Standout Papers
- Novel Modulator for Endothelial Adhesion Molecules (1999)
- cDNA Cloning and Expression of a Novel Adipose Specific Collagen-like Factor, apM1 (AdiposeMost Abundant Gene Transcript 1) (1996)
- Adiponectin, an Adipocyte-Derived Plasma Protein, Inhibits Endothelial NF-κB Signaling Through a cAMP-Dependent Pathway (2000)
- A central role for JNK in obesity and insulin resistance (2002)
Citation Impact
Citing Papers
S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction
2015 Science
Hepatic NF-κB essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis
2008
JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation
2012 Science
A Sulfilimine Bond Identified in Collagen IV
2009 StandoutScienceNobel
A Stress Signaling Pathway in Adipose Tissue Regulates Hepatic Insulin Resistance
2008 Science
Sfrp5 Is an Anti-Inflammatory Adipokine That Modulates Metabolic Dysfunction in Obesity
2010 Science
Adiponectin, a Fat Cell Product, Influences the Earliest Lymphocyte Precursors in Bone Marrow Cultures by Activation of the Cyclooxygenase-Prostaglandin Pathway in Stromal Cells
2003
Production of Prostaglandin E 2 by Iridial Melanocytes Exposed to Latanoprost Acid, A Prostaglandin F 2 α Analogue
2002
Suppressor of Cytokine Signaling 3 Is a Physiological Regulator of Adipocyte Insulin Signaling
2004
Visfatin, an Adipocytokine with Proinflammatory and Immunomodulating Properties
2007
Adiponectin and Functional Adiponectin Receptor 1 Are Expressed by Airway Epithelial Cells in Chronic Obstructive Pulmonary Disease
2009
Genetic Ablation of the Fatty Acid–Binding Protein FABP5 Suppresses HER2-Induced Mammary Tumorigenesis
2013
Saturated fatty acids regulate retinoic acid signalling and suppress tumorigenesis by targeting fatty acid-binding protein 5
2015
Hallmarks of Cancer: The Next Generation
2011 Standout
PKR is not obligatory for high-fat diet-induced obesity and its associated metabolic and inflammatory complications
2016
The human fatty acid-binding protein family: Evolutionary divergences and functions
2011
Regulation of vascular tone by adipocytes
2011
Distinct Roles for JNK and IKK Activation in Agouti-Related Peptide Neurons in the Development of Obesity and Insulin Resistance
2014
Small-molecule inhibitors of FABP4/5 ameliorate dyslipidemia but not insulin resistance in mice with diet-induced obesity
2011
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
2018 Standout
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
2021 Standout
The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
2003
Linking mitochondrial bioenergetics to insulin resistance via redox biology
2012
Low pre-transplant adiponectin multimers are associated with adverse allograft outcomes in kidney transplant recipients a 3-year prospective study
2012
Adipose tissue as a secretory organ: from adipogenesis to the metabolic syndrome
2006
Resistin Promotes Endothelial Cell Activation
2003
Effect of Weight Loss and Lifestyle Changes on Vascular Inflammatory Markers in Obese Women
2003
Obesity, adiponectin and vascular inflammatory disease
2003
Structural analysis of ibuprofen binding to human adipocyte fatty-acid binding protein (FABP4)
2015
Adipose tissue, adipokines, and inflammation
2005 Standout
Expression of adiponectin receptors in pancreatic β cells
2003
Adiponectin, Metabolic Risk Factors, and Cardiovascular Events among Patients with End-Stage Renal Disease
2002
Ceramides in insulin resistance and lipotoxicity
2005
Thiazolidinediones
2004 Standout
Adiponectin inhibits Toll‐like receptor family‐induced signaling
2005
Abdominal obesity and metabolic syndrome
2006 StandoutNature
Endocrine and signalling role of adipose tissue: new perspectives on fat
2005
Cytokine regulation of skeletal muscle fatty acid metabolism: effect of interleukin-6 and tumor necrosis factor-α
2004
MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
2006 Standout
Decreased Expression Of apM1 in Omental and Subcutaneous Adipose Tissue of HumansWith Type 2 Diabetes
2000
Human Immunodeficiency Virus/Highly Active Antiretroviral Therapy-Associated Metabolic Syndrome: Clinical Presentation, Pathophysiology, and Therapeutic Strategies
2003
Association of Plasma Adiponectin Levels with Oxidative Stress in Hemodialysis Patients
2007
Inflammation and metabolic disorders
2006 StandoutNature
Pioglitazone Ameliorates Insulin Resistance and Diabetes by Both Adiponectin-dependent and -independent Pathways
2006
Chromosomal Localization, Expression Pattern, and Promoter Analysis of the Mouse Gene Encoding Adipocyte-Specific Secretory Protein Acrp30
2001
Inflammatory links between obesity and metabolic disease
2011 Standout
Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes
2003
Cross-talk between adipose tissue and vasculature: role of adiponectin
2010
Human Genital Melanocytes as Androgen Target Cells
1997
ACRP30, a new hormone controlling fat and glucose metabolism
2002
Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity
1999 Standout
Control of Metabolic Homeostasis by Stress Signaling Is Mediated by the Lipocalin NLaz
2009
Innate Immunity Gone Awry: Linking Microbial Infections to Chronic Inflammation and Cancer
2006
Insulin resistance in adipose tissue: direct and indirect effects of tumor necrosis factor-α
2003
Fatty acid binding proteins in adipose tissue: A promising link between metabolic syndrome and atherosclerosis?
