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Citing Papers
The tryptophan synthase β‐subunit paralogs TrpB1 and TrpB2 in Thermococcus kodakarensis are both involved in tryptophan biosynthesis and indole salvage
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Directed evolution of the tryptophan synthase β-subunit for stand-alone function recapitulates allosteric activation
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Improved molecular replacement by density- and energy-guided protein structure optimization
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Pyridoxal phosphate-dependent enzymes
1995
Dominant forces in protein folding
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Selection and evolution of enzymes from a partially randomized non-catalytic scaffold
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2001
Structural Analyses of Covalent Enzyme–Substrate Analog Complexes Reveal Strengths and Limitations of De Novo Enzyme Design
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1998
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2004
The crystal structure of the tryptophan synthase β2 subunit from the hyperthermophile Pyrococcus furiosus
2004
Man-made antibodies
1991 NatureNobel
Verification of protein structures: Patterns of nonbonded atomic interactions
1993 Standout
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Monovalent Cations Partially Repair a Conformational Defect in a Mutant Tryptophan Synthase α2β2 Complex (β-E109A)
1995
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2006
Reconstruction of Functional β-Propeller Lectins via Homo-oligomeric Assembly of Shorter Fragments
2006
A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase
2017
Predicting protein structures with a multiplayer online game
2010 StandoutNatureNobel
Improved protein structure prediction using potentials from deep learning
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Identification of the Geometric Requirements for Allosteric Communication between the α- and β-Subunits of Tryptophan Synthase
2005
Allosteric regulation of substrate channeling and catalysis in the tryptophan synthase bienzyme complex
2012
A Novel Tryptophan Synthase β-Subunit from the HyperthermophileThermotoga maritima
2002
De novo design of a fluorescence-activating β-barrel
2018 StandoutNatureNobel
Substitution of glutamic acid 109 by aspartic acid alters the substrate specificity and catalytic activity of the .beta.-subunit in the tryptophan synthase bienzyme complex from Salmonella typhimurium
1992
Crystal Structure of the βSer178 → Pro Mutant of Tryptophan Synthase
2002
Constructing high complexity synthetic libraries of long ORFs using In Vitro selection
2000 StandoutNobel
A synthetic homing endonuclease-based gene drive system in the human malaria mosquito
2011 StandoutNatureNobel
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1991
Tryptophan synthase: the workings of a channeling nanomachine
2008
Cold Adaptation of a Mesophilic Subtilisin-like Protease by Laboratory Evolution
2000 StandoutNobel
Combining evolutionary information and neural networks to predict protein secondary structure
1994
Catalytic promiscuity and the evolution of new enzymatic activities
1999
The TIM‐barrel fold: a versatile framework for efficient enzymes
2001
Exploring the repeat protein universe through computational protein design
2015 StandoutNatureNobel
Making antibody fragments using phage display libraries
1991 StandoutNatureNobel
Computational design of ligand-binding proteins with high affinity and selectivity
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Principles determining the structure of β-sheet barrels in proteins II. The observed structures
1994
Rational engineering of enzyme stability
2004
Structural and Functional Aspects of Domain Motions in Proteins
1984 StandoutNobel
Protein Hydration Changes in the Formation of the Nicotinamide Adenine Dinucleotide Complexes of Glyceraldehyde 3-Phosphate Dehydrogenase of Yeast
1973
Allosteric pathways in imidazole glycerol phosphate synthase
2012
Studies of asymmetry in the three-dimensional structure of lobster D-glyceraldehyde-3-phosphate dehydrogenase
1975
Structural principles of parallel beta-barrels in proteins.
