Citation Impact
Citing Papers
The Human Tim/Tipin Complex Coordinates an Intra-S Checkpoint Response to UV That Slows Replication Fork Displacement
2007 StandoutNobel
Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion
2015 StandoutScienceNobel
PARP inhibitors: Synthetic lethality in the clinic
2017 StandoutScience
Hallmarks of Cancer: The Next Generation
2011 Standout
MCPH1 Functions in an H2AX-dependent but MDC1-independent Pathway in Response to DNA Damage
2007
An Integrated Approach for Analysis of the DNA Damage Response in Mammalian Cells
2015 StandoutNobel
Protein Interactions of Phosphatase and Tensin Homologue (PTEN) and Its Cancer-associated G20E Mutant Compared by Using Stable Isotope Labeling by Amino Acids in Cell Culture-based Parallel Affinity Purification
2011
The DNA-damage response in human biology and disease
2009 StandoutNature
Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
2006 StandoutNature
Site-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structures
2006
Tipin-Replication Protein A Interaction Mediates Chk1 Phosphorylation by ATR in Response to Genotoxic Stress
2010 StandoutNobel
Regulation of PTEN Stability and Activity by Plk3
2010
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
2009 StandoutNature
Role for the p53 homologue p73 in E2F-1-induced apoptosis
2000 StandoutNatureNobel
AKT/PKB Signaling: Navigating Downstream
2007 Standout
Oncogenic kinase signalling
2001 StandoutNature
PARP inhibitor combination therapy
2016
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Cell-cycle checkpoints and cancer
2004 StandoutNature
Oxidative stress and gene regulation
2000
SQ/TQ cluster domains: concentrated ATM/ATR kinase phosphorylation site regions in DNA-damage-response proteins
2005
Cdk5rap2 exposes the centrosomal root of microcephaly syndromes
2011
Reconstitution of Human Claspin-mediated Phosphorylation of Chk1 by the ATR (Ataxia Telangiectasia-mutated and Rad3-related) Checkpoint Kinase
2009 StandoutNobel
The DNA Damage Response Kinases DNA-dependent Protein Kinase (DNA-PK) and Ataxia Telangiectasia Mutated (ATM) Are Stimulated by Bulky Adduct-containing DNA
2011 StandoutNobel
What primary microcephaly can tell us about brain growth
2006
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
2005 StandoutNature
Repeated Phosphopeptide Motifs in Human Claspin Are Phosphorylated by Chk1 and Mediate Claspin Function
2006
MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1–Cdc25 pathway
2011
Proliferation, cell cycle and apoptosis in cancer
2001 StandoutNature
Interactions of Human Mismatch Repair Proteins MutSα and MutLα with Proteins of the ATR-Chk1 Pathway
2009 StandoutNobel
Growth and folding of the mammalian cerebral cortex: from molecules to malformations
2014
The multilayered complexity of ceRNA crosstalk and competition
2014 StandoutNature
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
Antitumor activity of IFIX, a novel interferon-inducible HIN-200 gene, in breast cancer
2004
Claspin is phosphorylated in the Chk1-binding domain by a kinase distinct from Chk1
2008
Suppressor mutations in Mecp2 -null mice implicate the DNA damage response in Rett syndrome pathology
2020
E3 Ligase Nedd4 Promotes Axon Branching by Downregulating PTEN
2010
Formation of Arabidopsis Cryptochrome 2 Photobodies in Mammalian Nuclei
2013 StandoutNobel
The DNA Damage Response: Making It Safe to Play with Knives
2010 Standout
Human DNA damage response and repair deficiency syndromes: Linking genomic instability and cell cycle checkpoint proficiency
2009
Targeting RAS signalling pathways in cancer therapy
2003 Standout
Metabolic Regulation of Neocortical Expansion in Development and Evolution
2020
Phase transitions in the assembly of multivalent signalling proteins
2012 StandoutNature
Direct Role for the Replication Protein Treslin (Ticrr) in the ATR Kinase-mediated Checkpoint Response
2013 StandoutNobel
Chk2 Oligomerization Studied by Phosphopeptide Ligation
2008 StandoutNobel
Human Claspin Is a Ring-shaped DNA-binding Protein with High Affinity to Branched DNA Structures
2004 StandoutNobel
Taking the time to make important decisions: The checkpoint effector kinases Chk1 and Chk2 and the DNA damage response
2009
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4
2010
γH2AX and cancer
2008
A Role for the Deubiquitinating Enzyme USP28 in Control of the DNA-Damage Response
2006
Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells
2001
14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response
2009
Coupling of Human DNA Excision Repair and the DNA Damage Checkpoint in a Defined in Vitro System
