Citation Impact
Citing Papers
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
2001 StandoutScienceNobel
SNOSID, a proteomic method for identification of cysteine S-nitrosylation sites in complex protein mixtures
2006
Hypoxia‐inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype
2016 StandoutNobel
Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1
1996 StandoutNobel
Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains
2009 Standout
Concordant Regulation of Gene Expression by Hypoxia and 2-Oxoglutarate-dependent Dioxygenase Inhibition
2006 StandoutNobel
The angiopoietin‐2 gene of endothelial cells is up‐regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA‐2 and Ets‐1
2008
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors.
1992
Hypoxia — a key regulatory factor in tumour growth
2002 Standout
Oxygen sensing and response to hypoxia by mammalian cells
1996 StandoutNobel
A family of muscle gene promoter element (CArG) binding activities in Xenopus embryos: CArG/SRE discrimination and distribution during myogenesis
1991
HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes
2006 StandoutNobel
Discoveries in structure and physiology of mechanically activated ion channels
2020 StandoutNatureNobel
HIF-1α, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas
2005 StandoutNobel
Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo
1991 Nobel
C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation
2001 StandoutNobel
Identification of Hypoxia-response Element in the Human Endothelial Nitric-oxide Synthase Gene Promoter
2003
Human p300 Protein Is a Coactivator for the Transcription Factor MyoD
1996
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
2002 StandoutNatureNobel
HIF-1 and ventilatory acclimatization to chronic hypoxia
2008
The SIN3A histone deacetylase complex is required for a complete transcriptional response to hypoxia
2017 StandoutNobel
Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity
2019 Nature
Effects of hypoxia and intracellular iron chelation on hypoxia-inducible factor-1? and -1? in the rat carotid body and glomus cells
2003
Transactivation and Inhibitory Domains of Hypoxia-inducible Factor 1α
1997 StandoutNobel
Hypoxic Regulation of Lactate Dehydrogenase A
1995 StandoutNobel
Gene Expression in Low Oxygen Tension
1993
Transformation by activated ras or fos prevents myogenesis by inhibiting expression of MyoD1
1989
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
2012 StandoutNatureNobel
Deleterious mitochondrial DNA mutations accumulate in aging human tissues
1992
HIF-1α Induces Genetic Instability by Transcriptionally Downregulating MutSα Expression
2005 StandoutNobel
Hypoxia and cobalt stimulate lactate dehydrogenase (LDH) activity in vascular smooth muscle cells
1994
Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease
1992
Induction of interleukin (IL)-6 by hypoxia is mediated by nuclear factor (NF)-κB and NF-IL6 in cardiac myocytes
1999
Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation
1993 Standout
HIF-1 Inhibits Mitochondrial Biogenesis and Cellular Respiration in VHL-Deficient Renal Cell Carcinoma by Repression of C-MYC Activity
2007 StandoutNobel
Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling
2000 StandoutNobel
Proteomic identification of a role for the von Hippel Lindau tumour suppressor in changes in the expression of mitochondrial proteins and septin 2 in renal cell carcinoma
2006
Hypoxic Induction of Prolyl 4-Hydroxylase α(I) in Cultured Cells
2000
Functional antagonism between c-Jun and MyoD proteins: A direct physical association
1992
Regulation of angiogenesis by hypoxia: role of the HIF system
2003 StandoutNobel
Characterisation of functional domains within the mouse erythropoietin 3′ enhancer conveying oxygen-regulated responses in different cell lines
1994 StandoutNobel
Purification and Characterization of Hypoxia-inducible Factor 1
1995 StandoutNobel
Cooperativity of Stress-Responsive Transcription Factors in Core Hypoxia-Inducible Factor Binding Regions
2012
Intramyocardial injection of naked DNA encoding HIF-1 /VP16 hybrid to enhance angiogenesis in an acute myocardial infarction model in the rat
2002
Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology
2001 StandoutNobel
Mitochondrial mutations may increase oxidative stress: Implications for carcinogenesis and aging?
1990
MyoD and the regulation of myogenesis by helix-loop-helix proteins.
