Standout Papers
Citation Impact
Citing Papers
Lipoprotein-associated phospholipase A2 and risk of coronary disease, stroke, and mortality: collaborative analysis of 32 prospective studies
2010
Accelerated telomere shortening in response to life stress
2004 StandoutNobel
Quantitative analysis of the expression of ACAT genes in human tissues by real-time PCR2
2004
Bifluoride Ion Mediated SuFEx Trifluoromethylation of Sulfonyl Fluorides and Iminosulfur Oxydifluorides
2019 StandoutNobel
Studies on acyl-coenzyme A: cholesterol acyltransferase activity in human liver microsomes.
1989
Regulation of endoplasmic reticulum cholesterol by plasma membrane cholesterol
1999
Identification of a Domain That Mediates Association of Platelet-activating Factor Acetylhydrolase with High Density Lipoprotein
2008
Identification of the Interaction Site within Acyl-CoA:Cholesterol Acyltransferase 2 for the Isoform-specific Inhibitor Pyripyropene A
2008 StandoutNobel
N-linked glycosylation of macrophage-derived PAF-AH is a major determinant of enzyme association with plasma HDL
2001
Industrial biocatalysis today and tomorrow
2001 StandoutNature
Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance
2008
Phenylpyropene A and B, New Inhibitors of Acyl-CoA: Cholesterol Acyltransferase Produced by Penicillium griseofulvum F1959.
2002
N-1 substituted pyrimidin-4-ones: novel, orally active inhibitors of lipoprotein-associated phospholipase A2
2000
Abdominal obesity and metabolic syndrome
2006 StandoutNature
Glycoprotein 330/Low Density Lipoprotein Receptor-related Protein-2 Mediates Endocytosis of Low Density Lipoproteins via Interaction with Apolipoprotein B100
1995
Inflammation and metabolic disorders
2006 StandoutNature
The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
1998 StandoutNature
Progesterone Inhibits Cholesterol Biosynthesis in Cultured Cells
1996
The Enzymes of Neutral Lipid Synthesis
2001
Potent, orally active inhibitors of lipoprotein-associated phospholipase A2: 1-(biphenylmethylamidoalkyl)-pyrimidones
2002
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
2003 StandoutNatureNobel
Role for ELOVL3 and Fatty Acid Chain Length in Development of Hair and Skin Function
2004 StandoutNobel
Lipid absorptions passing through the unstirred layers, brush-border membrane, and beyond
1993
Mechanisms linking obesity with cardiovascular disease
2006 StandoutNature
Lipoprotein-associated PLA2 inhibition — a novel, non-lipid lowering strategy for atherosclerosis therapy
2001
Absence of ACAT-1 Attenuates Atherosclerosis but Causes Dry Eye and Cutaneous Xanthomatosis in Mice with Congenital Hyperlipidemia
2000
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Extracellular phospholipases in atherosclerosis
2010
Compartmentalized Production of Ceramide at the Cell Surface
1995
Τhe role of lipoprotein-associated phospholipase A2 in atherosclerosis may depend on its lipoprotein carrier in plasma
2009
Intestinal lipoprotein synthesis and secretion
1995
Apolipoprotein B: structure, biosynthesis and role in the lipoprotein assembly process
1987
Relationship of lipoprotein-associated phospholipase A2 and oxidized low density lipoprotein in carotid atherosclerosis
2009
Minireview: Lipid Metabolism, Metabolic Diseases, and Peroxisome Proliferator-Activated Receptors
2003
Catalysis for fluorination and trifluoromethylation
2011 StandoutNature
Recent Developments with Lipoprotein-Associated Phospholipase A2 Inhibitors
2009
Metabolic origins and clinical significance of LDL heterogeneity
2002
A prospective evaluation of lipoprotein-associated phospholipase A2levels and the risk of future cardiovascular events in women
2001
Plasma platelet activating factor-acetylhydrolase (PAF-AH)
2003
Platelet-activating factor acetylhydrolase and transacetylase activities in human plasma low-density lipoprotein
2001
Inflammatory bio‐markers and cardiovascular risk prediction
2002
Differential Roles for Sox15 and Sox2 in Transcriptional Control in Mouse Embryonic Stem Cells
2005 StandoutNobel
Future Role for Selective Phospholipase A2 Inhibitors in the Prevention of Atherosclerotic Cardiovascular Disease
2009
