Citation Impact
Citing Papers
Epigenetic Repression of DNA Mismatch Repair by Inflammation and Hypoxia in Inflammatory Bowel Disease–Associated Colorectal Cancer
2009 StandoutNobel
Genome-Wide Reprogramming in the Mouse Germ Line Entails the Base Excision Repair Pathway
2010 Science
Gastric Cancer Originating from Bone Marrow-Derived Cells
2004 Science
The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins
2019 StandoutNobel
AID Enzyme-Induced Hypermutation in an Actively Transcribed Gene in Fibroblasts
2002 StandoutScienceNobel
Mononucleotide microsatellite instability and germline MSH6 mutation analysis in early onset colorectal cancer.
1999
Mouse Embryonic Stem Cells, but Not Somatic Cells, Predominantly Use Homologous Recombination to Repair Double-Strand DNA Breaks
2010
Hallmarks of Cancer: The Next Generation
2011 Standout
Somatic Hypermutation in Muts Homologue (Msh)3-, Msh6-, and Msh3/Msh6-Deficient Mice Reveals a Role for the Msh2–Msh6 Heterodimer in Modulating the Base Substitution Pattern
2000
Mechanisms in Eukaryotic Mismatch Repair
2006 StandoutNobel
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions
1999
Mucins in cancer: function, prognosis and therapy
2009
IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer
2004 Standout
DNA Demethylation in Zebrafish Involves the Coupling of a Deaminase, a Glycosylase, and Gadd45
2008
Mismatch repair-dependent processing of methylation damage gives rise to persistent single-stranded gaps in newly replicated DNA
2007
The chemistry and biology of mucin-type O-linked glycosylation
2005 StandoutNobel
Physical Principles of Membrane Shape Regulation by the Glycocalyx
2019 StandoutNobel
Stem cells, cancer, and cancer stem cells
2001 StandoutNature
The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells
2002 Standout
Roles of divalent metal ions in flap endonuclease–substrate interactions
2004
The cancer glycocalyx mechanically primes integrin-mediated growth and survival
2014 StandoutNatureNobel
Mutations in the nucleotide-binding domain of MutS homologs uncouple cell death from cell survival
2004
Novel dominant mutations in Saccharomyces cerevisiae MSH6
2000
Macrophage Migration Inhibitory Factor Promotes Intestinal Tumorigenesis
2005
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia
1995
The role of mucin-type O-glycans in eukaryotic development
2010
Meiotic arrest and aneuploidy in MLH3-deficient mice
2002
Elite and stochastic models for induced pluripotent stem cell generation
2009 StandoutNatureNobel
Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility
2003
A Mutant Drosophila Homolog of Mammalian Clock Disrupts Circadian Rhythms and Transcription of period and timeless
1998 StandoutNobel
Blocking TNF-α in mice reduces colorectal carcinogenesis associated with chronic colitis
2008
Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis
2008
Interactions of Human Mismatch Repair Proteins MutSα and MutLα with Proteins of the ATR-Chk1 Pathway
2009 StandoutNobel
The FHIT Gene, Spanning the Chromosome 3p14.2 Fragile Site and Renal Carcinoma–Associated t(3;8) Breakpoint, Is Abnormal in Digestive Tract Cancers
1996 Standout
AID Is Required for c-myc/IgH Chromosome Translocations In Vivo
2004 StandoutNobel
Chemoprevention of Colorectal Cancer
2000
Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage
2003 StandoutNatureNobel
Isolation of human Dna2 endonuclease and characterization of its enzymatic properties
2006
DNA mismatch repair and mutation avoidance pathways
2002
Endonucleolytic Function of MutLα in Human Mismatch Repair
2006 StandoutNobel
Database of mouse strains carrying targeted mutations in genes affecting cellular responses to DNA damage. Version 4
2000
The multifaceted mismatch-repair system
2006
Signalling cell cycle arrest and cell death through the MMR System
2005
Mechanisms of carcinogenesis and the mutant mouse
1996
Cytosine Methylation and DNA Repair
2006
Structure of the Human MutSα DNA Lesion Recognition Complex
2007 StandoutNobel
Genomic DNA methylation: the mark and its mediators
2006 Standout
KLF4, p21 and context-dependent opposing forces in cancer
2005
Metazoan MicroRNAs
2018 Standout
Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family
2011 StandoutNobel
DNA mismatch repair proteins promote apoptosis and suppress tumorigenesis in response to UVB irradiation: an in vivo study
2004
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ
2000 StandoutNatureNobel
Stimulation of Flap Endonuclease-1 by the Bloom's Syndrome Protein
2004
p21 in cancer: intricate networks and multiple activities
2009 Standout
