Citation Impact
Citing Papers
Transposition-Driven Genomic Heterogeneity in the Drosophila Brain
2013 StandoutScienceNobel
The RNA Helicases AtMTR4 and HEN2 Target Specific Subsets of Nuclear Transcripts for Degradation by the Nuclear Exosome in Arabidopsis thaliana
2014
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Tumor Suppression: Lessons in p16 from phylum Falconium
1995
Germline p16 mutations in familial melanoma
1994
The INK4a/ARF tumor suppressor: one gene—two products—two pathways
1998
Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16
1995 Nature
Ordering S phase and M phase in the cell cycle
1994 StandoutNobel
Transcriptional regulator of programmed cell death encoded by Caenorhabditis elegans gene ces-2
1996 StandoutNatureNobel
Role for the p53 homologue p73 in E2F-1-induced apoptosis
2000 StandoutNatureNobel
Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition
1995 Nature
Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells
1997
Genetic alterations in human gastrointestinal cancers. The application to molecular diagnosis
1995
Cyclin‐dependent protein kinases: Key regulators of the eukaryotic cell cycle
1995
RSC, an Essential, Abundant Chromatin-Remodeling Complex
1996 StandoutNobel
BRAFE600-associated senescence-like cell cycle arrest of human naevi
2005 StandoutNature
Phosphorylation of E2F-1 modulates its interaction with the retinoblastoma gene product and the adenoviral E4 19 kDa protein
1994
Cdk inhibitors: on the threshold of checkpoints and development
1994
Tumor surveillance via the ARF–p53 pathway
1998
Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution.
1995
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
A Mutant Drosophila Homolog of Mammalian Clock Disrupts Circadian Rhythms and Transcription of period and timeless
1998 StandoutNobel
Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17: A New Group of Tauopathies
1998
The Hox-1.3 homeo box protein is a sequence-specific DNA-binding phosphoprotein.
1989
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties
1992 StandoutNobel
When Checkpoints Fail
1997 StandoutNobel
p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21
1994 Standout
Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
1997 StandoutNobel
The Hallmarks of Cancer
2000 Standout
Oncogene-Induced Cell Senescence — Halting on the Road to Cancer
2006
Role of the retinoblastoma protein in the pathogenesis of human cancer.
1997 StandoutNobel
A mediator required for activation of RNA polymerase II transcription in vitro
1991 StandoutNatureNobel
Homozygotes for CDKN2 (p16) germline mutation in Dutch familial melanoma kindreds
1995
CARMAweb: comprehensive R- and bioconductor-based web service for microarray data analysis
2006
The use of miRNA microarrays for the analysis of cancer samples with global miRNA decrease
2013
Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19
1997
A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
1994 StandoutNobel
Human chorionic gonadotropin α and human cytomegalovirus promoters are extremely active in the fission yeast Schizosaccharomyces pombe
1990
Structure of mammalian eIF3 in the context of the 43S preinitiation complex
2015 StandoutNatureNobel
The UV response involving the ras signaling pathway and AP-1 transcription factors is conserved between yeast and mammals
1994
A tiger behind many doors: multiple genetic pathways to malignant glioma
1995
pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest
1994 StandoutNature
Cell cycle checkpoints
1994
Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product
1991 StandoutNobel
E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation
1996 StandoutNobel
limma powers differential expression analyses for RNA-sequencing and microarray studies
2015 Standout
p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis
1999 StandoutNobel
Phenotype and Genotype of Advanced Premalignant Head and Neck Lesions After Chemopreventive Therapy
1998
Rescue of bicoid mutant Drosophila embryos by Bicoid fusion proteins containing heterologous activating sequences
1989 StandoutNatureNobel
Inhibitors of mammalian G1 cyclin-dependent kinases.
1995 Standout
Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting
2012 StandoutNatureNobel
Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation
1990 StandoutNatureNobel
Homeodomain-DNA recognition
1994 StandoutNobel
Abrogation of p27 by cDNA Antisense Suppresses Quiescence (G0 State) in Fibroblasts
1996
Cyclins and cancer II: Cyclin D and CDK inhibitors come of age
1994 Standout
A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo
1989 StandoutNobel
MAGMA: analysis of two-channel microarrays made easy
2007
A census of human cancer genes
2004 Standout
Role of the INK4a Locus in Tumor Suppression and Cell Mortality
1996
The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53
1998
DNA specificity of the bicoid activator protein is determined by homeodomain recognition helix residue 9
1989
Unknown Primary Head and Neck Squamous Cell Carcinoma: Molecular Identification of the Site of Origin
1999
Asterias: integrated analysis of expression and aCGH data using an open-source, web-based, parallelized software suite
2007
Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element
1988
Genetic Alterations of Cyclins, Cyclin-Dependent Kinases, and Cdk Inhibitors in Human Cancer
1996
CLOCK:BMAL1 is a pioneer-like transcription factor
2014 StandoutNobel
Head and Neck Cancer
2001 Standout
Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals
1994 Standout
Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma
1994
High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma.
1996
p27Kip1: chromosomal mapping to 12p12-12p13.1 and absence of mutations in human tumors.
1995
Inhibition of Ras-Induced Proliferation and Cellular Transformation by p16 INK4
1995 Science
Defining the Inside and Outside of a Catalytic RNA Molecule
1989 StandoutScienceNobel
Differential expression and cell cycle regulation of the cyclin-dependent kinase 4 inhibitor p16Ink4.
