Standout Papers
Citation Impact
Citing Papers
Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4
1993
Topography of early HPV 16 transcription in high-grade genital precancers.
1989
Angiogenesis and apoptosis are cellular parameters of neoplastic progression in transgenic mouse models of tumorigenesis
1998
Hallmarks of Cancer: The Next Generation
2011 Standout
Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage.
1993
Human papillomavirus as a risk factor for the increase in incidence of tonsillar cancer
2006
Effects of an Rb mutation in the mouse
1992 StandoutNature
The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus
1989
The INK4a/ARF tumor suppressor: one gene—two products—two pathways
1998
Transcription of the transforming genes of the oncogenic human papillomavirus-16 is stimulated by tumor promotors through AP1 binding sites
1990
Retinoblastoma protein switches the E2F site from positive to negative element
1992 Nature
Papillomaviruses Causing Cancer: Evasion From Host-Cell Control in Early Events in Carcinogenesis
2000 Standout
The Petinoblastoma Tumor Suppressor Protein
1994
Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis
1996 Standout
Expression of transcription factor E2F1 induces quiescent cells to enter S phase
1993 Nature
Papillomavirus infections — a major cause of human cancers
1996 StandoutNobel
A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F
1992
The retinoblastoma susceptibility gene product undergoes cell cycle-dependent dephosphorylation and binding to and release from SV40 large T
1990
Immortalization and Transformation of Human Cells by Human Papillomavirus
1994
The p53 protein and its interactions with the oncogene products of the small DNA tumor viruses
1990
Mechanism of active transcriptional repression by the retinoblastoma protein
1995 Nature
Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis
1992 Nature
Tumor suppressor genes: the p53 and retinoblastoma sensitivity genes and gene products
1990
An N-Terminal transformation-governing sequence of SV40 large T antigen contributes to the binding of both p110 and a second cellular protein, p120
1989
Coexpression of cdk2/cdc2 and retinoblastoma gene products in colorectal cancer
1995
Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells
1998 Nature
TGF-β signalling from cell membrane to nucleus through SMAD proteins
1997 StandoutNature
Both episomal and integrated forms of human papillomavirus type 16 are involved in invasive cervical cancers
1989
The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
1993 Standout
A cellular protein that competes with SV40 T antigen for binding to the retinoblastoma gene product
1991 Nature
Decreased type II/type I TGF-beta receptor ratio in cells derived from human atherosclerotic lesions. Conversion from an antiproliferative to profibrotic response to TGF-beta1.
1995
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
1999 StandoutNatureNobel
Human papillomaviruses in the pathogenesis of anogenital cancer
1991
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
1990 Standout
The retinoblastoma protein is phosphorylated during specific phases of the cell cycle
1989
Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins.
1994
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties
1992 StandoutNobel
Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation
1991
The multistep nature of cancer
1993
Molecular characterization of the retinoblastoma susceptibility gene
1993
Physical interaction of the retinoblastoma protein with human D cyclins
1993
Amplification of the E2F1 transcription factor gene in the HEL erythroleukemia cell line
1995
The short arm of chromosome 11 likely is involved in the regulation of the human papillomavirus type 16 early enhancer-promoter and in the suppression of the transforming activity of the viral DNA
1990
Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product
1991 Nature
The Hallmarks of Cancer
2000 Standout
Tumor suppressor genes
1991 Standout
The retinoblastoma gene and cell growth control
1990
TGF-β-receptor-mediated signaling
1994
Cellular targets for transformation by the adenovirus E1A proteins
1989
The E2F transcription factor is a cellular target for the RB protein
1991 Standout
A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex
1992
Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation
1993 Standout
Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6
1991 StandoutNature
Retinoblastoma in transgenic mice
1990 Nature
Role of the retinoblastoma protein in the pathogenesis of human cancer.