2014 StandoutNobel
Cdc7-Dbf4 and the Human S Checkpoint Response to UVC
2007 StandoutNobel
DNA Damage Response: Three Levels of DNA Repair Regulation
2013
Regulation of Claspin degradation by the ubiquitin‐proteosome pathway during the cell cycle and in response to ATR‐dependent checkpoint activation
2006
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
2005 StandoutNature
Cerebral organoids model human brain development and microcephaly
2013 StandoutNature
The functions and regulation of the PTEN tumour suppressor
2012 Standout
WWP2 is an E3 ubiquitin ligase for PTEN
2011
Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases
2012 StandoutNobel
Chk1 is required to maintain Claspin stability
2006
TopBP1 Activates the ATR-ATRIP Complex
2006
Human Tim/Timeless-interacting Protein, Tipin, Is Required for Efficient Progression of S Phase and DNA Replication Checkpoint
2006
Cytoskeletal genes regulating brain size
2005
The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator
2012 StandoutNobel
Initiating Cellular Stress Responses
2004
The Rad9-Hus1-Rad1 Checkpoint Clamp Regulates Interaction of TopBP1 with ATR
2007
DNA Damage and Its Links to Neurodegeneration
2014
E2F-1 Potentiates Cell Death by Blocking Antiapoptotic Signaling Pathways
1999
Histone H2A.X Tyr142 phosphorylation: A novel sWItCH for apoptosis?
2009
Tethering DNA Damage Checkpoint Mediator Proteins Topoisomerase IIβ-binding Protein 1 (TopBP1) and Claspin to DNA Activates Ataxia-Telangiectasia Mutated and RAD3-related (ATR) Phosphorylation of Checkpoint Kinase 1 (Chk1)
2011 StandoutNobel
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
DNA Repair Synthesis and Ligation Affect the Processing of Excised Oligonucleotides Generated by Human Nucleotide Excision Repair
2014 StandoutNobel
Roles of Replication Fork-interacting and Chk1-activating Domains from Claspin in a DNA Replication Checkpoint Response
2005
Expression analysis of the autosomal recessive primary microcephaly genes MCPH1 (microcephalin) and MCPH5 (ASPM, abnormal spindle-like, microcephaly associated) in human malignant gliomas
1994
Reconstitution of a human ATR-mediated checkpoint response to damaged DNA
2007 StandoutNobel
Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling
2010 StandoutNobel
Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals
2022 StandoutScienceNobel
How neuroinflammation contributes to neurodegeneration
2016 StandoutScience
In Vitro Analysis of the Role of Replication Protein A (RPA) and RPA Phosphorylation in ATR-mediated Checkpoint Signaling
2012 StandoutNobel
Replication protein A: directing traffic at the intersection of replication and repair
2010
Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells
2006 StandoutNobel
ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage
2007 StandoutScience
Tipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in Xenopus egg extracts
2007 Nobel
DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system
2005
The role of the DNA damage response pathways in brain development and microcephaly: Insight from human disorders
2008
Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline
2010 StandoutNobel
Works of Kaiyi Li being referenced
mTOR Inhibitors Suppress Homologous Recombination Repair and Synergize with PARP Inhibitors via Regulating SUV39H1 in BRCA-Proficient Triple-Negative Breast Cancer
2015
Tyrosine phosphorylation of Shc proteins and formation of Shc/Grb2 complex correlate to the transformation of NIH3T3 cells mediated by the point-mutation activated neu.
1995
Microcephalin/MCPH1 Associates with the Condensin II Complex to Function in Homologous Recombination Repair
2008
BRIT1/MCPH1 Is Essential for Mitotic and Meiotic Recombination DNA Repair and Maintaining Genomic Stability in Mice
2010
Inhibition of Nuclear Factor-κB Activity Is Involved in E1A-mediated Sensitization of Radiation-induced Apoptosis
1997
BRIT1/MCPH1: A Guardian of Genome and an Enemy of Tumors
2006
Rak Functions as a Tumor Suppressor by Regulating PTEN Protein Stability and Function
2009
BRIT1/MCPH1 links chromatin remodelling to DNA damage response
2009
BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer
2006
BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1–Chk1 pathway, implicating checkpoint dysfunction in microcephaly
2005
Multiple Roles of BRIT1/MCPH1 in DNA Damage Response, DNA Repair, and Cancer Suppression
2010
BRUCE regulates DNA double-strand break response by promoting USP8 deubiquitination of BRIT1
2015
Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation
2004