Standout Papers
Citation Impact
Citing Papers
β-Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2
2009 StandoutNobel
A monomeric G protein-coupled receptor isolated in a high-density lipoprotein particle efficiently activates its G protein
2007 StandoutNobel
Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists
2010 StandoutScience
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
Dishevelled 2 Recruits ß-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4
2003 StandoutScienceNobel
Spinophilin Blocks Arrestin Actions in Vitro and in Vivo at G Protein-Coupled Receptors
2004 StandoutScienceNobel
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ
2003 StandoutScienceNobel
Strategy for Dual-Analyte Luciferin Imaging: In Vivo Bioluminescence Detection of Hydrogen Peroxide and Caspase Activity in a Murine Model of Acute Inflammation
2013 StandoutNobel
The 2.6 Angstrom Crystal Structure of a Human A 2A Adenosine Receptor Bound to an Antagonist
2008 StandoutScience
De novo design of modular and tunable protein biosensors
2021 StandoutNatureNobel
Imaging Ligand-Dependent Activation of CXCR7
2009
β-Arrestin-dependent, G Protein-independent ERK1/2 Activation by the β2 Adrenergic Receptor
2005 StandoutNobel
Evolving Concepts in G Protein-Coupled Receptor Endocytosis: The Role in Receptor Desensitization and Signaling
2001 Standout
Acromegaly
2006 Standout
A rigorous experimental framework for detecting protein oligomerization using bioluminescence resonance energy transfer
2006
Pharmacological Onomastics: What's in a name?
2007
Homo- and Hetero-oligomerization of β-Arrestins in Living Cells
2005
Circular RNAs are a large class of animal RNAs with regulatory potency
2013 StandoutNature
Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma
2008
Inactive and active states and supramolecular organization of GPCRs: insights from computational modeling
2006
Development of Luciferin Analogues Bearing an Amino Group and Their Application as BRET Donors
2010
Essential role for the second extracellular loop in C5a receptor activation
2005
Quantitative Assessment of β1- and β2-Adrenergic Receptor Homo- and Heterodimerization by Bioluminescence Resonance Energy Transfer
2002
Crystal structure of the human β2 adrenergic G-protein-coupled receptor
2007 StandoutNatureNobel
High-resolution crystal structure of human protease-activated receptor 1
2012 StandoutNatureNobel
Imaging in the era of molecular oncology
2008 StandoutNature
Molecular defects in the pathogenesis of pituitary tumours
2003
G protein-coupled receptor interacting proteins: Emerging roles in localization and signal transduction
2002
Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and ß-arrestin proteins
2002
Multifarious Determinants of Cytokine Receptor Signaling Specificity
2014
β1/β2-Adrenergic Receptor Heterodimerization Regulates β2-Adrenergic Receptor Internalization and ERK Signaling Efficacy
2002
Itching for Insight
2009 StandoutNobel
The Interaction of β-Arrestin with the AP-2 Adaptor Is Required for the Clustering of β2-Adrenergic Receptor into Clathrin-coated Pits
2000
Bioluminescence Resonance Energy Transfer Reveals Ligand-induced Conformational Changes in CXCR4 Homo- and Heterodimers
2005
Genetically Encodable Fluorescent Biosensors for Tracking Signaling Dynamics in Living Cells
2011
De novo design of luciferases using deep learning
2023 StandoutNatureNobel
Regulated portals of entry into the cell
2003 StandoutNature
Network antibodies identify nuclear lamin B as a physiological attachment site for peripherin intermediate filaments
1991 StandoutNobel
Real-time monitoring of ubiquitination in living cells by BRET
2004
The development of allergic inflammation
2008 StandoutNature
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway
2008
The structure and function of G-protein-coupled receptors
2009 StandoutNatureNobel
Initial sequence of the chimpanzee genome and comparison with the human genome
2005 StandoutNature
Targeting proteinase-activated receptors: therapeutic potential and challenges
2012
A TRP Channel that Senses Cold Stimuli and Menthol
2002 StandoutNobel
Cellular and Molecular Mechanisms of Pain
2009 StandoutNobel
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
The rapid evolution of reproductive proteins
2002
Receptors and G proteins as primary components of transmembrane signal transduction
1995
Mite and Cockroach Allergens Activate Protease-Activated Receptor 2 and Delay Epidermal Permeability Barrier Recovery
2008
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
Seven-transmembrane-spanning receptors and heart function
2002 StandoutNatureNobel
Serine and alanine mutagenesis of the nine native cysteine residues of the human A1 adenosine receptor
2000
Mechanisms for pituitary tumorigenesis: the plastic pituitary
2003
Structure of a β1-adrenergic G-protein-coupled receptor
2008 StandoutNatureNobel
A Diverse Family of GPCRs Expressed in Specific Subsets of Nociceptive Sensory Neurons
2001
Orientation‐specific signalling by thrombopoietin receptor dimers
2011
Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation
2005
Oligomerization of G-protein-coupled transmitter receptors
2001
Cancer-related inflammation
2008 StandoutNature
Modulation of chemokine receptor activity through dimerization and crosstalk
2008
Vacuolar (H+)-ATPases in Caenorhabditis elegans: What can we learn about giant H+ pumps from tiny worms?