1997 StandoutNobel
In vitro phosphorylation of the tumor suppressor gene RB protein by mitosis-specific histone H1 kinase
1989
A region of SV40 large T antigen can substitute for a transforming domain of the adenovirus E1A products
1988 Nature
Loss of heterozygosity at the RB locus correlates with loss of RB protein in primary malignant neuro‐endocrine lung carcinomas
1994
Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV-16 E7 oncoprotein
1997
The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein
1991 StandoutNobel
A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle
1993
Negative regulation of human c-fos expression by thes retinoblastoma gene product
1990 Nature
Global cancer statistics
2011 Standout
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
1992 Standout
Transcriptional activation by viral regulatory proteins
1991
Papillomaviruses and cancer: from basic studies to clinical application
2002 StandoutNobel
The TGF-β family and its composite receptors
1994
Growth inhibition by TGF-β linked to suppression of retinoblastoma protein phosphorylation
1990
Cooperation between oncogenes
1991
The p53 tumour suppressor gene
1991 StandoutNature
The retinoblastoma protein binds E2F residues required for activation in vivo and TBP bindingin vitro
1993
The retinoblastoma protein and the regulation of cell cycling
1992
Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesis
1996 StandoutNobel
Retinoblastoma-repression of E2F-dependent transcription depends on the ability of the retinoblastoma protein to interact with E2F and is abrogated by the adenovirus E1A oncoprotein
1992
pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest
1994 StandoutNature
Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product
1991 StandoutNobel
The Retinoblastoma Protein Region Required for Interaction with the E2F Transcription Factor Includes the T/E1A Binding and Carboxy-Terminal Sequences
1992
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
2004 Standout
Molecular themes in oncogenesis
1991 StandoutNobel
Amino-terminal domains of c-myc and N-myc proteins mediate binding to the retinoblastoma gene product
1991 Nature
Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis
1999
Delineation of human papillomavirus type 18 enhancer binding proteins: the intracellular distribution of a novel octamer binding protein p92 is cell cycle regulated
1991
The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle
1991
The angiogenic switch in carcinogenesis
2009
Localization of p53, retinoblastoma and host replication proteins at sites of viral replication in herpes-infected cells
1991 Nature
The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element
1989
Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein
1991
TGFβ inhibition of Cdk4 synthesis is linked to cell cycle arrest
1993
Inhibitors of histone deacetylase arrest cell cycle and induce apoptosis in cervical carcinoma cells circumventing human papillomavirus oncogene expression
2001 StandoutNobel
The Tumor Suppressor Protein p16 and the Human Papillomavirus Oncoprotein-58 E7 Are Naturally Occurring Lysine-less Proteins That Are Degraded by the Ubiquitin System
2004 StandoutNobel
The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB
1994 Standout
Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: A novel mechanism for E1A trans-activation
1990
Altered Transforming Growth Factor β Signaling in Epithelial Cells when Ras Activation Is Blocked
1996
Autonomous functional domains of chemically synthesized human immunodeficiency virus tat trans-activator protein
1988 Standout
G1/S phosphorylation of the retinoblastoma protein is associated with an altered affinity for the nuclear compartment
1991
The Retinoblastoma Susceptibility Gene Product Represses Transcription When Directly Bound to the Promoter
1995
p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest
1994 Standout
Selective down-regulation of human papillomavirus transcription by 2-deoxyglucose
1998 StandoutNobel
p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens
1994 Nature
Functional interactions of the retinoblastoma protein with mammalian D-type cyclins
1993 Standout
A role for both RB and p53 in the regulation of human cellular senescence*1
1991
TGF-β stimulation and inhibition of cell proliferation: New mechanistic insights
1990 Standout
Conversion of HPV 18 positive non-tumorigenic HeLa-fibroblast hybrids to invasive growth involves loss of TNF-α mediated repression of viral transcription and modification of the AP-1 transcription complex
1999 StandoutNobel
The retinoblastoma protein copurifies with E2F-I, an E1A-regulated inhibitor of the transcription factor E2F
1991
C-terminal truncation of the retinoblastoma gene product leads to functional inactivation.