2008
Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2
2007 Nature
Increased oxidative stress in obesity and its impact on metabolic syndrome
2004 Standout
Close association of hypoadiponectinemia with arteriosclerosis obliterans and ischemic heart disease
2005
Adiponectin and Cardiovascular Outcomes among Hemodialysis Patients
2012
Melanin Pigmentation in Mammalian Skin and Its Hormonal Regulation
2004 Standout
Mechanisms linking obesity with cardiovascular disease
2006 StandoutNature
Myeloid Differentiation Factor 88 (MyD88)-Deficiency Increases Risk of Diabetes in Mice
2010
Adiponectin modulates inflammatory reactions via calreticulin receptor–dependent clearance of early apoptotic bodies
2007
A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia
2003
Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice
2006
Identification and Adipocyte Differentiation-dependent Expression of the Unique Disialic Acid Residue in an Adipose Tissue-specific Glycoprotein, Adipo Q
2001
Serum Retinol-Binding Protein Is More Highly Expressed in Visceral than in Subcutaneous Adipose Tissue and Is a Marker of Intra-abdominal Fat Mass
2007
Adiponectin Stimulates Angiogenesis in Response to Tissue Ischemia through Stimulation of AMP-activated Protein Kinase Signaling
2004
Adiponectin Stimulates Production of Nitric Oxide in Vascular Endothelial Cells
2003
Lower expression of adiponectin mRNA in visceral adipose tissue in lean and obese subjects
2004
Genomic structure and mutations in adipose-specific gene, adiponectin
2000
Role of platelet-derived growth factors in physiology and medicine
2008 Standout
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30
2002 Standout
Dissociation of Inositol-requiring Enzyme (IRE1α)-mediated c-Jun N-terminal Kinase Activation from Hepatic Insulin Resistance in Conditional X-box-binding Protein-1 (XBP1) Knock-out Mice
2011
Conditional disruption of IκB kinase 2 fails to prevent obesity-induced insulin resistance
2004
Alteration of JNK-1 Signaling in Skeletal Muscle Fails to Affect Glucose Homeostasis and Obesity-Associated Insulin Resistance in Mice
2013
Circulating Levels of Fatty Acid-Binding Protein Family and Metabolic Phenotype in the General Population
2013
Reduced gene expression of adiponectin in fat tissue from patients with end-stage renal disease
2004
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
2008 Standout
Serum visfatin concentration and endothelial dysfunction in chronic kidney disease
2007
The biological actions of estrogens on skin
2002
Adipokines: molecular links between obesity and atheroslcerosis
2005
Adipose tissue mass and location affect circulating adiponectin levels
2011
Plasminogen activator inhibitor-1, inflammation, obesity, insulin resistance and vascular risk
2003
Adiponectin deficiency: a model of pulmonary hypertension associated with pulmonary vascular disease
2009
Plasma Adiponectin Levels and Risk of Myocardial Infarction in Men
2004 Standout
The Adipose Tissue as an Endocrine Organ – A Nephrologists’ Perspective
2006
Plasma adiponectin concentration before and after successful kidney transplantation
2003
JNK Extends Life Span and Limits Growth by Antagonizing Cellular and Organism-Wide Responses to Insulin Signaling
2005
Hypoadiponectinemia is associated with visceral fat accumulation and insulin resistance in Japanese men with type 2 diabetes mellitus
2003
A Predominant Role for Parenchymal c-Jun Amino Terminal Kinase (JNK) in the Regulation of Systemic Insulin Sensitivity
2008
Tlr‐4 Deficiency Selectively Protects Against Obesity Induced by Diets High in Saturated Fat
2008
The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes
2014 Nature
Adipocytes as regulators of energy balance and glucose homeostasis
2006 StandoutNature
Inhibition by adiponectin of IL-8 production by human macrophages upon coculturing with late apoptotic cells
2005
The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
2001 Standout
Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects
2005
Adiponectin and Cardiovascular Remodeling in End-Stage Renal Disease and Co-Morbid Diabetes Mellitus
2006
Serum adiponectin and markers of endothelial injury in hemodialysis patients with arteriosclerosis obliterans
2008
Effects of pioglitazone on metabolic parameters, body fat distribution, and serum adiponectin levels in Japanese male patients with type 2 diabetes
2002
Adipose tissue as an endocrine organ
2009
Ageing and plasma adiponectin concentration in apparently healthy males and females
2004
Changes in adiponectin and the risk of sudden death, stroke, myocardial infarction, and mortality in hemodialysis patients
2009
C-reactive protein inhibits adiponectin gene expression and secretion in 3T3-L1 adipocytes
2007
Magnesium Replacement Improves the Metabolic Profile in Obese and Pre-Diabetic Patients with Mild-to-Moderate Chronic Kidney Disease: A 3-Month, Randomised, Double-Blind, Placebo-Controlled Study
2017 Standout
Mechanisms of obesity-associated insulin resistance: many choices on the menu
2007
Adiponectin protects against the development of systolic dysfunction following myocardial infarction
2007
From JNK to Pay Dirt: Jun Kinases, their Biochemistry, Physiology and Clinical Importance
2005
Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity
2006
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
2003 Standout
Macrophage PPARγ is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones
2007
Aspirin Inhibits Serine Phosphorylation of Insulin Receptor Substrate 1 in Tumor Necrosis Factor-treated Cells through Targeting Multiple Serine Kinases
2003
Irs1 Serine 307 Promotes Insulin Sensitivity in Mice