Muc2-Deficient Mice Spontaneously Develop Colitis, Indicating That MUC2 Is Critical for Colonic Protection
2006
Apc modulates embryonic stem-cell differentiation by controlling the dosage of β-catenin signaling
2002
CDX2 is mutated in a colorectal cancer with normal APC/β-catenin signaling
1999
Biochemical Characterization of the Interaction between the Saccharomyces cerevisiae MSH2-MSH6 Complex and Mispaired Bases in DNA
1999
Epigenetic Reprogramming of Mouse Germ Cells toward Totipotency
2010
TET enzymes, TDG and the dynamics of DNA demethylation
2013 StandoutNature
Comparative biology of mouse versus human cells: modelling human cancer in mice
2003
Glycosylation in health and disease
2019
Differential effects of cell cycle regulatory protein p21WAF1/Cip1 on apoptosis and sensitivity to cancer chemotherapy
2003
hMSH4-hMSH5 Recognizes Holliday Junctions and Forms a Meiosis-Specific Sliding Clamp that Embraces Homologous Chromosomes
2004
MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability
2000
Genetic dissection of the role of p21Cip1/Waf1 in p53-mediated tumour suppression
2006
Genome maintenance mechanisms for preventing cancer
2001 StandoutNature
Oncogenic functions of tumour suppressor p21Waf1/Cip1/Sdi1: association with cell senescence and tumour-promoting activities of stromal fibroblasts
2002
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
2011 StandoutNobel
Characterization of the Interactome of the Human MutL Homologues MLH1, PMS1, and PMS2
2006
Expression of CD44 in Apc and TcfMutant Mice Implies Regulation by the WNT Pathway
1999
Mismatch repair and immunoglobulin gene hypermutation: did we learn something?
1999
Do symbiotic bacteria subvert host immunity?
2009
Mucin Granule Intraluminal Organization in Living Mucous/Goblet Cells
2005 StandoutNobel
Isolation of MutSβ from Human Cells and Comparison of the Mismatch Repair Specificities of MutSβ and MutSα
1998 StandoutNobel
A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses
2009
DNA methyltransferase Dnmt1 and mismatch repair
2004
Characterization of human exonuclease 1 in complex with mismatch repair proteins, subcellular localization and association with PCNA
2003
DNA mismatch repair and cancer
2001
Structural Basis for FEN-1 Substrate Specificity and PCNA-Mediated Activation in DNA Replication and Repair
2004
DNA Mismatch Repair-dependent Response to Fluoropyrimidine-generated Damage
2004
ATR Kinase Activation Mediated by MutSα and MutLα in Response to Cytotoxic O6-Methylguanine Adducts
2006
Mucins in cancer: protection and control of the cell surface
2003
Cancer-related inflammation
2008 StandoutNature
A Defined Human System That Supports Bidirectional Mismatch-Provoked Excision
2004 StandoutNobel
Mechanisms and functions of DNA mismatch repair
2007
Inactivation of p21 Enhances Intestinal Tumor Formation in Muc2−/− Mice
2005
DNA mismatch repair: Molecular mechanism, cancer, and ageing
2008
The genetic basis of colorectal cancer: Insights into critical pathways of tumorigenesis
2000
Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme
2000 StandoutNobel
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Structural basis for recruitment of human flap endonuclease 1 to PCNA
2004
Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
1998
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
1997 Standout
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
PCNA function in the activation and strand direction of MutLα endonuclease in mismatch repair
2010 StandoutNobel
Increased susceptibility to colitis and colorectal tumors in mice lacking core 3–derived O-glycans
2007
Mammalian DNA Mismatch Repair
1999
The protein disulfide isomerase AGR2 is essential for production of intestinal mucus
2009
Binding of Ovarian Cancer Antigen CA125/MUC16 to Mesothelin Mediates Cell Adhesion
2004 Standout
Lynch Syndrome Genes
2005
DNA MISMATCH REPAIR AND GENETIC INSTABILITY
2000
The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon
2002
p21(WAF1/cip1) is an important determinant of intestinal cell response to sulindac in vitro and in vivo.
2001
DNA MISMATCH REPAIR
2005
The Curious Chemical Biology of Cytosine: Deamination, Methylation,and Oxidation as Modulators of Genomic Potential
2011
ATM and p21 Cooperate to Suppress Aneuploidy and Subsequent Tumor Development
2005
MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice
2000
Eukaryotic DNA mismatch repair
1999
The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system
2014
APC-dependent suppression of colon carcinogenesis by PPARγ
2002
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria
2008 Standout
Germ-line msh6 mutations in colorectal cancer families.