1991
Hypoxia-induced Protein Binding to O2-responsive Sequences on the Tyrosine Hydroxylase Gene
1995
Hypoxic gene expression and metastasis
2004
De novo design of bioactive protein switches
2019 StandoutNatureNobel
Transcriptional Regulation of the Rat Vascular Endothelial Growth Factor Gene by Hypoxia
1995
Sp1 Increases Expression of Cyclooxygenase-2 in Hypoxic Vascular Endothelium
2000
Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation
1995 Nature
Hypoxia-driven selection of the metastatic phenotype
2007
HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells
2007 StandoutNobel
HIF-1 as a target for drug development
2003
Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α
1999 StandoutNobel
Transcriptional Regulation by Hypoxia-Inducible Factor 1 Molecular Mechanisms of Oxygen Homeostasis
1996 StandoutNobel
p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload
2007 Nature
Quantitative reactivity profiling predicts functional cysteines in proteomes
2010 StandoutNatureNobel
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
Endothelin-1 mediates hypoxia-induced inhibition of voltage-gated K+ channel expression in pulmonary arterial myocytes
2007 StandoutNobel
The Role of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) in Hypoxic Induction of Gene Expression
1996 StandoutNobel
Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
2003
Detection of a specific mitochondrial DNA deletion in tissues of older humans
1990
Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide.
1995
The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease
2004
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
2011 StandoutNobel
Oxygen homeostasis
2009 StandoutNobel
The transcription factors ATF-1 and CREB-1 bind constitutively to the hypoxia-inducible factor-1 (HIF-1)DNA recognition site
1995
Oxidative damage and mitochondrial decay in aging.
1994 Standout
HIF-1: mediator of physiological and pathophysiological responses to hypoxia
2000 StandoutNobel
Life with Oxygen
2007 StandoutScienceNobel
Mammalian Oxygen Sensing, Signalling and Gene Regulation
2000
The myoD Gene Family: Nodal Point During Specification of the Muscle Cell Lineage
1991 Science
Hypoxia, Clonal Selection, and the Role of HIF-1 in Tumor Progression
2000 StandoutNobel
General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.
1993 StandoutNobel
PTEN Activity Is Modulated During Ischemia and Reperfusion
2005 StandoutNobel
Differences and Similarities in DNA-Binding Preferences of MyoD and E2A Protein Complexes Revealed by Binding Site Selection
1990 Science
Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α
2002 StandoutNobel
Domains outside of the DNA-binding domain impart target gene specificity to myogenin and MRF4.
1991
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
1995 StandoutNobel
Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment.
2000
Nitric Oxide Synthase Is the Mediator of Late Preconditioning Against Myocardial Infarction in Conscious Rabbits
1998
Domains Outside of the DNA-Binding Domain Impart Target Gene Specificity to Myogenin and MRF4
1991
Differential Activation of Cardiac c-Jun Amino-Terminal Kinase and Extracellular Signal-Regulated Kinase in Angiotensin II–Mediated Hypertension
1998 StandoutNobel
Inhibition of mitochondrial respiration elevates oxygen concentration but leaves regulation of hypoxia-inducible factor (HIF) intact
2005
Role of endothelin and endothelin A-type receptor in adaptation of the carotid body to chronic hypoxia
2002
Hypoxia-inducible Factor-1 Mediates Transcriptional Activation of the Heme Oxygenase-1 Gene in Response to Hypoxia
1997 StandoutNobel
Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2
2012 StandoutNobel
Mitochondrial Genetics: A Paradigm for Aging and Degenerative Diseases?
1992 Science
Glucose-Induced Transcription of the Insulin Gene Is Mediated by Factors Required for β-Cell-Type-Specific Expression
1994
The DNA-binding protein E12 co-operates with XMyoD in the activation of muscle-specific gene expression in Xenopus embryos.
1992 StandoutNobel
Regulation of Erythropoietin Production: New Insights Into Molecular Mechanisms of Oxygen Homeostasis
1994 StandoutNobel
Cellular adaptation to hypoxia: O 2 ‐sensing protein hydroxylases, hypoxia‐inducible transcription factors, and O 2 ‐regulated gene expression
2002
Stimulation of erythropoietin gene transcription during hypoxia and cobalt exposure
1989
The Oxygen Sensor Factor-Inhibiting Hypoxia-Inducible Factor-1 Controls Expression of Distinct Genes through the Bifunctional Transcriptional Character of Hypoxia-Inducible Factor-1α
2006
Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism.
1993 StandoutNobel
Partial HIF-1α deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia
2001 StandoutNobel
A clinical study of hypoxia and metallothionein protein expression in squamous cell carcinomas.
2000
Skeletal muscle phenotypes initiated by ectopic MyoD in transgenic mouse heart
1992
Inefficient Homooligomerization Contributes to the Dependence of Myogenin on E2A Products for Efficient DNA Binding
1991
Targeting the Receptor-G q Interface to Inhibit in Vivo Pressure Overload Myocardial Hypertrophy
1998 StandoutScienceNobel
Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin.
1994
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer.
