2004 Standout
Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses
2012 StandoutNobel
The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction
2004
Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA
2005
RIP1 is an essential mediator of Toll-like receptor 3–induced NF-κB activation
2004
Pattern Recognition Receptors and Inflammation
2010 Standout
Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6
2004
Type I Inteferon Gene Induction by the Interferon Regulatory Factor Family of Transcription Factors
2006
Does Toll-like receptor 3 play a biological role in virus infections?
2004
Sequential control of Toll-like receptor–dependent responses by IRAK1 and IRAK2
2008
Toll-like receptors in innate immunity
2004 Standout
Modulating vaccine responses with dendritic cells and Toll‐like receptors
2004
Recognition of microbial infection by Toll-like receptors
2003
The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation
2008
Intracellular Toll-like Receptors
2010 StandoutNobel
The Toll–IL-1 receptor adaptor family grows to five members
2003
Distinct Poly(I-C) and Virus-activated Signaling Pathways Leading to Interferon-β Production in Hepatocytes
2005
Reciprocal Modulation of Toll-like Receptor-4 Signaling Pathways Involving MyD88 and Phosphatidylinositol 3-Kinase/AKT by Saturated and Polyunsaturated Fatty Acids
2003
The human adaptor SARM negatively regulates adaptor protein TRIF–dependent Toll-like receptor signaling
2006
Poxvirus Protein N1L Targets the I-κB Kinase Complex, Inhibits Signaling to NF-κB by the Tumor Necrosis Factor Superfamily of Receptors, and Inhibits NF-κB and IRF3 Signaling by Toll-like Receptors
2004
Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock
2003
Prospects for a vaccine against the hepatitis C virus
2005 StandoutNatureNobel
Immune Signaling by RIG-I-like Receptors
2011
Toll-like receptor signalling
2004 Standout
Mouse Hepatic Cells Support Assembly of Infectious Hepatitis C Virus Particles
2011
CD36 is a sensor of diacylglycerides
2005 StandoutNatureNobel
Poly(dI·dC)-induced Toll-like Receptor 3 (TLR3)-mediated Activation of NFκB and MAP Kinase Is through an Interleukin-1 Receptor-associated Kinase (IRAK)-independent Pathway Employing the Signaling Components TLR3-TRAF6-TAK1-TAB2-PKR
2003
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
2005 Standout
TIR-containing Adapter Molecule (TICAM)-2, a Bridging Adapter Recruiting to Toll-like Receptor 4 TICAM-1 That Induces Interferon-β
2003
A cell biological view of Toll-like receptor function: regulation through compartmentalization
2009
Therapeutic targeting of Toll-like receptors for inflammatory and infectious diseases
2003
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
2004 Standout
A FADD-dependent innate immune mechanism in mammalian cells
2004 Nature
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Innate immune recognition of viral infection
2006 Standout
TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain
2008
TLR signaling
2007
Therapeutics targeting the innate immune system
2004
Dendritic-cell control of pathogen-driven T-cell polarization
2003
VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling
2005 Standout
The cytoplasmic 'linker region' in Toll-like receptor 3 controls receptor localization and signaling
2004
TLR3 and TLR7 Are Targeted to the Same Intracellular Compartments by Distinct Regulatory Elements
2005
TLR-independent control of innate immunity in Caenorhabditis elegans by the TIR domain adaptor protein TIR-1, an ortholog of human SARM
2004
Toll-like receptors and innate antiviral responses
2003
Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA
2005 StandoutNobel
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
2003 StandoutNatureNobel
Signaling to NF-κB
2004 Standout
Functional Proteomics Reveals the Biochemical Niche of C. elegans DCR-1 in Multiple Small-RNA-Mediated Pathways
2006 StandoutNobel
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9
2006 StandoutNobel
Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1–polarizing program in dendritic cells
2005
Key Role of Ubc5 and Lysine-63 Polyubiquitination in Viral Activation of IRF3
2009
Toll-like receptors and innate immunity
2009
TIR-containing adaptors in Toll-like receptor signalling
2009
MyD88S, a splice variant of MyD88, differentially modulates NF‐κB‐ and AP‐1‐dependent gene expression
2003
Identification of Ser-386 of Interferon Regulatory Factor 3 as Critical Target for Inducible Phosphorylation That Determines Activation
2004
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β
2008
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Pathogen Recognition and Innate Immunity
2006 Standout
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Phagosome Maturation Proceeds Independently of Stimulation of Toll-like Receptors 2 and 4
2005
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells
2010 StandoutNobel
The Roles of Two IκB Kinase-related Kinases in Lipopolysaccharide and Double Stranded RNA Signaling and Viral Infection
2004
Toll-like Receptor 9–mediated Recognition of Herpes Simplex Virus-2 by Plasmacytoid Dendritic Cells
2003
Differential Requirement for TANK-binding Kinase-1 in Type I Interferon Responses to Toll-like Receptor Activation and Viral Infection