2010
Effect of Lifestyle Modification on Adipokine Levels in Obese Subjects with Insulin Resistance
2003
Hydroxylation and Glycosylation of the Four Conserved Lysine Residues in the Collagenous Domain of Adiponectin
2002 Standout
Inflammation, stress, and diabetes
2005 Standout
Inflammation and insulin resistance
2006 Standout
Adiponectin: A Novel Adipokine Linking Adipocytes and Vascular Function
2004
The role of the novel adipocyte-derived hormone adiponectin in human disease
2003
Conjugated linoleic acid enhances plasma adiponectin level and alleviates hyperinsulinemia and hypertension in Zucker diabetic fatty (fa/fa) rats
2003
Differential Regulation of Adiponectin Secretion from Cultured Human Omental and Subcutaneous Adipocytes: Effects of Insulin and Rosiglitazone
2002
Decreased plasma adiponectin concentration in patients with essential hypertension
2003
Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice
2010
Adiponectin in renal disease: Relationship to phenotype and genetic variation in the gene encoding adiponectin
2003
Organization of the gene for gelatin-binding protein (GBP28)
1999
TLR4 links innate immunity and fatty acid–induced insulin resistance
2006 Standout
JNK1 in Hematopoietically Derived Cells Contributes to Diet-Induced Inflammation and Insulin Resistance without Affecting Obesity
2007
Phosphorylation of Ser24 in the Pleckstrin Homology Domain of Insulin Receptor Substrate-1 by Mouse Pelle-like Kinase/Interleukin-1 Receptor-associated Kinase
2005
Adipokines in inflammation and metabolic disease
2011 Standout
Testosterone Selectively Reduces the High Molecular Weight Form of Adiponectin by Inhibiting Its Secretion from Adipocytes
2005
Prevention of Steatosis by Hepatic JNK1
2009
Regulation of Tyrosinase Expression and Activity in Human Melanoma Cells via Histamine Receptors
1991
Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians
2002
Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis
2010
N-acetylcysteine attenuates TNF-α induced changes in secretion of interleukin-6, plasminogen activator inhibitor-1 and adiponectin from 3T3-L1 adipocytes
2006
Production of adiponectin, an anti-inflammatory protein, in mesenteric adipose tissue in Crohn’s disease
2005
Cigarette Smoke Decreases Airway Epithelial FABP5 Expression and Promotes Pseudomonas aeruginosa Infection
2013
Structure-Function Studies of the Adipocyte-secreted Hormone Acrp30/Adiponectin
2003
Adipose Tissue as an Endocrine Organ
2000
Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
2010 Standout
Obesity, haemostasis and the fibrinolytic system
2002
Serum adiponectin complexes and cardiovascular risk in children with chronic kidney disease
2011
Adiponectin gene expression is inhibited by β‐adrenergic stimulation via protein kinase A in 3T3‐L1 adipocytes
2001
A novel ELISA system for selective measurement of human adiponectin multimers by using proteases
2006
Plasma adiponectin concentration and left ventricular hypertrophy in kidney transplant patients
2010
Lipid signalling in disease
2008
Role of Adiponectin in Preventing Vascular Stenosis
2002
Insulin Receptor Signaling in Normal and Insulin-Resistant States
2014
Hypoxia dysregulates the production of adiponectin and plasminogen activator inhibitor-1 independent of reactive oxygen species in adipocytes
2006
Histamine Induces Melanogenesis and Morphologic Changes by Protein Kinase A Activation via H2 Receptors in Human Normal Melanocytes
2000
Insulin resistance and pancreatic cell failure
2006
Serine Phosphorylation of Insulin Receptor Substrate 1 by Inhibitor κB Kinase Complex
2002
The metabolic syndrome and adipocytokines
2006
Reciprocal Association of Plasma Adiponectin and Serum C-Reactive Protein Concentration in Haemodialysis Patients with End-Stage Kidney Disease – A Follow-Up Study
2005
Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action
2009
Effects of Etanercept in Patients With the Metabolic Syndrome
2006
Adiponectin Is Associated with Brain Natriuretic Peptide and Left Ventricular Hypertrophy in Hemodialysis Patients with Type 2 Diabetes Mellitus
2007
Isolation and Characterization of GBP28, a Novel Gelatin-Binding Protein Purified from Human Plasma
1996
JNK and Tumor Necrosis Factor-α Mediate Free Fatty Acid-induced Insulin Resistance in 3T3-L1 Adipocytes
2005
MyD88 Signaling in the CNS Is Required for Development of Fatty Acid-Induced Leptin Resistance and Diet-Induced Obesity
2009
The release of the adipocytokine visfatin is regulated by glucose and insulin
2006
Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2–dependent mechanisms
2005
Adiponectin Inhibits Cell Proliferation by Interacting with Several Growth Factors in an Oligomerization-dependent Manner
2005
Mechanism of Hepatic Insulin Resistance in Non-alcoholic Fatty Liver Disease
2004
Inflammation Improves Glucose Homeostasis through IKKβ-XBP1s Interaction
2016
Impaired Multimerization of Human Adiponectin Mutants Associated with Diabetes
2003
Adiponectin and HIV-Lipodystrophy: Taking HAART
2004
An Integrated View of Immunometabolism
2018
Macrophages are Novel Sites of Expression and Regulation of RetinolBinding Protein-4 (RBP4)
2010
Mechanisms linking obesity to insulin resistance and type 2 diabetes
2006 StandoutNature
From endoplasmic-reticulum stress to the inflammatory response
2008 StandoutNature
Associations among plasma adiponectin, hypertension, left ventricular diastolic function and left ventricular mass index
2004
Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide
2004
Influence of Serum High-Molecular-Weight and Total Adiponectin on Arteriosclerosis in IgA Nephropathy Patients
