Standout Papers
- Changes in growth properties on passage in tissue culture of viruses derived from infectious molecular clones of HIV-1LAI, HIV-1MAL, and HIV-1ELI (1991)
- VPX mutants of HIV-2 are infectious in established cell lines but display a severe defect in peripheral blood lymphocytes. (1989)
- Amino acid changes in the fourth conserved region of human immunodeficiency virus type 2 strain HIV-2ROD envelope glycoprotein modulate fusion (1993)
Citation Impact
Citing Papers
[6] Use of T7 RNA polymerase to direct expression of cloned genes
1990 Standout
Dendritic Cells Express Multiple Chemokine Receptors Used as Coreceptors for HIV Entry
1998 StandoutNobel
The CCR5 and CXCR4 Coreceptors—Central to Understanding the Transmission and Pathogenesis of Human Immunodeficiency Virus Type 1 Infection
2004
HIV-1 rev regulation involves recognition of non-Watson-Crick base pairs in viral RNA
1991 StandoutNobel
X4 and R5 HIV-1 Have Distinct Post-entry Requirements for Uracil DNA Glycosylase during Infection of Primary Cells
2010 StandoutNobel
SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene
1988 Standout
Regulation of progression through the Gl phase of the cell cycle by the rum1+ gene
1994 StandoutNatureNobel
Identification of a novel nuclear pore-associated protein as a functional target of the HIV-1 Rev protein in yeast
1995 StandoutNobel
The β-Chemokine Receptors CCR3 and CCR5 Facilitate Infection by Primary HIV-1 Isolates
1996 Standout
MicroRNAs
2004 Standout
The p53 proto-oncogene can act as a suppressor of transformation
1989 Standout
The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T
1990
Evidence for Direct Involvement of the Capsid Protein in HIV Infection of Nondividing Cells
2007
Unwelcomed Guests with Master Keys: How HIV Uses Chemokine Receptors for Cellular Entry
1997
Role of dendritic and follicular dendritic cells in HIV infection and pathogenesis
1997
Identification oftrans-dominant HIV-1 rev protein mutants by direct transfer of bacterially produced proteins into human cells
1990
Quality control of mRNA 3′-end processing is linked to the nuclear exosome
2001 StandoutNatureNobel
Chemokine Receptor Regulation and HIV Type 1 Tropism in Monocyte-Macrophages
1998
The HIV-1 Rev protein: prototype of a novel class of eukaryotic post-transcriptional regulators
1991
Trans-dominant inactivation of HTLV-I and HIV-1 gene expression by mutation of the HTLV-I Rex transactivator
1989 Nature
HIV-1 structural gene expression requires binding of the rev trans-activator to its RNA target sequence
1990
Specific binding of HIV-1 recombinant Rev protein to the Rev-responsive element in vitro
1989 Nature
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
1993 StandoutNobel
Linkage of a prion protein missense variant to Gerstmann–Sträussler syndrome
1989 StandoutNatureNobel
Sequence-specific RNA binding by the HIV-1 Rev protein
1989 Nature
DC-SIGN, a Dendritic Cell–Specific HIV-1-Binding Protein that Enhances trans-Infection of T Cells
2000 Standout
Host factors in the pathogenesis of HIV disease
1997
MX2 is an interferon-induced inhibitor of HIV-1 infection
2013 StandoutNatureNobel
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Human occludin is a hepatitis C virus entry factor required for infection of mouse cells
2009 StandoutNatureNobel
HIV-1 regulator of virion expression (Rev) protein binds to an RNA stem-loop structure located within the Rev response element region
1990
Genome linking with yeast artificial chromosomes
1988 StandoutNatureNobel
Fluorescence ratio imaging of cyclic AMP in single cells
1991 StandoutNatureNobel
1H NMR studies of the high-affinity Rev binding site of the Rev responsive element of HIV-1 mRNA: base pairing in the core binding element
1994 StandoutNobel
Co-receptors for HIV-1 entry
1997
Regulation of gene expression by transfected subunits of cAMP‐dependent protein kinase
1990
Integrase-mediated spacer acquisition during CRISPR–Cas adaptive immunity
2015 StandoutNatureNobel
Single amino-acid changes in HIV envelope affect viral tropism and receptor binding
1989 StandoutNatureNobel
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
2011 StandoutNatureNobel
Specific regulation of mRNA splicing in vitro by a peptide from HIV-1 Rev
1991
Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation
1990 StandoutNatureNobel
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
2000 StandoutNatureNobel
Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor
1997 StandoutNatureNobel
Regulation by HIV Rev depends upon recognition of splice sites
1989 StandoutNobel
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
1988 StandoutNatureNobel
Cyclin A and the retinoblastoma gene product complex with a common transcription factor
1991 StandoutNatureNobel
Suppression of induced pluripotent stem cell generation by the p53–p21 pathway
2009 StandoutNatureNobel
Deletion of 43 amino acids in the NH2-terminal half of the large tumor antigen of simian virus 40 results in a non-karyophilic protein capable of transforming established cells.