1988
Antibody–antigen flexibility
1987 StandoutNatureNobel
Novel cysteine-rich motif and homeodomain in the product of the Caenorhabditis elegans cell lineage gene lin-II
1990 StandoutNatureNobel
Protein folding
1990
Amino-acid Sequence of Glyceraldehyde 3-Phosphate Dehydrogenase from Lobster Muscle
1967 Nature
Synthetic applications of tryptophan synthase
2004
Positive and negative cooperativity in yeast glyceraldehyde 3-phosphate dehydrogenase
1970
Tryptophan Synthase Uses an Atypical Mechanism To Achieve Substrate Specificity
2016 StandoutNobel
Experimental studies of protein folding and unfolding
1979
Immune Versus Natural Selection: Antibody Aldolases with Enzymic Rates But Broader Scope
1997 StandoutScienceNobel
Characterization of the reaction of L-serine and indole with Escherichia coli tryptophan synthase via rapid-scanning ultraviolet-visible spectroscopy
1986
Rates and equilibria at the acetylcholine receptor of Electrophorus electroplaques: a study of neurally evoked postsynaptic currents and of voltage-jump relaxations.
1977
The Cation−π Interaction
1997 Standout
Tryptophan Synthase: Structure and Function of the Monovalent Cation Site
2009
High thermodynamic stability of parametrically designed helical bundles
2014 StandoutScienceNobel
Molecular Matchmakers
1993 StandoutScienceNobel
Sequence and structure of D-glyceraldehyde 3-phosphate dehydrogenase from Bacillus stearothermophilus
1977 StandoutNatureNobel
Intersubunit Communication in Tryptophan Synthase by Carbon-13 and Fluorine-19 REDOR NMR
1996
Mechanism of mutual activation of the tryptophan synthase alpha and beta subunits. Analysis of the reaction specificity and substrate-induced inactivation of active site and tunnel mutants of the beta subunit.
1991
Estimation of sedimentation coefficients of globular proteins: An application of small-angle X-ray scattering
1982
X-ray and NMR Crystallography in an Enzyme Active Site: The Indoline Quinonoid Intermediate in Tryptophan Synthase
2010
Stereochemistry of sodium borohydride reduction of tryptophan synthase of Escherichia coli and its amino acid Schiff's bases.
1982
Isolation of two tissue-specific Drosophila paired box genes, Pox meso and Pox neuro.
1989
NMR Crystallography of a Carbanionic Intermediate in Tryptophan Synthase: Chemical Structure, Tautomerization, and Reaction Specificity
2016
Change in synaptic channel gating during neuromuscular development
1978 StandoutNatureNobel
Macromolecular Modeling with Rosetta
2008 StandoutNobel
Protein secondary structure prediction with a neural network.
1989
Characterization of an Extremely Large, Ligand-Induced Conformational Change in Plasminogen
1990 StandoutScienceNobel
Three-dimensional structure of d-glyceraldehyde-3-phosphate dehydrogenase
1974
Structural domains in proteins and their role in the dynamics of protein function
1983
Aliphatic alcohols stabilize an alternative conformation of the tryptophan synthase alpha 2 beta 2 complex from Salmonella typhimurium.
1994
Structural design and molecular evolution of a cytokine receptor superfamily.
1990 Standout
Protein Structure Prediction and Structural Genomics
2001 StandoutScienceNobel
Three-dimensional structure of the tryptophan synthase alpha 2 beta 2 multienzyme complex from Salmonella typhimurium.
1988
Iterative approach to computational enzyme design
2012
Specificity of induced conformational changes. Case of yeast glyceraldehyde-3-phosphate dehydrogenase
1975
STUDIES OF ASYMMETRY IN THE THREE-DIMENSIONAL STRUCTURE OF LOBSTER D-GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE
1975
Catalytic Mechanism and Performance of Computationally Designed Enzymes for Kemp Elimination
2008 StandoutNobel
Protonation States of the Tryptophan Synthase Internal Aldimine Active Site from Solid-State NMR Spectroscopy: Direct Observation of the Protonated Schiff Base Linkage to Pyridoxal-5′-Phosphate
2014
Protein Design by Directed Evolution
2008
Study of the Position of NAD and Its Effect on the Conformation of d ‐Glyceraldehyde‐3‐phosphate Dehydrogenase by Small‐Angle X‐Ray Scattering
1972
An Engineered Tryptophan Synthase Opens New Enzymatic Pathways to β‐Methyltryptophan and Derivatives
2016
Serine modulates substrate channeling in tryptophan synthase. A novel intersubunit triggering mechanism
1991
Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin
2011 StandoutScienceNobel
De Novo Computational Design of Retro-Aldol Enzymes
2008 StandoutScienceNobel
Neural Computing in Cancer Drug Development: Predicting Mechanism of Action
1992 StandoutScienceNobel
The binding of nicotinamide-adenine dimucleotide to glyceraldehyde 3-phosphate dehydrogenase from Bacillus stearothermophilus
1975
Nucleation of COPII Vesicular Coat Complex by Endoplasmic Reticulum to Golgi Vesicle SNAREs
1998 StandoutScienceNobel
Human placenta protein-tyrosine-phosphatase: amino acid sequence and relationship to a family of receptor-like proteins.