2008
Adipokines and blood pressure control
2010
Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin
2013
Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: a new insight into adipocytokine–endothelial cell interactions
2004
Adiponectin: mechanistic insights and clinical implications
2012
Disordered Lipid Metabolism and the Pathogenesis of Insulin Resistance
2007
CCR2 modulates inflammatory and metabolic effects of high-fat feeding
2005
Adiponectin Stimulates Angiogenesis by Promoting Cross-talk between AMP-activated Protein Kinase and Akt Signaling in Endothelial Cells
2004
Human melanoma cells generate leukotrienes B 4 and C 4 from leukotriene A 4
1997
Ectopic fat storage in heart, blood vessels and kidneys in the pathogenesis of cardiovascular diseases
2004
Serum adiponectin predicts all-cause mortality and end stage renal disease in patients with type I diabetes and diabetic nephropathy
2008
Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis
2006
Up-regulation of the anti-inflammatory adipokine adiponectin in acute liver failure in mice
2005
The current biology of resistin
2004
The immunomodulating role of exercise in metabolic disease
2014
Adiponectin and protection against type 2 diabetes mellitus
2003 Standout
Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex
2003
The twentieth century struggle to decipher insulin signalling
2006
Alveolar macrophage activation and an emphysema-like phenotype in adiponectin-deficient mice
2008
Secretion of Adiponectin and Regulation of apM1 Gene Expression in Human Visceral Adipose Tissue
2001
A Subpopulation of Macrophages Infiltrates Hypertrophic Adipose Tissue and Is Activated by Free Fatty Acids via Toll-like Receptors 2 and 4 and JNK-dependent Pathways
2007
Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance†
2008
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
2004 Nature
Reactive oxygen species have a causal role in multiple forms of insulin resistance
2006 StandoutNature
Disruption of Adiponectin Causes Insulin Resistance and Neointimal Formation
2002
Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes
2015
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance
2010
An immune origin of type 2 diabetes?
2005
Metabolic Reprogramming of Macrophages
2014
Crohn's disease clinical course and severity in obese patients
2002
GRP78 expression inhibits insulin and ER stress–induced SREBP-1c activation and reduces hepatic steatosis in mice
2009
Hydrogen Sulfide Promotes Adipogenesis in 3T3L1 Cells
2015
Mechanisms for Insulin Resistance: Common Threads and Missing Links
2012 Standout
A Cysteine-rich Adipose Tissue-specific Secretory Factor Inhibits Adipocyte Differentiation
2001
Expression of adiponectin receptors in human macrophages and regulation by agonists of the nuclear receptors PPARα, PPARγ, and LXR
2003
Lipoexpediency: de novo lipogenesis as a metabolic signal transmitter
2010
A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity
2013 Nature
Structural Basis for Ligand Regulation of the Fatty Acid-binding Protein 5, Peroxisome Proliferator-activated Receptor β/δ (FABP5-PPARβ/δ) Signaling Pathway
2014
Activation of double-stranded RNA-dependent protein kinase inhibits proliferation of pancreatic β-cells
2013
Up-regulation of adiponectin, its isoforms and receptors in end-stage kidney disease
2006
Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases
2010
Hypoadiponectinemia in Obesity and Type 2 Diabetes: Close Association with Insulin Resistance and Hyperinsulinemia
2001 Standout
Insulin resistance causes inflammation in adipose tissue
2018
The Role of Endoplasmic Reticulum in Hepatic Lipid Homeostasis and Stress Signaling
2012
Interleukin-6-deficient mice develop hepatic inflammation and systemic insulin resistance
2010
Use of Salsalate to Target Inflammation in the Treatment of Insulin Resistance and Type 2 Diabetes
2008
Adiponectin downregulates its own production and the expression of its AdipoR2 receptor in transgenic mice
2006
ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism
2002
Pathophysiological levels of the obesity related peptides resistin and ghrelin increase adhesion molecule expression on human vascular endothelial cells
2005
Molecular Mechanism of Metabolic Syndrome X: Contribution of Adipocytokines · Adipocyte‐derived Bioactive Substances
1999
Effects of Melanogenesis‐Inducing Nitric Oxide and Histamine on the Production of Eumelanin and Pheomelanin in Cultured Human Melanocytes
2003
Increment and impairment of adiponectin in renal failure
2009
Insulin Resistance Due to Phosphorylation of Insulin Receptor Substrate-1 at Serine 302
2004
Mechanisms linking obesity to hypertension
2011
Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin
2003
Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets
2008
Obesity is associated with macrophage accumulation in adipose tissue
2003 Standout
Protein Kinase C θ Inhibits Insulin Signaling by Phosphorylating IRS1 at Ser1101
2004
Renal extraction of circulating adiponectin in patients with renovascular hypertension
2007
Chapter 21 Interleukin‐6 and Insulin Resistance
2009
The Drosophila TNF Eiger Is an Adipokine that Acts on Insulin-Producing Cells to Mediate Nutrient Response
2016
Inflammation, metaflammation and immunometabolic disorders
2017 StandoutNature
Human recombinant stem-cell factor induces melanocytic hyperplasia in susceptible patients
1995
Adiponectin protects LPS-induced liver injury through modulation of TNF-α in KK-Ay obese mice
2004
Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism
2008
Adiponectin, driver or passenger on the road to insulin sensitivity?
