Citation Impact
Citing Papers
Treatment for Acute Myelogenous Leukemia by Low-Dose, Total-Body, Irradiation-Based Conditioning and Hematopoietic Cell Transplantation From Related and Unrelated Donors
2005
Results of a HOVON/SAKK donor versus no-donor analysis of myeloablative HLA-identical sibling stem cell transplantation in first remission acute myeloid leukemia in young and middle-aged adults: benefits for whom?
2007
Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet
2009 Standout
Ceramide: an intracellular mediator of apopotosis and growth supression
1996
Impaired immune and acute-phase responses in interleukin-6-deficient mice
1994 StandoutNatureNobel
A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
1997 StandoutNature
Regulation of Cytochrome P450 2C11 (CYP2C11) Gene Expression by Interleukin-1, Sphingomyelin Hydrolysis, and Ceramides in Rat Hepatocytes
1995
The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling
1994
Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling
1994
Phospholipid signaling
1995
A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor
1994
The Cytotoxicity of Tumor Necrosis Factor Depends on Induction of the Mitochondrial Permeability Transition
1996
Activation of a Mitogen-activated Protein Kinase (ERK2) by the 5-Hydroxytryptamine1A Receptor Is Sensitive Not Only to Inhibitors of Phosphatidylinositol 3-Kinase, but to an Inhibitor of Phosphatidylcholine Hydrolysis
1996
Apoptosis by Death Factor
1997 Standout
Regulation of the NF-ηB/rel transcription factor and IηB inhibitor system
1993 Nobel
Compartmentalized Production of Ceramide at the Cell Surface
1995
Insulin Stimulates Hypoxia-inducible Factor 1 through a Phosphatidylinositol 3-Kinase/Target of Rapamycin-dependent Signaling Pathway
2002 StandoutNobel
Ceramide: an endogenous regulator of apoptosis and growth suppresion
1995
When Checkpoints Fail
1997 StandoutNobel
Ubiquitin-mediated Processing of NF-κB Transcriptional Activator Precursor p105
1995 StandoutNobel
Phosphorylation of IκB-α Inhibits Its Cleavage by Caspase CPP32 in Vitro
1997 StandoutNobel
Induction of Vascular Endothelial Growth Factor by Tumor Necrosis Factor α in Human Glioma Cells
1996
Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor
1995
Requirement of AP-1 for Ceramide-induced Apoptosis in Human Leukemia HL-60 Cells
1995
Allogeneic Transplantation for the Elderly Patient With Acute Myelogenous Leukemia or Myelodysplastic Syndrome
2006
Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis
1996 StandoutNature
The Formation of Ceramide-1-phosphate during Neutrophil Phagocytosis and Its Role in Liposome Fusion
1998 StandoutNobel
The stress-activated protein kinase subfamily of c-Jun kinases
1994 StandoutNature
Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB
1995 StandoutNatureNobel
FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway
1995
Toll-like receptors in the induction of the innate immune response
2000 StandoutNature
TREM-1 amplifies inflammation and is a crucial mediator of septic shock
2001 StandoutNature
Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate
1996 StandoutNature
Raft ceramide in molecular medicine
2003
PU.1 and Interferon Consensus Sequence-binding Protein Regulate the Myeloid Expression of the Human Toll-like Receptor 4 Gene
2000 StandoutNobel
TAK1 is a ubiquitin-dependent kinase of MKK and IKK
2001 StandoutNature
Angiotensin-converting enzyme 2 protects from severe acute lung failure
2005 StandoutNature
Tumor necrosis factor alpha -induced activation of c-jun N-terminal kinase is mediated by TRAF2
1997
Phosphatidylcholine breakdown and signal transduction
1994
Cell-mediated cytotoxicity
1993 StandoutNobel
Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species
1997
Ceramide Activates the Stress-activated Protein Kinases
1995
The Fas Death Factor
1995 StandoutScience
Serotonin 5-HT1A Receptor-mediated Erk Activation Requires Calcium/Calmodulin-dependent Receptor Endocytosis