2010
Mechanisms of normal and malignant breast epithelial growth regulation
1989
Generation of functional thyroid from embryonic stem cells
2012 Nature
The molecular architecture of protein–protein binding sites
2007
A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans
2015 StandoutNobel
G Protein-Coupled Receptor Dimerization: Function and Ligand Pharmacology
2004
The structural and energetic basis for high selectivity in a high-affinity protein-protein interaction
2010 StandoutNobel
Dynamin and Its Role in Membrane Fission
2000
Roles of G‐protein‐coupled receptor dimerization
2004
Distinct conformational changes in β-arrestin report biased agonism at seven-transmembrane receptors
2008 StandoutNobel
JAK2 activation by growth hormone and other cytokines
2015
Antibodies to the binding site of the receptor for luteinizing hormone-releasing hormone (LHRH): generation with a synthetic decapeptide encoded by an RNA complementary to LHRH mRNA.
1986
Parallel Patterns of Evolution in the Genomes and Transcriptomes of Humans and Chimpanzees
2005 StandoutScienceNobel
Cholesterol increases kinetic, energetic, and mechanical stability of the human β2-adrenergic receptor
2012 StandoutNobel
Rapid Transfer of Transmembrane Proteins for Single Molecule Dimerization Assays in Polymer-Supported Membranes
2014
G Protein–Coupled Receptor Oligomerization
2004
Lysosomal activity regulatesCaenorhabditis elegansmitochondrial dynamics through vitamin B12 metabolism
2020 StandoutNobel
Development and Applications of Bioluminescent and Chemiluminescent Reporters and Biosensors
2019
Current State of Imaging Protein-Protein Interactions In Vivo with Genetically Encoded Reporters
2007
Heterozygous α 2A -adrenergic receptor mice unveil unique therapeutic benefits of partial agonists
2002 StandoutNobel
β-arrestin- but not G protein-mediated signaling by the “decoy” receptor CXCR7
2009 StandoutNobel
Organogenesis in a dish: Modeling development and disease using organoid technologies
2014 StandoutScience
Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix
2007
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Applications of bioluminescence in biotechnology and beyond
2021
Live cell micropatterning reveals the dynamics of signaling complexes at the plasma membrane
2014
Computational Modeling Approaches to Structure−Function Analysis of G Protein-Coupled Receptors
2005
Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation
2018
Functional antagonism of different G protein-coupled receptor kinases for β-arrestin-mediated angiotensin II receptor signaling
2005 StandoutNobel
Growth Factors and Cancer
1991 StandoutScience
Imaging the glycome
2008 StandoutNobel
Dimerization: An Emerging Concept for G Protein–Coupled Receptor Ontogeny and Function
2002
Update 1 of: Computational Modeling Approaches to Structure–Function Analysis of G Protein-Coupled Receptors
2011
Preferential transformation of human neuronal cells by human adenoviruses and the origin of HEK 293 cells
2002
Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands
2009 StandoutNobel
The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex
2009 StandoutNobel
Growth Factors, Matrices, and Forces Combine and Control Stem Cells
2009 StandoutScience
Spectral-Resolved Gene Technology for Multiplexed Bioluminescence and High-Content Screening
2007
TGF-β and cancer
2005
Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling
2015
ß-Arrestin 2 Mediates Endocytosis of Type III TGF-ß Receptor and Down-Regulation of Its Signaling
2003 StandoutScienceNobel
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Works of Karin A. Eidne being referenced
G-protein coupled receptor oligomerization in neuroendocrine pathways
2003
αvβ3 Integrin Interacts with the Transforming Growth Factor β (TGFβ) Type II Receptor to Potentiate the Proliferative Effects of TGFβ1 in Living Human Lung Fibroblasts
2004
Illuminating insights into protein-protein interactions using bioluminescence resonance energy transfer (BRET)
2006
Structure of the thyrotrophin‐releasing hormone receptor in human pituitary adenomas
1996
Bioluminescence resonance energy transfer (BRET) for the real-time detection of protein-protein interactions
2006
Cytoplasmic Terminus of Vacuolar Type Proton Pump Accessory Subunit Ac45 Is Required for Proper Interaction with V0 Domain Subunits and Efficient Osteoclastic Bone Resorption
2008
Effects of Asn87 and Asp318 mutations on ligand binding and signal transduction in the rat GnRH receptor.