1990
The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein.
1992
Human papillomavirus type 16 E6 increases the degradation rate of p53 in human keratinocytes
1992
Inverse relationship between human papillomavirus (HPV) type 16 early gene expression and cell differentiation in nude mouse epithelial cysts and tumors induced by HPV-positive human cell lines
1991 StandoutNobel
Quantitative keratinocyte assay detects two biological activities of human papillomavirus DNA and identifies viral types associated with cervical carcinoma.
1988
Point Mutational Inactivation of the Retinoblastoma Antioncogene
1989 Science
Progression of human papillomavirus type 18-immortalized human keratinocytes to a malignant phenotype.
1991
Identification of a growth suppression domain within the retinoblastoma gene product.
1992 StandoutNobel
Association of the human papillomavirus type 16 E7 protein with the S-phase-specific E2F-cyclin A complex.
1993
Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides.
1991
Genetic predisposition and parameters of malignant progression in K14-HPV16 transgenic mice.
1996
Multiple members of the E2F transcription factor family are the products of oncogenes.
1995
Transforming growth factors beta 1 and 2 transcriptionally regulate human papillomavirus (HPV) type 16 early gene expression in HPV-immortalized human genital epithelial cells
1990
E1A induces phosphorylation of the retinoblastoma protein independently of direct physical association between the E1A and retinoblastoma products.
1991
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
Frequent inactivation of the retinoblastoma anti-oncogene is restricted to a subset of human tumor cells.
1990
Association of the Human Papillomavirus Type 16 E7 Protein with the S-Phase-Specific E2F-Cyclin A Complex
1993
Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins.
1993
Interactions of the p107 and Rb proteins with E2F during the cell proliferation response.
1993
Long-term genome stability and minimal genotypic and phenotypic alterations in HPV16 E7-, but not E6-, immortalized human uroepithelial cells.
1994
Definition of the Minimal Simian Virus 40 Large Τ Antigen- and Adenovirus E1A-Binding Domain in the Retinoblastoma Gene Product
1990 StandoutNobel
p53: oncogene or anti-oncogene?
1990
Continued expression of HPV-16 E7 protein is required for maintenance of the transformed phenotype of cells co-transformed by HPV-16 plus EJ-ras.
1989
Repression of the human papillomavirus type 18 enhancer by the cellular transcription factor Oct-1
1991 StandoutNobel
Direct Transcriptional Repression by pRB and Its Reversal by Specific Cyclins
1995
Extinction of the HPV18 upstream regulatory region in cervical carcinoma cells after fusion with non-tumorigenic human keratinocytes under non-selective conditions.
1991 StandoutNobel
The retinoblastoma protein physically associates with the human cdc2 kinase.
1992
A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites.
1995 StandoutNobel
The role of differentiation in the suppression of malignancy*
1990
The enhancer of human papillomavirus type 16: binding sites for the ubiquitous transcription factors oct-1, NFA, TEF-2, NF1, and AP-1 participate in epithelial cell-specific transcription
1991
Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes.
1990
Tumor Suppressor Genes: The Puzzle and the Promise
1989 Science
Tumor Suppressor Genes
1991 Science
Expression and state of phosphorylation of the retinoblastoma susceptibility gene product in cycling and noncycling human hematopoietic cells.
1990
Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7.
1994
Molecular Cloning of Cellular Genes Encoding Retinoblastoma-Associated Proteins: Identification of a Gene with Properties of the Transcription Factor E2F
1992
The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells
1991
Identification of a transforming gene of human papillomavirus type 16
1989
Immunization with viruslike particles from cottontail rabbit papillomavirus (CRPV) can protect against experimental CRPV infection
1995
Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein
1990
A Genetic Tool Used to Identify Thioredoxin as a Mediator of a Growth Inhibitory Signal
1991 Science
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product.
1993 StandoutNobel
Properties of p53 mutations detected in primary and secondary cervical cancers suggest mechanisms of metastasis and involvement of environmental carcinogens.