Immunological Quantitation and Localization of ACAT-1 and ACAT-2 in Human Liver and Small Intestine
2000
The identification of intestinal scavenger receptor class B, type I (SR-BI) by expression cloning and its role in cholesterol absorption
2002
Inflammatory Markers and the Risk of Coronary Heart Disease in Men and Women
2004
Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs
2007 Standout
The identification of a potent, water soluble inhibitor of lipoprotein-associated phospholipase A2
2001
The ADAM metalloproteinases
2008
Lipoprotein Associated Phospholipase A2 Inhibition Reduces Generation of Oxidized Fatty Acids
2008
Crystal structure of a bacterial non-haem iron hydroxylase that catalyses the biological oxidation of methane
1993 StandoutNature
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
2005 StandoutNature
Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
2010 Standout
3 ACAT Inhibitors: The Search for a Novel and Effective Treatment of Hypercholesterolemia and Atherosclerosis
2002
Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1
2000
Mammalian acyl-CoA:cholesterol acyltransferases
2000
C-Reactive Protein and Other Circulating Markers of Inflammation in the Prediction of Coronary Heart Disease
2004 Standout
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
2000 StandoutNature
ACAT-2, A Second Mammalian Acyl-CoA:Cholesterol Acyltransferase
1998
1-(Arylpiperazinylamidoalkyl)-pyrimidones: orally active inhibitors of lipoprotein-associated phospholipase A 2
2001
Generation of germline-competent induced pluripotent stem cells
2007 StandoutNatureNobel
Inhibition of acyl-CoA: cholesterol acyltransferase in chinese hamster ovary (CHO) cells by short-chain ceramide and dihydroceramide
1995
Lipoprotein-Associated Phospholipase A2: An Independent Predictor of Coronary Artery Disease Events in Primary and Secondary Prevention
2008
The Biosynthesis of Hepatic Cholesterol Esters and Triglycerides Is Impaired in Mice with a Disruption of the Gene for Stearoyl-CoA Desaturase 1
2000
A Simple Enantioconvergent and Chemoenzymatic Synthesis of Optically Active α‐Substituted Amides
2011 StandoutNobel
Human Acyl-CoA:Cholesterol Acyltransferase-1 in the Endoplasmic Reticulum Contains Seven Transmembrane Domains
1999
Inhibition of lipoprotein‐associated phospholipase A2 diminishes the death‐inducing effects of oxidised LDL on human monocyte‐macrophages
2001
The Effect of Darapladib on Plasma Lipoprotein-Associated Phospholipase A2 Activity and Cardiovascular Biomarkers in Patients With Stable Coronary Heart Disease or Coronary Heart Disease Risk Equivalent
2008
2-(Alkylthio)pyrimidin-4-ones as novel, reversible inhibitors of lipoprotein-associated phospholipase A2
2000
The discovery of SB-435495
2002
C-reactive protein and incident coronary heart disease in the Atherosclerosis Risk In Communities (ARIC) study
2002
Inflammation, Atherosclerosis, and Coronary Artery Disease
2005 Standout
Therapeutic potential of ACAT inhibitors as lipid lowering and anti-atherosclerotic agents
1991
Atherosclerosis
2000 StandoutNature
Macrophage biology in development, homeostasis and disease
2013 StandoutNature
Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein
2008 Standout
C-Reactive Protein and Other Emerging Blood Biomarkers to Optimize Risk Stratification of Vulnerable Patients
2006
Trial of Atorvastatin in Rheumatoid Arthritis (TARA): double-blind, randomised placebo-controlled trial
2004
Crystal Structure of Human Plasma Platelet-activating Factor Acetylhydrolase
2008
Electrospray Ionization Mass Spectrometry Identifies Substrates and Products of Lipoprotein-associated Phospholipase A2 in Oxidized Human Low Density Lipoprotein
2007
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
2010 StandoutNature
Multiple Functions of Jab1 Are Required for Early Embryonic Development and Growth Potential in Mice
2004 StandoutNobel
Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development
2008
The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells
2003 StandoutNobel
Inhibition of Acyl‐CoA Cholesterol Acyltransferase by F12511 (Eflucimibe): Could it be a New Antiatherosclerotic Therapeutic?