2013
Resistin and obesity-associated insulin resistance
2002
Plasma adiponectin and mortality in critically ill subjects with acute respiratory failure*
2010
Resistin: molecular history and prognosis
2003
A crucial role for adipose tissue p53 in the regulation of insulin resistance
2009
Total and high molecular weight adiponectin concentrations in plasma of patients with end‐stage renal disease before and after peritoneal dialysis
2008
Adiponectin Is Related to Carotid Artery Plaque and a Predictor of Cardiovascular Outcome in a Cohort of Non-Diabetic Peritoneal Dialysis Patients
2008
Secretory, Endocrine and Autocrine/Paracrine Function of the Adipocyte
2000
Adipocyte-Derived Th2 Cytokines and Myeloid PPARδ Regulate Macrophage Polarization and Insulin Sensitivity
2008
Adipocytokines: mediators linking adipose tissue, inflammation and immunity
2006 Standout
Induction of Adiponectin in Skeletal Muscle by Inflammatory Cytokines:in Vivoandin VitroStudies
2004
Insulin disrupts β-adrenergic signalling to protein kinase A in adipocytes
2005 StandoutNatureNobel
Adiponectin as a growth inhibitor in prostate cancer cells
2005
Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism
2005
Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes
2004
Delayed ERK activation by ceramide reduces melanin synthesis in human melanocytes
2002
Adipose Tissue as an Endocrine Organ
2004 Standout
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
2009 Standout
Insulin/Foxo1 Pathway Regulates Expression Levels of Adiponectin Receptors and Adiponectin Sensitivity
2004
Decreased plasma adiponectin concentrations in women with low-grade C-reactive protein elevation
2003
Adiponectin ameliorates hypoxia-induced pulmonary arterial remodeling
2009
Regulation of T Cell-Mediated Hepatic Inflammation by Adiponectin and Leptin
2005
Hypoadiponectinemia Is Associated with Insulin Resistance, Hypertriglyceridemia, and Fat Redistribution in Human Immunodeficiency Virus-Infected Patients Treated with Highly Active Antiretroviral Therapy
2003
Adiponectin Promotes Macrophage Polarization toward an Anti-inflammatory Phenotype
2009
Collagen Hydroxylases and the Protein Disulfide Isomerase Subunit of Prolyl 4‐Hydroxylases
1998
Sustained peripheral expression of transgene adiponectin offsets the development of diet-induced obesity in rats
2003
Role of resistin in obesity, insulin resistance and Type II diabetes
2005
Molecular Mechanisms of Insulin Resistance in Humans and Their Potential Links With Mitochondrial Dysfunction
2006
Selective Suppression of Endothelial Cell Apoptosis by the High Molecular Weight Form of Adiponectin
2004
Liver Cancer: Connections with Obesity, Fatty Liver, and Cirrhosis
2015
Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism
2010
A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease
2006
Conditional disruption of IκB kinase 2 fails to prevent obesity-induced insulin resistance
2004
The immune response attenuates growth and nutrient storage in Drosophila by reducing insulin signaling
2009
Measurement of the High–Molecular Weight Form of Adiponectin in Plasma Is Useful for the Prediction of Insulin Resistance and Metabolic Syndrome
2006
Mechanisms of Insulin Resistance in Humans and Possible Links With Inflammation
2005
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
2006 Standout
Selective Inactivation of c-Jun NH2-Terminal Kinase in Adipose Tissue Protects Against Diet-Induced Obesity and Improves Insulin Sensitivity in Both Liver and Skeletal Muscle in Mice
2011
Weight Reduction Increases Plasma Levels of an Adipose-Derived Anti-Inflammatory Protein, Adiponectin
2001 Standout
Plasma Adiponectin and Gastric Cancer
2005
Adiponectin Inhibits the Production of CXC Receptor 3 Chemokine Ligands in Macrophages and Reduces T-Lymphocyte Recruitment in Atherogenesis
2007
Adipose Tissue-Derived Factors: Impact on Health and Disease
2006
Adiponectin Deficiency, Diastolic Dysfunction, and Diastolic Heart Failure
2009
Reciprocal Relationships Between Insulin Resistance and Endothelial Dysfunction
2006 Standout
FROM MICE TO MEN: Insights into the Insulin Resistance Syndromes
2005
PAI-1 and the Metabolic Syndrome
2006
Tauroursodeoxycholic Acid May Improve Liver and Muscle but Not Adipose Tissue Insulin Sensitivity in Obese Men and Women
2010
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
Adiponectin as a Biomarker of the Metabolic Syndrome
2004
Decreased Plasma Adiponectin Concentrations in Women with Dyslipidemia
2002
Association of serum adiponectin levels with breast cancer risk.