1999 StandoutNobel
Inhibition of Carnitine Palmitoyltransferase I Augments Sphingolipid Synthesis and Palmitate-induced Apoptosis
1997 StandoutNobel
Dual Roles of Sphingolipids in Signaling of the Escape from and Onset of Apoptosis in a Mouse Cytotoxic T-cell Line, CTLL-2
1996
Hematopoietic stem-cell transplantation from unrelated donors in elderly patients (age>55 years) with hematologic malignancies: older age is no longer a contraindication when using reduced intensity conditioning
2004
Interaction of Ceramides, Sphingosine, and Sphingosine 1-Phosphate in Regulating DNA Synthesis and Phospholipase D Activity
1995
Long-term survival in refractory acute myeloid leukemia after sequential treatment with chemotherapy and reduced-intensity conditioning for allogeneic stem cell transplantation
2006
Comparative outcome of reduced intensity and myeloablative conditioning regimen in HLA identical sibling allogeneic haematopoietic stem cell transplantation for patients older than 50 years of age with acute myeloblastic leukaemia: a retrospective survey from the Acute Leukemia Working Party (ALWP) of the European group for Blood and Marrow Transplantation (EBMT)
2005
Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB
1993 Nature
Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection
1993
Comparative Study of the Metabolic Pools of Sphingomyelin and Phosphatidylcholine Sensitive to Tumor Necrosis Factor
1996
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function
1997 StandoutNature
The TRAF Family of Signal Transducers Mediates NF-κB Activation by the TRANCE Receptor
1998 StandoutNobel
Fas Antigen and Sphingomyelin‐Ceramide Turnover‐Mediated Signaling: Role in Life and Death of T Lymphocytes1
1994
TRAF6 is a signal transducer for interleukin-1
1996 Nature
The Tumor Necrosis Factor Ligand and Receptor Families
1996 StandoutNobel
Sphingomyelin‐Derived Lipids Differentially Regulate the Extracellular Signal‐Regulated Kinase 2 (ERK‐2) and c‐Jun N‐Terminal Kinase (JNK) Signal Cascades in Airway Smooth Muscle
1996
Impaired Cytokine Signaling in Mice Lacking the IL-1 Receptor-Associated Kinase
1999
Divergent signalling via APO-1/Fas and the TNF receptor, two homologous molecules involved in physiological cell death.
1994
Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis.
1994 Standout
Pretreatment cytogenetics add to other prognostic factors predicting complete remission and long-term outcome in patients 60 years of age or older with acute myeloid leukemia: results from Cancer and Leukemia Group B 8461
2006
Activation of NF-kappa B in vivo is regulated by multiple phosphorylations.
1994
Dissociation of endogenous cellular ceramide from NF-kappa B activation.
1994
Tumor necrosis factor-alpha (TNF-alpha) signal transduction through ceramide. Dissociation of growth inhibitory effects of TNF-alpha from activation of nuclear factor-kappa B.
1993
Leukocyte lipid body formation and eicosanoid generation: cyclooxygenase-independent inhibition by aspirin.
1996 StandoutNobel
Mechanisms of platelet-activating factor-induced lipid body formation: requisite roles for 5-lipoxygenase and de novo protein synthesis in the compartmentalization of neutrophil lipids.
1996
Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B.
1996 Standout
Cell Activation and Apoptosis by Bacterial Lipoproteins Through Toll-like Receptor-2
1999 StandoutScience
Evidence against involvement of the acid lysosomal sphingomyelinase in the tumor-necrosis-factor- and interleukin-1-induced sphingomyelin cycle and cell proliferation in human fibroblasts
1994
Functional rafts in cell membranes
1997 StandoutNature
Daunorubicin-induced apoptosis: triggering of ceramide generation through sphingomyelin hydrolysis.
1996
Cell Cycle Arrest Induced by an Inhibitor of Glucosylceramide Synthase
1995
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
1995 StandoutScience
Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase.