2008
The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2
2003
Cofactor Regeneration for Enzyme-Catalysed Synthesis
1988
Potent Modification of Low Density Lipoprotein by Group X Secretory Phospholipase A2 Is Linked to Macrophage Foam Cell Formation
2002
Lewis Base Catalysis in Organic Synthesis
2008
Substrate specificity of soluble methane monooxygenase
1989
Asymmetric Fluorination, Trifluoromethylation, and Perfluoroalkylation Reactions
2004
Angiopoietin-like 4 is a potent angiogenic factor and a novel therapeutic target for patients with proliferative diabetic retinopathy
2015 StandoutNobel
Diagnosis and Management of the Metabolic Syndrome
2005 Standout
Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)
2013 Standout
Peroxisome Proliferator-Activated Receptor-β/δ Regulates Angiogenic Cell Behaviors and Oxygen-Induced Retinopathy
2013
Elevated Alanine Aminotransferase Predicts New-Onset Type 2 Diabetes Independently of Classical Risk Factors, Metabolic Syndrome, and C-Reactive Protein in the West of Scotland Coronary Prevention Study
2004
Functional rafts in cell membranes
1997 StandoutNature
Bioisosterism: A Rational Approach in Drug Design
1996
Nuclear Receptors and Lipid Physiology: Opening the X-Files
2001 StandoutScience
Lipoprotein-Associated Phospholipase A 2 , Platelet-Activating Factor Acetylhydrolase, Is Expressed by Macrophages in Human and Rabbit Atherosclerotic Lesions
1999
Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling
1998 StandoutScience
Total Synthesis of α-Pyrone Meroterpenoids, Novel Bioactive Microbial Metabolites
2005 StandoutNobel
Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: Evidence suggesting multiple cholesterol esterification enzymes in mammals
1996
Human Platelets Secrete the Plasma Type of Platelet-Activating Factor Acetylhydrolase Primarily Associated With Microparticles
2006
A Receptor-Mediated Pathway for Cholesterol Homeostasis
1986 StandoutScienceNobel
Lipoprotein-Associated and Secreted Phospholipases A 2 in Cardiovascular Disease
2010
Potent hypocholesterolemic activity of novel ureido phenoxyisobutyrates correlates with their intrinsic fibrate potency and not with their ACAT inhibitory activity
1997
Expression profiling with arrays of randomly disrupted genes in mouse embryonic stem cells leads to in vivo functional analysis
2004 StandoutNobel
ACAT2 Is Localized to Hepatocytes and Is the Major Cholesterol-Esterifying Enzyme in Human Liver
2004 StandoutNobel
Fluorine in Pharmaceuticals: Looking Beyond Intuition
2007 StandoutScience
Functions of Ceramide in Coordinating Cellular Responses to Stress
1996 StandoutScience
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability
2009 StandoutNobel
Lipoprotein-Associated Phospholipase A 2 , High-Sensitivity C-Reactive Protein, and Risk for Incident Coronary Heart Disease in Middle-Aged Men and Women in the Atherosclerosis Risk in Communities (ARIC) Study
2004
The Human Nuclear Xenobiotic Receptor PXR: Structural Determinants of Directed Promiscuity
2001 Science
Defective forebrain development in mice lacking gp330/megalin.
1996 Standout
Lipoprotein-Associated Phospholipase A2 Predicts 5-Year Cardiac Mortality Independently of Established Risk Factors and Adds Prognostic Information in Patients with Low and Medium High-Sensitivity C-Reactive Protein (The Ludwigshafen Risk and Cardiovascular Health Study)
2007
The assembly and secretion of apoB 100 containing lipoproteins in Hep G2 cells. Evidence for different sites for protein synthesis and lipoprotein assembly.
1990
Metabolic Syndrome With and Without C-Reactive Protein as a Predictor of Coronary Heart Disease and Diabetes in the West of Scotland Coronary Prevention Study
2003
The Val279Phe Variant of the Lipoprotein-Associated Phospholipase A2 Gene Is Associated with Catalytic Activities and Cardiovascular Disease in Korean Men
2006
Biosynthesis of Apolipoprotein B48-containing Lipoproteins
1996 StandoutNobel
Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding
2009 StandoutScience
cDNA cloning of the bovine low density lipoprotein receptor: feedback regulation of a receptor mRNA.