1994
The transcription factor, the Cdk, its cyclin and their regulator: directing the transcriptional response to a nutritional signal.
1994
Transcriptional repression by a novel member of the bZIP family of transcription factors.
1992
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.
1994
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
Novel cysteine-rich motif and homeodomain in the product of the Caenorhabditis elegans cell lineage gene lin-II
1990 StandoutNatureNobel
Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer.
1995
Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases.
1991
RNA Polymerase II Initiation Factor Interactions and Transcription Start Site Selection
1994 StandoutScienceNobel
Mechanisms of DNA Excision Repair
1994 StandoutScienceNobel
Regulation of p16CDKN2 Expression and Its Implications for Cell Immortalization and Senescence
1996
Contingent Genetic Regulatory Events in T Lymphocyte Activation
1989 Science
Cancer Cell Cycles
1996 StandoutScience
Phosphate-Regulated Inactivation of the Kinase PHO80-PHO85 by the CDK Inhibitor PHO81
1994 Science
Reciprocal Rb inactivation and p16INK4 expression in primary lung cancers and cell lines.
1995
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
Design of Sequence-Specific DNA-Binding Molecules
1986 Science
A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in Caenorhabditis elegans
2009 StandoutNobel
Helix-turn-helix, zinc-finger, and leucine-zipper motifs for eukaryotic transcriptional regulatory proteins
1989
Essential role of Swp73p in the function of yeast Swi/Snf complex.
1996
Frequent deletion of p16INK4a/MTS1 and p15INK4b/MTS2 in pediatric acute lymphoblastic leukemia
1995
CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas.
1994
Novel Jun- and Fos-related proteins in Drosophila are functionally homologous to enhancer factor AP-1.
1988
Immunohistochemical detection of CDK4 and 9 16INK4proteins in cutaneous malignant melanoma
1996
The retinoblastoma protein and cell cycle control
1995 Standout
Promoter hypermethylation patterns of p16, O6-methylguanine-DNA-methyltransferase, and death-associated protein kinase in tumors and saliva of head and neck cancer patients.
2001
CDK4 amplification is an alternative mechanism to p16 gene homozygous deletion in glioma cell lines.
1994
5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
1995 Standout
Mammalian cAMP-responsive element can activate transcription in yeast and binds a yeast factor(s) that resembles the mammalian transcription factor ANF.
1989
Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins
1989 StandoutScience
Scissors-Grip Model for DNA Recognition by a Family of Leucine Zipper Proteins
1989 Science
Engineering allosteric regulation in protein kinases
2018
Growth suppression by p16ink4 requires functional retinoblastoma protein.
1995
Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
1995
p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.
1995
Cooperative Interactions Between the Caenorhabditis elegans Homeoproteins UNC-86 and MEC-3
1993 StandoutScienceNobel
Mutations and altered expression of p16INK4 in human cancer.
1994
Oncogenic capacity of the E2F1 gene.
1994
Cognate DNA Binding Specificity Retained After Leucine Zipper Exchange Between GCN4 and C/EBP
1989 StandoutScienceNobel
Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb.
1994
Novel INK4 Proteins, p19 and p18, Are Specific Inhibitors of the Cyclin D-Dependent Kinases CDK4 and CDK6
1995
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product.
1995
Regulation of the Ets-Related Transcription Factor Elf-1 by Binding to the Retinoblastoma Protein
1993 StandoutScienceNobel
Identification of Human and Mouse p19, a Novel CDK4 and CDK6 Inhibitor with Homology to p16ink4
1995
The INK4a/ARF locus and melanoma
2003
A p16 INK4a -Insensitive CDK4 Mutant Targeted by Cytolytic T Lymphocytes in a Human Melanoma
1995 Science
Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.
1994
Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site.
1995
Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes.
1995
DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1
1996 StandoutScience
Candidate tumor-suppressor genes MTS1 (p16INK4A) and MTS2 (p15INK4B) display frequent homozygous deletions in primary cells from T- but not from B-cell lineage acute lymphoblastic leukemias [see comments]
1994
Works of Keith Harshman being referenced
Genome-Wide RNA Polymerase II Profiles and RNA Accumulation Reveal Kinetics of Transcription and Associated Epigenetic Changes During Diurnal Cycles
2012
RACE: Remote Analysis Computation for gene Expression data
2005
Impact of normalization on miRNA microarray expression profiling
2009
Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma
2011
A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types
1994 StandoutScience
Localization of the VHR Phosphatase Gene and Its Analysis as a Candidate for BRCA1
1994
Transcriptional activation by the SV40 AP-1 recognition element in yeast is mediated by a factor similar to AP-1 that is distinct from GCN4
1988
Context-Dependent Dual Role of SKI8 Homologs in mRNA Synthesis and Turnover
2012
BRCA1 mRNA is expressed highly during meiosis and spermiogenesis but not during mitosis of male germ cells.
1996
Yeast YAP1 encodes a novel form of the jun family of transcriptional activator proteins.
1989
Response : Rates of p16 ( MTS1 ) Mutations in Primary Tumors with 9p Loss
1994 Science
Molecular recognition of B-DNA by Hoechst 33258
1985