Standout Papers
Citation Impact
Citing Papers
Transforming Growth Factor-β Signaling–Deficient Fibroblasts Enhance Hepatocyte Growth Factor Signaling in Mammary Carcinoma Cells to Promote Scattering and Invasion
2008
Structural Roles for Human Translation Factor eIF3 in Initiation of Protein Synthesis
2005 StandoutScienceNobel
CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus
2015 StandoutNatureNobel
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
2018 StandoutScienceNobel
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Base-modification mRNA editing through deamination — the good, the bad and the unregulated
1996
Specific interaction between the nonphosphorylated form of RNA polymerase II and the TATA-binding protein
1992
Advances in CRISPR-Cas9 genome engineering: lessons learned from RNA interference
2015
Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown
2018 StandoutNobel
Bacterial CRISPR/Cas DNA endonucleases: A revolutionary technology that could dramatically impact viral research and treatment
2015
Harnessing the clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated Cas9 system to disrupt the hepatitis B virus
2015
Isolation of cDNA encoding a binding protein specific to 5'-phosphorylated single-stranded DNA with G-rich sequences
1993 StandoutNobel
New CRISPR–Cas systems from uncultivated microbes
2016 StandoutNatureNobel
The Cold Shock Domain Protein LIN-28 Controls Developmental Timing in C. elegans and Is Regulated by the lin-4 RNA
1997 StandoutNobel
A CRISPR toolbox to study virus–host interactions
2017
Purification of tetrahymena telomerase and cloning of genes encoding the two protein components of the enzyme
1995 StandoutNobel
Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK
1994 StandoutNobel
A decade of discovery: CRISPR functions and applications
2017
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
2017 StandoutNatureNobel
Suppression of hepatitis B virus DNA accumulation in chronically infected cells using a bacterial CRISPR/Cas RNA-guided DNA endonuclease
2014
Editing of glutamate receptor subunit B pre-mRNA in vitro by site-specific deamination of adenosine
1995 StandoutNatureNobel
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
2016 StandoutNobel
Three-dimensional structure of Escherichia coli RNA polymerase holoenzyme determined by electron crystallography
1989 StandoutNatureNobel
Glutamate Signaling in Benign and Malignant Disorders: Current Status, Future Perspectives, and Therapeutic Implications
2013
Analysis of the gene encoding the largest subunit of RNA polymerase II in Drosophila
1989
Conformational control of DNA target cleavage by CRISPR–Cas9
2015 StandoutNatureNobel
Dual roles of a multiprotein complex from S. cerevisiae in transcription and DNA repair
1993 StandoutNobel
Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx
1995 StandoutNobel
Applications of CRISPR technologies in research and beyond
2016 StandoutNobel
CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus
2015 StandoutNobel
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
2020 StandoutNobel
Paradoxical roles of the immune system during cancer development
2006 Standout
Inhibition of HBV Expression in HBV Transgenic Mice Using AAV-Delivered CRISPR-SaCas9
2018
Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II
1994 StandoutNatureNobel
A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II
1994 StandoutNobel
Use of the CRISPR/Cas9 system as an intracellular defense against HIV-1 infection in human cells
2015
Dual gRNAs guided CRISPR/Cas9 system inhibits hepatitis B virus replication
2015
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
Translational activation of the lck proto-oncogene
1988 StandoutNatureNobel
Human general transcription factor IIH phosphorylates the C-terminal domain of RNA polymerase II
1992 Nature
RNA editing of AMPA receptor subunit GluR-B: A base-paired intron-exon structure determines position and efficiency
1993
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
CasX enzymes comprise a distinct family of RNA-guided genome editors
2019 StandoutNatureNobel
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
1996 StandoutNatureNobel
Three-dimensional structure of yeast RNA polymerase II at 16 Å resolution
1991 StandoutNobel
Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme
2000 StandoutNobel
Fluorescent indicators for Ca2+based on green fluorescent proteins and calmodulin
1997 StandoutNatureNobel
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts
2012
Genome-editing revolution: My whirlwind year with CRISPR
2015 StandoutNatureNobel
Delivery and Specificity of CRISPR/Cas9 Genome Editing Technologies for Human Gene Therapy
2015
Subunits shared by eukaryotic nuclear RNA polymerases.
1990
A prudent path forward for genomic engineering and germline gene modification
2015 StandoutScienceNobel
Molecular cloning of cDNA for double-stranded RNA adenosine deaminase, a candidate enzyme for nuclear RNA editing.
1994
A Cas9–guide RNA complex preorganized for target DNA recognition
2015 StandoutScienceNobel
Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems
2016 Science
Effects of intercistronic length on the efficiency of reinitiation by eucaryotic ribosomes.
1987
Purification and characterization of double-stranded RNA adenosine deaminase from bovine nuclear extracts.