1983 StandoutNobel
Platelet-Activating Factor Acetylhydrolase Is Mainly Associated With Electronegative Low-Density Lipoprotein Subfraction
2003
Lipoprotein-Associated Phospholipase A2 Activity Is a Marker of Small, Dense LDL Particles in Human Plasma
2005
Enhanced Expression of Lp-PLA 2 and Lysophosphatidylcholine in Symptomatic Carotid Atherosclerotic Plaques
2008
Phospholipase A2Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention
2011 Standout
Promotion of direct reprogramming by transformation-deficient Myc
2010 StandoutNobel
Update 1 of: Asymmetric Fluorination, Trifluoromethylation, and Perfluoroalkylation Reactions
2008
A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport
2001
Hepatic ACAT activity in African green monkeys is highly correlated to plasma LDL cholesteryl ester enrichment and coronary artery atherosclerosis.
1992
White Cell Telomere Length and Risk of Premature Myocardial Infarction
2003
Niemann-Pick C1 Like 1 Protein Is Critical for Intestinal Cholesterol Absorption
2004 StandoutScience
The Pathogenesis of Atherosclerosis — An Update
1986 Standout
Liver Transplantation to Provide Low-Density-Lipoprotein Receptors and Lower Plasma Cholesterol in a Child with Homozygous Familial Hypercholesterolemia
1984 StandoutNobel
Defective Lipoprotein Receptors and Atherosclerosis
1983
Works of Keith E. Suckling being referenced
Lipoprotein-Associated Phospholipase A2as an Independent Predictor of Coronary Heart Disease
2000
The Peroxisome Proliferator-activated Receptor δ Promotes Lipid Accumulation in Human Macrophages
2001
Phospholipase A2s: Developing drug targets for atherosclerosis
2010
Animal models of human lipid metabolism
1993
SR-12813 lowers plasma cholesterol in beagle dogs by decreasing cholesterol biosynthesis
1997
The Novel Cholesterol-lowering Drug SR-12813 Inhibits Cholesterol Synthesis via an Increased Degradation of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase
1996
Bile acid synthesis in hamster hepatocytes in primary culture: Sources of cholesterol and comparison with other species
1993
The PPARδ agonist GW0742X reduces atherosclerosis in LDLR−/− mice
2005
Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase: a potential new risk factor for coronary artery disease
2000
The effects of feeding a saturated fat-rich diet on enzymes of cholesterol metabolism in the liver, intestine and aorta of the hamster
1990
Metabolism of cholesteryl ester in monolayers of bovine adrenal cortical cells. Effect of an inhibitor of acyl-CoA : cholesterol acyltransferase
1985
Synthesis and coenzyme A-dependent esterification of cholesterol in rat intestinal epithelium. Differences in cellular localization and mechanisms of regulation.
1983
The oxidation of cyclopropyl benzene by rat liver microsomal cytochrome P‐450: an unusual triple oxidation of a substrate
1982
The synthesis of A- and B-ring fluorinated analogues of cholesterol
1999
Role of acyl-CoA: cholesterol acyltransferase in cellular cholesterol metabolism.
1985
Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase, generates two bioactive products during the oxidation of low-density lipoprotein: use of a novel inhibitor
1999
Cholesterol synthesis in vivo and in vitro in the WHHL rabbit, an animal with defective low density lipoprotein receptors
1983 StandoutNobel
Anti-atherosclerotic effect of SB-244323, a lipoprotein associated phospholipase A2 inhibitor, in WHHL rabbits
2000
In vivo modulation of rat liver acyl‐coenzyme A:cholesterol acyltransferase by phosphorylation and substrate supply
1983
Enzymes in organic synthesis
1974
Apolipoprotein B overproduction by the perfused liver of the St. Thomas' mixed hyperlipidemic (SMHL) rabbit
1999
Dual modulation of hepatic and intestinal acyl‐CoA: cholesterol acyltransferase activity by (de‐)phosphorylation and substrate supply in vitro
1983
Novel Candidate Genes in Unstable Areas of Human Atherosclerotic Plaques
2006
Biological Chemistry: The Molecular Approach to Biological Systems
1980
Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase, generates two bioactive products during the oxidation of low-density lipoprotein: use of a novel inhibitor
1999
Lipoprotein-associated phospholipase A(2) as an independent predictor of coronary heart disease
2000
Lipoprotein-associated Phospholipase A2 (Lp PLA2), an inflammatory marker and novel independent risk factor in the West of Scotland Coronary Prevention Study (WOSCOPS)
2000
Lipoprotein-associated phospholipase A2: a target directed at the atherosclerotic plaque
2002
The role of acyl-CoA:cholesterol acyltransferase in the metabolism of free cholesterol to cholesteryl esters or bile acids in primary cultures of rat hepatocytes
1987