2003
Adipose Tissue, Inflammation, and Cardiovascular Disease
2005 Standout
Inflammatory Markers, Adiponectin, and Risk of Type 2 Diabetes in the Pima Indian
2003
CCR2 modulates inflammatory and metabolic effects of high-fat feeding
2006
Muscle-Specific IRS-1 Ser→Ala Transgenic Mice Are Protected From Fat-Induced Insulin Resistance in Skeletal Muscle
2008
Adipocyte-Derived Plasma Protein, Adiponectin, Suppresses Lipid Accumulation and Class A Scavenger Receptor Expression in Human Monocyte-Derived Macrophages
2001
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
2003 Standout
The Emerging Functions and Mechanisms of Mammalian Fatty Acid–Binding Proteins
2008
Inflammatory mechanisms linking obesity and metabolic disease
2017
Adipose Tissue
2006
Adipogenesis in Obesity Requires Close Interplay Between Differentiating Adipocytes, Stromal Cells, and Blood Vessels
2007
Adiponectin and Coronary Heart Disease
2006
Association of Hypoadiponectinemia With Coronary Artery Disease in Men
2003
The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
2003
Regulation of Plasma PAI-1 Concentrations in HAART-Associated Lipodystrophy During Rosiglitazone Therapy
2003
Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans
2003
Adiponectin: Stability in Plasma over 36 Hours and Within-Person Variation over 1 Year
2003
Adiponectin Multimeric Complexes and the Metabolic Syndrome Trait Cluster
2006
Inflammation, stress, and diabetes
2005
Adiponectin Inhibits Endothelial Synthesis of Interleukin-8
2005
Interactions Between Noncontiguous Haplotypes in the Adiponectin Gene ACDC Are Associated With Plasma Adiponectin
2006
Adiponectin and Adiponectin Receptors
2005 Standout
Diet‐induced obesity, adipose inflammation, and metabolic dysfunction correlating with PAR2 expression are attenuated by PAR2 antagonism
2013
Lipocalin-2 Is an Inflammatory Marker Closely Associated with Obesity, Insulin Resistance, and Hyperglycemia in Humans
2006
Generation of Globular Fragment of Adiponectin by Leukocyte Elastase Secreted by Monocytic Cell Line THP-1
2004
The Role of Endoplasmic Reticulum Stress in the Progression of Atherosclerosis
2010
Blockade of the Renin-Angiotensin System Increases Adiponectin Concentrations in Patients With Essential Hypertension
2003
Phosphoinositide 3-Kinase Catalytic Subunit Deletion and Regulatory Subunit Deletion Have Opposite Effects on Insulin Sensitivity in Mice
2005
Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages
2000
Role of Muscle c-Jun NH2-Terminal Kinase 1 in Obesity-Induced Insulin Resistance
2009
Overexpression of Sphingosine Kinase 1 Prevents Ceramide Accumulation and Ameliorates Muscle Insulin Resistance in High-Fat Diet–Fed Mice
2012
Association Between Adiponectin and Mediators of Inflammation in Obese Women
2003
Circulating Concentrations of the Adipocyte Protein Adiponectin Are Decreased in Parallel With Reduced Insulin Sensitivity During the Progression to Type 2 Diabetes in Rhesus Monkeys
2001
Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice
2001 Standout
The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins
2011 StandoutNobel
Inhibition of Insulin Sensitivity by Free Fatty Acids Requires Activation of Multiple Serine Kinases in 3T3-L1 Adipocytes
2004
Minireview: The Adipocyte—At the Crossroads of Energy Homeostasis, Inflammation, and Atherosclerosis
2003
MAPK signalling in cellular metabolism: stress or wellness?