1999
PMS2 endonuclease activity has distinct biological functions and is essential for genome maintenance
2010 StandoutNobel
Repair and Genetic Consequences of Endogenous DNA Base Damage in Mammalian Cells
2004 StandoutNobel
Epigenetic regulation of the MGMT and hMSH6 DNA repair genes in cells resistant to methylating agents
2000
Methylator-induced, Mismatch Repair-dependent G2Arrest Is Activated through Chk1 and Chk2
2005
The recombinant C-terminus of the human MUC2 mucin forms dimers in Chinese-hamster ovary cells and heterodimers with full-length MUC2 in LS 174T cells
2003
Down-regulation of beta-catenin TCF signaling is linked to colonic epithelial cell differentiation.
2001
Epigenetic regulation in pluripotent stem cells: a key to breaking the epigenetic barrier
2012 StandoutNobel
Heterozygous Germ Line hCHK2 Mutations in Li-Fraumeni Syndrome
1999 Science
Viruses in Human Cancers
1991 StandoutScienceNobel
Expression of the MutL Homologue hMLH3 in Human Cells and its Role in DNA Mismatch Repair
2005
Tumor susceptibility of p21(Waf1/Cip1)-deficient mice.
2001
Epstein-Barr viral DNA in tissues of Hodgkin's disease.
1987
Immunotherapy: Bewitched, Bothered, and Bewildered No More
2004 StandoutScienceNobel
APC binds to the novel protein EB1.
1995
Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair
2008 StandoutNobel
Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas
2003 StandoutNobel
Human DNA Repair Genes
2001 StandoutScienceNobel
Direct Cellular Responses to Platinum-Induced DNA Damage
2007
Interaction of mismatch repair protein PMS2 and the p53-related transcription factor p73 in apoptosis response to cisplatin
2003
O6-methylguanine-induced cell death involves exonuclease 1 as well as DNA mismatch recognition in vivo
2009
Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase
2010 StandoutNobel
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Active DNA Demethylation Mediated by DNA Glycosylases
2009
Differential effects of p21(WAF1/CIP1) deficiency on MMTV-ras and MMTV-myc mammary tumor properties.
2002
Dual Roles for Immunity in Gastrointestinal Cancers
2010
Chemical Glycoproteomics
2016 StandoutNobel
Works of Kan Yang being referenced
Interaction of Muc2 and Apc on Wnt Signaling and in Intestinal Tumorigenesis: Potential Role of Chronic Inflammation
2008
Colorectal Cancer in Mice Genetically Deficient in the Mucin Muc2
2002 Science
An Msh2 Point Mutation Uncouples DNA Mismatch Repair and Apoptosis
2004
Contributions by MutL Homologues Mlh3 and Pms2 to DNA Mismatch Repair and Tumor Suppression in the Mouse
2005
The DNA mismatch repair genes Msh3 and Msh6 cooperate in intestinal tumor suppression.
2000
Pathology of mouse models of intestinal cancer: Consensus report and recommendations
2003
Dominant effects of an Msh6 missense mutation on DNA repair and cancer susceptibility
2004
Mouse models for colorectal cancer
1999
Novel Roles for MLH3 Deficiency and TLE6-Like Amplification in DNA Mismatch Repair-Deficient Gastrointestinal Tumorigenesis and Progression
2008 StandoutNobel
Modulation of Abnormal Colonic Epithelial Cell Proliferation and Differentiation by Low-Fat Dairy Foods
1998
Mutation in the Mismatch Repair Gene Msh6 Causes Cancer Susceptibility
1997
Mbd4 inactivation increases C→T transition mutations and promotes gastrointestinal tumor formation
2002
A targeted chain-termination mutation in the mouse Apc gene results in multiple intestinal tumors.
1994
Short-chain fatty acid metabolism, apoptosis, and Apc-initiated tumorigenesis in the mouse gastrointestinal mucosa.
1999
A mouse model of human familial adenomatous polyposis
1997
Mir505–3p regulates axonal development via inhibiting the autophagy pathway by targeting Atg12
2017
Targeted inactivation of the p21(WAF1/cip1) gene enhances Apc-initiated tumor formation and the tumor-promoting activity of a Western-style high-risk diet by altering cell maturation in the intestinal mucosal.
2001
Tumorigenesis in Mlh1 and Mlh1/Apc1638N mutant mice.
1999
Proliferation of esophageal epithelial cells among residents of Linxian, People's Republic of China.
1987
Haploinsufficiency of Flap endonuclease ( Fen1 ) leads to rapid tumor progression
2002
Phenotypic expression of Hodgkin's and Reed-Sternberg cells in Hodgkin's disease.
1985