1992
p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein.
1994
The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations.
1990
Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F.
1992
Reversible repression of papillomavirus oncogene expression in cervical carcinoma cells: consequences for the phenotype and E6-p53 and E7-pRB interactions
1994
Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-β in cells lacking the CDK inhibitor p15
1997 Nature
HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes.
1989 Standout
Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein
2000
The retinoblastoma protein is phosphorylated on multiple sites by human cdc2.
1991
Suppression in vivo of human papillomavirus type 18 E6-E7 gene expression in nontumorigenic HeLa X fibroblast hybrid cells
1990 StandoutNobel
The Transcription Factor E2F-1 Is a Downstream Target of RB Action
1995 StandoutNobel
The adenovirus E4 17-kilodalton protein complexes with the cellular transcription factor E2F, altering its DNA-binding properties and stimulating E1A-independent accumulation of E2 mRNA
1990
Regulation of transforming growth factor beta 1 gene expression by the product of the retinoblastoma-susceptibility gene.
1991
Kinase requirements in human cells: III. Altered kinase requirements inVHL−/− cancer cells detected in a pilot synthetic lethal screen
2008 StandoutNobel
Interaction of the human papillomavirus type 16 E6 oncoprotein with wild-type and mutant human p53 proteins
1992
Human papillomavirus type 16 transformation of primary human embryonic fibroblasts requires expression of open reading frames E6 and E7
1989
Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53.
1994
Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein.
1993
Infrequent inactivation of the retinoblastoma gene despite frequent loss of chromosome 13q in head and neck squamous cell carcinoma.
1994
Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin.
1994
Transcriptional repression of the E2-containing promoters EIIaE, c-myc, and RB1 by the product of the RB1 gene.
1992
Role of the human papillomaviruses in human cancer.
1991
A phase I trial of a human papillomavirus (HPV) peptide vaccine for women with high-grade cervical and vulvar intraepithelial neoplasia who are HPV 16 positive.
2000
Differential regulation of E2F transactivation by cyclin/cdk2 complexes.
1994
Deletion of a splice donor site ablates expression of the following exon and produces an unphosphorylated RB protein unable to bind SV40 T antigen.
1990
The retinoblastoma protein and cell cycle control
1995 Standout
Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.
1995 StandoutNobel
Regions of the Retinoblastoma Gene Product Required for its Interaction with the E2F Transcription Factor are Necessary for E2 Promoter Repression and pRb-Mediated Growth Suppression
1993
Hyperphosphorylation of the retinoblastoma gene product is determined by domains outside the simian virus 40 large-T-antigen-binding regions.
1990
A novel inhibitor of cyclin-Cdk activity detected in transforming growth factor beta-arrested epithelial cells.
1994
Disruption of retinoblastoma protein function by coexpression of its C pocket fragment.
1995
Interplay of viral and cellular proteins along the long control region of human papillomavirus type 18
1988
The human papillomavirus type 18 (HPV18) E2 gene product is a repressor of the HPV18 regulatory region in human keratinocytes
1989
Adenovirus E1a prevents the retinoblastoma gene product from repressing the activity of a cellular transcription factor.
1992
Antioxidant-induced changes of the AP-1 transcription complex are paralleled by a selective suppression of human papillomavirus transcription
1997 StandoutNobel
A transcriptional tryst
1991 Nature
Regulation of retinoblastoma protein functions by ectopic expression of human cyclins
1992 Standout
Viruses in Human Cancers
1991 StandoutScienceNobel
Increased sensitivity of human keratinocytes immortalized by human papillomavirus type 16 DNA to growth control by retinoids.
1992
Definition of the minimal simian virus 40 large T antigen- and adenovirus E1A-binding domain in the retinoblastoma gene product.