2010
JNK1 and IKKβ: molecular links between obesity and metabolic dysfunction
2010
Stromal Cells Are the Main Plasminogen Activator Inhibitor-1-Producing Cells in Human Fat
2002
Uses for JNK: the Many and Varied Substrates of the c-Jun N-Terminal Kinases
2006
Different effects of adiponectin isoforms in human monocytic cells
2006
Understanding Adipocyte Differentiation
1998 Standout
Infliximab Restores Glucose Homeostasis in an Animal Model of Diet-Induced Obesity and Diabetes
2007
Low Plasma Adiponectin Levels Predict Progression of Coronary Artery Calcification
2005
Insulin Resistance and Chronic Cardiovascular Inflammatory Syndrome
2003
Increase in Endoplasmic Reticulum Stress–Related Proteins and Genes in Adipose Tissue of Obese, Insulin-Resistant Individuals
2008
Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes
2002 Standout
Modulation of Circulating and Adipose Tissue Adiponectin Levels by Antidiabetic Therapy
2003
Hypoadiponectinemia Is an Independent Risk Factor for Hypertension
2004
Changes of Adiponectin Oligomer Composition by Moderate Weight Reduction
2005
Adiposity and Cardiovascular Disorders
2007
Disruption of adiponectin causes insulin resistance and neointimal formation
2002
Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis
2004
Adiponectin Prevents Cerebral Ischemic Injury Through Endothelial Nitric Oxide Synthase–Dependent Mechanisms
2007
Adiponectin: a key adipocytokine in metabolic syndrome
2006
The Effect of Thiazolidinediones on Plasma Adiponectin Levels in Normal, Obese, and Type 2 Diabetic Subjects
2002
Exacerbation of Albuminuria and Renal Fibrosis in Subtotal Renal Ablation Model of Adiponectin-Knockout Mice
2007
A Burning Question
2005
Association between dietary factors and plasma adiponectin concentrations in men
2005
Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation
2007
Expression of Adiponectin Receptor mRNA in Human Skeletal Muscle Cells Is Related to In Vivo Parameters of Glucose and Lipid Metabolism
2004
Therapeutic approaches targeting inflammation for diabetes and associated cardiovascular risk
2017
Development of a therapeutic monoclonal antibody that targets secreted fatty acid–binding protein aP2 to treat type 2 diabetes
2015
Association of Adiponectin Mutation With Type 2 Diabetes
2002
Plasma Adiponectin Concentrations in Relation to Endometrial Cancer: A Case-Control Study in Greece
2003
Increased oxidative stress in obesity and its impact on metabolic syndrome
2004
Comparison of Circulating Adiponectin and Proinflammatory Markers Regarding Their Association With Metabolic Syndrome in Japanese Men
2006
Low-Grade Systemic Inflammation and the Development of Type 2 Diabetes
2003
Endothelin-1 is a paracrine growth factor that modulates melanogenesis of human melanocytes and participates in their responses to ultraviolet radiation.
1998
PPARγ Ligands Increase Expression and Plasma Concentrations of Adiponectin, an Adipose-Derived Protein
2001
Ser/Thr Phosphorylation of IRS Proteins: A Molecular Basis for Insulin Resistance
2005
Critical nodes in signalling pathways: insights into insulin action
2006 Standout
Glucocorticoids and insulin promote plasminogen activator inhibitor 1 production by human adipose tissue.
1999
Pulmonary Arterial Hypertension Is Linked to Insulin Resistance and Reversed by Peroxisome Proliferator–Activated Receptor-γ Activation
2007
Decreased Serum Levels of Adiponectin Are a Risk Factor for the Progression to Type 2 Diabetes in the Japanese Population
2003
Requirement of JNK2 for Scavenger Receptor A-Mediated Foam Cell Formation in Atherogenesis
2004 Science
Regulation of metabolism by the innate immune system
2015
Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
2004 StandoutScience
Adiponectin: More Than Just Another Fat Cell Hormone?
2003
Opposing Effects of Adiponectin Receptors 1 and 2 on Energy Metabolism
2007
Reciprocal Association of C-Reactive Protein With Adiponectin in Blood Stream and Adipose Tissue
2003
New therapeutic approaches for the treatment of obesity
2016
Obesity is associated with macrophage accumulation in adipose tissue
2003 Standout
Noncanonical Wnt Signaling Promotes Obesity-Induced Adipose Tissue Inflammation and Metabolic Dysfunction Independent of Adipose Tissue Expansion
2014
Integrative physiology of human adipose tissue
2003
Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance
2006
Determinants of Serum High Molecular Weight (HMW) Adiponectin Levels in Patients with Coronary Artery Disease: Associations with Cardio-renal-anemia Syndrome
2011
Induction of Adiponectin, a Fat-Derived Antidiabetic and Antiatherogenic Factor, by Nuclear Receptors
2003
Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption
2010
Androgens Decrease Plasma Adiponectin, an Insulin-Sensitizing Adipocyte-Derived Protein
2002
Visceral adipose tissue-derived serine protease inhibitor: A unique insulin-sensitizing adipocytokine in obesity
2005
Leptin and Cardiovascular Disease
2008
Obesity-induced inflammatory changes in adipose tissue
2003
Multiple Abnormalities in Glucose and Energy Metabolism and Coordinated Changes in Levels of Adiponectin, Cytokines, and Adhesion Molecules in Subjects With Metabolic Syndrome
2004
Adiponectin Reduces Atherosclerosis in Apolipoprotein E-Deficient Mice
2002
Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages
2000
An RNA interference-based screen identifies MAP4K4/NIK as a negative regulator of PPARγ, adipogenesis, and insulin-responsive hexose transport
2006
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue
2016 StandoutNobel
Association of Hypoadiponectinemia With Impaired Vasoreactivity
2003
Adiponectin, an Adipocyte-Derived Protein, Predicts Future Insulin Resistance: Two-Year Follow-Up Study in Japanese Population
2004
Young Men With High-Normal Blood Pressure Have Lower Serum Adiponectin, Smaller LDL Size, and Higher Elevated Heart Rate Than Those With Optimal Blood Pressure
2002
Macrophages, Inflammation, and Insulin Resistance
2010 Standout
Plasma PAI-1 Levels Are More Strongly Related to Liver Steatosis Than to Adipose Tissue Accumulation
2003
Grp78 Heterozygosity Promotes Adaptive Unfolded Protein Response and Attenuates Diet-Induced Obesity and Insulin Resistance
2009
Plasma Adiponectin Levels and Sonographic Phenotypes of Subclinical Carotid Artery Atherosclerosis
2005
Identification and Characterization of a Small Molecule Inhibitor of Fatty Acid Binding Proteins
2009
Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults--The Evidence Report. National Institutes of Health.