1989 StandoutNobel
Catalytic Versatility, Stability, and Evolution of the (βα)8-Barrel Enzyme Fold
2005
Glyceraldehyde 3-phosphate dehydrogenases
1965
Molecular Biology of Prion Diseases
1991 StandoutScienceNobel
A quantitative description of end‐plate currents
1972
Sequential conformational changes with the binding of NAD+ to rabbit muscle glyceraldehyde-3-phosphate dehydrogenase
1972
Single acetylcholine-activated channels show burst-kinetics in presence of desensitizing concentrations of agonist
1980 StandoutNatureNobel
D-Glyceraldehyde-3-Phosphate Dehydrogenase: Three-Dimensional Structure and Evolutionary Significance
1973
Preparation and active-site specific properties of sturgeon muscle glyceraldehyde-3-phosphate dehydrogenase
1973
Allostery and Substrate Channeling in the Tryptophan Synthase Bienzyme Complex: Evidence for Two Subunit Conformations and Four Quaternary States
2013
Works of Kasper Kirschner being referenced
A histidine gene cluster of the hyperthermophile Thermotoga maritima : sequence analysis and evolutionary significance
1998
Improving the prediction of secondary structure of ‘TIM-barrel’ enzymes
1991
[23] Phosphoribosylanthranilate isomerase and indoleglycerol-phosphate synthase: Tryptophan biosynthetic enzymes from Thermotoga maritima
2001
Structure and function of mutationally generated monomers of dimeric phosphoribosylanthranilate isomerase from Thermotoga maritima
2000
Reciprocal communication between the lyase and synthase active sites of the tryptophan synthase bienzyme complex
1991
An 8-fold βα barrel protein with redundant folding possibilities
1990
Phosphoribosyl anthranilate isomerase from Thermotoga maritima is an extremely stable and active homodimer
1996
The Catalytic Mechanism of Indole-3-glycerol Phosphate Synthase: Crystal Structures of Complexes of the Enzyme from Sulfolobus solfataricus with Substrate Analogue, Substrate, and Product
2002
Phosphoribosyl Anthranilate Isomerase Catalyzes a Reversible Amadori Reaction
1995
The Crystal Structure of Indoleglycerol-phosphate Synthase from Thermotoga maritima
2002
Prediction of secondary structure by evolutionary comparison: Application to the α subunit of tryptophan synthase
1987
The importance of surface loops for stabilizing an eightfold βα barrel protein
1992
Stabilization of a (βα)8‐barrel protein by an engineered disulfide bridge
2002
Mechanism of the physiological reaction catalyzed by tryptophan synthase from Escherichia coli
1991
Structural conservation in parallel .beta./.alpha.-barrel enzymes that catalyze three sequential reactions in the pathway of tryptophan biosynthesis
1991
The Crystal Structure of Indole-3-glycerol Phosphate Synthase from the Hyperthermophilic ArchaeonSulfolobus solfataricusin Three Different Crystal Forms: Effects of Ionic Strength
1996
Reversible dissociation and unfolding of aspartate aminotransferase from Escherichia coli: characterization of a monomeric intermediate
1990
Three-dimensional structure of the bifunctional enzyme N-(5'-phosphoribosyl)anthranilate isomerase-indole-3-glycerol-phosphate synthase from Escherichia coli.
