Standout Papers
Citation Impact
Citing Papers
Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow
2009
In vivo cellular imaging pinpoints the role of reactive oxygen species in the early steps of adult hematopoietic reconstitution
2009
A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche
2007
In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter
2010 StandoutNobel
Extracellular matrix protein tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration
2012
Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants
2019 StandoutScienceNobel
ZBTB1 is a determinant of lymphoid development
2011 StandoutNobel
( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
2013 StandoutScienceNobel
Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow
2012
ATM Activation by Oxidative Stress
2010 Science
Cancer metabolism: fatty acid oxidation in the limelight
2013
Transcriptomic portrait of human Mesenchymal Stromal/Stem cells isolated from bone marrow and placenta
2014
SIRT3 Reverses Aging-Associated Degeneration
2013
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Noncanonical Wnt Signaling Maintains Hematopoietic Stem Cells in the Niche
2012
Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells
2008
Maintenance of the Hematopoietic Stem Cell Pool by CXCL12-CXCR4 Chemokine Signaling in Bone Marrow Stromal Cell Niches
2006 Standout
An apical hypoxic niche sets the pace of shoot meristem activity
2019 Nature
Resolving the Controversy about N-Cadherin and Hematopoietic Stem Cells
2010
Pharmacological inhibition of fatty-acid oxidation synergistically enhances the effect of l-asparaginase in childhood ALL cells
2015
Modulation of Longevity and Tissue Homeostasis by the Drosophila PGC-1 Homolog
2011
Self-Renewing Osteoprogenitors in Bone Marrow Sinusoids Can Organize a Hematopoietic Microenvironment
2007 Standout
Critical Role of Thrombopoietin in Maintaining Adult Quiescent Hematopoietic Stem Cells
2007
Stem Cell Self-Renewal and Cancer Cell Proliferation Are Regulated by Common Networks That Balance the Activation of Proto-oncogenes and Tumor Suppressors
2005
CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance
2013 Nature
Rb Regulates Interactions between Hematopoietic Stem Cells and Their Bone Marrow Microenvironment
2007
Hematopoietic Stem Cells
2006
Foxo3 is required for the regulation of oxidative stress in erythropoiesis
2007
Engraftment and Reconstitution of Hematopoiesis Is Dependent on VEGFR2-Mediated Regeneration of Sinusoidal Endothelial Cells
2009
Thrombopoietin/MPL Signaling Regulates Hematopoietic Stem Cell Quiescence and Interaction with the Osteoblastic Niche
2007
Tie receptors and their angiopoietin ligands are context-dependent regulators of vascular remodeling
2005
Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair
2008
Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes
2010
Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche
2011 StandoutNobel
Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche
2007 Standout
N-Cadherin Expression Level Distinguishes Reserved versus Primed States of Hematopoietic Stem Cells
2008
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
2007 Nature
PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention
2006 Nature
Mesenchymal stem cells in health and disease
2008 Standout
Cellular Senescence in Cancer and Aging
2007 Standout
S6K1 determines the metabolic requirements for BCR-ABL survival
2012
Modulation of oxidative stress as an anticancer strategy
2013 Standout
Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance
2012
Multiplex assessment of protein variant abundance by massively parallel sequencing
2018
mTOR Activation Induces Tumor Suppressors that Inhibit Leukemogenesis and Deplete Hematopoietic Stem Cells after Pten Deletion
2010
Tie2-dependent knockout of HIF-1 impairs burn wound vascularization and homing of bone marrow-derived angiogenic cells
2011 StandoutNobel
Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche
2011
Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche
2008 Nature
DNA Repair, Genome Stability, and Aging
2005
The bone marrow niche for haematopoietic stem cells
2014 StandoutNature
Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region
2007
ROS Function in Redox Signaling and Oxidative Stress
2014 Standout
Mitochondria: In Sickness and in Health
2012 Standout
Haematopoietic stem cells do not asymmetrically segregate chromosomes or retain BrdU
2007 Nature
Cadherin-Based Adhesion Is a Potential Target for Niche Manipulation to Protect Hematopoietic Stem Cells in Adult Bone Marrow
2010