1998 Standout
Adiponectin Promotes Revascularization of Ischemic Muscle through a Cyclooxygenase 2-Dependent Mechanism
2009
Adiponectin and Metabolic Syndrome
2003
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
A Haplotype at the Adiponectin Locus Is Associated With Obesity and Other Features of the Insulin Resistance Syndrome
2002
Synthetic Peroxisome Proliferator-Activated Receptor-γ Agonist, Rosiglitazone, Increases Plasma Levels of Adiponectin in Type 2 Diabetic Patients
2002
Retinol-Binding Protein 4 Inhibits Insulin Signaling in Adipocytes by Inducing Proinflammatory Cytokines in Macrophages through a c-Jun N-Terminal Kinase- and Toll-Like Receptor 4-Dependent and Retinol-Independent Mechanism
2012
Alternative Macrophage Activation and Metabolism
2011
Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome
2000
Works of Kazuhisa Maeda being referenced
Circulating Concentrations of Adiponectin, an Endogenous Lipopolysaccharide Neutralizing Protein, Decrease in Rats with Polymicrobial Sepsis
2006
Mechanisms for Hyperpigmentation in Postinflammatory Pigmentation, Urticaria pigmentosa and Sunburn
1989
Melanocyte‐stimulating Properties of Secretory Phospholipase A2
1997
Fatty Acid Binding Protein 4 and 5 Play a Crucial Role in Thermogenesis under the Conditions of Fasting and Cold Stress
2014
Adipose Tissue-Derived Stromal Cells as a Novel Option for Regenerative Cell Therapy
2006
cDNA Cloning and Expression of a Novel Adipose Specific Collagen-like Factor, apM1 (AdiposeMost Abundant Gene Transcript 1)
1996 Standout
Adiponectin deficiency is associated with severe polymicrobial sepsis, high inflammatory cytokine levels, and high mortality
2009
Enhanced expression of PAI–1 in visceral fat: Possible contributor to vascular disease in obeisty
1996
A central role for JNK in obesity and insulin resistance
2002 StandoutNature
Disturbed secretion of mutant adiponectin associated with the metabolic syndrome
2003
Melanocyte‐Stimulating Properties of Arachidonic Acid Metabolites: Possible Role in Postinflammatory Pigmentation
1992
Effects of staurosporine, PMA and A23187 on human melanocyte cultures with dibutyryl cyclic AMP
1992
Histamine stimulates normal human melanocytes in vitro: one of the possible inducers of hyperpigmentation in urticaria pigmentosa
1993
Effect of Pituitary and Ovarian Hormones on Human Melanocytes In Vitro
1996
Lack of macrophage fatty-acid–binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis
2001
Analysis of an expression profile of genes in the human adipose tissue
1997
Adiponectin Replenishment Ameliorates Obesity-Related Hypertension
2006
Combined Adipocyte-Macrophage Fatty Acid–Binding Protein Deficiency Improves Metabolism, Atherosclerosis, and Survival in Apolipoprotein E–Deficient Mice
2004
Novel Modulator for Endothelial Adhesion Molecules
1999 Standout
Role of the Fatty Acid Binding Protein mal1 in Obesity and Insulin Resistance
2003
Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes
2005
Regulation of Metabolic Responses by Adipocyte/ Macrophage Fatty Acid–Binding Proteins in Leptin-Deficient Mice
2006
Stimulatory effect of histamine on normal human melanocytes in vitro.
1988
Leukotrienes and thromboxane B2 stimulate normal human melanocytes in vitro: Possible inducers of postinflammatory pigmentation.
1988
Adipocyte-Derived Plasma Protein Adiponectin Acts as a Platelet-Derived Growth Factor-BB–Binding Protein and Regulates Growth Factor–Induced Common Postreceptor Signal in Vascular Smooth Muscle Cell
2002
Phospholipases Induce Melanogenesis in Organ‐Cultured Skin
1996
Adiponectin, an Adipocyte-Derived Plasma Protein, Inhibits Endothelial NF-κB Signaling Through a cAMP-Dependent Pathway
2000 Standout
Adipocyte Fatty Acid–Binding Protein, aP2, Alters Late Atherosclerotic Lesion Formation in Severe Hypercholesterolemia
2002
Adiponectin Specifically Increased Tissue Inhibitor of Metalloproteinase-1 Through Interleukin-10 Expression in Human Macrophages
2004
Role of Adipocytokines on the Pathogenesis of Atherosclerosis in Visceral Obesity.
1999