1994
Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis
1995 StandoutScience
Matched Unrelated or Matched Sibling Donors Result in Comparable Survival After Allogeneic Stem-Cell Transplantation in Elderly Patients With Acute Myeloid Leukemia: A Report From the Cooperative German Transplant Study Group
2008
Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes
2008 StandoutScience
Cloned mammalian neutral sphingomyelinase: Functions in sphingolipid signaling?
1998
Coupling of a Signal Response Domain in IκBα to Multiple Pathways for NF-κB Activation
1995
Involvement of the sphingomyelin pathway in autocrine tumor necrosis factor signaling for human immunodeficiency virus production in chronically infected HL-60 cells
1994
Tumor necrosis factor and lymphotoxin. Qualitative and quantitative differences in the mediation of early and late cellular response.
1994
Human Toll-like Receptor 2 Confers Responsiveness to Bacterial Lipopolysaccharide
1998
Acute Myeloid Leukemia and Acute Promyelocytic Leukemia
2003
Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.
1994
Ceramide does not mediate the effect of tumour necrosis factor α on superoxide generation in human neutrophils
1994
NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation
1998 StandoutScience
Ceramide induces interleukin 6 gene expression in human fibroblasts.
1995
Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1
2000 StandoutScience
Functions of Ceramide in Coordinating Cellular Responses to Stress
1996 StandoutScience
Integrins and Signal Transduction Pathways: the Road Taken
1995 StandoutScience
Ceramide: a signal for apoptosis or mitogenesis?
1995
Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer.
1994 StandoutNobel
Reconstitution of nuclear factor kappa B activation induced by tumor necrosis factor requires membrane-associated components. Comparison with pathway activated by ceramide.
1994
A Dominant Negative Protein Kinase C ζ Subspecies Blocks NF-κ B Activation
1993
Tumor necrosis factor activation of the sphingomyelin pathway signals nuclear factor kappa B translocation in intact HL-60 cells.
1993
Cell-permeable ceramides inhibit the stimulation of DNA synthesis and phospholipase D activity by phosphatidate and lysophosphatidate in rat fibroblasts.
1994
Ceramide formation during heat shock: a potential mediator of alpha B-crystallin transcription.
1995
Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase.
1994
Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.
1995 StandoutNobel
Ceramide activates heterotrimeric protein phosphatase 2A
1993
Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations
2000 StandoutScienceNobel
The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis
1997 StandoutScience
Cellular and Molecular Dissection of Reperfusion Injury
2000 StandoutNobel
Mitochondria and Apoptosis
1998 StandoutScience
The role of diacylglycerol and ceramide in tumor necrosis factor and interleukin-1 signal transduction
1994
Identification of a distinct pool of sphingomyelin involved in the sphingomyelin cycle.
1994
Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction.
1994
Disulfide cross-linking in crude embryonic lysates reveals three complexes of the Drosophila morphogen dorsal and its inhibitor cactus.
1994 StandoutNobel
TUMOR NECROSIS FACTOR RECEPTOR AND Fas SIGNALING MECHANISMS
1999
Multiple pathways originate at the Fas/APO-1 (CD95) receptor: sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal.
1995
PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid.
1995
IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation
1997 StandoutScience
The sphingomyelin cycle and the second messenger function of ceramide.
1994
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-kappa B.
1996 StandoutNobel
PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide
2004
Sphingomyelinase and ceramide activate mitogen-activated protein kinase in myeloid HL-60 cells
1993
Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.
1993
Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation.
1993
Unraveling Function in the TNF Ligand and Receptor Families
1994 StandoutScienceNobel
TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB
1996 StandoutScience
Works of Karin Potthoff being referenced
TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced “Acidic” sphingomyelin breakdown
1992
Reduced-toxicity conditioning with fludarabine, BCNU, and melphalan in allogeneic hematopoietic cell transplantation: particular activity against advanced hematologic malignancies
2008
Allogeneic Stem-Cell Transplantation From Related and Unrelated Donors in Older Patients With Myeloid Leukemia
2003