2004
DEC-205 receptor on dendritic cells mediates presentation of HIV gag protein to CD8 + T cells in a spectrum of human MHC I haplotypes
2007 StandoutNobel
Expression of MicroRNA miR-122 Facilitates an Efficient Replication in Nonhepatic Cells upon Infection with Hepatitis C Virus
2012
Activation of TBK1 and IKKε Kinases by Vesicular Stomatitis Virus Infection and the Role of Viral Ribonucleoprotein in the Development of Interferon Antiviral Immunity
2004
Differential Involvement of BB Loops of Toll-IL-1 Resistance (TIR) Domain-Containing Adapter Proteins in TLR4- versus TLR2-Mediated Signal Transduction
2005
ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization
2009
Hepatitis C Virus Entry
2013
Ultrastructural analysis of hepatitis C virus particles
2013 StandoutNobel
Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems
2014 StandoutNobel
Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires' disease
2005 StandoutNobel
Caspase-1 targets the TLR adaptor Mal at a crucial TIR-domain interaction site
2010
Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA
2008 Science
Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
2006 StandoutNobel
Impaired Production of Proinflammatory Cytokines and Host Resistance to Acute Infection withTrypanosoma cruziin Mice Lacking Functional Myeloid Differentiation Factor 88
2004
Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection
2011 StandoutNobel
Essential role of IRF-3 in lipopolysaccharide-induced interferon-β gene expression and endotoxin shock
2003
Toll/IL-1 Receptor Domain-Containing Adaptor Inducing IFN-β (TRIF) Associates with TNF Receptor-Associated Factor 6 and TANK-Binding Kinase 1, and Activates Two Distinct Transcription Factors, NF-κB and IFN-Regulatory Factor-3, in the Toll-Like Receptor Signaling
2003
How we detect microbes and respond to them: the Toll-like receptors and their transducers
2003 StandoutNobel
Toll-Like Receptor Signaling Pathways
2003 Science
Vaccinia virus protein A46R targets multiple Toll-like–interleukin-1 receptor adaptors and contributes to virulence
2005
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus
2006 StandoutNobel
Variegation of the Immune Response with Dendritic Cells and Pathogen Recognition Receptors
2005
SIDT1 Localizes to Endolysosomes and Mediates Double-Stranded RNA Transport into the Cytoplasm
2019
Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis
2006 StandoutNobel
Endosomal Translocation of Vertebrate DNA Activates Dendritic Cells via TLR9-Dependent and -Independent Pathways
2005
In vivo hematopoietic stem cell modification by mRNA delivery
2023 StandoutScienceNobel
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection
2004 StandoutNobel
Interferon-Stimulated Gene (ISG)-Expression Screening Reveals the Specific Antibunyaviral Activity of ISG20
2018 StandoutNobel
Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling
2004
Transcriptional regulation of the human TRIF (TIR domain-containing adaptor protein inducing interferon beta) gene
2004
GENETIC ANALYSIS OF HOST RESISTANCE: Toll-Like Receptor Signaling and Immunity at Large
2006 StandoutNobel
TLR3 Is Essential for the Induction of Protective Immunity against Punta Toro Virus Infection by the Double-Stranded RNA (dsRNA), Poly(I:C12U), but not Poly(I:C): Differential Recognition of Synthetic dsRNA Molecules
2007
Genetic and Functional Characterization of the N-Terminal Region of the Hepatitis C Virus NS2 Protein
2013 StandoutNobel
Toll-like Receptor 9–Dependent and –Independent Dendritic Cell Activation by Chromatin–Immunoglobulin G Complexes
2004
Innate immunity to virus infection
2008
Adjuvant-Enhanced Antibody Responses in the Absence of Toll-Like Receptor Signaling
2006 StandoutScienceNobel
The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling
2007 StandoutNobel
The microbial mimic poly IC induces durable and protective CD4+T cell immunity together with a dendritic cell targeted vaccine
2008 StandoutNobel
Works of Kenji Funami being referenced
NAK-Associated Protein 1 Participates in Both the TLR3 and the Cytoplasmic Pathways in Type I IFN Induction
2006
The Clathrin-Mediated Endocytic Pathway Participates in dsRNA-Induced IFN-β Production
2008
TICAM-1, an adaptor molecule that participates in Toll-like receptor 3–mediated interferon-β induction
2003
Homo-oligomerization Is Essential for Toll/Interleukin-1 Receptor Domain-containing Adaptor Molecule-1-mediated NF-κB and Interferon Regulatory Factor-3 Activation
2008
C-terminal LRRs of human Toll-like receptor 3 control receptor dimerization and signal transmission
2007
Toll‐like receptor‐mediated tyrosine phosphorylation of paxillin via MyD88‐dependent and ‐independent pathways
2003
Lipoprotein lipase and hepatic triglyceride lipase reduce the infectivity of hepatitis C virus (HCV) through their catalytic activities on HCV-associated lipoproteins
2010
Infectivity of Hepatitis C Virus Is Influenced by Association with Apolipoprotein E Isoforms
2010
Interferon-stimulated gene of 20 kDa protein (ISG20) degrades RNA of hepatitis B virus to impede the replication of HBVin vitroandin vivo
2016
Subcellular Localization of Toll-Like Receptor 3 in Human Dendritic Cells
2003
Toll‐Like Receptor 3: A Link between Toll‐Like Receptor, Interferon and Viruses
2004