1987
The domain structure of tryptophan synthase. A neutron scattering study
1985
Correct Folding of Circularly Permuted Variants of a βα Barrel Enzyme in Vivo
1989 Science
Tryptophan Synthase from Saccharomyces cerevisiae Is a Dimer of Two Polypeptide Chains of Mr 76000 Each
1979
Subunit interactions of tryptophan synthase from Escherichia coli as revealed by binding studies with pyridoxal phosphate analogs
1980
[48] Phosphoribosylanthranilate isomerase—indoleglycerol-phosphate synthase from Escherichia coli
1987
Improving the Catalytic Activity of a Thermophilic Enzyme at Low Temperatures
2000
X‐Ray Small‐Angle Scattering of Yeast Glyceraldehyde‐3‐phosphate Dehydrogenase as a Function of Saturation with Nicotinamide‐Adenine‐Dinucleotide
1971
Crystal Structure at 2.0 Å Resolution of Phosphoribosyl Anthranilate Isomerase from the Hyperthermophile Thermotoga maritima: Possible Determinants of Protein Stability,
1997
Identification of three sites of proteolytic cleavage in the hinge region between the two domains of the .beta.2 subunit of tryptophan synthase of Escherichia coli or Salmonella typhimurium
1986
THE BINDING OF NICOTINAMIDE-ADENINE DINUCLEOTIDE TO YEAST D-GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE: TEMPERATURE-JUMP RELAXATION STUDIES ON THE MECHANISM OF AN ALLOSTERIC ENZYME
1966
The Binding of Oxidized and Reduced Nicotinamide Adenine-Dinucleotide to Yeast Glyceraldehyde-3-phosphate Dehydrogenase
1972
The crystal structure of anthranilate synthase from Sulfolobus solfataricus : Functional implications
1999
Allosteric regulation of enzyme activity. An introduction to the molecular basis of and the experimental approaches to the problem.
1968
The Tryptophan Synthase from Escherichia coli
1975
(Beta alpha)8-barrel proteins of tryptophan biosynthesis in the hyperthermophile Thermotoga maritima.
1995
The Mechanism of Tryptophan Binding to Tryptophan Synthase from Escherichia coli
1981
Co-operative binding of nicotinamide-adenine dinucleotide to yeast glyceraldehyde-3-phosphate dehydrogenase
1971
Steady‐State Kinetic Studies of the Synthesis of Indoleglycerol Phosphate Catalyzed by the α Subunit of Tryptophan Synthase from Escherichia coli
1976
Kinetics of cooperative ligand binding to the apo.beta.2 subunit of tryptophan synthase and its modulation by the .alpha. subunit
1980
Small‐Angle X‐Ray Scattering Studies of Tryptophan Synthase from Escherichia coli and Its α and β2 Subunits
1982
The mechanism of self-assembly of the multi-enzyme complex tryptophan synthase from Escherichia coli.
1984
Two (βα)8-Barrel Enzymes of Histidine and Tryptophan Biosynthesis Have Similar Reaction Mechanisms and Common Strategies for Protecting Their Labile Substrates,
2002
Co-operative binding of nicotinamide-adenine dinucleotide to yeast glyceraldehyde-3-phosphate dehydrogenase
1971
Reinheitskriterien für das kristallisierbare Isoenzym der D-Glycerinaldehyd-3-phosphat-Dehydrogenase aus Bäckerhefe
1968
Multifunctional Proteins
1976
The Mechanism of the Synthesis of Indoleglycerol Phosphate Catalyzed by Tryptophan Synthase from Escherichia coli
1976
The Mechanism of Binding of L‐Serine to Tryptophan Synthase from Escherichia coli
1983
The Catalytic Mechanism of Tryptophan Synthase from Escherichia coli
1983
The Quarternary Structure of Tryptophan Synthase from Escherichia coli
1983