1990 StandoutNobel
Sequential activation of cyclin E and cyclin A gene expression by human papillomavirus type 16 E7 through sequences necessary for transformation
1995
Expression of Dominant-Negative Mutant DP-1 Blocks Cell Cycle Progression in G1
1996
Cancer Genome Landscapes
2013 StandoutScience
Mutational analysis of cis elements involved in E2 modulation of human papillomavirus type 16 P97 and type 18 P105 promoters
1990
Cell Cycle-Dependent Regulation of Phosphorylation of the Human Retinoblastoma Gene Product
1989 Science
Cell Cycle Analysis of E2F in Primary Human T Cells Reveals Novel E2F Complexes and Biochemically Distinct Forms of Free E2F
1993
Retinoic acid-mediated repression of human papillomavirus 18 transcription and different ligand regulation of the retinoic acid receptor beta gene in non-tumorigenic and tumorigenic HeLa hybrid cells.
1992 StandoutNobel
Frequent loss of heterozygosity at the retinoblastoma locus in human esophageal cancers.
1991
G 1 Events and Regulation of Cell Proliferation
1989 StandoutScience
Nonfunctional mutants of the retinoblastoma protein are characterized by defects in phosphorylation, viral oncoprotein association, and nuclear tethering.
1991
Structure and expression of the murine retinoblastoma gene and characterization of its encoded protein.
1989
Identification of HPV-16 E7 peptides that are potent antagonists of E7 binding to the retinoblastoma suppressor protein.
1990
Inactivation of the Type II Receptor Reveals Two Receptor Pathways for the Diverse TGF-β Activities
1993 Science
Interaction of p107 with Cyclin A Independent of Complex Formation with Viral Oncoproteins
1992 Science
Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.
1994 StandoutNobel
Purification and characterization of human papillomavirus type 16 E7 protein with preferential binding capacity to the underphosphorylated form of retinoblastoma gene product
1991
E5 Protein of Human Papillomavirus Type 16 Protects Human Foreskin Keratinocytes from UV B-Irradiation-Induced Apoptosis
2002
Deletion of the human retinoblastoma gene in primary leukemias
1990
A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18.
1991
Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner.
1992
Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis.
1994
Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein.
1994
Degradation of the tumor suppressor protein p53 by the ubiquitin-mediated proteolytic system requires a novel species of ubiquitin-carrier protein, E2
1994 StandoutNobel
DNA tumor virus oncoproteins and retinoblastoma gene mutations share the ability to relieve the cell's requirement for cyclin D1 function in G1.
1994
Immortalization and altered differentiation of human keratinocytes in vitro by the E6 and E7 open reading frames of human papillomavirus type 18
1990
Inhibition of E2F-1 Transactivation by Direct Binding of the Retinoblastoma Protein
1993
A single amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein binding.
1990
Transcriptional repression of the D-type cyclin-dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb.
1994
Transcriptional Activation of the Telomerase hTERT Gene by Human Papillomavirus Type 16 E6 Oncoprotein
2001
Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1
1993
Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53.
1993
Identification of human papillomavirus type 18 transforming genes in immortalized and primary cells
1989
Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes.
1993
Negative Regulation of G1 in Mammalian Cells: Inhibition of Cyclin E-Dependent Kinase by TGF-β
1993 Science
Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53
1990 StandoutScience
Failure to Phosphorylate the Retinoblastoma Gene Product in Senescent Human Fibroblasts
1990 Science
Suppression of cyclin-dependent kinase 4 during induced differentiation of erythroleukemia cells.
1994
Regulation of the Ets-Related Transcription Factor Elf-1 by Binding to the Retinoblastoma Protein
1993 StandoutScienceNobel
Evolution of in vitro transformation and tumorigenesis of HPV16 and HPV18 immortalized primary cervical epithelial cells.
1991
Protein domains governing interactions between E2F, the retinoblastoma gene product, and human papillomavirus type 16 E7 protein.
1993
Transcriptional activation by the papillomavirus E6 zinc finger oncoprotein.
1990
Two distinct and frequently mutated regions of retinoblastoma protein are required for binding to SV40 T antigen.
1990
Human papilloma virus DNAs immortalize normal human mammary epithelial cells and reduce their growth factor requirements.
