Standout Papers
- Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2 (1999)
- Potentiation of beta-adrenergic signaling by adenoviral-mediated gene transfer in adult rabbit ventricular myocytes. (1997)
- G Protein-coupled Receptor Kinase 3 (GRK3) Gene Disruption Leads to Loss of Odorant Receptor Desensitization (1997)
- Ex Vivo Adenovirus-Mediated Gene Transfer To The Adult Rat Heart (1998)
- A tumor necrosis factor (TNF) receptor-IgG heavy chain chimeric protein as a bivalent antagonist of TNF activity. (1991)
- β-Arrestins Regulate Atherosclerosis and Neointimal Hyperplasia by Controlling Smooth Muscle Cell Proliferation and Migration (2008)
- The biosynthesis of tumor necrosis factor during pregnancy: studies with a CAT reporter transgene and TNF inhibitors. (1993)
- Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer. (1994)
- Restoration of β-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer (1997)
- Receptor-mediated label-transfer assay (RELAY): a novel method for the detection of plasma tumor necrosis factor at attomolar concentrations (1994)
- Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3 (1999)
- Monoclonal antibodies reveal receptor specificity among G-protein-coupled receptor kinases. (1996)
- Expression of a TNF inhibitor in transgenic mice. (1993)
Citation Impact
Citing Papers
Spinophilin Blocks Arrestin Actions in Vitro and in Vivo at G Protein-Coupled Receptors
2004 StandoutScienceNobel
β-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation
2009 StandoutNobel
β-Arrestin-dependent, G Protein-independent ERK1/2 Activation by the β2 Adrenergic Receptor
2005 StandoutNobel
Evolving Concepts in G Protein-Coupled Receptor Endocytosis: The Role in Receptor Desensitization and Signaling
2001 Standout
Independent β-Arrestin2 and Gq/Protein Kinase Cζ Pathways for ERK Stimulated by Angiotensin Type 1A Receptors in Vascular Smooth Muscle Cells Converge on Transactivation of the Epidermal Growth Factor Receptor
2009 StandoutNobel
G-protein-coupled Receptor Kinase Specificity for β-Arrestin Recruitment to the β2-Adrenergic Receptor Revealed by Fluorescence Resonance Energy Transfer
2006 StandoutNobel
Classical and new roles of β-arrestins in the regulation of G-PROTEIN-COUPLED receptors
2001 StandoutNobel
Muscarinic Supersensitivity and Impaired Receptor Desensitization in G Protein–Coupled Receptor Kinase 5–Deficient Mice
1999 StandoutNobel
Clathrin-mediated Endocytosis of the β-Adrenergic Receptor Is Regulated by Phosphorylation/Dephosphorylation of β-Arrestin1
1997 StandoutNobel
The GRK4 Subfamily of G Protein-coupled Receptor Kinases
1999 StandoutNobel
Prolonged Kappa Opioid Receptor Phosphorylation Mediated by G-protein Receptor Kinase Underlies Sustained Analgesic Tolerance
2004 StandoutNobel
G Protein-coupled Receptor Kinase 5 in Cultured Vascular Smooth Muscle Cells and Rat Aorta
1997 StandoutNobel
Feedback Inhibition of G Protein-coupled Receptor Kinase 2 (GRK2) Activity by Extracellular Signal-regulated Kinases
1999 StandoutNobel
Arrestin Development: Emerging Roles for β-arrestins in Developmental Signaling Pathways
2009 StandoutNobel
Anti–β1-adrenergic receptor antibodies and heart failure: causation, not just correlation
2004 StandoutNobel
An Evolutionary and Functional Approach to the TNF Receptor/Ligand Family
1994 StandoutNobel
Regulation of G Protein-Coupled Receptor Kinases and Arrestins During Receptor Desensitization
2003 StandoutNobel
β-Arrestin Binding to the β2-Adrenergic Receptor Requires Both Receptor Phosphorylation and Receptor Activation
2005 Nobel
The molecular acrobatics of arrestin activation
2004
Morphine Side Effects in β-Arrestin 2 Knockout Mice
2005
Arresting angiotensin type 1 receptors
2003
Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary β2-adrenergic receptor gene delivery
1999 StandoutNobel
β-Arrestin2 Is Critically Involved in CXCR4-mediated Chemotaxis, and This Is Mediated by Its Enhancement of p38 MAPK Activation
2002
The Akt–GSK-3 signaling cascade in the actions of dopamine
2007
A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior
2008 StandoutNobel
The tissue distribution of tumor necrosis factor biosynthesis during endotoxemia.