1985
The LDL Receptor Gene: A Mosaic of Exons Shared with Different Proteins
1985 StandoutScienceNobel
Amino acid substitutions in the human immunodeficiency virus type 1 gp120 V3 loop that change viral tropism also alter physical and functional properties of the virion envelope
1994
Posttranscriptional regulation by the human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex proteins through a heterologous RNA binding site
1992
The long and the short of long–term memory—a molecular framework
1986 StandoutNatureNobel
The human immunodeficiency virus type 1 vpr gene prevents cell proliferation during chronic infection
1995
A functional interaction between Rev and yeast pre-mRNA is related to splicing complex formation.
1994 StandoutNobel
Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages
1999 StandoutNobel
Capsid Is a Dominant Determinant of Retrovirus Infectivity in Nondividing Cells
2004
U1 small nuclear RNA plays a direct role in the formation of a rev-regulated human immunodeficiency virus env mRNA that remains unspliced.
1990
Replicative function and neutralization sensitivity of envelope glycoproteins from primary and T-cell line-passaged human immunodeficiency virus type 1 isolates
1995
Construction and characterization of an SV40 mutant defective in nuclear transport of T antigen
1984
Mechanisms of nonhomologous recombination in mammalian cells.
1985
Identification of a set of genes expressed during the G0/G1 transition of cultured mouse cells.
1985 Nobel
Crystal Structure of a Group I Ribozyme Domain: Principles of RNA Packing
1996 StandoutScienceNobel
Human immunodeficiency virus type 1 Vpr protein binds to the uracil DNA glycosylase DNA repair enzyme
1996
Altering the Genome by Homologous Recombination
1989 StandoutScienceNobel
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
1983 Standout
CCR5 Expression Correlates with Susceptibility of Maturing Monocytes to Human Immunodeficiency Virus Type 1 Infection
1998
Novel cysteine-rich motif and homeodomain in the product of the Caenorhabditis elegans cell lineage gene lin-II
1990 StandoutNatureNobel
Binding of the von Hippel-Lindau Tumor Suppressor Protein to Elongin B and C
1995 StandoutScienceNobel
Human Immunodeficiency Virus Type 1 T-Lymphotropic Strains Enter Macrophages via a CD4- and CXCR4-Mediated Pathway: Replication Is Restricted at a Postentry Level
1998
Human immunodeficiency virus env expression becomes Rev-independent if the env region is not defined as an intron
1994
Rev and the fate of pre-mRNA in the nucleus: implications for the regulation of RNA processing in eukaryotes.
1993
Adenylyl Cyclase Amino Acid Sequence: Possible Channel- or Transporter-Like Structure
1989 StandoutScienceNobel
Steroid-receptor fusion of the human immunodeficiency virus type 1 Rev transactivator: mapping cryptic functions of the arginine-rich motif.
1990
Characterization of the Bovine Papilloma virus plasmid maintenance sequences
1984
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
Diversity of murine gamma genes and expression in fetal and adult T lymphocytes
1986 StandoutNatureNobel
Rev and the Fate of Pre-mRNA in the Nucleus: Implications for the Regulation of RNA Processing in Eukaryotes
1993
An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins
1987 StandoutNatureNobel
The basic domain of Rev from human immunodeficiency virus type 1 specifically blocks the entry of U4/U6.U5 small nuclear ribonucleoprotein in spliceosome assembly
1993
Two DNA-binding factors recognize specific sequences at silencers, upstream activating sequences, autonomously replicating sequences, and telomeres in Saccharomyces cerevisiae.
1988 StandoutNobel
Structural analysis of the interaction between the human immunodeficiency virus Rev protein and the Rev response element.
1991
The human immunodeficiency virus type 1 Rev protein shuttles between the cytoplasm and nuclear compartments.
1994
Tissue-specific inactivation of p53 tumor suppression in the mouse.