Cancer stem cells in solid tumours: accumulating evidence and unresolved questions
2008 Standout
How stem cells age and why this makes us grow old
2007
DNA-Damage Response in Tissue-Specific and Cancer Stem Cells
2011
Redox Regulation by Keap1 and Nrf2 Controls Intestinal Stem Cell Proliferation in Drosophila
2011
FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress
2007
Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia
2006
Regulation of reactive oxygen species in stem cells and cancer stem cells
2011
The Lkb1 metabolic sensor maintains haematopoietic stem cell survival
2010 Nature
Acquisition of G0 state by CD34-positive cord blood cells after bone marrow transplantation
2010
Redox regulation of stem/progenitor cells and bone marrow niche
2012
Stem Cells and Niches: Mechanisms That Promote Stem Cell Maintenance throughout Life
2008
Bmi1 regulates mitochondrial function and the DNA damage response pathway
2009 Nature
Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells
2010 Nature
Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase–substrate complex
2010
Intrinsic Immunity Shapes Viral Resistance of Stem Cells
2017 StandoutNobel
Synthetic Par polarity induces cytoskeleton asymmetry in unpolarized mammalian cells
2023 StandoutNobel
SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells
2005 Standout
Uncertainty in the niches that maintain haematopoietic stem cells
2008
Therapeutic targeting of a stem cell niche
2007
Integrating Physiological Regulation with Stem Cell and Tissue Homeostasis
2011
Polycomb Group Proteins: Multi-Faceted Regulators of Somatic Stem Cells and Cancer
2010
Stems Cells and the Pathways to Aging and Cancer
2008
Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematopoietic stem cells
2006
Regulation of SDF-1 (CXCL12) production by osteoblasts; a possible mechanism for stem cell homing
2005
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
2010 StandoutNature
Molecular regulation of angiogenesis and lymphangiogenesis
2007 Standout
Detection of functional haematopoietic stem cell niche using real-time imaging
2008 Nature
Hematopoietic Stem Cells Do Not Depend on N-Cadherin to Regulate Their Maintenance
2009
Endothelial and perivascular cells maintain haematopoietic stem cells
2012 Nature
The common biology of cancer and ageing
2007 Nature
Direct measurement of local oxygen concentration in the bone marrow of live animals
2014 Nature
The stem-cell niche as an entity of action
2006 Nature
Reducing Mitochondrial ROS Improves Disease-related Pathology in a Mouse Model of Ataxia-telangiectasia
2012
The molecular signature of therapeutic mesenchymal stem cells exposes the architecture of the hematopoietic stem cell niche synapse
2007
Bone-marrow haematopoietic-stem-cell niches
2006
ROS Are Required for Mouse Spermatogonial Stem Cell Self-Renewal
2013
c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation
2004
Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors
2005
Endothelial Cells Are Essential for the Self-Renewal and Repopulation of Notch-Dependent Hematopoietic Stem Cells
2010
FoxOs Cooperatively Regulate Diverse Pathways Governing Neural Stem Cell Homeostasis
2009
Cripto Regulates Hematopoietic Stem Cells as a Hypoxic-Niche-Related Factor through Cell Surface Receptor GRP78
2011
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
Mitochondria: The Next (Neurode)Generation
2011
Endochondral ossification is required for haematopoietic stem-cell niche formation
2008 Nature
The ATM–BID pathway regulates quiescence and survival of haematopoietic stem cells
2012
The functions and regulation of the PTEN tumour suppressor
2012 Standout
The Hallmarks of Aging
2013 Standout
Haematopoietic stem cell release is regulated by circadian oscillations
2008 Nature
Matrix-Embedded Osteocytes Regulate Mobilization of Hematopoietic Stem/Progenitor Cells
2013
TGF-β–FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia
2010 Nature
Cellular mechanisms and physiological consequences of redox-dependent signalling
2014 Standout
Asymmetric lysosome inheritance predicts activation of haematopoietic stem cells
2019 Nature
Cancer-related inflammation
2008 StandoutNature
Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells
2010
Hematopoietic Stem Cell Trafficking
2007
Lack of Evidence that Hematopoietic Stem Cells Depend on N-Cadherin-Mediated Adhesion to Osteoblasts for Their Maintenance
2007
Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system
2009
Cdc42 Activity Regulates Hematopoietic Stem Cell Aging and Rejuvenation
2012
Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?