1992 StandoutNobel
Therapeutic potential of G-protein coupled receptor kinases in the heart
1999
G Protein-coupled Receptor Kinase 5 Regulates β1-Adrenergic Receptor Association with PSD-95
2002 StandoutNobel
Regulation of Membrane Targeting of the G Protein-coupled Receptor Kinase 2 by Protein Kinase A and Its Anchoring Protein AKAP79
2001 StandoutNobel
The G Protein-coupled Receptor Kinase 2 Is a Microtubule-associated Protein Kinase That Phosphorylates Tubulin
1998 StandoutNobel
An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior
2005 StandoutNobel
Phosphorylation and Desensitization of Human Endothelin A and B Receptors
1997 StandoutNobel
Differential Effects of CC Chemokines on CC Chemokine Receptor 5 (CCR5) Phosphorylation and Identification of Phosphorylation Sites on the CCR5 Carboxyl Terminus
1999
Analysis of tumor necrosis factor promoter responses to ultraviolet light.
1994 StandoutNobel
Molecular Determinants Underlying the Formation of Stable Intracellular G Protein-coupled Receptor-β-Arrestin Complexes after Receptor Endocytosis*
2001
β-Arrestin1 mediates nicotinic acid–induced flushing, but not its antilipolytic effect, in mice
2009 StandoutNobel
Mechanism of β-Adrenergic Receptor Desensitization in Cardiac Hypertrophy Is Increased β-Adrenergic Receptor Kinase
1997
The Ile164 beta2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure.
1998
Control of Myocardial Contractile Function by the Level of β-Adrenergic Receptor Kinase 1 in Gene-targeted Mice
1998 StandoutNobel
Expanding roles for β-arrestins as scaffolds and adapters in GPCR signaling and trafficking
2001 StandoutNobel
Seven-transmembrane-spanning receptors and heart function
2002 StandoutNatureNobel
The β2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange
1998 StandoutNatureNobel
Myocardial G Protein‐Coupled Receptor Kinases: Implications for Heart Failure Therapy
1999
Dopaminergic Supersensitivity in G Protein-Coupled Receptor Kinase 6-Deficient Mice
2003 StandoutNobel
Seven-transmembrane receptors
2002 StandoutNobel
Bimodal Regulation of the Human H1 Histamine Receptor by G Protein-coupled Receptor Kinase 2
2004
β-Arrestin-2 regulates the development of allergic asthma
2003 StandoutNobel
Adenovirus-mediated gene transfer of the β2-adrenergic receptor to donor hearts enhances cardiac function
1999 StandoutNobel
Crystal Structure of β-Arrestin at 1.9 Å
2001
G-protein-coupled receptor kinases
1996
Arresting developments in heptahelical receptor signaling and regulation
2002 StandoutNobel
The Tumor Necrosis Factor Ligand and Receptor Families
1996 StandoutNobel
Dual modulation of cell survival and cell death by β 2 -adrenergic signaling in adult mouse cardiac myocytes
2001 StandoutNobel
THE ROLE OF RECEPTOR KINASES AND ARRESTINS IN G PROTEIN–COUPLED RECEPTOR REGULATION
1998
β-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking
2001 StandoutNobel
β-Arrestin2 mediates the initiation and progression of myeloid leukemia
2012 StandoutNobel
Extinction of the tumor necrosis factor locus, and of genes encoding the lipopolysaccharide signaling pathway.
1993 StandoutNobel
In Vivo Ventricular Gene Delivery of a β-Adrenergic Receptor Kinase Inhibitor to the Failing Heart Reverses Cardiac Dysfunction
2001 StandoutNobel
Constitutive synthesis of tumor necrosis factor in the thymus.
1992 StandoutNobel
Culture and adenoviral infection of adult mouse cardiac myocytes: methods for cellular genetic physiology
2000 StandoutNobel
Altered CXCR2 Signaling in β-Arrestin-2-Deficient Mouse Models
2005
Defective lymphocyte chemotaxis in β-arrestin2- and GRK6-deficient mice
2002 StandoutNobel
Physiological Roles of G Protein–Coupled Receptor Kinases and Arrestins
2007
Targeting G βγ signaling in arterial vascular smooth muscle proliferation: A novel strategy to limit restenosis
1999 StandoutNobel
Functional Consequences of Altering Myocardial Adrenergic Receptor Signaling
2000 StandoutNobel
μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence
2000 StandoutNatureNobel
β-Arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes
2006 StandoutNobel
β-arrestin- but not G protein-mediated signaling by the “decoy” receptor CXCR7
2009 StandoutNobel
The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals
2002 StandoutNobel
β-Adrenergic Receptor Signaling: An Acute Compensatory Adjustment—Inappropriate for the Chronic Stress of Heart Failure?