1994 StandoutNobel
Xenopus embryos contain a somite-specific, MyoD-like protein that binds to a promoter site required for muscle actin expression.
1991 StandoutNobel
Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia
1998
Cellular and Molecular Dissection of Reperfusion Injury
2000 StandoutNobel
Direct Interaction between Nucleosome Assembly Protein 1 and the Papillomavirus E2 Proteins Involved in Activation of Transcription
2004
Regulation of Mammalian O2Homeostasis by Hypoxia-Inducible Factor 1
1999 StandoutNobel
Endothelin ETA receptor antagonist blocks cardiac hypertrophy provoked by hemodynamic overload.
1994
Primary and Secondary Signaling Pathways in Early Preconditioning That Converge on the Mitochondria to Produce Cardioprotection
2004
104 candidate genes for the hypoxic tumor phenotype
1999
Hypoxic activation of the atrial natriuretic peptide gene promoter through direct and indirect actions of hypoxia-inducible factor-1
2003
Hypoxia Stimulates Urokinase Receptor Expression Through a Heme Protein-Dependent Pathway
1998
Evidence for Developmentally Programmed Transdifferentiation in Mouse Esophageal Muscle
1995 StandoutScienceNobel
Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene.
1991 StandoutNobel
Identification of the Hypoxia-Inducible Factor 1α-Responsive HGTD-P Gene as a Mediator in the Mitochondrial Apoptotic Pathway
2004
Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1
2007 StandoutNobel
Expression of genes encoding the transcription factor SRF during early development of Xenopus laevis: identification of a CArG box-binding activity as SRF.
1991
Erythropoietin mRNA levels are governed by both the rate of gene transcription and posttranscriptional events
1991
Modulating Hypoxia-Inducible Transcription by Disrupting the HIF-1–DNA Interface
2007
Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.
1994 Standout
Inefficient homooligomerization contributes to the dependence of myogenin on E2A products for efficient DNA binding.
1991
Works of Keith A. Webster being referenced
Hypoxia Regulates Expression of the Endothelin-1 Gene through a Proximal Hypoxia-Inducible Factor-1 Binding Site on the Antisense Strand
1998
Molecular Regulation of the Endothelin-1 Gene by Hypoxia
2001
BNip3 and signal-specific programmed death in the heart
2004
Cell-specificity and signaling pathway of endothelin-1 gene regulation by hypoxia
1995
Coordinate reciprocal trends in glycolytic and mitochondrial transcript accumulations during the in vitro differentiation of human myoblasts
1990
Sequence analysis of cDNAs for the human and bovine ATP synthase β subunit: mitochondrial DNA genes sustain seventeen times more mutations
1987
Oxidation of Zinc Finger Transcription Factors: Physiological Consequences
2001
Hypoxia-activated apoptosis of cardiac myocytes requires reoxygenation or a pH shift and is independent of p53
1999
Adenovirus E1A products suppress myogenic differentiation and inhibit transcription from muscle-specific promoters
1988 Nature
Regulation of glycolytic enzyme RNA transcriptional rates by oxygen availability in skeletal muscle cells
1987
Positive regulation of the skeletal alpha-actin gene by Fos and Jun in cardiac myocytes.
1992
Induction and nuclear accumulation of fos and jun proto-oncogenes in hypoxic cardiac myocytes
1993
Reperfusion-Activated Akt Kinase Prevents Apoptosis in Transgenic Mouse Hearts Overexpressing Insulin-Like Growth Factor-1
2001
Muscle-specific expression of the cardiac alpha-actin gene requires MyoD1, CArG-box binding factor, and Sp1.
1990
Hypoxia/Reoxygenation Stimulates Jun Kinase Activity Through Redox Signaling in Cardiac Myocytes
1997
Hypoxia and acidosis activate cardiac myocyte death through the Bcl-2 family protein BNIP3
2002
Control of Cardiac-specific Transcription by p300 through Myocyte Enhancer Factor-2D
2001
Regulation of fos and jun immediate-early genes by redox or metabolic stress in cardiac myocytes.
1994
Hypoxia Regulates β-Enolase and Pyruvate Kinase-M Promoters by Modulating Sp1/Sp3 Binding to a Conserved GC Element
1998
Mitochondrial signals initiate the activation of c‐Jun N ‐terminal kinase (JNK) by hypoxia‐reoxygenation
2004
Activation of metallothionein gene expression by hypoxia involves metal response elements and metal transcription factor-1.
1999
Rapid Activation of Neutral Sphingomyelinase by Hypoxia-Reoxygenation of Cardiac Myocytes
2000