2009 Standout
Maintaining Hematopoietic Stem Cells in the Vascular Niche
2006
PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2
2016 StandoutNobel
Mdm2 Is Required for Survival of Hematopoietic Stem Cells/Progenitors via Dampening of ROS-Induced p53 Activity
2010
Stress-induced recrystallization of a protein crystal by electron irradiation
1999 StandoutNatureNobel
Cellular and Molecular Regulation of Hematopoietic and Intestinal Stem Cell Behavior
2005
Signals from the Sympathetic Nervous System Regulate Hematopoietic Stem Cell Egress from Bone Marrow
2006
Stem Cell Defects in ATM-Deficient Undifferentiated Spermatogonia through DNA Damage-Induced Cell-Cycle Arrest
2008
Mechanisms that Regulate Stem Cell Aging and Life Span
2013
Redox Regulation and Its Emerging Roles in Stem Cells and Stem-Like Cancer Cells
2008
Cell Cycle Regulation by Oncogenic Tyrosine Kinases in Myeloid Neoplasias: From Molecular Redox Mechanisms to Health Implications
2008
Regulation of Reactive Oxygen Species and Genomic Stability in Hematopoietic Stem Cells
2008
Oxidative Stress Regulation of Stem and Progenitor Cells
2009
Novel Role of NADPH Oxidase in Angiogenesis and Stem/Progenitor Cell Function
2009
Oxidative Stress in the Regulation of Normal and Neoplastic Hematopoiesis
2008
Carboxy-terminal domain of AID required for its mRNA complex formation in vivo
2009 StandoutNobel
Self-organized criticality in a continuous, nonconservative cellular automaton modeling earthquakes
1992
The journey of developing hematopoietic stem cells
2006
Strontium can increase some osteoblasts without increasing hematopoietic stem cells
2007
Avalanche dynamics in evolution, growth, and depinning models
1996
SLAM family markers are conserved among hematopoietic stem cells from old and reconstituted mice and markedly increase their purity
2005
Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells
2005
Bone marrow dysfunction in mice lacking the cytokine receptor gp130 in endothelial cells
2005
Human Mesenchymal Stem Cells Promote Survival of T Cells in a Quiescent State
2007
Telomere length is paternally inherited and is associated with parental lifespan
2007 StandoutNobel
Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size
2005
The Phase Boundary Between α- and β-Mg 2 SiO 4 Determined by in Situ X-ray Observation
1994 StandoutScienceNobel
PDGFRα and CD51 mark human Nestin+ sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion
2013
ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair
2010
DNA polymerase β is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination
2007
Foxo3a is essential for maintenance of the hematopoietic stem cell pool
2009
Osteoblastic N-cadherin is not required for microenvironmental support and regulation of hematopoietic stem and progenitor cells
2012
Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells
2007
Reconstitution of the functional human hematopoietic microenvironment derived from human mesenchymal stem cells in the murine bone marrow compartment
2005
Programmed assembly of 3-dimensional microtissues with defined cellular connectivity
2009 StandoutNobel
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression
2014 StandoutNobel
Telomerase reverse transcriptase protects ATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere-independent mechanism
2011
Signal transduction by reactive oxygen species
2011 Standout
Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia
2007
Kinetics of high-pressure phase transformations: Implications to the evolution of the olivine → spinel transition in the downgoing lithosphere and its consequences on the dynamics of the mantle
1976
AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination
2009 StandoutNobel
Somatic Progenitor Cell Vulnerability to Mitochondrial DNA Mutagenesis Underlies Progeroid Phenotypes in Polg Mutator Mice
2012
Loss of Cxcl12/Sdf-1 in adult mice decreases the quiescent state of hematopoietic stem/progenitor cells and alters the pattern of hematopoietic regeneration after myelosuppression
2010
Essential Role of Endothelial Notch1 in Angiogenesis
2005
The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways
2022 StandoutNobel
The C-terminal region of activation-induced cytidine deaminase is responsible for a recombination function other than DNA cleavage in class switch recombination
2009 StandoutNobel
Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair
2011
Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice
2006
Rapid local synchronization of action potentials: toward computation with coupled integrate-and-fire neurons.