1994
Dynamics of CRISPR-Cas9 genome interrogation in living cells
2015 StandoutScienceNobel
Inhibition of HIV-1 infection of primary CD4+ T-cells by gene editing of CCR5 using adenovirus-delivered CRISPR/Cas9
2015
Translational control of cytomegalovirus gene expression is mediated by upstream AUG codons
1988
Localization of an alpha-amanitin resistance mutation in the gene encoding the largest subunit of mouse RNA polymerase II.
1987
The transition of RNA polymerase II from initiation to elongation is associated with phosphorylation of the carboxyl-terminal domain of subunit IIa
1989
Extinction of the HPV18 upstream regulatory region in cervical carcinoma cells after fusion with non-tumorigenic human keratinocytes under non-selective conditions.
1991 StandoutNobel
Both VP2 and VP3 are synthesized from each of the alternative spliced late 19S RNA species of simian virus 40
1988
RNA Polymerase II Initiation Factor Interactions and Transcription Start Site Selection
1994 StandoutScienceNobel
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
CRISPR-Cas: biology, mechanisms and relevance
2016 StandoutNobel
Messenger RNA synthesis in mammalian cells is catalyzed by the phosphorylated form of RNA polymerase II.
1987
Alternative processing of RNA transcribed from NMYC.
1987 StandoutNobel
Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation.
1994
Regulation of apoptosis by the circadian clock through NF-κB signaling
2011 StandoutNobel
Cloning of a Subunit of Yeast RNA Oolymerase II Transcription Factor b and CTD Kinase
1992 StandoutScienceNobel
Effects of Intercistronic Length on the Efficiency of Reinitiation by Eucaryotic Ribosomes
1987
Photocrosslinking of 5-Iodouracil-Substituted RNA and DNA to Proteins
1993 ScienceNobel
Human RNA-specific adenosine deaminase ADAR1 transcripts possess alternative exon 1 structures that initiate from different promoters, one constitutively active and the other interferon inducible
1999
Expression of herpes simplex virus type 1 DNA polymerase gene by in vitro translation and effects of gene deletions on activity
1988
Sequence-specific RNA Recognition by the Xenopus Y-box Proteins
1995
Viruses in Human Cancers
1991 StandoutScienceNobel
Purification of the Xenopus laevis double-stranded RNA adenosine deaminase
1994
A profusion of controls.
1988
Cloning and sequence analysis of the mouse genomic locus encoding the largest subunit of RNA polymerase II.
1987
Architecture of RNA Polymerase II and Implications for the Transcription Mechanism
2000 StandoutScienceNobel
Antagonism of Catecholamine Receptor Signaling by Expression of Cytoplasmic Domains of the Receptors
1993 StandoutScienceNobel
Genetic analysis of the repetitive carboxyl-terminal domain of the largest subunit of mouse RNA polymerase II.
1988
Translational regulation of B19 parvovirus capsid protein production by multiple upstream AUG triplets.
1988
Structural Basis of Transcription: RNA Polymerase II at 2.8 Ångstrom Resolution
2001 StandoutScienceNobel
The scanning model for translation: an update.
1989 Standout
Mechanism of interferon action: functionally distinct RNA-binding and catalytic domains in the interferon-inducible, double-stranded RNA-specific adenosine deaminase
1996
Works of Kamel Khalili being referenced
RNA-directed gene editing specifically eradicates latent and prevents new HIV-1 infection
2014
Regulation of MCP-1 gene transcription by Smads and HIV-1 Tat in human glial cells
2003
Molecular mechanisms of necrosis in glioblastoma: The role of glutamate excitotoxicity
2009
Excision of HIV-1 DNA by gene editing: a proof-of-concept in vivo study
2016
Infectious agents and cancer: criteria for a causal relation
2004
Identification of a Sequence-specific Single-stranded DNA Binding Protein That Suppresses Transcription of the Mouse Myelin Basic Protein Gene
1995
Inhibition of IGF-I receptor in anchorage-independence attenuates GSK-3β constitutive phosphorylation and compromises growth and survival of medulloblastoma cell lines
2006
Nuclear factors in human brain cells bind specifically to the JCV regulatory region.
1988
Translational regulation of SV40 early mRNA defines a new viral protein
1987
A recombinant cDNA derived from human brain encodes a DNA binding protein that stimulates transcription of the human neurotropic virus JCV
1991
Actin mRNAs in HeLa cells
1984
Spacing between simian virus 40 early transcriptional control sequences is important for regulation of early RNA synthesis and gene expression
1986
Double-stranded RNA unwinding and modifying activity is detected ubiquitously in primary tissues and cell lines.
1990
Cell type-specific expression of JC virus early promoter is determined by positive and negative regulation
1989
Transcription of a human neurotropic virus promoter in glial cells: effect of YB-1 on expression of the JC virus late gene
1994
The gene encoding the large subunit of human RNA polymerase II.
1985
Double-Stranded RNA Unwinding and Modifying Activity Is Detected Ubiquitously in Primary Tissues and Cell Lines
1990