1996
Purification of DNA from formaldehyde fixed and paraffin embedded human tissue
1985
Elements distinct from human immunodeficiency virus type 1 splice sites are responsible for the Rev dependence of env mRNA
1994
Altered DNA conformations detected by mung bean nuclease occur in promoter and terminator regions of supercoiled pBR322 DNA
1985
Synthetic peptides as nuclear localization signals
1986 StandoutNatureNobel
Somatic deletion and duplication of genes on chromosome 11 in Wilms' tumours
1984 Nature
Loss of genes on the short arm of chromosome 11 in bladder cancer
1985 Nature
Identification and immunochemical analysis of biologically active Drosophila P element transposase
1986
Simian virus 40 origin DNA-binding domain on large T antigen
1986
Specific interaction of the human immunodeficiency virus Rev protein with a structured region in the env mRNA.
1990
Genetic and biochemical analysis of transformation-competent, replication-defective simian virus 40 large T antigen mutants
1985
Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor
1987 Standout
Mutational analysis of the human immunodeficiency virus type 1 Rev transactivator: essential residues near the amino terminus
1990
Human immunodeficiency virus rev protein recognizes a target sequence in rev-responsive element RNA within the context of RNA secondary structure
1990
Viruses in Human Cancers
1991 StandoutScienceNobel
SV40 small t antigen enhances the transformation activity of limiting concentrations of SV40 large T antigen
1987
CHEMOKINE RECEPTORS AS HIV-1 CORECEPTORS: Roles in Viral Entry, Tropism, and Disease
1999 Standout
Negative regulatory sequences in the lin-14 3'-untranslated region are necessary to generate a temporal switch during Caenorhabditis elegans development.
1991 StandoutNobel
Expression of simian virus 40 T antigen in Escherichia coli: localization of T-antigen origin DNA-binding domain to within 129 amino acids
1988
The Molecular Genetics of Cancer
1987 StandoutScienceNobel
Complementation of murine cells for human immunodeficiency virus envelope/CD4-mediated fusion in human/murine heterokaryons
1992
CXCR-4 Is Expressed by Primary Macrophages and Supports CCR5-Independent Infection by Dual-Tropic but Not T-Tropic Isolates of Human Immunodeficiency Virus Type 1
1998
Cloning, Sequencing, and Expression of the Gene Coding for the Human Platelet α 2 -Adrenergic Receptor
1987 StandoutScienceNobel
In vitro mutagenesis of a putative DNA binding domain of SV40 large-T
1984
trans-dominant inhibition of human immunodeficiency virus type 1 Rev occurs through formation of inactive protein complexes
1992
The HIV-1 Rev trans-activator shuttles between the nucleus and the cytoplasm.
1994
Functional Analysis of CAR, the Target Sequence for the Rev Protein of HIV-1
1989 Science
Simian Virus 40 Large T-Antigen Point Mutants That Are Defective in Viral DNA Replication but Competent in Oncogenic Transformation
1984
Effects of CCR5 and CD4 Cell Surface Concentrations on Infections by Macrophagetropic Isolates of Human Immunodeficiency Virus Type 1
1998
Multiple Point Mutations Affecting the Simian Virus 40 Enhancer
1983 Science
A cis-acting repressive sequence that overlaps the Rev-responsive element of human immunodeficiency virus type 1 regulates nuclear retention of env mRNAs independently of known splice signals.
1994
Induction versus progression of brain tumor development: differential functions for the pRB- and p53-targeting domains of simian virus 40 T antigen.
1994
Replication and transformation functions of in vitro-generated simian virus 40 large T antigen mutants
1986
HIV-1 coreceptor preference is distinct from target cell tropism: a dual-parameter nomenclature to define viral phenotypes
2006
Oligomerization and RNA binding domains of the type 1 human immunodeficiency virus Rev protein: a dual function for an arginine-rich binding motif.
1991
Stabilization of the 53,000-Dalton Nonviral Tumor Antigen Is Not Required for Transformation by Simian Virus 40
1983
Diverse CD81 Proteins Support Hepatitis C Virus Infection
2006 StandoutNobel
Cell-type-specific contacts to immunoglobulin enhancers in nuclei
1985 StandoutNatureNobel
Potential Metal-Binding Domains in Nucleic Acid Binding Proteins
1986 Science
Mutational definition of the human immunodeficiency virus type 1 Rev activation domain
1991
In vivoHIV-1 infection of CD45RA+CD4+T cells is established primarily by syncytium-inducing variants and correlates with the rate of CD4+T cell decline
2000
Structure and function of telomeres
1991 StandoutNatureNobel
Evolution of HIV-1 coreceptor usage through interactions with distinct CCR5 and CXCR4 domains
1997
Role of Polyadenylation in Nucleocytoplasmic Transport of mRNA
1996
Evidence that HIV-1 Rev directly promotes the nuclear export of unspliced RNA.