1995 StandoutNobel
F‐domain valency determines outcome of signaling through the angiopoietin pathway
2021 StandoutNobel
TSC–mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
2008
Pharmacologic stabilization of HIF-1α increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation
2012
Long‐term p110α PI3K inactivation exerts a beneficial effect on metabolism
2013
Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase
2014 StandoutNobel
Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development
2013
AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species
2010
Hypoxic retinal Müller cells promote vascular permeability by HIF-1–dependent up-regulation of angiopoietin-like 4
2013 StandoutNobel
G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow
2005
Osteoblastic regulation of B lymphopoiesis is mediated by G s α-dependent signaling pathways
2008
Mechanism and Regulation of Class Switch Recombination
2008
N-cadherin in osteolineage cells is not required for maintenance of hematopoietic stem cells
2012
Oxidative stress and cancer: have we moved forward?
2006
Polysialic acid governs T-cell development by regulating progenitor access to the thymus
2009 StandoutNobel
Quantum dot/antibody conjugates for in vivo cytometric imaging in mice
2015 StandoutNobel
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
Diabetes Impairs Hematopoietic Stem Cell Mobilization by Altering Niche Function
2011
STEM CELL NICHE: Structure and Function
2005
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination
2014 StandoutNobel
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
2008 StandoutNobel
Coexistence of Quiescent and Active Adult Stem Cells in Mammals
2010 StandoutScience
Signaling and Functions of Angiopoietin-1 in Vascular Protection
2006
Top-down design of protein architectures with reinforcement learning
2023 StandoutScienceNobel
Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs
2010
The Essential Functions of Adipo-osteogenic Progenitors as the Hematopoietic Stem and Progenitor Cell Niche
2010
Lattice models of failure: Sensitivity to the local dynamics
1994
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells
2010
Accurate proteome-wide missense variant effect prediction with AlphaMissense
2023 StandoutScienceNobel
Stem Cells and Their Niches
2006 Science
Heme oxygenase-1 deficiency leads to disrupted response to acute stress in stem cells and progenitors
2008
Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning
2012 StandoutNobel
Annexin II expressed by osteoblasts and endothelial cells regulates stem cell adhesion, homing, and engraftment following transplantation
2007
Works of Keisuke Ito being referenced
PML Regulates Apoptosis at Endoplasmic Reticulum by Modulating Calcium Release
2010 Science
Regulation of Reactive Oxygen Species by Atm Is Essential for Proper Response to DNA Double-Strand Breaks in Lymphocytes
2007
Self-renewal of a purified Tie2 + hematopoietic stem cell population relies on mitochondrial clearance
2016 Science
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
2004 Nature
A metabolic prosurvival role for PML in breast cancer
2012
Cancer-Associated PTEN Mutants Act in a Dominant-Negative Manner to Suppress PTEN Protein Function
2014
Function of oxidative stress in the regulation of hematopoietic stem cell-niche interaction
2007
Systemic Elevation of PTEN Induces a Tumor-Suppressive Metabolic State
2012
Tie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche
2004 Standout
Zerumbone, a bioactive sesquiterpene, induces G2/M cell cycle arrest and apoptosis in leukemia cells via a Fas‐ and mitochondria‐mediated pathway
2006
PML targeting eradicates quiescent leukaemia-initiating cells
2008 Nature
Metabolic requirements for the maintenance of self-renewing stem cells
2014
LRF Is an Essential Downstream Target of GATA1 in Erythroid Development and Regulates BIM-Dependent Apoptosis
2009
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells
2006
A novel signaling network as a critical rheostat for the biology and maintenance of the normal stem cell and the cancer-initiating cell
2009
Arteriolar niches maintain haematopoietic stem cell quiescence
2013 Nature
A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance
2012
Earthquakes as self‐organized critical phenomena
1990
Punctuated-equilibrium model of biological evolution is also a self-organized-criticality model of earthquakes
1995
Olivine-Spinel transformation in a natural forsterite
1971