1993
Casein Kinase II Sites in the Intracellular C-terminal Domain of the Thyrotropin-releasing Hormone Receptor and Chimeric Gonadotropin-releasing Hormone Receptors Contribute to β-Arrestin-dependent Internalization
2001
G protein-coupled receptor dimers: Functional consequences, disease states and drug targets
2008
A Novel Mechanism for Isolated Central Hypothyroidism: Inactivating Mutations in the Thyrotropin-Releasing Hormone Receptor Gene1
1997
An Intramolecular Disulfide Bond between Conserved Extracellular Cysteines in the Gonadotropin-Releasing Hormone Receptor Is Essential for Binding and Activation1
1997
The Duffy Antigen/Receptor for Chemokines Exists in an Oligomeric Form in Living Cells and Functionally Antagonizes CCR5 Signaling through Hetero-Oligomerization
2008
Agonist-Induced Endocytosis and Recycling of the Gonadotropin-Releasing Hormone Receptor: Effect of β-Arrestin on Internalization Kinetics
1998
Applications of novel resonance energy transfer techniques to study dynamic hormone receptor interactions in living cells
2002
Homo- and Hetero-oligomerization of Thyrotropin-releasing Hormone (TRH) Receptor Subtypes
2002 StandoutNobel
Extended bioluminescence resonance energy transfer (eBRET) for monitoring prolonged protein–protein interactions in live cells
2006
Study of G-Protein-Coupled Receptor–Protein Interactions by Bioluminescence Resonance Energy Transfer
2004
Selection of Peptides Targeting the Human Sperm Surface Using Random Peptide Phage Display Identify Ligands Homologous to ZP3
2000
Model for growth hormone receptor activation based on subunit rotation within a receptor dimer
2005
Pivotal Role for the Cytoplasmic Carboxyl-Terminal Tail of a Nonmammalian Gonadotropin-Releasing Hormone Receptor in Cell Surface Expression, Ligand Binding, and Receptor Phosphorylation and Internalization
1999
Gonadotropin-Releasing Hormone Binding Sites in Human Breast Carcinoma
1985 Science
Rapid desensitization of the thyrotropin-releasing hormone receptor expressed in single human embryonal kidney 293 cells
1995
House Dust Mite Allergens Induce Proinflammatory Cytokines from Respiratory Epithelial Cells: The Cysteine Protease Allergen, Der p 1, Activates Protease-Activated Receptor (PAR)-2 and Inactivates PAR-1
2002
Pivotal Role for the Cytoplasmic Carboxyl-Terminal Tail of a Nonmammalian Gonadotropin-Releasing Hormone Receptor in Cell Surface Expression, Ligand Binding, and Receptor Phosphorylation and Internalization
1999
Demonstration of a 60K Molecular Weight Luteinizing Hormone-Releasing Hormone Receptor in Solubilized Adrenal Membranes by a Ligand-Immunoblotting Technique*
1985
Constitutive and Agonist-dependent Homo-oligomerization of the Thyrotropin-releasing Hormone Receptor
2001
The Rat Gonadotropin-Releasing Hormone Receptor Internalizes via a β-Arrestin-Independent, but Dynamin-Dependent, Pathway: Addition of a Carboxyl-Terminal Tail Confers β-Arrestin Dependency
2000
A disulfide bonding interaction role for cysteines in the extracellular domain of the thyrotropin-releasing hormone receptor.
1996
Monitoring the formation of dynamic G-protein-coupled receptor–protein complexes in living cells
2005