1990
Identification of a negative regulatory domain in the human papillomavirus type 18 promoter: interaction with the transcriptional repressor YY1.
1992 StandoutNobel
E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins
1992 Science
Overexpression of E2F-1 in rat embryo fibroblasts leads to neoplastic transformation.
1994
Cell type and differentiation dependent heterogeneity in retinoblastoma protein expression in SCID mouse fetuses.
1992
Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein.
1993
A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma.
1991 Standout
The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F.
1992
Overexpression of p16INK4A as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri
2001
Identification of distinct roles for separate E1A domains in disruption of E2F complexes.
1993
The amino-terminal region of the adenovirus serotype 5 E1a protein performs two separate functions when expressed in primary baby rat kidney cells.
1988
Works of Karl Münger being referenced
The human papillomavirus E7 protein as a transforming and transactivating factor
1993
The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2
1997
Human papillomaviruses and associated malignancies.
1998
Functions of Human Papillomavirus Proteins
1994
The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to those of adenovirus E1A
1988
Human papillomavirus immortalization and transformation functions
2002
Dimerization of the Human Papillomavirus E7 Oncoproteinin Vivo
1995
Interactions of the human papillomavirus E7 protein with cell cycle regulators
1996
A Novel Human DnaJ Protein, hTid-1, a Homolog of the Drosophila Tumor Suppressor Protein Tid56, Can Interact with the Human Papillomavirus Type 16 E7 Oncoprotein
1998
Oncoproteins Encoded by the Cancer-associated Human Papillomaviruses Target the Products of the Retinoblastoma and p53 Tumor Suppressor Genes
1991
Efficiency of binding the retinoblastoma protein correlates with the transforming capacity of the E7 oncoproteins of the human papillomaviruses.
1992
Transforming growth factor beta 1 regulation of c-myc expression, pRB phosphorylation, and cell cycle progression in keratinocytes.
1992
The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines.
1991
Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product.
1989
Role of the human papillomavirus oncoproteins in transformation and carcinogenic progression.
1991
The human papillomavirus E7 oncoprotein and the cellular transcription factor E2F bind to separate sites on the retinoblastoma tumor suppressor protein
1993
Targeted degradation of the retinoblastoma protein by human papillomavirus E7-E6 fusion proteins.
1992
Functional and Sequence Similarities Between HPV16 E7 and Adenovirus E1A
1989
The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes
1989 Standout
NF-kappaB-mediated induction of p21(Cip1/Waf1) by tumor necrosis factor alpha induces growth arrest and cytoprotection in normal human keratinocytes.
2003
TGF-β1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains
1990
Analysis of trans activation by human papillomavirus type 16 E7 and adenovirus 12S E1A suggests a common mechanism
1991
Kinase requirements in human cells: I. Comparing kinase requirements across various cell types
2008
Analysis of the p53-mediated G1 growth arrest pathway in cells expressing the human papillomavirus type 16 E7 oncoprotein
1997
Factor-binding element in the human c-myc promoter involved in transcriptional regulation by transforming growth factor beta 1 and by the retinoblastoma gene product.
1991
Human papillomavirus type 16 E7 oncoprotein-induced abnormal centrosome synthesis is an early event in the evolving malignant phenotype.
2001
Human Papillomaviruses and Cervical Cancer
2005
Biochemical and biological differences between E7 oncoproteins of the high- and low-risk human papillomavirus types are determined by amino-terminal sequences
1991
Progressive squamous epithelial neoplasia in K14-human papillomavirus type 16 transgenic mice
1994
Structure-function analysis of the human papillomavirus type 16 E7 oncoprotein
1992
Interactions of HPV E6 and E7 oncoproteins with tumour suppressor gene products.
1992
Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins
1992
Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product.
1992
The Human Papilloma Virus-16 E7 Oncoprotein Is Able to Bind to the Retinoblastoma Gene Product
1989 StandoutScience