2000
Adjuvant Arthritis Induces Down-Regulation of G Protein-Coupled Receptor Kinases in the Immune System
2001
β-Arrestins and Cell Signaling
2007 StandoutNobel
Progressive hypertrophy and heart failure in β 1 -adrenergic receptor transgenic mice
1999
Enhanced Rewarding Properties of Morphine, but not Cocaine, in βarrestin-2 Knock-Out Mice
2003 StandoutNobel
beta -Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking
2001
Molecular β-adrenergic signaling abnormalities in failing rabbit hearts after infarction
1999
Intracoronary Adenovirus-Mediated Delivery and Overexpression of the β 2 -Adrenergic Receptor in the Heart
2000 StandoutNobel
Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice.
2002 StandoutNobel
Functional antagonism of different G protein-coupled receptor kinases for β-arrestin-mediated angiotensin II receptor signaling
2005 StandoutNobel
G PROTEIN–COUPLED RECEPTOR KINASES
1998 StandoutNobel
Multifaceted roles of β-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling
2003 StandoutNobel
Chimeric tumor necrosis factor receptors with constitutive signaling activity.
1995 StandoutNobel
Reciprocal In Vivo Regulation of Myocardial G Protein–Coupled Receptor Kinase Expression by β-Adrenergic Receptor Stimulation and Blockade
1998 StandoutNobel
β-Arrestin-2 regulates the development of allergic asthma
2003 StandoutNobel
Receptor and Gβγ isoform-specific interactions with G protein-coupled receptor kinases
1997 StandoutNobel
A reporter transgene indicates renal-specific induction of tumor necrosis factor (TNF) by shiga-like toxin. Possible involvement of TNF in hemolytic uremic syndrome.
1993 StandoutNobel
DESENSITIZATION OF G PROTEIN–COUPLED RECEPTORS AND NEURONAL FUNCTIONS
2004 StandoutNobel
In Vivo Inhibition of Elevated Myocardial β-Adrenergic Receptor Kinase Activity in Hybrid Transgenic Mice Restores Normal β-Adrenergic Signaling and Function
1999 StandoutNobel
Catecholamines, Cardiac β-Adrenergic Receptors, and Heart Failure
2000 StandoutNobel
Preservation of myocardial β-adrenergic receptor signaling delays the development of heart failure after myocardial infarction
2000 StandoutNobel
What Is the Role of β-Adrenergic Signaling in Heart Failure?
2003
Identification of cysteine-rich domains of the type 1 tumor necrosis factor receptor involved in ligand binding.
1992
G-protein-coupled Receptor (GPCR) Kinase Phosphorylation and β-Arrestin Recruitment Regulate the Constitutive Signaling Activity of the Human Cytomegalovirus US28 GPCR
2003 StandoutNobel
ß-Arrestin 2 Mediates Endocytosis of Type III TGF-ß Receptor and Down-Regulation of Its Signaling
2003 StandoutScienceNobel
Unraveling Function in the TNF Ligand and Receptor Families
1994 StandoutScienceNobel
Works of Karsten Peppel being referenced
Gene Transfer Strategies for Augmenting Cardiac Function
1997
The Adaptor Protein β-Arrestin2 Enhances Endocytosis of the Low Density Lipoprotein Receptor
2003
Potentiation of beta-adrenergic signaling by adenoviral-mediated gene transfer in adult rabbit ventricular myocytes.
1997 StandoutNobel
The Platelet-derived Growth Factor Receptor-β Phosphorylates and Activates G Protein-coupled Receptor Kinase-2
2005
Ex Vivo Adenovirus-Mediated Gene Transfer To The Adult Rat Heart
1998 StandoutNobel
G Protein-coupled Receptor Kinase 3 (GRK3) Gene Disruption Leads to Loss of Odorant Receptor Desensitization
1997 StandoutNobel
The biosynthesis of tumor necrosis factor during pregnancy: studies with a CAT reporter transgene and TNF inhibitors.
1993 StandoutNobel
Expression of a TNF inhibitor in transgenic mice.
1993 StandoutNobel
Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2
1999 StandoutScienceNobel
A tumor necrosis factor (TNF) receptor-IgG heavy chain chimeric protein as a bivalent antagonist of TNF activity.
1991 StandoutNobel
Overexpression of G Protein–Coupled Receptor Kinase-2 in Smooth Muscle Cells Attenuates Mitogenic Signaling via G Protein–Coupled and Platelet-Derived Growth Factor Receptors
2000
Monoclonal antibodies reveal receptor specificity among G-protein-coupled receptor kinases.
1996 StandoutNobel
Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer.
1994 StandoutNobel
Restoration of β-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer
1997 StandoutNobel
Overexpression of wild‐type Gαi‐2 suppresses β‐adrenergic signaling in cardiac myocytes
2003
Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3
1999 StandoutNobel
β-Arrestins Regulate Atherosclerosis and Neointimal Hyperplasia by Controlling Smooth Muscle Cell Proliferation and Migration
2008 StandoutNobel