1994
Secondary Structure is the Major Determinant for Interaction of HIV rev Protein with RNA
1990 Science
Sequences from polyomavirus and simian virus 40 large T genes capable of immortalizing primary rat embryo fibroblasts
1985
Hypomethylation distinguishes genes of some human cancers from their normal counterparts
1983 StandoutNature
Territorial limits and functional anatomy of the simian virus 40 replication origin.
1982
Control of rDNA replication in Tetrahymena involves a cis-acting upstream repeat of a promoter element
1986 StandoutNobel
Primary isolates of human immunodeficiency virus type 1 are relatively resistant to neutralization by monoclonal antibodies to gp120, and their neutralization is not predicted by studies with monomeric gp120
1995
Chemokine receptors and human immunodeficiency virus infection
1998
Influence of theCCR2-V64IPolymorphism on Human Immunodeficiency Virus Type 1 Coreceptor Activity and on Chemokine Receptor Function of CCR2b, CCR3, CCR5, and CXCR4
1998
Sequence requirements for nuclear location of simian virus 40 large-T antigen
1984 Nature
Works of Keith Peden being referenced
Increased Replication of Non-Syncytium-Inducing HIV Type 1 Isolates in Monocyte-Derived Macrophages Is Linked to Advanced Disease in Infected Children
2002
The rev gene product of the human immunodeficiency virus affects envelope-specific RNA localization
1989
Mutants with changes within or near a hydrophobic region of simian virus 40 large tumor antigen are defective for binding cellular protein p53
1989
Changes in growth properties on passage in tissue culture of viruses derived from infectious molecular clones of HIV-1LAI, HIV-1MAL, and HIV-1ELI
1991 StandoutNobel
HIV coreceptors: role of structure, posttranslational modifications, and internalization in viral-cell fusion and as targets for entry inhibitors
2003
CXCR4 and CCR5 on Human Thymocytes: Biological Function and Role in HIV-1 Infection
1998
Biochemical activities of T-antigen proteins encoded by simian virus 40 A gene deletion mutants.
1983 Nobel
Revised sequence of the tetracycline-resistance gene of pBR322
1983
Changes in both gp120 and gp41 can account for increased growth potential and expanded host range of human immunodeficiency virus type 1
1992
Homology between mammalian cell DNA sequences and human herpesvirus genomes detected by a hybridization procedure with high-complexity probe
1982
Mutational analysis of simian virus 40 T antigen: stimulation of cellular DNA synthesis and activation of rRNA genes by mutants with deletions in the T-antigen gene.
1983
CD4, CXCR-4, and CCR-5 dependencies for infections by primary patient and laboratory-adapted isolates of human immunodeficiency virus type 1
1997
Functional organization of the simian virus 40 origin of DNA replication.
1986
Transfection of neonatal rat Schwann cells with SV-40 large T antigen gene under control of the metallothionein promoter.
1987
Properties of a simian virus 40 mutant T antigen substituted in the hydrophobic region: defective ATPase and oligomerization activities and altered phosphorylation accompany an inability to complex with cellular p53
1989
Mutational Analysis of Simian Virus 40 T Antigen: Stimulation of Cellular DNA Synthesis and Activation of rRNA Genes by Mutants with Deletions in the T-Antigen Gene
1983
Increase in soluble CD4 binding to and CD4-induced dissociation of gp120 from virions correlates with infectivity of human immunodeficiency virus type 1
1994
Isolation of Mutants of an Animal Virus in Bacteria
1980 ScienceNobel
Deletion Mutants of SV40 That Affect the Structure of Viral Tumor Antigens
1980 Nobel
Site-directed mutagenesis of the simian virus 40 large T-antigen gene: replication-defective amino acid substitution mutants that retain the ability to induce morphological transformation
1985
The large tumor antigen of simian virus 40 encodes at least two distinct transforming functions
1989
Enhancement of human immunodeficiency virus type 1 envelope-mediated fusion by a CD4-gp120 complex-specific monoclonal antibody
1997
Biochemical Activities of T-Antigen Proteins Encoded by Simian Virus 40 A Gene Deletion Mutants
1983 Nobel
Mutational Analysis of Simian Virus 40 T Antigen: Isolation and Characterization of Mutants with Deletions in the T-Antigen Gene
1983 Nobel
STRL33, A Novel Chemokine Receptor–like Protein, Functions as a Fusion Cofactor for Both Macrophage-tropic and T Cell Line–tropic HIV-1
1997
Mutational analysis of simian virus 40 T antigen: isolation and characterization of mutants with deletions in the T-antigen gene.
1983 Nobel